Article
Hematology
Darae Ko, Sarah R. Preis, Andrew D. Johnson, Ramachandran S. Vasan, Emelia J. Benjamin, Naomi M. Hamburg, Gary F. Mitchell
Summary: The study did not find any significant association between arterial vascular function measures and the risk of VTE after multivariable adjustment in a comprehensive examination.
THROMBOSIS RESEARCH
(2021)
Article
Endocrinology & Metabolism
Wenjin Liu, Zhensen Chen, Dakota Ortega, Xuebing Liu, Xiaoqin Huang, Lulu Wang, Li Chen, Jie Sun, Thomas S. Hatsukami, Chun Yuan, Haige Li, Junwei Yang
Summary: In older hypertensive males, arterial stiffness and endothelial dysfunction are associated with reduced brain perfusion and overall cerebral vascular injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Food Science & Technology
Banafsheh Jafari Azad, Javad Heshmati, Elnaz Daneshzad, Andriko Palmowski
Summary: Through a systematic review and meta-analysis of multiple studies, it was found that coffee intake has a beneficial short-term effect on endothelial function, while it may have an unfavorable impact on arterial stiffness. The long-term effects of coffee intake on endothelial function and arterial stiffness remain controversial.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Geriatrics & Gerontology
Rogerio N. Soares, Francisco Ramirez-Perez, Francisco J. Cabral-Amador, Mariana Morales-Quinones, Christopher A. Foote, Thaysa Ghiarone, Neekun Sharma, Gavin Power, James A. Smith, R. Scott Rector, Luis A. Martinez-Lemus, Jaume Padilla, Camila Manrique-Acevedo
Summary: The study demonstrates that SGLT2 inhibition with Empa improves endothelial function and reduces arterial stiffness in an aging preclinical model, offering a potential therapeutic alternative for reducing the progression of cardiovascular disease in older individuals.
Article
Biochemistry & Molecular Biology
Jose L. Sanchez-Gloria, Constanza E. Martinez-Olivares, Leonardo Del Valle-Mondragon, Fernando Cortes-Camacho, Oscar R. Zambrano-Vasquez, Rogelio Hernandez-Pando, Fausto Sanchez-Munoz, Laura G. Sanchez-Lozada, Horacio Osorio-Alonso
Summary: In this study, we evaluated the effects of allicin on vascular remodeling, endothelial function, and oxidative stress in experimental pulmonary arterial hypertension (PAH). Allicin administration improved body weight, survival rate, and prevented wall thickness and right ventricle hypertrophy. Allicin also maintained normal levels of angiotensin II and its receptors, increased nitric oxide and other beneficial molecules, and prevented oxidative stress and hypoxia response. These effects of allicin contribute to preventing endothelial dysfunction, remodeling of the pulmonary arteries, and heart failure in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sophia A. Mahoney, Ravinandan Venkatasubramanian, Mary A. Darrah, Katelyn R. Ludwig, Nicholas S. Vandongen, Nathan T. Greenberg, Abigail G. Longtine, David A. Hutton, Vienna E. Brunt, Judith Campisi, Simon Melov, Douglas R. Seals, Matthew J. Rossman, Zachary S. Clayton
Summary: This study found that fisetin can improve arterial function and reduce arterial stiffness by reducing vascular cell senescence and inflammation. Fisetin enhances endothelial function by increasing the bioavailability of nitric oxide and reducing oxidative stress.
Article
Medicine, General & Internal
Anna Oliveras, Isabel Galceran, Albert Goday, Susana Vazquez, Laia Sans, Marta Riera, David Benaiges, Julio Pascual
Summary: The study revealed an improvement in AS one month post-bariatric surgery, which correlated with changes in blood pressure and RAAS components, but was less effective in patients with higher PWV.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Yisha Li, Xinru Guo, Shuang Liang, Ping Li, Pu Chen, Ying Zheng, Jie Wu, Xiangmei Chen, Guangyan Cai
Summary: The aim of this study was to assess the role of endothelial function, arterial stiffness, and Framingham's cardiovascular disease risk score in kidney function decline in patients with chronic kidney disease. The study found that the risk score was independently associated with the progression of kidney function. However, adding the risk score to a model containing kidney function markers did not improve risk prediction for kidney outcome. Participants with higher risk scores were at increased risk of kidney function decline.
HYPERTENSION RESEARCH
(2023)
Article
Clinical Neurology
Seong-Joon Lee, Jin Soo Lee, Min Kim, So Young Park, Ji Hyun Park, Bumhee Park, Woo Sang Jung, Jin Wook Choi, Ji Man Hong
Summary: This study investigated the effects of endothelial function and arterial stiffness on CCAD using FMD and PWV measurements. The results showed that preserved endothelial function was associated with spontaneous arterial healing, while higher arterial stiffness was associated with ischemic presentation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Md Torikul Islam, Shelby A. Hall, Tavia Dutson, Samuel I. Bloom, R. Colton Bramwell, John Kim, Jordan R. Tucker, Daniel R. Machin, Anthony J. Donato, Lisa A. Lesniewski
Summary: Inhibition of mTOR can delay aging and improve age-related conditions, but the specific mechanisms and tissues involved are unclear. This study found that activation of mTOR in endothelial cells is associated with arterial and metabolic dysfunction. Reducing endothelial mTOR can reverse arterial stiffening, improve arterial and metabolic function, and reduce senescence, inflammation, and oxidative stress in arteries, lungs, adipose tissue, and liver.
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Maria Anastasiou, Evangelos Oikonomou, Panagiotis Theofilis, George Angelos Papamikroulis, Maria Gazouli, Konstantinos Kalogeras, Stavroula Lygkoni, Theodoros Pesiridis, Athina Goliopoulou, Alkistis Papatheodoridi, Amanda Psyrri, Flora Zagouri, Gerasimos Siasos, Dimitris Tousoulis
Summary: This study examined the impact of anthracycline-based chemotherapy, with or without trastuzumab, on endothelial function and arteriosclerosis in breast cancer patients. The results showed that there was a significant deterioration in endothelial function and arterial stiffness up to 15 months after chemotherapy initiation in breast cancer patients, and trastuzumab had no significant effect on these parameters.
VASCULAR PHARMACOLOGY
(2023)
Article
Cell Biology
Shir Lynn Lim, Xiao Liu, Qi Gao, Shwe Zin Nyunt, Lingli Gong, Josephine B. Lunaria, Carolyn S. P. Lam, Arthur Mark Richards, Shiou Liang Wee, Lieng Hsi Ling, Tze Pin Ng
Summary: Frailty in older adults is associated with subclinical vasculopathy, with carotid intima-media thickness showing a significant correlation with gait speed. The relationship between subclinical vasculopathy and muscle mass/function is modified by age and sex, with stronger associations found in those aged 70 and above. Further evaluation of mediating pathways is warranted.
Article
Medicine, General & Internal
Ivan Cavero-Redondo, Alicia Saz-Lara, Irene Martinez-Garcia, Bruno Bizzozero-Peroni, Valentina Diaz-Goni, Ana Diez-Fernandez, Nerea Moreno-Herraiz, Carlos Pascual-Morena
Summary: This study aims to compare the efficacy of combined training and high intensity interval training (HIIT) on exercise capacity, diastolic function, endothelial function, and arterial stiffness in participants with HFpEF. The study will be a single-blind, 3-arm, randomized clinical trial (RCT) to evaluate the efficacy of physical exercise programs on exercise capacity, diastolic function, endothelial function, and arterial stiffness in HFpEF patients. The findings will be published in a peer-reviewed journal.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Ran Wei, Weihao Wang, Qi Pan, Lixin Guo
Summary: This systematic review and meta-analysis evaluated the effects of SGLT-2 inhibitors on endothelial function and arteriosclerosis in diabetic patients. The results showed that SGLT-2 inhibitors significantly improved endothelial function, but had no significant effect on arteriosclerosis levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)