Article
Endocrinology & Metabolism
Marga A. G. Helmink, Marieke de Vries, Frank L. J. Visseren, Wendela L. de Ranitz, Harold W. de Valk, Jan Westerink
Summary: This prospective cohort study found that insulin resistance measured by eGDR is associated with cardiovascular events, vascular interventions, and mortality in individuals with type 1 diabetes, and high eGDR levels are independently associated with lower risks of these outcomes. Therefore, modifying insulin resistance through lifestyle interventions or pharmacological treatments could be a promising therapeutic target to reduce the risk of cardiovascular disease in this population.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Anastasios Mangelis, Nikolaos Fountoulakis, Antonella Corcillo, Julian Collins, Prashant Vas, Sufyan Hussain, David Hopkins, Luigi Gnudi, Stephen Thomas, Salma Ayis, Janaka Karalliedde
Summary: African Caribbean ethnicity is associated with an increased risk of kidney function decline in individuals with type 1 diabetes, independent of other risk factors.
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Endocrinology & Metabolism
Phoebe Loxton, Kruthika Narayan, Craig F. Munns, Maria E. Craig
Summary: This study found abnormal bone development and reduced bone mineral density in youth with type 1 diabetes through systematic review and meta-analysis using multiple modalities. Routine assessment of bone mineral density should be considered for all youth with type 1 diabetes.
Article
Endocrinology & Metabolism
Xiaodie Mu, Aihua Wu, Huiyue Hu, Hua Zhou, Min Yang
Summary: This study compared the performance of QRISK3 and FRS as cardiovascular disease (CVD) risk assessment tools in T2DM patients and found that QRISK3 was able to comprehensively and accurately predict the risk of CVD events in these patients compared to FRS. However, larger studies are needed to further validate the predictive ability of QRISK3.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Michael C. Riddell, Anne L. Peters
Summary: Regular physical activity has numerous benefits for individuals with type 1 diabetes mellitus, but careful management of blood glucose levels is necessary.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Endocrinology & Metabolism
Minghao Chen, Rui Hu, Cristina Cavinato, Zhenwu W. Zhuang, Jiasheng Zhang, Sanguk Yun, Pablo Fernandez Tussy, Abhishek Singh, Sae-Il Murtada, Keiichiro Tanaka, Min Liu, Carlos Fernandez-Hernando, Jay D. Humphrey, Martin A. Schwartz
Summary: Vascular complications are a major cause of illness and death in patients with type 1 diabetes. Fibronectin (FN) signaling through integrin alpha 5 is a major contributor to diabetic vascular disease, but not through its interaction with PDE4D.
Article
Endocrinology & Metabolism
Zhigao Song, Cong Chen, Jipei He, Bixia Liu, Weidong Ji, Liangping Wu, Li He
Summary: This study found that AIP1 plays a crucial role in the development of type 2 diabetes. It regulates the expression of TNF-alpha through multiple inflammatory pathways. AIP1 deficiency leads to increased inflammatory factors and impairs glucose uptake. The loss of AIP1 in human adipocytes activates the JNK, p38 MAPK, and ERK1/2 signaling pathways, and inhibition of these pathways can alleviate insulin resistance caused by AIP1 deficiency.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ji Hye Huh, Eun Roh, Seong Jin Lee, Sung-Hee Ihm, Kyung-Do Han, Jun Goo Kang
Summary: This retrospective, longitudinal study demonstrated that high levels of remnant cholesterol are associated with an increased risk of incident type 2 diabetes (T2D), particularly in individuals without traditional T2D risk factors and metabolic abnormalities. These findings suggest that remnant cholesterol profiles provide additional information in predicting future progression of T2D, independent of conventional lipid parameters.
Article
Medicine, General & Internal
Katsuhiro Ono, Sadahiko Uchimoto, Masamune Miyazaki, Natsuki Honda, Katsuhito Mori, Tomoaki Morioka, Takumi Imai, Tetsuo Shoji, Masanori Emoto
Summary: This study revealed that complete right bundle branch block (CRBBB) in patients with type 2 diabetes mellitus (T2DM) was associated with an increased risk of cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Catherine Pihoker, Barbara H. Braffett, Thomas J. Songer, William H. Herman, Melinda Tung, Shihchen Kuo, Anna Bellatorre, Elvira Isganaitis, Elizabeth T. Jensen, Jasmin Divers, Ping Zhang, David M. Nathan, Kimberly Drews, Dana Dabelea, Philip S. Zeitler
Summary: This study found that lack of health care coverage and an established source of diabetes care were associated with higher glycated hemoglobin levels for individuals with type 1 diabetes, but the results were inconsistent for individuals with type 2 diabetes. Increased access to diabetes care, such as through Medicaid expansion, may be associated with improved health outcomes. Additional strategies are needed for individuals with type 2 diabetes.
Article
Endocrinology & Metabolism
Gemma Llaurado, Nuria Amigo, Rocio Fuertes-Martin, Ana Romero, Albert Cano, Lara Albert, Olga Gimenez-Palop, Eugenio Berlanga, Sonia Fernandez-Veledo, Xavier Correig, Joan Vendrell, Jose-Miguel Gonzalez-Clemente
Summary: This study evaluated the utility of measuring serum GlycA and GlycB to assess vascular aging in adults with type 1 diabetes (T1D) of more than 10 years duration and no previous cardiovascular events. The results showed that GlycA and GlycB were positively correlated with the surrogate measure of arterial stiffness (aPWV) and independently associated with aPWV. Therefore, measuring serum GlycA and GlycB may be helpful in assessing vascular aging in adults with T1D.
Article
Multidisciplinary Sciences
Natasa Grulovic, Martina Rojnic Kuzman, Maja Baretic
Summary: This study evaluated the prevalence and identified the predictors of diabetes-related distress in adults with T1DM in Croatia. It found that 36% of participants experienced high diabetes-related distress, with higher HbA1c levels and the presence of microvascular complications being significant predictors. Worry about the future and chronic complications, as well as guilt when off-track with diabetes management, were identified as the main contributors to distress.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Emanuela Orsi, Anna Solini, Enzo Bonora, Martina Vitale, Monia Garofolo, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Gianpaolo Zerbini, Antonio Nicolucci, Giuseppe Pugliese
Summary: The presence and grade of diabetic retinopathy (DR) can predict all-cause mortality in individuals with type 2 diabetes mellitus, independent of cardiovascular disease (CVD) and other complications. The risk of death is higher in patients with advanced DR, especially proliferative DR. However, the impact of DR is more significant in patients without diabetic kidney disease (DKD) or CVD.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anna Syreeni, Emma H. Dahlstrom, Stefanie Hagg-Holmberg, Carol Forsblom, Marika I. Eriksson, Valma Harjutsalo, Jukka Putaala, Per-Henrik Groop, Niina Sandholm, Lena M. Thorn
Summary: This study aimed to investigate the relationship between the haptoglobin Hp1/2 genotype and stroke in individuals with type 1 diabetes. The results showed that the haptoglobin genotypes had no association with the risk of stroke or survival after stroke in this cohort.
Letter
Endocrinology & Metabolism
Erika B. Parente, Stefan Mutter, Lena M. Thorn, Valma Harjutsalo, Per-Henrik Groop
Article
Endocrinology & Metabolism
Patrik Smidtslund, Fanny Jansson Sigfrids, Anni Ylinen, Nina Elonen, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn
Summary: This study aims to investigate the prognosis after a first-ever myocardial infarction (MI) in individuals with type 1 diabetes and how different MI- and diabetes-related factors affect the prognosis and risk of secondary cardiovascular events. The study found that individuals with type 1 diabetes have a high cardiovascular and diabetes-related mortality after their first-ever MI, and poor kidney function is associated with high mortality and excessive risk of secondary cardiovascular events.
