Article
Cardiac & Cardiovascular Systems
Massimo R. Mannarino, Matteo Pirro, Bruna Gigante, Kai Savonen, Sudhir Kurl, Philippe Giral, Andries Smit, Fabrizio Veglia, Elena Tremoli, Damiano Baldassarre
Summary: The study found a U-shaped association between SUA levels and VEs in men at moderate-to-high CVD risk, with both low and high SUA levels being associated with an increased risk of VEs. Elevated SUA levels were also independently associated with cIMT progression in men. However, no significant associations were found in women between SUA levels, CVD end points, and cIMT progression.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Georgios Georgiopoulos, Georgios Mavraganis, Dimitrios Delialis, Stelios Georgiou, Evmorfia Aivalioti, Raphael Patras, Ioannis Petropoulos, Maria-Angeliki Dimopoulou, Lasthenis Angelidakis, Alexandros Sianis, Dimitrios Bampatsias, Anna Dimoula, Eleni Maneta, Marinos Kosmopoulos, Constantine Vardavas, Konstantinos Stellos, Kimon Stamatelopoulos
Summary: This study aimed to determine and validate the optimal values of carotid subclinical atherosclerosis markers for improving risk stratification in high ASCVD risk patients. The results showed that integrating carotid ultrasonography into guideline-defined risk stratification can help identify high-risk patients in need of further risk reduction and accurately assess their risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Karri Parkkila, Antti Kiviniemi, Mikko Tulppo, Juha Perkiomaki, Y. Antero Kesaniemi, Olavi Ukkola
Summary: In a prospective study with over 20 years of follow-up, the length of plaques in abdominal-pelvic main arteries (SUM) was found to be a superior indicator for evaluating overall cardiovascular risk compared to carotid intima-media thickness (IMT). SUM significantly predicted CV events and improved the discrimination and reclassification of patients when added to the established model, while IMT only predicted cardiovascular events in univariate analysis and did not improve discrimination or reclassification.
Review
Health Care Sciences & Services
Anna Maria Rychter, Dariusz Naskret, Agnieszka Zawada, Alicja Ewa Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Atherosclerosis is strongly associated with obesity, with carotid intima-media thickness (cIMT) serving as a predictor of cardiovascular events and subclinical atherosclerosis. Behavioral interventions can directly impact cIMT values, influencing cardiovascular disease risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Xue Bao, Biao Xu, Lars Lind, Gunnar Engstrom
Summary: Subclinical carotid atherosclerosis is an important factor in cardiovascular risk estimation by SCORE2. Carotid ultrasound improves the predictive performance of SCORE2 for cardiovascular risk assessment. SCORE2 may over-predict the risk in individuals without carotid plaque and under-predict the risk in those with carotid plaque.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gilles Neve, Pirjo Komulainen, Kai Savonen, Maija Hassinen, Reija Mannikko, Denis Infanger, Arno Schmidt-Trucksass, Rainer Rauramaa
Summary: In middle-aged to elderly Finns, higher adherence to the Life's Simple 7 is associated with lower carotid lumen diameter and higher distensibility, but not with carotid intima-media thickness. Adherence to healthy lifestyle habits is therefore linked to better carotid structure and function in this population.
Article
Cardiac & Cardiovascular Systems
Sophia J. Kiechl, Anna Staudt, Katharina Stock, Nina Gande, Benoit Bernar, Christoph Hochmayr, Bernhard Winder, Ralf Geiger, Andrea Griesmacher, Markus Anliker, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach, Raimund Pechlaner
Summary: The study revealed that systolic blood pressure, arterial hypertension, low-density and non-high-density lipoprotein cholesterol, and alanine transaminase predicted cIMT progression in adolescents, even when risk factor levels were within established reference ranges. These findings underline the importance of initiating prevention early in life and question the current focus on high-risk youngsters in guideline recommendations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jean-Baptiste Moretti, Reinemary Michael, Sylvie Gervais, Emilie Alchourron, Nina Stein, Ziad Farhat, Chantal Lapierre, Josee Dubois, Ramy El-Jalbout
Summary: This study aimed to determine the normal pediatric values of carotid artery intima-media thickness (IMT) by conducting a systematic review of the literature. The results showed that the average IMT in children using B-mode and radiofrequency techniques were 0.43mm and 0.41mm respectively. No significant relationship was found between IMT and age or sex.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pilar Cobeta, Roberto Pariente, Alvaro Osorio, Marta Marchan, Luis Blazquez, David Pestana, Julio Galindo, Jose Botella-Carretero
Summary: Obesity increases cardiovascular risk in men through mechanisms of chronic inflammation and hypogonadism. This study demonstrated that metabolic surgery can decrease carotid-intima media thickness by modulating inflammatory, endothelial biomarkers, and testosterone levels.
