Novel Soy Germ Pasta Enriched in Isoflavones Ameliorates Gastroparesis in Type 2 Diabetes A pilot study

OBJECTIVETo determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis.RESEARCH DESIGN AND METHODSThis randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t(1/2)) was measured using the [C-13]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load.RESULTSSoy germ pasta significantly accelerated the t(1/2) in these patients (161.2 17.5 min at baseline vs. 112.6 +/- 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 +/- 24.2 vs. 156.2 +/- 27.4 min), without affecting glucose or insulin concentrations.CONCLUSIONSThese findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy.