Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Pharmacology & Pharmacy
Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu, Chii-Min Hwu
Summary: In patients with both type 2 diabetes mellitus and chronic obstructive pulmonary disease, the use of metformin is associated with a lower risk of cardiovascular disease, and the longer the duration of metformin use, the lower the risk. Further prospective studies are needed to verify these findings.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Ling Zheng, Ya-Lin Jiang, Jun Fei, Peng Cao, Chen Zhang, Guo-Fang Xie, Li-Xiang Wang, Wei Cao, Lin Fu, Hui Zhao
Summary: This study found that circulatory Cd concentration was increased in COPD patients, while serum miR-30 was reduced and inversely associated with pulmonary function. Furthermore, Cd exposure may lead to decreased miR-30 levels and promote EMT in COPD patients. This suggests that miR-30 reduction may play a role in Cd-induced COPD by contributing to pulmonary EMT.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Critical Care Medicine
Siddharth S. Madapoosi, Charmion Cruickshank-Quinn, Kristopher Opron, John R. Erb-Downward, Lesa A. Begley, Gen Li, Igor Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, David J. Couper, Christopher B. Cooper, Christine M. Freeman, MeiLan K. Han, Robert J. Kaner, Wassim Labaki, Fernando J. Martinez, Victor E. Ortega, Stephen P. Peters, Robert Paine, Prescott Woodruff, Jeffrey L. Curtis, Gary B. Huffnagle, Kathleen A. Stringer, Russell P. Bowler, Charles R. Esther, Nichole Reisdorph, Yvonne J. Huang
Summary: The study found that lung microbiota and metabolites are associated with clinical markers in patients with milder COPD, suggesting their potential collaborative roles in disease pathogenesis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Kulothungan Gunasekaran, Swetha Murthi, Kalaimani Elango, Mandeep Singh Rahi, Bright Thilagar, Sathishkumar Ramalingam, Dinesh Voruganti, Vijaya Kumar Paramasivam, Krishna Prasad Kolandaivel, Ashish Arora, Arul Chandran
Summary: Investigating the impact of diabetes on COPD patient outcomes during inpatient hospitalization revealed that patients with COPD and diabetes had longer hospital stays and higher risks of complications, but lower odds of mortality during hospitalization compared to COPD patients without diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Lorenzo Marinelli, Fabio Lanfranco, Giovanna Motta, Marco Zavattaro
Summary: Erectile dysfunction is a common issue in men with COPD, caused by various factors including hormonal imbalance, smoking, inflammation, endothelial dysfunction, chronic hypoxia, psychiatric disorders, and medications. This can significantly impact the quality of life for COPD patients, but healthcare providers often do not address sexual health concerns due to patients' reluctance to discuss intimate issues.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Fu-Shun Yen, James Cheng-Chung Wei, Yu-Cih Yang, Chih-Cheng Hsu, Chii-Min Hwu
Summary: This study found that in patients with both T2DM and COPD, the use of TZD is associated with increased risks of cardiovascular events, ventilation use, pneumonia, and lung cancer. The study suggests that monitoring for cardiovascular and respiratory complications should be implemented when using TZD in these patients.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Alejandro A. Diaz, Jose L. Orejas, Scott Grumley, Hrudaya P. Nath, Wei Wang, Wojciech R. Dolliver, Andrew Yen, Seth J. Kligerman, Kathleen Jacobs, Padma P. Manapragada, Mostafa Abozeed, Muhammad Usman Aziz, Mohd Zahid, Asmaa N. Ahmed, Nina L. Terry, Ruben San Jose Estepar, Victor Kim, Barry J. Make, MeiLan K. Han, Sushilkumar Sonavane, George R. Washko, Michael Cho, Raul San Jose Estepar
Summary: The presence of mucus plugs in patients with COPD is associated with increased all-cause mortality, as observed in this study.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Medicine, Research & Experimental
Michael C. Ferrera, Wassim W. Labaki, MeiLan K. Han
Summary: COPD is a common respiratory disorder with high morbidity and mortality, often underdiagnosed until clinical advancement. Research focuses on early changes for better diagnosis and identifying patients for early intervention. Treatment options have significantly expanded in the past 20 years with new medications and procedures.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Hematology
Peter G. Miller, Dandi Qiao, Joselyn Rojas-Quintero, Michael C. Honigberg, Adam S. Sperling, Christopher J. Gibson, Alexander G. Bick, Abhishek Niroula, Marie E. McConkey, Brittany Sandoval, Brian C. Miller, Weiwei Shi, Kaushik Viswanathan, Matthew Leventhal, Lillian Werner, Matthew Moll, Brian E. Cade, R. Graham Barr, Adolfo Correa, L. Adrienne Cupples, Sina A. Gharib, Deepti Jain, Stephanie M. Gogarten, Leslie A. Lange, Stephanie J. London, Ani Manichaikul, George T. O'Connor, Elizabeth C. Oelsner, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Vasan Ramachandran, Bing Yu, Lynette Sholl, Donna Neuberg, Siddhartha Jaiswal, Bruce D. Levy, Caroline A. Owen, Pradeep Natarajan, Edwin K. Silverman, Peter van Galen, Yohannes Tesfaigzi, Michael H. Cho, Benjamin L. Ebert
Summary: Somatic mutations in blood cells are associated with the development and severity of chronic obstructive pulmonary disease (COPD), independent of age and smoking.
