Article
Cardiac & Cardiovascular Systems
Julia Binder, Pilar Palmrich, Erkan Kalafat, Petra Pateisky, Ebru Oeztuerk, Johanna Mittelberger, Asma Khalil
Summary: This study evaluated the predictive value of the sFlt-1/PlGF ratio in women with chronic hypertension for delivery due to superimposed preeclampsia, finding that angiogenic imbalance can predict delivery related to superimposed preeclampsia and is associated with a significantly shorter time to delivery interval.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Keiko Azuma, Atsushi Okubo, Takafumi Suzuki, Nozomi Igarashi, Yoko Nomura, Hirotsugu Soga, Hiroshi Murata, Ryosuke Fujino, Asako Ogawa, Haruka Matsui, Takeshi Nagamatsu, Takayuki Iriyama, Ryo Asaoka, Tatsuya Inoue, Maiko Maruyama-Inoue, Kazuaki Kadonosono, Ryo Obata
Summary: Anatomical differences in choroidal structure between pregnant women in the first trimester and healthy nonpregnant women were investigated using EDI-OCT and choroidal binarization analysis. The study identified a significant correlation between a larger choroidal luminal area and higher systolic blood pressure, particularly in the first trimester of pregnancy.
SCIENTIFIC REPORTS
(2021)
Review
Obstetrics & Gynecology
Stefan Verlohren, Lisa-Antonia Droege
Summary: The definition of preeclampsia is changing to include organ symptoms alongside hypertension in pregnancy, rather than relying solely on proteinuria. Angiogenic and antiangiogenic factors have emerged as important tools for predicting and diagnosing preeclampsia with high accuracy. This review highlights their central role in the differential diagnosis of high-risk women and their ability to predict preeclampsia-associated adverse outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Susana Vazquez, Julio Pascual, Xavier Duran-Jorda, Jose Luis Hernandez, Marta Crespo, Anna Oliveras
Summary: This study aimed to find the best predictor of preeclampsia (PE) and explore if it differs among women with and without hypertension. The study found that in the first trimester of pregnancy, mean blood pressure was the best predictor of PE in normotensive women, while renal parameters were the strongest predictors in women with chronic hypertension. Additionally, office blood pressure was non-inferior to 24-hour ambulatory blood pressure in predicting PE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Sunitha Suresh, Easha Patel, Ariel Mueller, Jessica Morgan, Whitney Lynn Lewandowski, Stefan Verlohren, Peter von Dadelszen, Laura A. Magee, Sarosh Rana
Summary: Hypertension complicates a significant percentage of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This study aimed to evaluate the prognostic value of the soluble fms-like tyrosine kinase-1/placental growth factor ratio in women with suspected preeclampsia who have already met the diagnostic criteria. The findings suggest that this ratio is associated with an increased risk of developing preeclampsia with severe features.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Physiology
Marcelo R. Luizon, Izabela M. C. A. Conceicao, Sarah Viana-Mattioli, Mayara Caldeira-Dias, Ricardo C. Cavalli, Valeria C. Sandrim
Summary: This study analyzed the expression profiles of circulating miRNAs in the plasma of pregnant women in the second trimester, identifying 23 upregulated miRNAs, with only miR-204-5p showing statistical significance as a potential predictive biomarker for the early development of PE. The target genes of miR-204-5p were found to be related to known pathophysiological pathways in PE, suggesting its potential role in the pathophysiology of the disease.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Nicoline Callesen Do, Marianne Vestgaard, Bjorg Asbjornsdottir, Lise Lotte Torvin Andersen, Dorte Moller Jensen, Lene Ringholm, Peter Damm, Elisabeth Reinhardt Mathiesen
Summary: In women with preexisting diabetes, both home blood pressure and office blood pressure are positively associated with the development of preeclampsia, and their predictive abilities are comparable. Home blood pressure is lower than office blood pressure in both early and late pregnancy, and the difference increases with increasing office blood pressure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Satoshi Shinohara, Tatsuya Yoshihara, Kana Mochizuki, Genki Yasuda, Mayuko Kasai, Rei Sunami
Summary: This study developed a prediction model for PE targeting the Japanese population, providing obstetricians with a tool to educate women about the specific prospect of PE development.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Environmental Sciences
Yi Zheng, Thomas McElrath, David Cantonwine, Hui Hu
Summary: This study aimed to investigate the longitudinal associations between ambient air pollution exposure and angiogenic factors in pregnant women. The results showed that exposures to PM2.5 during early pregnancy and to O3 and NO2 during late pregnancy were associated with increased sFlt-1/PlGF ratio, elevated sFlt-1, and decreased PlGF, which may contribute to adverse pregnancy and birth outcomes.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Immunology
Courtney Lynn Schubert, Kamran Yusuf
Summary: This study compared the serum levels of related factors in smoking and non-smoking pregnant women and found that TGF-β1 levels were significantly higher in smoking mothers, which may help explain the lower risk of preeclampsia in smoking mothers.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Madalina Nicoleta Nan, Alvaro Garcia-Osuna, Josefina Mora, Cristina Trilla, Assumpta Antonijuan, Vanesa Orantes, Monica Cruz-Lemini, Francisco Blanco-Vaca, Elisa Llurba
Summary: Algorithms for first-trimester prediction of pre-eclampsia lack sensitivity for predicting late-onset pre-eclampsia and other placental complications. This study aimed to assess the screening performance of biomarkers in the prediction of adverse obstetric outcomes related to placental insufficiency. PlGF, sFlt-1, NT-proBNP, and uric acid measurements combined with maternal factors improved the prediction of complications.
