Article
Nutrition & Dietetics
Ya-Jie Xu, Wen-Juan Wang, Qiu-Yi Zhang, Meng-Nan Yang, Lin Zhang, Hua He, Yu Dong, Fengxiu Ouyang, Ying Gao, Jun Zhang, Tao Zheng, Zhong-Cheng Luo
Summary: This study aimed to assess whether docosahexaenoic acid (DHA) supplementation in gestational diabetes mellitus (GDM) affects neonatal metabolic health biomarkers, especially leptin and adiponectin. The results showed that DHA supplementation at 500 mg/day did not have a significant impact on neonatal metabolic biomarkers including leptin, adiponectin, and IGF-1. This outcome is reassuring and suggests potential benefits to fetal growth and development.
FRONTIERS IN NUTRITION
(2023)
Article
Pediatrics
Olivia J. Hofer, Jane Alsweiler, Thach Tran, Caroline A. Crowther
Summary: This study found that using tighter glycemic targets did not affect the concentrations of maternal and infant biomarkers in women with gestational diabetes. However, compliance with tighter targets resulted in changes in these biomarkers.
PEDIATRIC RESEARCH
(2023)
Article
Health Care Sciences & Services
Watip Tangjittipokin, Tassanee Narkdontri, Nipaporn Teerawattanapong, Benyapa Thanatummatis, Fauchil Wardati, Prasert Sunsaneevithayakul, Dittakarn Boriboonhirunsarn
Summary: This study investigated the association between maternal circulating adipokine levels and ADIPOQ gene polymorphism among pregnant women with GDM and NGT. The results showed that ADIPOQ polymorphisms were significantly associated with adiponectin levels in GDM patients.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Endocrinology & Metabolism
Helene Affres, Marie-Victoire Senat, Alexandra Letourneau, Philippe Deruelle, Magali Coustols-Valat, Hanane Bouchghoul, Jean Bouyer
Summary: In women with gestational diabetes mellitus (GDM), glyburide is effective for reaching glycemic goals during pregnancy, but may increase the risk of maternal hypoglycemia. Switching to insulin therapy after glyburide treatment failure can improve glycemic control.
DIABETES & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yan Wang, Shihua Zhao, Wei Peng, Ying Chen, Jingwei Chi, Kui Che, Yangang Wang
Summary: In this study, the expression of Slit-2 in maternal peripheral blood and neonatal cord blood of gestational diabetes mellitus (GDM) patients was examined. The results showed that the levels of Slit-2 in GDM patients were higher than those in healthy pregnant women. Slit-2 levels were positively correlated with inflammatory factors and insulin resistance, and negatively correlated with beta cell function. Additionally, Slit-2 levels were related to neonatal blood glucose and weight. These findings suggest that Slit-2 may serve as a potential biomarker for GDM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Peng Xu, Shuai Dong, Linlin Wu, Yule Bai, Xueqing Bi, Yaping Li, Chang Shu
Summary: Gestational diabetes mellitus (GDM) is a significant metabolic complication of pregnancy that affects the future health of both the mother and the newborn. The pathogenesis of GDM is not fully understood, but it is clear that placental secretion of insulin-like growth factors, adipokines, tumor necrosis factor-alpha, cytokines, and insulin resistance play a key role. Additionally, DNA methylation of related molecules and pathway-related genes influence gene expression and contribute to the pathogenesis of GDM.