Article
Medicine, General & Internal
Nam Eun Kim, Eun-Hwa Kang, Eunhee Ha, Ji-Young Lee, Jin Hwa Lee
Summary: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of developing lung cancer, and type 2 diabetes mellitus (T2DM) may also increase this risk.
FRONTIERS IN MEDICINE
(2023)
Article
Environmental Sciences
Veronica A. Wang, Petros Koutrakis, Longxiang Li, Man Liu, Carolina L. Z. Vieira, Brent A. Coull, Edward F. Maher, Choong-Min Kang, Eric Garshick
Summary: This study found that short-term exposure to indoor radioactive particles was associated with a reduction in pulmonary function in patients with chronic obstructive pulmonary disease (COPD). The harmful effects of radon exposure in residential areas on pulmonary function in COPD patients are a matter of concern.
ENVIRONMENTAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Rachida Rafiq, Floor E. Aleva, Jasmijn A. Schrumpf, Johannes M. Daniels, Pierre M. Bet, Wim G. Boersma, Paul Bresser, Michiel Spanbroek, Paul Lips, Tim J. van den Broek, Bart J. F. Keijser, Andre J. A. M. van der Ven, Pieter S. Hiemstra, Martin den Heijer, Renate T. de Jongh
Summary: This study assessed the effect of vitamin D supplementation on exacerbation rate in vitamin D-deficient patients with COPD. The results showed that vitamin D supplementation did not affect the exacerbation rate in COPD patients.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Critical Care Medicine
Bartolome R. Celli, Julie A. Anderson, Nicholas J. Cowans, Courtney Crim, Benjamin F. Hartley, Fernando J. Martinez, Andrea N. Morris, Holly Quasny, Julie Yates, Jorgen Vestbo, Peter M. A. Calverley
Summary: The study found that pharmacotherapy for chronic obstructive pulmonary disease can slow down the decline in lung function, with relative benefits similar to those reported for health status and exacerbations. Guidelines should be adjusted based on these findings.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Substance Abuse
Torri D. Metz, Gwendolyn A. McMillin, Robert M. Silver, Amanda A. Allshouse, Kennon Heard, Triniti L. Jensen, Erica M. Wymore, Elaine Stickrath, Christine Conageski, Gregory L. Kinney, Ingrid A. Binswanger
Summary: The study found a strong correlation between the frequency of maternal marijuana use in the last month of pregnancy and quantified umbilical cord THC-COOH. Earlier use can be measured by either quantitative urine or serum assay.
Article
Critical Care Medicine
Stefanie E. Mason, Rafael Moreta-Martinez, Wassim W. Labaki, Matthew J. Strand, Elizabeth A. Regan, Jessica Bon, Ruben San Jose Estepar, Richard Casaburi, Merry-Lynn McDonald, Harry B. Rossiter, Barry Make, Mark T. Dransfield, MeiLan K. Han, Kendra Young, Jeffrey L. Curtis, Kathleen Stringer, Greg Kinney, John E. Hokanson, Raul San Jose Estepar, George R. Washko
Summary: The longitudinal loss of fat-free mass (FFM) is associated with increased all-cause mortality, regardless of initial body composition metrics, including BMI or muscle mass. This finding may improve risk stratification and identify novel therapeutic targets for patients with chronic obstructive pulmonary disease.
Article
Endocrinology & Metabolism
Halis Kaan Akturk, Janet Snell-Bergeon, Gregory L. Kinney, Anagha Champakanath, Andrew Monte, Viral N. Shah
Summary: The study aimed to differentiate between diabetic ketoacidosis (DKA) and hyperglycemic ketosis due to cannabis hyperemesis syndrome (HK-CHS) in adults with type 1 diabetes. It was found that cannabis users had higher levels of pH and bicarbonate compared to non-users. A positive urine test result for cannabis could be used to predict the occurrence of HK-CHS.
