Article
Surgery
Ugoeze Nwokedi, Mahnoor Zia, Jiaqiong Xu, Archana R. Sadhu, Flavio E. Baio, Bita S. Kash, Vadim Sherman, Nabil Tariq
Summary: Elevated HbA1c levels (> 8% or 10%) were not associated with increased postoperative complications in bariatric patients, but HbA1c levels lower than 10% were linked to some adverse outcomes in this study. Further research is needed to validate these findings. A high HbA1c alone may not preclude a patient from undergoing bariatric surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medical Laboratory Technology
Jeremy W. Jacobs, Savanah D. Gisriel, Krishna Iyer, Ronald G. Hauser, Joe M. El-Khoury
Summary: Glycated hemoglobin (HbA1c) assays are commonly used to monitor patients with type 2 diabetes, but enzymatic assays may be prone to interference from neoplastic lymphocytes, leading to inaccurate results. Awareness of this possibility and further investigation are necessary.
CLINICA CHIMICA ACTA
(2022)
Article
Hematology
Beibei Sun, Xiaoqian Ge, Xiao Li, Jianjian Zhang, Zizhou Zhao, Xiaosheng Liu, Yan Zhou, Jianrong Xu, Huilin Zhao, Jie Sun
Summary: This study evaluated the impact of diabetes on carotid plaque neovasculature as assessed by dynamic contrast-enhanced magnetic resonance imaging. The results showed that carotid plaques in patients with diabetes had higher K-trans values, indicating leaky plaque neovasculature. This leak was associated with hemoglobin A1c and may play a role in accelerated atherosclerosis progression in diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rahul Aggarwal, Deepak L. Bhatt, Michael Szarek, Christopher P. Cannon, Darren K. Mcguire, Silvio E. Inzucchi, Renato D. Lopes, Michael J. Davies, Phillip Banks, Bertram Pitt, Philippe Gabriel Steg
Summary: This study assessed the efficacy of Sotagliflozin on heart failure clinical outcomes in individuals with different baseline glycosylated hemoglobin levels. The results showed that Sotagliflozin reduced heart failure outcomes, regardless of baseline HbA1c.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medical Laboratory Technology
Yu Jeong Choi, Hyein Kang, Chan-Ik Cho, John Hoon Rim, Sang-Guk Lee, Jong-Baeck Lim
Summary: The performance of the DxC 700 AU immunoassay device in measuring HbA1c was evaluated. The device showed accuracy, precision, and linearity over a wide concentration range of HbA1c, but caution is needed in cases of high HbF and HbH concentrations.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Paul R. Conlin, Libin Zhang, Donglin Li, Richard E. Nelson, Julia C. Prentice, David C. Mohr
Summary: The treatment goals for hemoglobin A1c (A1c) in older adults should be personalized to balance risks and benefits. It is uncertain if stability of A1c within target ranges affects adverse outcomes.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Medicine, General & Internal
Alexandra Halalau, Sujoy Roy, Arpitha Hegde, Sumesh Khanal, Emily Langnas, Maidah Raja, Ramin Homayouni
Summary: This study aimed to determine the risk factors associated with rapid progression from normal or prediabetic hemoglobin A1c levels to type 2 diabetes mellitus. The results showed that progression to diabetes within a four-year period is associated with baseline BMI. A steady rise in HbA1c during the same period is associated with age and family history of type 2 diabetes, while rapid rise in HbA1c is associated with age and personal history of major cardiovascular events.
ANNALS OF MEDICINE
(2023)
Article
Environmental Sciences
Keyang Zheng, Zhijun Zeng, Jintao Huang, Qianwen Tian, Bo Cao, Xia Huo
Summary: This study investigated the association between exposure to multiple metal(loid)s in indoor dust in kindergartens and the risk of anemia in children. The results showed that exposure to Cd and Mn was associated with an increased risk of anemia in children, and this association was modified by child sex, age, and BMI.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Jiannan Li, Runzhen Chen, Jinying Zhou, Ying Wang, Xiaoxiao Zhao, Chen Liu, Peng Zhou, Yi Chen, Li Song, Shaodi Yan, Hongbing Yan, Hanjun Zhao
Summary: This study found that the level of plaque structural stress in ST-segment elevated myocardial infarction patients with plaque rupture is closely associated with glucose control (HbA1c level). Optical coherence tomography can be used to evaluate the risk of plaque rupture, highlighting the importance of glucose control in patients with coronary atherosclerotic disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Chemistry, Analytical
Huan Zhao, Xinghan Qiu, Enben Su, Li Huang, Yunfeng Zai, Yuan Liu, Hui Chen, Zunliang Wang, Zhu Chen, Song Li, Lian Jin, Yan Deng, Nongyue He
Summary: A time-resolved chemiluminescence assay was developed for detecting HbA1c and Hb, showing excellent repeatability and accuracy, demonstrating great potential for clinical application.
ANALYTICA CHIMICA ACTA
(2022)
Article
Oncology
Sarah E. R. Bailey, Gary A. Abel, Alex Atkins, Rachel Byford, Sarah-Jane Davies, Joe Mays, Timothy J. McDonald, Jon Miller, Catherine Neck, John Renninson, Paul Thomas, Fiona M. Walter, Sarah Warren, Willie Hamilton
Summary: This study found that the faecal immunochemical test (FIT) performed well in triaging patients with low-risk symptoms of colorectal cancer, with a positive predictive value of 7.0%, a negative predictive value of 99.8%, a sensitivity of 84.3%, and a specificity of 85.0%.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Ying Wei, Ming Cui, Shuwang Liu, Haiyi Yu, Jieli Feng, Wei Gao, Lei Li
Summary: This study found that elevated HbAlc levels were associated with decreased LAAV in non-valvular AF patients, reflecting potentially impaired contractile function of the left atrial appendage.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Vibhu Parcha, Brittain Heindl, Rajat Kalra, Peng Li, Barbara Gower, Garima Arora, Pankaj Arora
Summary: This study assessed the prevalence and trends of insulin resistance (IR) among young American adults, finding that four-in-ten young adults have IR, which occurs in a cluster with cardiometabolic risk factors. Additionally, nearly half of young adults with IR are nonobese. These findings suggest that screening efforts for IR may be necessary regardless of body mass index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biology
Monika Michalek-Zrabkowska, Piotr Macek, Helena Martynowicz, Pawel Gac, Grzegorz Mazur, Magda Grzeda, Rafal Poreba
Summary: Patients with obstructive sleep apnea (OSA) had a higher risk of insulin resistance when their AHI and ODI were elevated, while those with prolonged hypoxemia showed higher fasting glucose concentration.
Review
Medicine, General & Internal
Furong Qu, Qingyang Shi, Yang Wang, Yanjiao Shen, Kaixin Zhou, Ewan R. Pearson, Sheyu Li
Summary: This systematic review summarizes the evidence of HbAlc variability in patients with type 2 diabetes. The findings suggest that high HbAlc variability is associated with increased risks of all-cause mortality, cardiovascular events, progression to chronic kidney disease, amputation, and peripheral neuropathy. Therefore, patients with type 2 diabetes and high HbAlc variability require additional attention and care for potential adverse outcomes.
CHINESE MEDICAL JOURNAL
(2022)
Article
Geriatrics & Gerontology
Andrea L. C. Schneider, Charles Jonassaint, A. Richey Sharrett, Thomas H. Mosley, Brad C. Astor, Elizabeth Selvin, Josef Coresh, Rebecca F. Gottesman
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2016)
Article
Clinical Neurology
Melinda C. Power, Andrea L. C. Schneider, Lisa Wruck, Michael Griswold, Laura H. Coker, Alvaro Alonso, Clifford R. Jack, David Knopman, Thomas H. Mosley, Rebecca F. Gottesman
ALZHEIMERS & DEMENTIA
(2016)
Article
Medicine, General & Internal
Rebecca F. Gottesman, Andrea L. C. Schneider, Yun Zhou, Josef Coresh, Edward Green, Naresh Gupta, David S. Knopman, Akiva Mintz, Arman Rahmim, A. Richey Sharrett, Lynne E. Wagenknecht, Dean F. Wong, Thomas H. Mosley
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2017)
Article
Cardiac & Cardiovascular Systems
Brian A. Houston, Andrea L. C. Schneider, Joban Vaishnav, David M. Cromwell, P. Elliott Miller, Kamil F. Faridi, Ashish Shah, Chris Sciortino, Glenn Whitman, Ryan J. Tedford, Gerin R. Stevens, Daniel. P. Judge, Stuart D. Russell, Rosanne Rouf
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2017)
Article
Public, Environmental & Occupational Health
Andrea L. C. Schneider, Di Zhao, Pamela L. Lutsey, Rebecca F. Gottesman, A. Richey Sharrett, Andreea M. Rawlings, Alvaro Alonso, David Knopman, Thomas H. Mosley, Elizabeth Selvin, Erin D. Michos
Editorial Material
Clinical Neurology
Andrea L. C. Schneider, Kristen Dams-O'Connor
Article
Clinical Neurology
Andrea L. C. Schneider, Elizabeth Selvin, Lawrence Latour, L. Christine Turtzo, Josef Coresh, Thomas Mosley, Geoffrey Ling, Rebecca F. Gottesman
Summary: The study showed a dose-dependent relationship between head injury and dementia risk, with stronger associations among female and White participants.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Andrea L. C. Schneider, Dan Wang, Rebecca F. Gottesman, Elizabeth Selvin
Summary: This study aimed to investigate disability associated with prior head injury in the United States, finding that 47.4% of individuals aged 40 and above with a history of head injury experienced disability in at least one domain of functioning, affecting approximately 11.4 million people. Efforts are needed to enhance functioning among individuals with head injury.
Article
Clinical Neurology
Andrea L. C. Schneider, Rebecca F. Gottesman, Gregory L. Krauss, James Gugger, Ramon Diaz-Arrastia, Anna Kucharska-Newton, Juebin Huang, Emily L. Johnson
Summary: This study demonstrates an association between head injury and late-onset epilepsy, particularly when the head injuries occur at an older age. Multiple and more severe head injuries further increase the risk of developing late-onset epilepsy.
Article
Public, Environmental & Occupational Health
Tuan D. Le, Jennifer M. Gurney, Karan P. Singh, Shawn C. Nessen, Andrea L. C. Schneider, Yll Agimi, Vikhyat S. Bebarta, Paco S. Herson, Katharine C. Stout, Sylvain Cardin, Alicia T. Crowder, Geoffrey S. F. Ling, Mark E. Stackle, Anthony E. Pusateri
Summary: This study aims to characterize the epidemiology of traumatic brain injury (TBI) in U.S. service members and investigate the potential impacts of changes in policy, care, equipment, and tactics. Analysis of data from the U.S. Department of Defense Trauma Registry showed that nearly one third of injured service members treated at Role 3 medical treatment facilities had TBI. The proportion of TBI increased over time, suggesting the need for additional preventive measures and clinical guidelines for mild TBI management.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Clinical Neurology
Andrea L. C. Schneider, Carrie B. Peltz, Yixia Li, Amber Bahorik, Raquel C. Gardner, Kristine Yaffe
Summary: This study found that traumatic brain injury (TBI) is associated with long-term stroke risk, with differences observed in age, sex, race and ethnicity, and time since TBI diagnosis. The highest risk of stroke occurs in the first year after TBI diagnosis, but the risk remains elevated for more than 10 years. Both mild and moderate/severe/penetrating TBI increase the risk of stroke compared to individuals without TBI. Older individuals have a stronger association between TBI and stroke, while Black veterans have a weaker association compared to other races and ethnicities. These findings suggest that veterans with prior TBI should be targeted for primary stroke prevention measures.
Article
Cardiac & Cardiovascular Systems
Kelly L. Sloane, Scott E. Kasner, Christopher G. Favilla, Aaron Rothstein, Jens Witsch, Roy H. Hamilton, Andrea L. C. Schneider
Summary: This study investigates the roles of optimism and depression in stroke recovery and finds that patients who are optimistic and without depression have the best recovery, while patients who lack optimism and have depression have the slowest recovery.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Srishti Shrestha, Xiaoqian Zhu, Vidyulata Kamath, Kevin J. Sullivan, Jennifer A. Deal, A. Richey Sharrett, Andrea L. C. Schneider, Priya Palta, Rebecca F. Gottesman, B. Gwen Windham, Thomas H. Mosley, Michael E. Griswold, Honglei Chen, Antonios Dakanalis
Summary: Through analyzing 6053 participants in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study, it is found that factors such as age, sex, education level, race, and APOE epsilon 4 are associated with olfactory status and decline. Older age, male sex, lower education, Black race, APOE epsilon 4, etc. increase the probability of olfactory errors and anosmia, while factors such as physical activity and hypertension benefit olfaction. Long-term follow-up studies are needed in the future.
Article
Biochemistry & Molecular Biology
Samuel S. Shin, Vanessa M. Mazandi, Andrea L. C. Schneider, Sarah Morton, Jonathan P. Starr, M. Katie Weeks, Nicholas J. Widmann, David H. Jang, Shih-Han Kao, Michael K. Ahlijanian, Todd J. Kilbaugh
Summary: Traumatic brain injury (TBI) leads to the production of tau protein. Targeting hyperphosphorylated tau (p-tau) could potentially provide new therapy for TBI. In a study involving pigs, treatment with PNT001, a monoclonal antibody for p-tau, showed significant improvement in white matter injury and neural injury biomarkers compared to placebo treatment.
Article
Endocrinology & Metabolism
Andrea L. C. Schneider, Elizabeth Selvin, A. Richey Sharrett, Michael Griswold, Josef Coresh, Clifford R. Jack, David Knopman, Thomas Mosley, Rebecca F. Gottesman