Article
Endocrinology & Metabolism
Anne H. Y. Chu, Wen Lun Yuan, See Ling Loy, Shu E. Soh, Jonathan Y. Bernard, Mya-Thway Tint, Sarah S. T. Ho-Lim, Huecin Goh, Adaikalavan Ramasamy, Mukkesh Kumar, Claire Goh, Li Ting Ang, Lynette Pei-Chi Shek, Yap Seng Chong, Kok Hian Tan, Lin Lin Su, Arijit Biswas, Fabian Yap, Yung Seng Lee, Claudia Chi, Keith M. Godfrey, Johan Gunnar Eriksson, Shiao-Yng Chan
Summary: The study found an association between height and gestational diabetes (GDM) diagnosis and complications during pregnancy, with shorter women more likely to be diagnosed with GDM, and GDM being more strongly associated with complications such as preterm delivery and higher birthweight among taller women.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Yoshifumi Kasuga, Tomoko Kawai, Kei Miyakoshi, Yoshifumi Saisho, Masumi Tamagawa, Keita Hasegawa, Satoru Ikenoue, Daigo Ochiai, Mariko Hida, Mamoru Tanaka, Kenichiro Hata
Summary: This study revealed an association between gestational diabetes mellitus and neonatal plasma glucose level at 1 hour after birth as well as DNA methylation changes at the alternative transcription start site of ZNF696 in cord blood cells.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaolei Wang, Jin Huang, Yixiang Zheng, Sisi Long, Huijun Lin, Na Zhang, Mengyuan Tian, Xinrui Wu, Rongjing An, Shujuan Ma, Hongzhuan Tan
Summary: Genome-wide DNA methylation profiling was used to identify maternal CpG sites associated with gestational diabetes mellitus (GDM). Changes in methylation levels of specific CpG sites in early pregnancy blood samples were found to potentially predict the development of GDM. High methylation levels at certain CpG sites were associated with an increased risk of GDM, while low methylation levels at others were linked to a decreased risk.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Fuyan Yang, Wenfa Yang, Guohua Wang, Yaqiong Liu, Jun Jin
Summary: The study showed that betatrophin levels were significantly lower in both maternal and cord blood of GDM patients compared to the control group. Betatrophin levels were positively associated with 25-(OH)D levels, but negatively associated with hsCRP and HOMA-IR levels in the GDM group. Fetal weight was higher in the GDM group and negatively associated with cord blood betatrophin levels. These findings suggest the potential for developing new predictive biomarkers or therapeutic targets for GDM.
Article
Obstetrics & Gynecology
Guixue Hou, Ya Gao, Liona C. Poon, Yan Ren, Chunwei Zeng, Bo Wen, Argyro Syngelaki, Liang Lin, Jin Zi, Fengxia Su, Weiwei Xie, Fang Chen, Kypros H. Nicolaides
Summary: This study defined the lipidomic profile in plasma during pregnancy and identified lipid biomarkers for the prediction of gestational diabetes mellitus (GDM) in early pregnancy.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anais Serati, Chiara Novielli, Gaia Maria Anelli, Maria Mandalari, Francesca Parisi, Irene Cetin, Renata Paleari, Chiara Mando
Summary: Maternal obesity and gestational diabetes mellitus (GDM) are associated with adverse maternal and foetal outcomes, and involve epigenetic alterations contributing to the pathogenesis of metabolic diseases. This pilot study analyzed plasma microRNAs in obese pregnant women with/without GDM, revealing differentially expressed microRNAs related to oxidative stress, inflammation, nutrients, and hormones metabolism. These findings provide insight into the complex epigenetic network regulating metabolic pathways in MO and GDM, but further investigations are needed.
Article
Endocrinology & Metabolism
Zhuoyan Li, Yujian Wu, Bowen Du, Xiaodan Yu, Hualing Wang, Yiwei Niu, Jian Wang, Sun Chen, Kun Sun
Summary: This study found that maternal gestational diabetes mellitus (GDM) is associated with cardiovascular alterations in early childhood, particularly in male offspring, independent of maternal and child characteristics.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Food Science & Technology
Yan Yang, Zixin Cai, Jingjing Zhang
Summary: The study suggests that pregnant women with GDM are more likely to have higher folate levels. Furthermore, high maternal folate levels may predict a higher risk of GDM. Further large population studies are needed to confirm these findings.
FOOD SCIENCE & NUTRITION
(2021)
Article
Endocrinology & Metabolism
Marie Parfaite Uwimana Muhuza, Lixia Zhang, Qi Wu, Lu Qi, Danqing Chen, Zhaoxia Liang
Summary: This study investigated the association between HbA1c levels and adverse outcomes in women with gestational diabetes mellitus (GDM), considering maternal age, pre-pregnancy BMI, and gestational weight gain (GWG). The results showed that HbA1c was significantly associated with macrosomia, pregnancy-induced hypertension (PIH), preterm birth, and primary Cesarean section. The associations varied with maternal age, pre-pregnancy BMI, and GWG.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Cesar Fernandez-Lazaro, Estefania Toledo, Pilar Buil-Cosiales, Jordi Salas-Salvado, Dolores Corella, Montserrat Fito, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Emilio Ros, Clotilde Vazquez, Lidia Daimiel, Beatriz SanJulian, Jesus F. Garcia-Gavilan, Jose Sorli, Olga Castaner, M. Angeles Zulet, Lucas Tojal-Sierra, Napoleon Perez-Farinos, Alejandro Oncina-Canovas, Manuel Monino, Antonio Garcia-Rios, Emilio Sacanella, Rosa M. Bernal-Lopez, Jose Manuel Santos-Lozano, Zenaida Vazquez-Ruiz, Jananee Muralidharan, Carolina Ortega-Azorin, Alberto Goday, Cristina Razquin, Leire Goicolea-Guemez, Miguel Ruiz-Canela, Nerea Becerra-Tomas, Helmut Schroder, Miguel A. Martinez Gonzalez
Summary: The study indicated that participants with high baseline perceived self-efficacy, higher fiber intake, multiple chronic conditions (especially depression) were more likely to successfully comply with an energy-reduced Mediterranean diet. Tailored interventions focusing on these factors may lead to greater dietary changes and nutritional improvements.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Pediatrics
Alejandra Rojas-Gomez, Pol Sole-Navais, Pere Cavalle-Busquets, Gemma Ornosa-Martin, Carme Grifoll, Carla Ramos-Rodriguez, Joan Fernandez-Ballart, Luis Masana, Monica Ballesteros, Per Magne Ueland, Michelle M. Murphy
Summary: This study found that inadequate cobalamin status during pregnancy is associated with adverse metabolic health in mid-childhood, particularly in boys. These findings highlight the importance of maintaining adequate cobalamin levels during pregnancy to reduce the risk of negative health outcomes in offspring.
PEDIATRIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yuan-Di Halvorsen, John Paul Lock, Juan P. Frias, Francisco Jose Tinahones, Dominik Dahl, Annie L. Conery, Mason W. Freeman
Summary: This study compared the effects of bexagliflozin tablets and glimepiride on the treatment of patients with type 2 diabetes. It was found that bexagliflozin tablets were noninferior to glimepiride in lowering HbA1c levels, and were superior in reducing body mass and systolic blood pressure. Additionally, bexagliflozin tablets were associated with fewer hypoglycemic events and had a favorable effect on estimated glomerular filtration rate (eGFR).
DIABETES OBESITY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Nieves Luisa Gonzalez-Gonzalez, Enrique Gonzalez-Davila, Ana Megia, Pilar Pintado, Begona Vega, Erika Padron, Laura Perez-Conde, Nazaret Villalba, Fernando Bugatto
Summary: The effects of substituting the National Diabetes Data Group (NDDG) criteria with the International Association of Diabetes and Pregnancy Study Groups (IADPSG) or American Diabetes Association (ADA) criteria for the diagnosis of early-onset gestational diabetes mellitus (Early-GDM) or first trimester abnormal glucose tolerance (1 t-AGT) were analyzed. Replacing the NDDG recommendations with the IADPSG or ADA criteria resulted in a large number of women with higher risks of adverse perinatal outcomes being deprived of early treatment and other women with lower risks being treated.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Nutrition & Dietetics
Hatim Boughanem, Pallavi Kompella, Francisco J. Tinahones, Manuel Macias-Gonzalez
Summary: Gene expression can be regulated by epigenomic modifications such as DNA methylation, histone modification, and chromosome remodeling. Vitamins, as natural bioactive compounds, have been found to modify epigenetic patterns and potentially impact the risk of cancer, including colorectal cancer (CRC). This review examines the relationship between vitamins and CRC risk through epidemiological and observational studies and discusses the potential of using vitamins as epigenetic modifiers for CRC treatment. Although more studies with better designs are needed, understanding the molecular mechanisms of vitamin-mediated epigenetic regulation can help identify effective therapeutic targets for CRC prevention and treatment.
Article
Cardiac & Cardiovascular Systems
Maria Rubin-Garcia, Facundo Vitelli-Storelli, Laura Alvarez-Alvarez, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Alvaro Hernaez, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Luis Serra-Majem, Naomi Cano-Ibanez, Josep A. Tur, Alba Marcos-Delgado, Anna Tresserra-Rimbau, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emili Ros, Zenaida Vazquez-Ruiz, Nancy Babio, Rocio Barragan, Olga Castaner-Nino, Cristina Razquin, Lucas Tojal-Sierra, Enrique Gomez-Gracia, Sandra Gonzalez-Palacios, Marga Morey, Antonio Garcia-Rios, Sara Castro-Barquero, Maria Rosa Bernal-Lopez, Jose Manuel Santos-Lozano, Miguel Ruiz-Canela, Antoni Castro-Salomo, Eva Cristina Pascual-Castello, Veronica Moldon, Vanessa Bullon-Vela, Carolina Sorto-Sanchez, Juan Carlos Cenoz-Osinaga, Liliana Gutierrez, Maira Mengual, Rosa Maria Lamuela-Raventos, Vicente Martin-Sanchez
Summary: This study found an inverse association between the intake of certain subclasses of polyphenols and serum uric acid levels and hyperuricemia in individuals with metabolic syndrome. Further research is needed to confirm these findings.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Pathology
Manuel Sanchez-Prieto, Laura Perdomo, Berta Cortes, Ignacio Rodriguez, Pilar Prats, Alberto Rodriguez-Melcon, Pere Barri-Soldevila, Bernat Serra, Gerard Albaiges
Summary: This study evaluated the obstetrical outcomes, ultrasonographic characteristics, and final diagnosis of fetal megacystis (FM). The results showed that most FM cases were detected in the second trimester, and the majority of pregnancies were electively terminated. FM was often associated with other ultrasound abnormalities, with the most common being umbilical cord cyst. About 44% of FM cases had an identifiable cause.