Article
Public, Environmental & Occupational Health
Elizabeth C. Oelsner, Akshaya Krishnaswamy, Pallavi P. Balte, Norrina Bai Allen, Tauqeer Ali, Pramod Anugu, Howard F. Andrews, Komal Arora, Alyssa Asaro, R. Graham Barr, Alain G. Bertoni, Jessica Bon, Rebekah Boyle, Arunee A. Chang, Grace Chen, Sean Coady, Shelley A. Cole, Josef Coresh, Elaine Cornell, Adolfo Correa, David Couper, Mary Cushman, Ryan T. Demmer, Mitchell S. Elkind, Aaron R. Folsom, Amanda M. Fretts, Kelley P. Gabriel, Linda C. Gallo, Jose Gutierrez, Mei Lan K. Han, Joel M. Henderson, Virginia J. Howard, Carmen R. Isasi, David R. Jacobs, Suzanne E. Judd, Debora Kamin Mukaz, Alka M. Kanaya, Namratha R. Kandula, Robert C. Kaplan, Gregory L. Kinney, Anna Kucharska-Newton, Joyce S. Lee, Cora E. Lewis, Deborah A. Levine, Emily B. Levitan, Bruce D. Levy, Barry J. Make, Kimberly Malloy, Jennifer J. Manly, Carolina Mendoza-Puccini, Katie A. Meyer, Yuan-I Nancy Min, Matthew R. Moll, Wendy C. Moore, David Mauger, Victor E. Ortega, Priya Palta, Monica M. Parker, Wanda Phipatanakul, Wendy S. Post, Lisa Postow, Bruce M. Psaty, Elizabeth A. Regan, Kimberly Ring, Veronique L. Roger, Jerome Rotter, Tatjana Rundek, Ralph L. Sacco, Michael Schembri, David A. Schwartz, Sudha Seshadri, James M. Shikany, Mario Sims, Karen D. Hinckley Stukovsky, Gregory A. Talavera, Russell P. Tracy, Jason G. Umans, Ramachandran S. Vasan, Karol E. Watson, Sally E. Wenzel, Karen Winters, Prescott G. Woodruff, Vanessa Xanthakis, Ying Zhang, Yiyi Zhang
Summary: The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national prospective study comprising 14 established US cohort studies that aims to evaluate risk factors and outcomes of COVID-19, as well as assess the long-term societal and behavioral impact of the pandemic on health trajectories.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Endocrinology & Metabolism
Brianna F. Moore, Katherine A. Sauder, Allison L. B. Shapiro, Tessa Crume, Gregory L. Kinney, Dana Dabelea
Summary: The study assessed the impact of fetal exposure to cannabis on adiposity and glucose-insulin traits in early life. The results suggest that fetal exposure to cannabis may be associated with increased adiposity and fasting glucose in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Genetics & Heredity
Pierrick Wainschtein, Deepti Jain, Zhili Zheng, L. Adrienne Cupples, Aladdin H. Shadyab, Barbara McKnight, Benjamin M. Shoemaker, Braxton D. Mitchell, Bruce M. Psaty, Charles Kooperberg, Ching-Ti Liu, Christine M. Albert, Dan Roden, Daniel Chasman, Dawood Darbar, Donald M. Lloyd-Jones, Donna K. Arnett, Elizabeth A. Regan, Eric Boerwinkle, Jerome Rotter, Jeffrey R. O'Connell, Lisa R. Yanek, Mariza de Andrade, Matthew A. Allison, Merry-Lynn N. Mcdonald, Mina K. Chung, Myriam Fornage, Nathalie Chami, Nicholas L. Smith, Patrick T. Ellinor, Ramachandran S. Vasan, Rasika A. Mathias, Ruth J. F. Loos, Stephen S. Rich, Steven A. Lubitz, Susan R. Heckbert, Susan Redline, Xiuqing Guo, Y-D Ida Chen, Cecelia A. Laurie, Ryan D. Hernandez, Stephen T. McGarvey, Michael E. Goddard, Cathy C. Laurie, Kari E. North, Leslie A. Lange, Bruce S. Weir, Loic Yengo, Jian Yang, Peter M. Visscher
Summary: The analysis of whole-genome sequences of 25,465 individuals of European ancestry reveals that rare variants play a significant role in the heritability of height and body mass index.
