Article
Cardiac & Cardiovascular Systems
Viktor Lind, Niklas Hammar, Pia Lundman, Leif Friberg, Mats Talback, Goran Walldius, Anna Norhammar
Summary: Dysglycaemia, even at prediabetes levels, is associated with an increased risk of developing atrial fibrillation and heart failure. The study found that individuals with diagnosed diabetes had the highest risk. However, the associations were somewhat weakened when BMI data was taken into account, with only diagnosed diabetes remaining statistically significant for atrial fibrillation.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Yingting Zuo, Xinsheng Han, Xue Tian, Shuohua Chen, Shouling Wu, Anxin Wang
Summary: The study revealed that individuals without traditional ASCVD risk factors are at increased risk of developing CVD with higher levels of abnormal fasting plasma glucose, underlining the importance of prevention strategies targeting elevated FPG levels in addition to other traditional ASCVD risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Fariba Ahmadizar, Kan Wang, Elif Aribas, Lana Fani, Alis Heshmatollah, M. Kamran Ikram, Maryam Kavousi
Summary: This study found that impaired fasting glucose (IFG) is associated with a higher risk of cardiovascular disease compared to normal glycemia, especially among overweight and obese individuals. The risk of IFG in men is comparable to that of type 2 diabetes (T2D). Overweight/obesity increases the burden of lifetime cardiovascular disease risk in individuals with IFG.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Clinical Neurology
Satoyo Ikehara, Hiroyasu Iso, Yoshihiro Kokubo, Kazumasa Yamagishi, Isao Saito, Hiroshi Yatsuya, Takashi Kimura, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane
Summary: Higher peanut consumption was associated with reduced risk of stroke, particularly ischemic stroke, but not with the risk of ischemic heart disease in Japanese men and women.
Article
Multidisciplinary Sciences
C. R. Lewis, J. S. Talboom, M. D. De Both, A. M. Schmidt, M. A. Naymik, A. K. Haberg, T. Rundek, B. E. Levin, S. Hoscheidt, Y. Bolla, R. D. Brinton, M. Hay, C. A. Barnes, E. Glisky, L. Ryan, M. J. Huentelman
Summary: This study investigated the relationship between smoking, sex, cardiovascular disease, and verbal learning and memory function. They found significant interactions, with smoking being associated with verbal learning performance more in women and cardiovascular disease more in men across a wide age range. The results suggest that smoking and cardiovascular disease may impact verbal learning and memory differently for men and women throughout adulthood.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jianing Bi, Lulu Song, Lulin Wang, Mingyang Wu, Shouhua Chen, Youjie Wang, Shouling Wu, Yaohua Tian
Summary: Higher fasting blood glucose variability is associated with an increased lifetime risk of cardiovascular disease, especially in men. Focusing on FBG variability may serve as a valuable clinical tool in reducing the lifetime risk of CVD.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yilin Yoshida, Jia Wang, Yuanhao Zu, Vivian A. Fonseca, Franck Mauvais-Jarvis
Summary: The prevalence of prediabetes and undiagnosed diabetes has increased among premenopausal women in the past two decades, and they face a significant cardiovascular risk burden associated with these conditions. Improvement in cardiovascular risk screening and patient education should be prioritized for young and early middle-aged adults, particularly women.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Hyunjin Lee, Bohyun Kim, Youngshin Song
Summary: This study compared health behaviors and health literacy between individuals with non-IFG and IFG, identifying factors associated with IFG by sex. In males, age, high BMI, frequent drinking, and nutrition label usage were significant factors, while low economic status and high BMI were affecting factors in females. Employment status, perceived stress, and job type were not related to IFG in both genders. Strategies should target specific groups to improve health behaviors and literacy, with healthcare providers understanding barriers for effective service delivery.
Article
Endocrinology & Metabolism
Haewon Byeon
Summary: This epidemiological study identified factors associated with impaired fasting glucose and developed a nomogram using machine learning to predict groups vulnerable to impaired fasting glucose.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Myung Ji Nam, Hyunjin Kim, Yeon Joo Choi, Kyung-Hwan Cho, Seon Mee Kim, Yong-Kyun Roh, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Joo-Hyun Park, Do-Hoon Kim
Summary: This study investigated the association between obesity indicators and the risk of impaired fasting glucose (IFG) in women, and found that obesity and abdominal obesity were consistently associated with increased odds of developing IFG after 8 years in both pre- and postmenopausal groups, with a stronger association in the premenopausal group. This highlights the need for weight management and lifestyle modification in premenopausal women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Maria C. Magnus, Abigail Fraser, Janet W. Rich-Edwards, Per Magnus, Deborah A. Lawlor, Siri E. Haberg
Summary: The study found that both women and men with prolonged time-to-pregnancy have a slightly increased risk of cardiovascular disease. Further research is needed to investigate the clinical significance of this phenomenon and the underlying causes of the increased risk of CVD associated with prolonged TTP.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Xin Zhang, Yankun Yue, Shaobo Liu, Xiangfeng Cong, Wenjuan Wang, Jianhong Li
Summary: This study investigates the relationship between BMI and the risk of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) in Chinese adults. The results show that obesity is an important risk factor for IGT and IFG in China, and the risk of IGT increases during the overweight stage.
Article
Cardiac & Cardiovascular Systems
Xianxuan Wang, Yan-Feng Zhou, Zegui Huang, Xinran Yu, Zekai Chen, Zefeng Cai, Yulong Lan, Werijian Li, Zhiwei Cai, Wei Fang, Guanzhi Chen, Weiqiang Wu, Shouling Wu, Youren Chen
Summary: This study characterized the relationships between changes in impaired fasting glucose (IFG) and borderline high low-density lipoprotein-cholesterol (LDL-C) status and cardiovascular disease (CVD). The findings suggest that individuals with IFG and borderline high LDL-C status have an increased risk of CVD, highlighting the importance of focusing on these individuals for prevention and control of CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Yun Hwan Oh, Seogsong Jeong, Sun Jae Park, Joseph C. Ahn, Sang Min Park
Summary: The changes in NAFLD status are associated with the risk of cardiovascular disease (CVD), with an increased risk observed in patients who develop NAFLD and a reduced risk in individuals who recover from NAFLD.
Article
Multidisciplinary Sciences
Min Jin Lee, Ah Reum Khang, Dongwon Yi, Yang Ho Kang
Summary: This study investigated the association between relative hand grip strength and glycemic status. The results showed that individuals with lower relative hand grip strength had a higher risk of both diabetes and impaired fasting glucose. This association was stronger in younger adults compared to older adults.
Article
Medicine, General & Internal
Myunghee Hong, Yusuke Ebana, Jaemin Shim, Eue-Keun Choi, Hong Euy Lim, Inseok Hwang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Seil Oh, Moon-Hyoung Lee, Young-Hoon Kim, Sun Ha Jee, Hui-Nam Pak
Summary: Nineteen AF-associated genetic loci in individuals of European descent were successfully replicated in Far East Asian populations, indicating extensive sharing of AF genetic risks among Far East Asian populations.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Infectious Diseases
Siyeon Suh, Sol Lee, Ho Gym, Sanghyuk Yoon, Seunghwan Park, Jihi Cha, Do-Hyung Kwon, YunSu Yang, Sun Ha Jee
Summary: COVID-19, caused by SARS-CoV-2, is a global threat that directly and indirectly affects the entire population. Multiple studies have been conducted to understand the transmission and severity of the disease, revealing that ACE2, TMPRSS2, and IFITM3 are key genes involved in SARS-CoV-2 infection, with certain SNPs associated with increased infection and severity.
BMC INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Dong-Hyuk Park, Wonhee Cho, Yong-Ho Lee, Sun Ha Jee, Justin Y. Jeon
Summary: This study aimed to improve the predictability of undiagnosed diabetes mellitus (UnDM) by adding resting heart rate (RHR) to the existing prediction model, and to develop a model using easily assessable variables such as gender, RHR, age, and waist circumference (WC). The results showed that adding RHR to the model improved specificity and the Youden index. Furthermore, using only gender, RHR, age, and WC in the model yielded comparable outcomes to the existing model.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Oncology
Xiang Shu, Zhishan Chen, Jirong Long, Xingyi Guo, Yaohua Yang, Conghui Qu, Yoon-Ok Ahn, Qiuyin Cai, Graham Casey, Stephen B. Gruber, Jeroen R. Huyghe, Sun Ha Jee, Mark A. Jenkins, Wei-Hua Jia, Keum Ji Jung, Yoichiro Kamatani, Dong-Hyun Kim, Jeongseon Kim, Sun-Seog Kweon, Loic Le Marchand, Koichi Matsuda, Keitaro Matsuo, Polly A. Newcomb, Jae Hwan Oh, Jennifer Ose, Isao Oze, Rish K. Pai, Zhi-Zhong Pan, Paul D. P. Pharoah, Mary C. Playdon, Ze-Fang Ren, Robert E. Schoen, Aesun Shin, Min-Ho Shin, Xiao-Ou Shu, Xiaohui Sun, Catherine M. Tangen, Chizu Tanikawa, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Wei Zheng
Summary: This study identified potential novel risk biomarkers for colorectal cancer by integrating genetics and circulating metabolomics data. The results highlight the importance of lipids, especially certain glycerophospholipids and triacylglycerols, in the etiology of colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Jie Ping, Yaohua Yang, Wanqing Wen, Sun-Seog Kweon, Koichi Matsuda, Wei-Hua Jia, Aesun Shin, Yu-Tang Gao, Keitaro Matsuo, Jeongseon Kim, Dong-Hyun Kim, Sun Ha Jee, Qiuyin Cai, Zhishan Chen, Ran Tao, Min-Ho Shin, Chizu Tanikawa, Zhi-Zhong Pan, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, Zefang Ren, Xiao-Ou Shu, Jirong Long, Wei Zheng
Summary: PRS constructed using East Asian-specific data showed better performance in predicting colorectal cancer risk compared to PRS constructed using European descendants data. Individuals in the highest 5% risk group had a 2.52-fold elevated risk of colorectal cancer compared to the medium risk group.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Hye Won Yun, Keum Ji Jung, Sun Ha Jee, Heejin Kimm
Summary: This study aimed to analyze smoking cessation among healthy adult triple users of conventional cigarettes, e-cigarettes, and heated tobacco products. The majority of ever triple users continued to use these tobacco products instead of quitting. Age, gender, hyperlipidemia, and marital status were significantly associated with overall quit.
Article
Environmental Sciences
SuHyun Lee, YoungWook Lim, YounSeok Kang, KeumJi Jung, SunHa Jee
Summary: This study aimed to examine the association between blood concentration of dioxin-like polychlorinated biphenyls (DL-PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) and the risk of type 2 diabetes mellitus (T2DM) and thyroid cancer. The results showed a significant positive association between PCDD/DFs concentrations and both T2DM and thyroid cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Eugene Han, Sun Ok Song, Hye Soon Kim, Kang Ju Son, Sun Ha Jee, Bong-Soo Cha, Byung-Wan Lee
Summary: The age at death of people with diabetes has increased and reached a comparable level to those without diabetes. The increase in death age is higher in the subgroup of diabetes patients with dyslipidemia and/or hypertension. In contrast, deaths from vascular disease and diabetes have decreased, while deaths from cancer and pneumonia have increased. The findings suggest a narrowing gap in life expectancy between people with and without diabetes.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Environmental Sciences
Jae Kwan Kim, Jian Zhang, Seungwoo Hwang, Seongha Cho, Wook-Joon Yu, Ji-Seong Jeong, Il-Hyun Park, Byung-Chul Lee, Sun Ha Jee, Kyung-Min Lim, Youngja H. Park
Summary: In this study, the mechanism of di2-ethylhexyl phthalate (DEHP) induced thyroid hyperplasia was explored through a transcriptome-metabolome-wide association study. It was found that metabolic shifts were significantly altered at doses above 30 mg DEHP/kg bw/day. RNA-seq analysis revealed several cancer-related genes that were upregulated or downregulated. Integration of these genes and the whole metabolome data uncovered thyroid cancer-related metabolic pathways, particularly those related to eicosanoids. These findings provide further insight into the mechanism of DEHP-associated thyroid cancer.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Dong-Hyuk Park, Seon Young Goo, Sung Hyun Hong, Ji-hee Min, Ji Yong Byeon, Mi-Kyung Lee, Hae Dong Lee, Byoung Wook Ahn, Heejin Kimm, Sun Ha Jee, Dong Hoon Lee, Yong-ho Lee, Eun Seok Kang, Justin Y. Jeon
Summary: This study aimed to investigate the association between resting heart rate (RHR) and the prevalence of undiagnosed diabetes. The results showed that participants with higher RHR had a significantly higher prevalence of undiagnosed diabetes, and this association was stronger among younger and leaner individuals. Therefore, RHR can be used as an indicator to identify and prevent undiagnosed diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Oncology
Guen Hui Kim, Joyce Mary Kim, Sun Ha Jee, Keum Ji Jung
Summary: This study suggests that NMR may be an effective marker for predicting lung cancer risk, particularly in fast metabolizers and heavy smokers.
Article
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Bien, Virginia Diez-Obrero, Li Li, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Harris, Victoria Svinti, Kevin McDonnell, Susan Farrington, James Studd, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Scacheri, James Studd, Jeroen Huyghe, Tabitha Harrison, David Shibata, Christopher Haiman, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Potter, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Shibata, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Boehm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Shibata, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Gruber, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Summary: This study identified 205 independent risk associations for colorectal cancer through a genome-wide association study meta-analysis. Transcriptome and methylome analysis further revealed 53 risk associations. These findings provide insights into the genetic and molecular mechanisms of colorectal oncogenesis and suggest potential targets for new treatment and prevention strategies.
Article
Multidisciplinary Sciences
Seong Gyu Choi, Minsuk Oh, Dong-Hyuk Park, Byeongchan Lee, Yong-ho Lee, Sun Ha Jee, Justin Y. Jeon
Summary: This study compares the prediction performance of machine learning-based undiagnosed diabetes prediction models and traditional statistics-based prediction models. The results show that the machine learning-based models have higher AUC values when using features such as sex, age, and waist circumference. Similarly, when additional features including family history of diabetes, hypertension, alcohol consumption, and smoking status are included, the machine learning-based models still outperform the traditional statistics-based models. The study concludes that machine learning-based prediction models using anthropometric and lifestyle measurements may be more accurate in predicting undiagnosed diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Youngmin Han, Hye Jin Yoo, Sun Ha Jee, Jong Ho Lee
Summary: Monitoring metabolic biomarkers could be used as an effective tool for the early detection of gastric cancer risk. This study discovered that changes in serum levels of l-carnitine and citric acid are associated with gastric cancer occurrence, and may serve as predictive serum biomarkers for gastric cancer.
Article
Gastroenterology & Hepatology
Hyun-Soo Zhang, Yeunsoo Yang, Sunmi Lee, Sohee Park, Chung Mo Nam, Sun Ha Jee
Summary: This study employs three statistical methods to avoid immortal time bias and compares their results with a naive time-fixed analysis, concluding that metformin use is not associated with colorectal cancer incidence.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)