Article
Endocrinology & Metabolism
Meghan E. Pauley, Carissa Vinovskis, Alexis MacDonald, Madison Baca, Laura Pyle, R. Paul Wadwa, Alessia Fornoni, Kristen J. Nadeau, Meda Pavkov, Robert G. Nelson, Daniel Gordin, Ian H. de Boer, Kalie L. Tommerdahl, Petter Bjornstad
Summary: This study found that elevated triglycerides in youth with type 1 diabetes (T1D) are associated with kidney disease development and progression, and the distribution of triglycerides across lipoprotein subclasses can predict kidney dysfunction in adults. Little is known about these relationships in youth.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Genetics & Heredity
Niina Sandholm, Ronja Hotakainen, Jani K. Haukka, Fanny Jansson Sigfrids, Emma H. Dahlstrom, Anni A. Antikainen, Erkka Valo, Anna Syreeni, Elina Kilpelainen, Anastasia Kytola, Aarno Palotie, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop
Summary: The study identified variants associated with lipoproteins and lipids, as well as rare loss-of-function protein-altering variants, suggesting novel therapeutic targets for preventing cardiovascular disease.
Correction
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
Summary: This study investigated the association between long-term glycemic variability and arterial stiffness in patients with type 1 diabetes. The results showed that the variability of HbA1c was significantly correlated with arterial stiffness. Importantly, this association was independent of the HbA1c mean.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo, Raija Lithovius, Sinnakaruppan Mathavan, Markku Lehto, Timo P. Hiltunen, Kimmo K. Kontula, Per-Henrik Groop
Summary: This study investigated the effect of L-type calcium channel blockers (LTCCBs) on VEGF concentrations in retinal cells and human serum, and evaluated the association between LTCCB usage and risk of severe diabetic eye disease (SDED). The results showed that LTCCBs increase VEGF concentrations in retinal cells and human serum, but they are not associated with the risk of SDED in adults with type 1 diabetes.
Article
Endocrinology & Metabolism
Aleksi Tarkkonen, Tor-Bjorn Claesson, Marika I. Eriksson, Carol Forsblom, Lena M. Thorn, Paula Summanen, Per-Henrik Groop, Jukka Putaala, Daniel Gordin, Juha Martola
Summary: Using magnetic resonance imaging, we found that the optic tracts of individuals with type 1 diabetes were smaller than those of healthy controls, suggesting that chronic hyperglycemia also damages the optic tract. This damage was associated with various metabolic measures as well as diabetic complications such as eye disease, kidney disease, neuropathy, and cerebral microbleeds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Rim Bouslama, Vincent Dumont, Sonja Lindfors, Lassi Paavolainen, Jukka Tienari, Harry Nisen, Tuomas Mirtti, Moin A. Saleem, Daniel Gordin, Per-Henrik Groop, Shiro Suetsugu, Sanna Lehtonen
Summary: Changes in the podocytes, the glomerular epithelial cells, can lead to kidney dysfunction. The phosphorylation of PACSIN2 at serine 313 (S313) is increased in the glomeruli of rats with diabetic kidney disease, and this phosphorylation is associated with kidney dysfunction and increased free fatty acids. PACSIN2 phosphorylation is a dynamic process that regulates cell morphology and cytoskeletal arrangement in cooperation with N-WASP. The phosphorylation of PACSIN2 at S313 is important for regulating cytoskeletal reorganization.
Article
Health Care Sciences & Services
Valma Harjutsalo, Milla Kallio, Carol Forsblom, Per-Henrik Groop, FinnDiane Study Grp
Summary: This study investigated the impact of diabetic nephropathy and diabetic retinopathy on the risk of chronic limb threatening ischemia (CLTI) in patients with type 1 diabetes. It found that diabetic nephropathy and severe diabetic retinopathy were key risk factors for CLTI in these patients.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Endocrinology & Metabolism
Anne Kathrine Nissen Pedersen, Lars Christian Gormsen, Soren Nielsen, Niels Jessen, Mette Bjerre
Summary: The study found that treatment with metformin in patients with type 2 diabetes can suppress circulating FAP activity, increase the expression of FGFR1c and beta-klotho, and improve the sensitivity of adipose tissue to FGF21.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
M. I. Eriksson, A. Syreeni, N. Sandholm, E. H. Dahlstrom, D. Gordin, T. Tatlisumak, J. Putaala, Per-Henrik Groop, J. Martola, L. M. Thorn
Summary: This study aimed to evaluate the association between haptoglobin genotype and cerebral small-vessel disease (SVD). The results showed no significant association between haptoglobin genotype and SVD.
ACTA DIABETOLOGICA
(2023)