Letter
Public, Environmental & Occupational Health
Yisha Li, Ran Dai, Yeongjin Gwon, Stephen Rennard, Barry J. Make, Dinah Foer, Matthew J. Strand, Erin Austin, Kendra A. Young, John E. Hokanson, Katherine A. Pratte, Rebecca Conway, Gregory L. Kinney
CLINICAL EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Abebaw M. Yohannes, Martino Belvederi Murri, Nicola A. Hanania, Elizabeth A. Regan, Anand Iyer, Surya P. Bhatt, Victor Kim, Gregory L. Kinney, Robert A. Wise, Michelle N. Eakin, Karin F. Hoth
Summary: This study used network analyses to examine the associations between symptoms of COPD, depression, and anxiety. The results showed that chest-tightness was related to acute anxiety, while cough and weakness were connected with core depressive symptoms. Chronic anxiety was linked with acute anxiety and depressive symptoms. Findings were confirmed after accounting for confounding factors.
RESPIRATORY MEDICINE
(2022)
Article
Medicine, General & Internal
Anurag Verma, Jennifer E. Huffman, Lina Gao, Jessica Minnier, Wen-Chih Wu, Kelly Cho, Yuk-Lam Ho, Bryan R. Gorman, Saiju Pyarajan, Nallakkandi Rajeevan, Helene Garcon, Jacob Joseph, John E. McGeary, Ayako Suzuki, Peter D. Reaven, Emily S. Wan, Julie A. Lynch, Jeffrey M. Petersen, James B. Meigs, Matthew S. Freiberg, Elise Gatsby, Kristine E. Lynch, Seyedeh Maryam Zekavat, Pradeep Natarajan, Sharvari Dalal, Darshana N. Jhala, Mehrdad Arjomandi, Robert A. Bonomo, Trevor K. Thompson, Gita A. Pathak, Jin J. Zhou, Curtis J. Donskey, Ravi K. Madduri, Quinn S. Wells, Joel Gelernter, Rose D. L. Huang, Renato Polimanti, Kyong-Mi Chang, Katherine P. Liao, Philip S. Tsao, Yan Sun, Peter W. F. Wilson, Christopher J. O'Donnell, Adriana M. Hung, J. Michael Gaziano, Richard L. Hauger, Sudha K. Iyengar, Shiuh-Wen Luoh
Summary: This genetic association study indicates that sickle cell trait (SCT) is associated with preexisting kidney comorbidities, increased COVID-19 mortality, and kidney morbidity.
JAMA INTERNAL MEDICINE
(2022)
Review
Respiratory System
Patricia M. Bamonti, Stephanie A. Robinson, Emily S. Wan, Marilyn L. Moy
Summary: This paper reviews research conducted with US Veteran samples targeting improvement in COPD outcomes, focusing on key physiological, physical, and psychological health outcomes and intervention research. Despite the efforts made by the VHA to improve the condition of Veterans with COPD, it remains a significant health issue for them.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Letter
Critical Care Medicine
Emily S. Wan, Anurag Verma, Jessica Minnier, Shiuh-Wen Luoh, Sudha K. Iyengar
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Patricia M. Bamonti, Christine Perndorfer, Stephanie A. Robinson, Maria A. Mongiardo, Emily S. Wan, Marilyn L. Moy
Summary: US Veterans with high rates of chronic obstructive pulmonary disease (COPD) often suffer from depression symptoms which can hinder the effectiveness of technology-based interventions promoting physical activity. This study analyzed data from two cohorts of US veterans and found that greater depression symptoms were associated with less improvement in daily step count, and individuals with cognitive-affective symptoms of depression showed no improvement in daily step count when assigned to the intervention group.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Emily S. Wan, Jamaica Plain
Article
Medicine, General & Internal
Yisha Li, Sarah J. Schmiege, Heather Anderson, Nicole E. Richmond, Kendra A. Young, John E. Hokanson, Stephen I. Rennard, Tessa L. Crume, Erin Austin, Katherine A. Pratte, Rebecca Conway, Gregory L. Kinney
Summary: This study aimed to assess the medication patterns for multiple chronic diseases in COPD patients and explore if the patterns are similar between phase 1 and phase 2. The study found four medication patterns at both phases, and the medication patterns were similar between the two phases.
MEDICINA-LITHUANIA
(2023)
Article
Endocrinology & Metabolism
Halis Kaan Akturk, Janet Snell-Bergeon, Gregory L. Kinney, Anagha Champakanath, Andrew Monte, Viral N. Shah
Summary: The study found that cannabis users had significantly higher pH and bicarbonate levels compared to non-users, and the accuracy of predicting HK-CHS with a positive cannabis urine test result was high.