Article
Anesthesiology
Mimmi Gillving, Dyveke Demant, Jakob Holbech, Lene Vase, Flemming W. Bach, Troels S. Jensen, Nanna B. Finnerup, Soren H. Sindrup
Summary: This study aimed to investigate whether the variability in baseline pain levels would influence the placebo response. The results showed that the variability in baseline pain did not have a significant impact on the placebo response.
Article
Chemistry, Medicinal
Martin Rakusa, Iris Marolt, Zorica Stevic, Sandra Vuckovic Rebrina, Tatjana Milenkovic, Adam Stepien
Summary: This study evaluates the efficacy of two generic medications, pregabalin and duloxetine, for treating pain in PDPN patients. The results demonstrate that both medications are effective in treating pain in over 86% of all randomised patients.
Article
Anesthesiology
Marko S. Todorovic, Karen Frey, Robert A. Swarm, Michael Bottros, Lesley Rao, Danielle Tallchief, Kristin Kraus, Kathleen Meacham, Kristopher Bakos, Xiaowei Zang, Jong Bong Lee, Leonid Kagan, Simon Haroutounian
Summary: Intravenous lidocaine can alleviate painful diabetic peripheral neuropathy (DPN), but quantitative sensory testing (QST) cannot predict treatment response.
CLINICAL JOURNAL OF PAIN
(2022)
Article
Anesthesiology
Rafaela F. Rodrigues, Taila Kawano, Rodrigo Placido, Lellis H. Costa, Marcia H. M. C. Podesta, Rafaela S. Santos, Giovane Galdino, Carlos M. Barros, Vanessa B. Boralli
Summary: This study investigated the pharmacokinetics and efficacy of pregabalin in combination with amitriptyline or duloxetine in a rodent model of neuropathic pain. The results showed that the combination of pregabalin with amitriptyline improved pregabalin's bioavailability and potentiated its antiallodynic effect, proving to be advantageous for the treatment of sciatic neuropathic pain.
Article
Immunology
Emily Pickering, Elizabeth L. Steels, Kathryn J. Steadman, Amanda Rao, Luis Vitetta
Summary: This study demonstrated that a palmitoylethanolamide (PEA) formulation can reduce diabetic peripheral neuropathic pain and inflammation, while improving mood and sleep. Further research is needed to investigate the effectiveness of PEA as an adjunct medicine or monotherapy pain analgesic.
INFLAMMOPHARMACOLOGY
(2022)
Article
Anesthesiology
Didier Bouhassira, Serge Perrot, Thibault Riant, Gaelle Martine-Fabre, Gisele Pickering, Caroline Maindet, Nadine Attal, Stephanie Ranque Garnier, Jean-Paul Nguyen, Emmanuelle Kuhn, Eric Viel, Patrick Kieffert, Thomas Toelle, Claire Delorme, Rodrigue Deleens, Patrick Ginies, Virginie Corand-Dousset, Clemence Dal-Col, Alain Serrie, Emmanuel Chevrillon, Christian Gov, Juan Fernando Ramirez-Gil, Cecile Delval, Manuella Schaller, Baptiste Bessiere, Patrick Houeto, Claudia Sommer
Summary: Nitrous oxide (N2O) is commonly used for anesthesia and short-duration analgesia. Research suggests that N2O/O-2 50%-50% mixture can induce long-lasting analgesic effects. A study on chronic peripheral neuropathic pain patients showed that a 1-hour administration of EMONO significantly improved evoked pain intensity and overall impression of change, with effects lasting up to 4 weeks after treatment.
Article
Anesthesiology
Mohsen Saheban Maleki, Zahra Zamani, Roya Amiri, Samaneh Kakhki, Mojtaba Jafari, Behnam Amani, Bahman Amani, Nasir Amanat
Summary: This study aimed to investigate the safety and efficacy of pregabalin versus placebo in post-traumatic peripheral neuropathic pain (PTNP). The meta-analysis of three randomized clinical trials involving 821 patients showed that pregabalin was more effective than placebo in reducing PTNP and improving sleep interference, but it was associated with higher adverse events. Further randomized controlled trials are needed to confirm these findings.
Article
Gastroenterology & Hepatology
Jayendra Seetharaman, Ujjal Poddar, Surender Kumar Yachha, Anshu Srivastava, Moinak Sen Sarma
Summary: This open-label trial evaluated the efficacy of amitriptyline in pediatric functional abdominal pain disorder (FAPD). The results showed that amitriptyline significantly improved pain and quality of life compared to placebo. Amitriptyline was the only factor predictive of treatment response. This study suggests that more frequent use of amitriptyline in clinical settings is warranted due to its safety and efficacy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Anesthesiology
Baptiste Letellier, Melanie Kremer, Lea J. Becker, Virginie Andry, Yannick Goumon, Quentin Leboulleux, Pierre Hener, Perrine Inquimbert, Nolwenn Couqueberg, Elisabeth Waltisperger, Ipek Yalcin, Franck Mouthon, Marine Droguerre, Mathieu Charveriat, Michel Barrot
Summary: The connexin inhibitor mefloquine potentiates the therapeutic effect of amitriptyline in neuropathic pain by modulating noradrenergic descending pathways and recruiting alpha(2) adrenoceptors. In addition, another connexin blocker, carbenoxolone, also improves the action of amitriptyline. Furthermore, in vitro studies suggest that mefloquine may also directly act on serotonin transporters and adenosine receptors A(1) and A(2A), but drugs targeting these other pathways failed to amplify the action of amitriptyline.
Article
Biochemistry & Molecular Biology
Yurong Ma, Wenwen Liu, Lingzhi Liang, Jiaqi Ye, Chaonan Huang, Tao Zhuang, Guisen Zhang
Summary: This study evaluates the potential synergistic antinociceptive effects of indomethacin-pregabalin and meloxicam-pregabalin in neuropathic pain and inflammatory pain. The results show significant synergistic effects in neuropathic pain models, but antagonistic effects in inflammatory pain models.
Article
Chemistry, Medicinal
Ye Zhang, Bin He, Jinqiu Zhao, Muzi Zhang, Qinsong Ren, Wei Zhang, Shuai Xu, Zhengxue Quan, Yunsheng Ou
Summary: The study demonstrates that combination analgesia with celebrex, pregabalin, and ropivacaine is effective in alleviating pain after posterior spinal surgery, with reduced consumption of PCA compared to controls.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Food Science & Technology
Samuel A. Goldlust, Mojgan Kavoosi, Jennifer Nezzer, Mehran Kavoosi, Walter Korz, Kenneth Deck
Summary: The study found that tetrodotoxin (TTX) may have potential efficacy in treating chemotherapy-induced neuropathic pain (CINP). Although there was no significant difference in average Numeric Pain Rating Scale (NPRS) scores, the 30 μg twice daily TTX cohort showed significant differences from the placebo group in some secondary quality of life (QOL) indicators. Adverse events were mostly mild to moderate, with oral paresthesia and hypoesthesia being the most common.
Review
Anesthesiology
Igor Dykukha, Rolf Malessa, Ute Essner, Michael A. Ueberall
Summary: The pooled analysis of nine RCTs demonstrated that nabiximols was superior to placebo in reducing chronic neuropathic pain with a small effect size. Larger RCTs are needed to further evaluate the efficacy of nabiximols in neuropathic pain.
Article
Medicine, General & Internal
Solomon Tesfaye, Gordon Sloan, Jennifer Petrie, David White, Mike Bradburn, Stephen Julious, Satyan Rajbhandari, Sanjeev Sharma, Gerry Rayman, Ravikanth Gouni, Uazman Alam, Cindy Cooper, Amanda Loban, Katie Sutherland, Rachel Glover, Simon Waterhouse, Emily Turton, Michelle Horspool, Rajiv Gandhi, Deirdre Maguire, Edward B. Jude, Syed H. Ahmed, Prashanth Vas, Christian Hariman, Claire McDougall, Marion Devers, Vasileios Tsatlidis, Martin Johnson, Andrew S. C. Rice, Didier Bouhassira, David L. Bennett, Dinesh Selvarajah
Summary: This study demonstrated that amitriptyline, duloxetine, and pregabalin have similar analgesic efficacy in treating DPNP. Combination therapy was well tolerated and led to improved pain relief in patients with suboptimal pain control with a monotherapy. Adverse events were predictable for the monotherapies, with certain side effects observed in each pathway.
Article
Urology & Nephrology
Geoffrey H. Rosen, Paige A. Hargis, Alp Kahveci, Connor Lough, Andrew Moss, Mojgan Golzy, Katie Murray
Summary: This study aimed to investigate the safety and efficacy of single-dose perioperative pregabalin in reducing pain after ureteroscopy. The results showed that patients who received pregabalin had higher postoperative pain scores compared to placebo, indicating that pregabalin did not decrease postoperative pain.
JOURNAL OF UROLOGY
(2023)