FETAL AND PEDIATRIC PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sergiy Klid, Elsa Maymo-Masip, Francisco Algaba-Chueca, Monica Ballesteros, Montserrat Ingles-Puig, Albert Guarque, Ana Madeira, Carlos Jareno, Joan Vendrell, Sonia Fernandez-Veledo, Ana Megia
Summary: This study evaluated the response of ANGPTL3, 4, and 8 after a meal intake in women with gestational diabetes and normal glucose tolerance, and examined their gene expressions in different placental locations. It was observed that ANGPTL4 did not respond after the meal intake in the gestational diabetes group, unlike the control group. The expression pattern of ANGPTL3 in the placenta was glucose tolerance-dependent. Additionally, the expressions of ANGPTL3, 4, and 8 were associated with birth weight and placental weight in the gestational diabetes group, suggesting a role in regulating nutrient passage across the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Endocrinology & Metabolism
Jose-Miguel Gonzalez-Clemente, Gemma Llaurado, Albert Cano, Olga Gimenez-Palop, Lara Albert, Joan Vendrell
Article
Acoustics
G. Albaiges, I. Papastefanou, I. Rodriguez, P. Prats, M. Echevarria, M. A. Rodriguez, A. Rodriguez Melcon
Summary: This study examines the external validity of the new Fetal Medicine Foundation (FMF) competing-risks model for predicting small-for-gestational-age (SGA) neonates in midgestation. The study finds that the model performs well in a large independent Spanish population.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Psychology, Clinical
Sangeetha Shyam, Carlos Gomez-Martinez, Indira Paz-Graniel, Jose J. Gaforio, Miguel Angel Martinez-Gonzalez, Dolores Corella, Montserrat Fito, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Manuel Santos-Lozano, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Maria Ramos, Josep Vidal, Maria Mar Alcarria, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia Regata, Estefania Toledo, Jose V. Sorli, Olga Castaner, Antonio Garcia-Rios, Rafael Valls-Enguix, Napoleon Perez-Farinos, M. Angeles Zulet, Elena Rayo-Gago, Rosa Casas, Mario Rivera-Izquierdo, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Pilar Buil-Cosiales, Rebeca Fernandez-Carrion, Albert Goday, Patricia J. Pena-Orihuela, Laura Compan-Gabucio, Javier Diez-Espino, Susanna Tello, Ana Gonzalez-Pinto, Victor de la O, Miguel Delgado-Rodriguez, Nancy Babio, Jordi Salas-Salvado
Summary: COVID-19 is associated with long-term depression risk in older adults, especially in women. Long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are necessary for older adults.
PSYCHOLOGICAL MEDICINE
(2023)
Correction
Cell & Tissue Engineering
Sergiy Klid, Francisco Algaba-Chueca, Elsa Maymo-Masip, Albert Guarque, Monica Ballesteros, Cristina Diaz-Perdigones, Cristina Gutierrez, Joan Vendrell, Ana Megia, Sonia Fernandez-Veledo
STEM CELL RESEARCH & THERAPY
(2023)
Article
Endocrinology & Metabolism
Juan J. Diez, Emma Anda, Victoria Alcazar, Maria L. Isidro, Cristina Familiar, Miguel Paja, Patricia Martin Rojas-Marcos, Begona Perez-Corral, Elena Navarro, Ana R. Romero-Lluch, Amelia Oleaga, Maria J. Pamplona, Jose C. Fernandez-Garcia, Ana Megia, Laura Manjon-Miguelez, Cecilia Sanchez-Ragnarsson, Pedro Iglesias, Julia Sastre
Summary: There is limited information on healthcare resource consumption in older patients with differentiated thyroid cancer. In this study, we analyzed the consumption of resources in older patients and compared patients aged 75 and older with those aged 60-74. The results showed that age is not an independent determining factor in healthcare resource consumption in older patients with differentiated thyroid cancer.