Article
Environmental Sciences
Yue Leon Guo, Rosario D. Ampon, Ivan C. Hanigan, Luke D. Knibbs, Christy Geromboux, Ta-Chen Su, Kazuaki Negishi, Leanne Poulos, Geoffrey G. Morgan, Guy B. Marks, Bin Jalaludin
Summary: The study found that long-term exposure to low levels of PM2.5 in children may have measurable adverse impacts on cardiovascular risk marker, carotid intima-media thickness (CIMT), by age 11-12 years.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, General & Internal
Ettore Dinoto, Domenico Mirabella, Francesca Ferlito, Graziella Tortomasi, Davide Turchino, Salvatore Evola, Massimiliano Zingales, Emanuela Bologna, Felice Pecoraro
Summary: The intima-media thickness (IMT) and its irregularities or ulcerations in the common carotid artery (CCA) can serve as biomarkers for cardiovascular system integrity. Total homocysteine and lipoprotein levels are commonly used for cardiovascular risk stratification. Duplex ultrasound (DUS) combined with serum biomarkers can assess atherosclerotic disease and cardiovascular risk effectively.
Article
Surgery
Aashir Kaul, Arun Kumar, Aditya Baksi, Vitish Singla, Sandeep Aggarwal, Gurpreet Gulati, Rajiv Narang, Lokesh Kashyap
Summary: This study demonstrates that bariatric surgery can significantly reduce CIMT and CVD risk in patients with morbid obesity. Additionally, it also shows positive improvements in lipid profile, fasting blood sugar, and HbA(1C) levels.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Peripheral Vascular Disease
Xiaoxiang Ma, Yue Zhuo, Yu Huang, Pengming He, Zhaoyi Huang, Li Jiang, Luyao Tong, Xiaoqin Yao, Xueping Wen, Xuemei Zhong, Shihan Yang, Changqiong Li, Yuping Liu, Zhixin Zhang
Summary: This study reveals that abnormal T-cell responses may play important roles in the progression of essential hypertension and its subclinical target organ damage. The TCR beta repertoires of patients with essential hypertension are significantly different, and are correlated with carotid plaque formation.
Article
Peripheral Vascular Disease
Maria del Mar Vila, Beatriz Remeseiro, Laura Igual, Roberto Elosua, Rafel Ramos, Jose Manuel Valdivielso, Ruth Marti-Lluch, Jaume Marrugat, Maria Grau
Summary: In men, autoimmune diseases were associated with increased common carotid intima-media thickness and higher percentage of individuals with thicker IMT. However, no significant differences were observed in arterial stiffness. Women, on the other hand, did not show significant differences in any of the carotid features between those with and without autoimmune diseases. Sex was found to be an effect modifier in the association between common carotid IMT values and autoimmune diseases diagnosis.
HYPERTENSION RESEARCH
(2021)
Article
Dermatology
Sumeyre Seda Ertekin, Ayse Esra Koku Aksu, Abdurrahim Kocyigit, Eray Metin Guler, Melis Baykara Ulusan, Mehmet Salih Gurel
Summary: In this study, patients with rosacea showed significantly higher levels of serum proinflammatory markers compared to healthy controls, but no significant difference in mean CIMT values. However, subgroups of patients with moderate to severe rosacea or with eye involvement had increased subclinical atherosclerosis, indicating a potential need for additional attention in cardiovascular disease prevention for these specific groups.
DERMATOLOGIC THERAPY
(2021)
Editorial Material
Endocrinology & Metabolism
Hirotaka Watada
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Eiichi Araki, Yasuo Terauchi, Hirotaka Watada, Srikanth Deenadayalan, Erik Christiansen, Hiroshi Horio, Takashi Kadowaki
Summary: The study aimed to evaluate the efficacy and safety of oral semaglutide compared to other drugs in Japanese patients with type 2 diabetes. The results showed that oral semaglutide effectively lowered HbA1c levels and body weight in Japanese patients, with gastrointestinal adverse events being the most common. Overall, oral semaglutide was well tolerated and showed promising results in Japanese patients.
DIABETES OBESITY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Motonori Sato, Yoshifumi Tamura, Hideyoshi Kaga, Nozomu Yamasaki, Mai Kiya, Satoshi Kadowaki, Daisuke Sugimoto, Takashi Funayama, Yuki Someya, Saori Kakehi, Shuko Nojiri, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The study showed that SGLT2i tofogliflozin did not affect the metabolic clearance rate of insulin, but could improve glycated hemoglobin levels and reduce body weight.
Article
Endocrinology & Metabolism
Caroline Reilhac, Julie Dubourg, Carole Thang, Jean-Marie Grouin, Pascale Fouqueray, Hirotaka Watada
Summary: This study evaluated the efficacy and safety of imeglimin as combination therapy with insulin in Japanese patients with type 2 diabetes. The results showed that imeglimin significantly improved HbA1c levels and had a similar safety profile to placebo.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Shugo Sasaki, Michelle Y. Y. Lee, Yuka Wakabayashi, Luka Suzuki, Helena Winata, Miwa Himuro, Taka-aki Matsuoka, Iichiro Shimomura, Hirotaka Watada, Francis C. Lynn, Takeshi Miyatsuka
Summary: This study investigates the characteristics of newborn beta cells and their transcriptomic profiles using a time-resolved reporter system. The findings reveal spatial and transcriptional heterogeneity in beta cell neogenesis, providing insights into beta cell differentiation and future cell therapy.