Article
Genetics & Heredity
Yunyun Liu, Xiaosha Jing, Lingling Xing, Sha Liu, Jianlong Liu, Jing Cheng, Cechuan Deng, Ting Bai, Tianyu Xia, Xiang Wei, Yuan Luo, Quanfang Zhou, Qian Zhu, Hongqian Liu
Summary: The study assessed the clinical application of NIPS in low-risk pregnant women, revealing that SCA were more common than autosomal trisomy, and EICF was the most frequent USM but least predictive. Further evaluation is suggested for low-risk pregnant women with specific USMs.
FRONTIERS IN GENETICS
(2021)
Article
Obstetrics & Gynecology
Julia Binder, Erkan Kalafat, Pilar Palmrich, Petra Pateisky, Asma Khalil
Summary: Maternal serum angiogenic markers, specifically soluble fms-like tyrosine kinase 1 and placental growth factor, show high predictive accuracy in determining adverse maternal and perinatal outcomes for women with chronic hypertension. Repeated measurements of the soluble fms-like tyrosine kinase-1 to placental growth factor ratio provide better predictive accuracy compared to a single measurement alone. Implementing angiogenic markers in clinical management guidelines for pregnant women with chronic hypertension is recommended based on the study findings.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Hua Zou, Wei Zou, Qian Li, Zhen Chen, Yuanju Shi, Chunli Li
Summary: Recent studies have shown that gut fungi play a crucial role in many noninfectious inflammatory diseases, but their role in the pathogenesis of preeclampsia remains unclear. In this study, the gut mycobiota of preeclampsia, pregnancy with chronic hypertension, and normal pregnancy groups were compared using internal transcribed spacer sequencing. The results revealed changes in the gut mycobiota in the third trimester of pregnant women with preeclampsia. Additionally, the correlation analysis indicated a positive correlation between Candida spp. and glycerophosphocholine, which was significantly increased in preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Mingxi Liu, Yue Niu, Kongyang Ma, Peter C. K. Leung, Zi-Jiang Chen, Daimin Wei, Yan Li
Summary: Novel first-trimester serum biomarkers were identified and an effective prediction model for preeclampsia (PE) was developed using immune-related factors and placental growth factor (PlGF), which could aid in the development of early diagnostic strategies for PE and provide new insights into its immunological mechanisms.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Ophthalmology
Ravilla D. Ravindran, Periasamy Sundaresan, Tiruvengada Krishnan, Praveen Vashist, Giovanni Maraini, Vijayan Saravanan, Usha Chakravarthy, Liam Smeeth, Dorothea Nitsch, Ian S. Young, Astrid E. Fletcher
BRITISH JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Nutrition & Dietetics
Claire Casey, Jayne Woodside, Ann McGinty, Ian S. Young, Jennifer McPeake, Usha Chakravarthy, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Jesus Vioque, A. E. Fletcher
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Endocrinology & Metabolism
P. K. Thaware, C. C. Patterson, I. S. Young, C. Casey, D. R. McCance
Article
Cell Biology
Giovanni Fiorito, Cathal McCrory, Oliver Robinson, Cristian Carmeli, Carolina Ochoa Rosales, Yan Zhang, Elena Colicino, Pierre-Antoine Dugue, Fanny Artaud, Gareth J. Mckay, Ayoung Jeong, Pashupati P. Mishra, Therese H. Nost, Vittorio Krogh, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Domenico Palli, Giuseppe Matullo, Simonetta Guarrera, Martina Gandini, Murielle Bochud, Emmanouil Dermitzakis, Taulant Muka, Joel Schwartz, Pantel S. Vokonas, Allan Just, Allison M. Hodge, Graham G. Giles, Melissa C. Southey, Mikko A. Hurme, Ian Young, Amy Jayne McKnight, Sonja Kunze, Melanie Waldenberger, Annette Peters, Lars Schwettmann, Eiliv Lund, Andrea Baccarelli, Roger L. Milne, Rose A. Kenny, Alexis Elbaz, Hermann Brenner, Frank Kee, Trudy Voortman, Nicole Probst-Hensch, Terho Lehtimaki, Paul Elliot, Silvia Stringhini, Paolo Vineis, Silvia Polidoro, Jan Alberts, Harri Alenius, Mauricio Avendano, Valeria Baltar, Mel Bartley, Henrique Barros, Michele Bellone, Eloise Berger, David Blane, Murielle Bochud, Giulia Candiani, Cristian Carmeli, Luca Carra, Raphaele Castagne, Marc Chadeau-Hyam, Sergio Cima, Francoise Clavel-Chapelon, Giuseppe Costa, Emilie Courtin, Cyrille Delpierre, Angelo D'Errico, Manolis, Dermitzakis, Pierre-Antoine Dugue, Marko Elovainio, Paul Elliott, Guy Fagherazzi, Giovanni Fiorito, Silvia Fraga, Martina Gandini, Valerie Gares, Pascale Gerbouin-Rerolle, Graham Giles, Marcel Goldberg, Dario Greco, Idris Guessous, Jose Haba-Rubio, Raphael Heinzer, Allison Hodge, Stephane Joost, Maryam Karimi, Michelle Kelly-Irving, Mika Kahonen, Piia Karisola, Leyla Khenissi, Mika Kivimaki, Vittorio Krogh, Jessica Laine, Thierry Lang, Audrey Laurent, Richard Layte, Benoit Lepage, Dori Lorsch, Frances MacGuire, Giles Machell, Johan Mackenbach, Michael Marmot, Carlos de Mestral, Cathal McCrory, Cynthia Miller, Roger Milne, Peter Muennig, Wilma Nusselder, Salvatore Panico, Dusan Petrovic, Lourdes, Pilapil, Silvia Polidoro, Martin Preisig, Laura Pulkki-Raback, Olli Raitakari, Ana Isabel Ribeiro, Fulvio Ricceri, Paolo Recalcati, Erica Reinhard, Oliver Robinson, Jose Rubio Valverde, Severine Saba, Carlotta Sacerdote, Frank Santegoets, Roberto Satolli, Terrence Simmons, Gianluca Severi, Martin J. Shipley, Silvia Stringhini, Adam Tabak, Vesa Terhi, Joannie Tieulent, Rosario Tumino, Salvatore Vaccarella, Federica Vigna-Taglianti, Paolo Vineis, Peter Vollenweider, Nicolas Vuilleumier, Marie Zins
Article
Nutrition & Dietetics
Karen Mullan, Lesley Hamill, Katy Doolan, Ian Young, Peter Smyth, Albert Flynn, Janette Walton, Andrew A. Meharg, Manus Carey, Claire McKernan, Marcia Bell, Neil Black, Una Graham, David McCance, Cathy McHugh, Paul McMullan, Siobhan McQuaid, Aonghus O'Loughlin, Antoinette Tuthill, Sarah C. Bath, Margaret Rayman, Jayne Woodside
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Nutrition & Dietetics
Helen J. Wallace, Lauren Holmes, Cieran N. Ennis, Christopher R. Cardwell, Jayne V. Woodside, Ian S. Young, Patrick M. Bell, Steven J. Hunter, Michelle C. McKinley
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Ophthalmology
Paul McCann, Ruth E. Hogg, David M. Wright, Bernadette McGuinness, Ian S. Young, Frank Kee, Augusto Azuara-Blanco
Article
Nutrition & Dietetics
Amy Wotherspoon, Sarah Elshahat, Nicholas McAlinden, Katrina Dean, Ian S. Young, Peter C. Sharpe, Stefan Blankenburg, Chris C. Patterson, Michelle C. McKinley, Alun Evans, Jayne Woodside
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2020)
Article
Water Resources
Natalia V. de Moraes, Manus Carey, Charlotte E. Neville, Sharon Cruise, Bernadette McGuinness, Frank Kee, Ian S. Young, Jayne V. Woodside, Andrew A. Meharg
EXPOSURE AND HEALTH
(2020)
Article
Ophthalmology
Paul McCann, Ruth Hogg, David M. Wright, Sara Pose-Bazarra, Usha Chakravarthy, Tunde Peto, Sharon Cruise, Bernardette McGuinness, Ian S. Young, Frank Kee, Augusto Azuara-Blanco
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Medical Laboratory Technology
Kelly-Ann Eastwood, Alyson J. Hunter, Christopher C. Patterson, David R. Mc Cance, Ian S. Young, Valerie A. Holmes
ANNALS OF CLINICAL BIOCHEMISTRY
(2020)
Article
Nutrition & Dietetics
Alyson J. Hill, C. C. Patterson, I. S. Young, V. A. Holmes, D. R. McCance
Summary: This study explored the relationships between carbohydrate intake, BMI, and glycaemic control in pregnant women with type 1 diabetes. The findings suggest that the average quantity of dietary carbohydrate influences HbA1c, while BMI has less impact. Additionally, differences were observed in fibre and glycaemic index in relation to glycaemic control.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Ophthalmology
Nicola B. Quinn, David H. Steel, Usha Chakravarthy, Tunde Peto, Barbra Hamill, Alyson Muldrew, Katie Graham, David Elliott, Riona Hennessy, Sharon Cruise, Bernadette McGuinness, Ian S. Young, Frank Kee, Ruth E. Hogg
OPHTHALMOLOGY RETINA
(2020)
Article
Cardiac & Cardiovascular Systems
Gavin Robertson, Alan Fleming, Michelle Claire Williams, Emanuele Trucco, Nicola Quinn, Ruth Hogg, Gareth J. Mckay, Frank Kee, Ian Young, Enrico Pellegrini, David E. Newby, Edwin J. R. van Beek, Tunde Peto, Baljean Dhillon, Jano van Hemert, Thomas J. MacGillivray