Do GLP-1-Based Therapies Increase Cancer Risk?

Insulin therapy and cancer risk in diabetes mellitus

(2013) J. Platts   CLINICAL MEDICINE

Predictors of Emergency Department and Outpatient Visits for Hypoglycemia in Type 2 Diabetes: An Analysis of a Large US Administrative Claims Database

(2012) J. C. Simeone et al.   ANNALS OF PHARMACOTHERAPY

Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12DMouse Model

(2012) Belinda Gier et al.   DIABETES

The Human GLP-1 Analog Liraglutide and the Pancreas

(2012) Niels C.B. Nyborg et al.   DIABETES

Relative risk of acute pancreatitis in initiators of exenatide twice daily compared with other anti-diabetic medication: a follow-up study

(2012) M. Wenten et al.   DIABETIC MEDICINE

Unleashing the Mini-Sentinel

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

The organizational structure and governing principles of the Food and Drug Administration's Mini-Sentinel pilot program

(2012) Susan Forrow et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Rapid Tachyphylaxis of the Glucagon-Like Peptide 1-Induced Deceleration of Gastric Emptying in Humans

(2011) M. A. Nauck et al.   DIABETES

A cohort study of acute pancreatitis in relation to exenatide use

(2011) D. D. Dore et al.   DIABETES OBESITY & METABOLISM

Pancreatitis, Pancreatic, and Thyroid Cancer With Glucagon-Like Peptide-1–Based Therapies

(2011) Michael Elashoff et al.   GASTROENTEROLOGY

GLP-1–Based Therapies: The Dilemma of Uncertainty

(2011) Joachim Spranger et al.   GASTROENTEROLOGY

Detection bias and the association between inflammatory bowel disease andSalmonellaandCampylobacterinfection

(2011) Mark S Riddle et al.   GUT

GLP-1 and Calcitonin Concentration in Humans: Lack of Evidence of Calcitonin Release from Sequential Screening in over 5000 Subjects with Type 2 Diabetes or Nondiabetic Obese Subjects Treated with the Human GLP-1 Analog, Liraglutide

(2011) Laszlo Hegedüs et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glucagon Like Peptide-1 Receptor Expression in the Human Thyroid Gland

(2011) Belinda Gier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Incretin Receptors in Non-Neoplastic and Neoplastic Thyroid C Cells in Rodents and Humans: Relevance for Incretin-Based Diabetes Therapy

(2011) Beatrice Waser et al.   NEUROENDOCRINOLOGY

Acute Pancreatitis in Type 2 Diabetes Treated With Exenatide or Sitagliptin: A retrospective observational pharmacy claims analysis

(2010) R. Garg et al.   DIABETES CARE

Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation

(2010) Lotte Bjerre Knudsen et al.   ENDOCRINOLOGY

Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis

(2010) S. S. Engel et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

A potential competition bias in the detection of safety signals from spontaneous reporting databases

(2010) Antoine Pariente et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide

(2009) David D. Dore et al.   CURRENT MEDICAL RESEARCH AND OPINION

Glucagon-Like Peptide-1 Receptor Activation Modulates Pancreatitis-Associated Gene Expression But Does Not Modify the Susceptibility to Experimental Pancreatitis in Mice

(2009) J. A. Koehler et al.   DIABETES

Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With Metformin

(2009) A. V. Matveyenko et al.   DIABETES

Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?

(2009) P. C. Butler et al.   DIABETOLOGIA

Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas

(2009) J. S. Nachnani et al.   DIABETOLOGIA

Pancreatic Duct Glands Are Distinct Ductal Compartments That React to Chronic Injury and Mediate Shh-Induced Metaplasia

(2009) Oliver Strobel et al.   GASTROENTEROLOGY

GLP-1: Broadening the incretin concept to involve gut motility

(2009) Per M. Hellström   REGULATORY PEPTIDES

Identifying patterns of adverse event reporting for four members of the angiotensin II receptor blockers class of drugs: revisiting the Weber effect

(2008) Mara A. McAdams et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY