Article
Endocrinology & Metabolism
Dan Ziegler, Ruediger Landgraf, Ralf Lobmann, Karlheinz Reiners, Kristian Rett, Oliver Schnell, Alexander Strom
Summary: Despite the majority of physicians reporting regular screening for DSPN, there is a low willingness to implement standardized testing procedures and assessments, as well as follow clinical guidelines.
PRIMARY CARE DIABETES
(2022)
Article
Nutrition & Dietetics
Camelia Munteanu, Mihaela Mihai, Francisc Dulf, Andreea Ona, Leon Muntean, Floricuta Ranga, Camelia Urda, Daria Pop, Tania Mihaiescu, Sorin Marian Marza, Ionel Papuc
Summary: This pilot study investigated the impact of hemp seeds on blood biochemical changes in diabetic rats. The study analyzed the composition, antioxidant activity, and identification of phenols and fatty acids in industrial hemp seeds. The experiment showed that high doses of hemp seeds reduced diabetes-induced biochemical damage in rats, possibly due to their high content of active compounds. Further research is needed to identify the specific hemp compounds responsible for these effects and to conduct longer-term studies for a more comprehensive understanding.
Article
Multidisciplinary Sciences
W. Grabowska, R. King, S. Roll, I. V. Habermann, S. Hoerder, K. Hahn, S. N. Willich, S. Schroeder, B. Brinkhaus, J. Dietzel
Summary: This study aimed to assess the reliability of DPNCheck for repeated sural nerve conduction parameters. A post hoc analysis was conducted using data from a randomized controlled trial, which found moderate to good reliability of DPNCheck for nerve velocity and amplitude, but weak correlation with Total Neuropathy Score clinical. Given the limitations of this analysis, further long-term, pre-specified studies are needed to fully determine the suitability of DPNCheck for monitoring DPN progression.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Manal Mohammed Hashem, Ahmed Esmael, Abdelfattah Kasem Nassar, Mohammed El-Sherif
Summary: The study found that diabetics treated with metformin have lower levels of vitamin B12 and higher levels of homocysteine, which are associated with more severe diabetic peripheral neuropathy.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Trevor M. Poitras, Easton Munchrath, Douglas W. Zochodne
Summary: This review explores potential translational directions for treating diabetic polyneuropathy (DPN), focusing on supporting the viability and growth of peripheral neurons and their ability to resist diabetic alterations. Most of the molecules and pathways discussed have not yet reached clinical trials, with many trials yielding negative results.
Article
Endocrinology & Metabolism
Simona Cernea, Itamar Raz
Summary: Diabetic neuropathy is a common complication of diabetes that requires timely intervention and management. Strategies for management include optimizing glycemic control, multifactorial intervention, lifestyle changes, and drug therapy, with further research needed to alter the natural progression of the disease.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Nutrition & Dietetics
Ruey-Yu Hsieh, I-Chen Huang, Chiehfeng Chen, Jia-Ying Sung
Summary: Alpha-lipoic acid (ALA) improves symptoms in patients with diabetic sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and improving microcirculation. A meta-analysis of randomized controlled trials (RCTs) evaluated the effects of orally-administered ALA versus placebo in patients with DSPN, finding that ALA treatment had favorable effects on sensory symptoms, total symptoms' score (TSS), neurological disability score (NDS), and global satisfaction. However, it did not produce favorable results for vibration perception, nerve conduction, and neuropathy impairment.
Article
Clinical Neurology
Monica Alcantara, Mylan Ngo, James de la Cruz, Deepak Menon, Carolina Barnett-Tapia, Hans Katzberg, Vera Bril
Summary: The duration and temporal dispersion of the distal compound muscle action potential (CMAP) did not contribute to distinguishing between chronic inflammatory demyelinating polyneuropathy (CIDP), diabetic sensorimotor polyneuropathy (DSP), and CIDP+DSP. However, other parameters such as F-wave latencies, conduction blocks, and the number of demyelinating parameters were useful in differentiating these conditions.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Carla Greco, Fabio Nascimbeni, Francesca Carubbi, Pietro Andreone, Manuela Simoni, Daniele Santi
Summary: This meta-analysis found a significantly higher prevalence of diabetic polyneuropathy (DPN) in patients with nonalcoholic fatty liver disease (NAFLD) compared to those without NAFLD, especially in type 2 diabetes. Additionally, NAFLD patients had higher body mass index and longer duration of diabetes. Physicians should focus on early detection of DPN, particularly in patients with NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Jenny L. Davies, Karen A. Lodermeier, Diane M. Klein, Rickey E. Carter, P. James B. Dyck, William J. Litchy, Peter J. Dyck
Summary: This study evaluated 13 attributes and 6 composite nerve conduction scores and signs in healthy subjects and patients with diabetes. The results showed that measuring conduction velocities and distal latencies can sensitively diagnose diabetic sensorimotor polyneuropathy. Nerve conduction amplitudes provide a stronger measure of disease severity. The study also categorized diabetic sensorimotor polyneuropathy into different stages.
Review
Endocrinology & Metabolism
Dan Ziegler, Nikolaos Papanas, Oliver Schnell, Bich Dao Thi Nguyen, Khue Thy Nguyen, Kongkiat Kulkantrakorn, Chaicharn Deerochanawong
Summary: Diabetic sensorimotor polyneuropathy (DSPN) affects approximately one-third of people with diabetes, leading to neuropathic pain and foot ulcerations. Treatment of DSPN should consist of a multimodal approach considering individual risk, pathogenetic treatment, pain management using pharmacotherapy, and non-pharmacological options.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Haitao Zhang, Yan Shen, Il-man Kim, Neal L. Weintraub, Yaoliang Tang
Summary: Diabetes leads to abnormal cellular metabolism in CMECs, affecting glycolysis and mitochondrial oxidative phosphorylation, resulting in increased intracellular ROS levels. Gene expression and protein levels differ between diabetic and WT CMECs. Additionally, diabetic CMECs exhibit decreased cell proliferation and increased cellular apoptosis compared to WT CMECs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Mohammad A. Alfhili, Jawaher Alsughayyir, Ahmed Basudan, Mohammed Alfaifi, Zuhier A. Awan, Mohammed R. Algethami, Yazeed A. Al-Sheikh
Summary: This study investigated the changes in platelet-lymphocyte ratio (PLR) in relation to glycemic control. The results showed that PLR was significantly reduced in subjects with hyperglycemia and high PLR was less prevalent in hyperglycemic individuals. Furthermore, PLR performed better than C-reactive protein as a marker for glycemic control in females.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Medicine, General & Internal
Yolanda Garcia-Mesa, Jorge Feito, Mario Gonzalez-Gay, Irene Martinez, Jorge Garcia-Piqueras, Jose Martin-Cruces, Eliseo Vina, Teresa Cobo, Olivia Garcia-Suarez
Summary: The study found a significant decrease in the number of cutaneous mechanoreceptors in diabetic patients with distal diabetic sensorimotor polyneuropathy, especially in those experiencing pain, leading to impaired mechanosensitivity system which may partly explain the progression of the disease. Increased severity of the disease may be associated with the development of painful neuropathic symptoms, but the exact mechanism linking the absence of cutaneous mechanoreceptors to pain remains unclear.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Rebeca Kababie-Ameo, Gabriela Gutierrez-Salmean, Carlos A. Cuellar
Summary: Diabetes and its prediabetic stage are associated with complications such as neuropathy, including peripheral neuropathy. Screening for peripheral neuropathy is recommended in diabetes management, but there are no guidelines for prediabetic individuals without symptoms. Clinical screening tests might be subjective and not accurately detect nerve damage. Recent evidence suggests using the impairment of the rate-dependent depression of the H-reflex as an objective biomarker to assess sensorimotor integration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Christopher J. Klein, Tatiana M. Foroud
MAYO CLINIC PROCEEDINGS
(2017)
Article
Medicine, General & Internal
Eelco F. M. Wijdicks, Christopher J. Klein
MAYO CLINIC PROCEEDINGS
(2017)
Article
Clinical Neurology
Wei Wang, William J. Litchy, Michelle L. Mauermann, P. James B. Dyck, Angela Dispenzieri, Jay Mandrekar, Peter J. Dyck, Christopher J. Klein
Article
Clinical Neurology
Rajat Lahoria, Sean J. Pittock, Avi Gadoth, Janean K. Engelstad, Vanda A. Lennon, Christopher J. Klein
Article
Clinical Neurology
Mohamed Kazamel, Christopher J. Klein, Eduardo E. Benarroch, Mrinal M. Patnaik, Jennifer A. Tracy
Article
Clinical Neurology
Divyanshu Dubey, Vanda A. Lennon, Avi Gadoth, Sean J. Pittock, Eoin P. Flanagan, John E. Schmeling, Andrew McKeon, Christopher J. Klein
Article
Ophthalmology
Farzana Choudhury, Stacy M. Meuer, Ronald Klein, Dandan Wang, Mina Torres, Xuejuan Jiang, Roberta Mckean-Cowdin, Rohit Varma
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Clinical Neurology
Divyanshu Dubey, Sean J. Pittock, Cecilia R. Kelly, Andrew McKeon, Alfonso Sebastian Lopez-Chiriboga, Vanda A. Lennon, Avi Gadoth, Carin Y. Smith, Sandra C. Bryant, Christopher J. Klein, Allen J. Aksamit, Michel Toledano, Bradley F. Boeve, Jan-Mendelt Tillema, Eoin P. Flanagan
ANNALS OF NEUROLOGY
(2018)
Article
Clinical Neurology
Jennifer M. Martinez-Thompson, Melissa R. Snyder, Michael Ettore, Andrew Mckeon, Sean J. Pittock, Matthew M. Roforth, Jay Mandrekar, Michelle L. Mauermann, Bruce V. Taylor, James B. Dyck, Anthony J. Windebank, Christopher J. Klein
Article
Ophthalmology
Ronald Klein, Kristine E. Lee, Lorraine Danforth, Michael Y. Tsai, Ronald E. Gangnon, Stacy E. Meuer, Tien Y. Wong, Carol Y. Cheung, Barbara E. K. Klein
Article
Clinical Neurology
Avi Gadoth, Anastasia Zekeridou, Christopher J. Klein, Colton J. Thoreson, Masoud Majed, Divyanshu Dubey, Eoin P. Flanagan, Andrew McKeon, Sarah M. Jenkins, Vanda A. Lennon, Sean J. Pittock
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2018)
Article
Multidisciplinary Sciences
Antonio B. Fernandez, Kevin D. Ballard, Tien Y. Wong, Mengye Guo, Robyn L. McClelland, Gregory Burke, Mary Frances Cotch, Barbara Klein, Matthew Allison, Ronald Klein
Article
Ophthalmology
Ronald Klein, Kristine E. Lee, Michael Y. Tsai, Karen J. Cruickshanks, Ronald E. Gangnon, Barbara E. K. Klein
Article
Rheumatology
Helgi Jonsson, Diana E. Fisher, Gudny Eiriksdottir, Thor Aspelund, Ronald Klein, Vilmundur Gudnason, Mary Frances Cotch
RHEUMATOLOGY INTERNATIONAL
(2019)
Article
Medicine, General & Internal
William Jones Dartora, Marcelo Krieger Maestri, Maria Ines Schmidt, Bruce Bartholow Duncan, Lloyd Chambless, Ronald Klein, Stacy Meuer, Vivian Cristine Luft
SAO PAULO MEDICAL JOURNAL
(2018)