Article
Cell & Tissue Engineering
Rica Tanaka, Satoshi Fujimura, Makiko Kado, Taro Fukuta, Kayo Arita, Rie Hirano-Ito, Tomoya Mita, Hirotaka Watada, Yoshiteru Kato, Katsumi Miyauchi, Hiroshi Mizuno
Summary: MNC-QQ therapy shows promising efficacy in chronic non-healing ischemic extremity wounds, improving vascular and skin perfusion and reducing pain intensity. It is also safe for patients.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Kazuhisa Takamura, Shinichiro Fujimoto, Tomoya Mita, Yuko Okano Kawaguchi, Mika Kurita, Satoshi Kadowaki, Yuki Kamo, Chihiro Aoshima, Yui Okada Nozaki, Daigo Takahashi, Ayako Kudo, Makoto Hiki, Nobuo Tomizawa, Fuki Ikeda, Hiroaki Satoh, Hirotaka Watada, Tohru Minamino
Summary: Among asymptomatic patients with type 2 diabetes, current smoking, Agatston score >= 100, and insulin treatment are independent predictive factors for high-risk coronary artery disease (CAD) patients. Non-invasive examinations, except for the Agatston score, are not independent predictors of high-risk CAD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Takashi Kadowaki, Hiroshi Maegawa, Hirotaka Watada, Daisuke Yabe, Koichi Node, Toyoaki Murohara, Jun Wada
Summary: There is a interaction between metabolic disorders, cardiovascular disease, and kidney dysfunction, known as cardio-renal-metabolic (CRM) disease. Understanding the molecular mechanisms and pathophysiological processes of CRM disease is crucial for improving patient outcomes, and there may be differences in CRM diseases between different regions.
DIABETES OBESITY & METABOLISM
(2022)
Article
Transplantation
Masanomi Nangaku, Hirotaka Takama, Tomohiro Ichikawa, Kazuya Mukai, Masahiro Kojima, Yusuke Suzuki, Hirotaka Watada, Takashi Wada, Kohjiro Ueki, Ichiei Narita, Naoki Kashihara, Takashi Kadowaki, Hiroki Hase, Tadao Akizawa
Summary: This study aims to evaluate the efficacy and safety of bardoxolone methyl in diabetic kidney disease (DKD) patients with reduced estimated glomerular filtration rate (eGFR) and elevated urinary albumin:creatinine ratio (UACR). Results show that patients enrolled in the study meet the criteria, and the study will investigate the long-term efficacy and safety of bardoxolone methyl in this patient population.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Mika Kurita, Hiroaki Satoh, Hideyoshi Kaga, Satoshi Kadowaki, Yuki Someya, Yuka Tosaka, Yuya Nishida, Fuki Ikeda, Yoshifumi Tamura, Hirotaka Watada
Summary: To achieve long-term management of diabetes, patients with type 2 diabetes mellitus need high treatment adherence, which is associated with treatment satisfaction and quality of life. Patient education about diabetes self-management is essential. This study investigates the improvement of quality of life and post-discharge glycemic control in patients with type 2 diabetes mellitus through a diabetes education program.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Katsuhiko Hagi, Kenji Kochi, Hirotaka Watada, Kohei Kaku, Kohjiro Ueki
Summary: This study analyzed the efficacy and safety of imeglimin 1,000 mg twice daily monotherapy in type 2 diabetes mellitus patients, considering their demographic and clinical characteristics. The results showed statistically significant differences in HbA1c levels between imeglimin and placebo across all patient subgroups analyzed. The efficacy and safety of imeglimin were confirmed across a broad spectrum of patients with type 2 diabetes mellitus, with no new safety concerns identified in any patient subpopulations.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Neurosciences
Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konishi
Summary: Insulin resistance may lead to structural and functional abnormalities in the human brain, which may be mediated through resting-state functional connectivity between the hypothalamus and the cerebral cortex.
Article
Endocrinology & Metabolism
Katsuhiko Hagi, Masahiro Nitta, Hirotaka Watada, Kohei Kaku, Kohjiro Ueki
Summary: This meta-analysis evaluated the efficacy and safety of imeglimin in monotherapy and adjunctive therapy for patients with type 2 diabetes mellitus. The results showed that imeglimin significantly reduced glycated hemoglobin levels as both monotherapy and adjunctive therapy, and it was well tolerated and safe.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Toshiki Kogai, Junko Sato, Marin Hirakata, Tatsuya Iwamoto, Kenichi Nakajima, Hiromasa Goto, Yuya Nishida, Hirotaka Watada
Summary: The FreeStyle Libre Flash Glucose Monitoring System can provide sensor glucose values through scanning. However, this case report highlights the importance of considering sensor defects as they can lead to severe complications like diabetic ketoacidosis. Even though the device showed lower glucose values, the patient mistook it for hypoglycemia and reduced insulin dosage, ultimately leading to diabetic ketoacidosis. It is crucial to remind patients about the potential risk of sensor defects despite the benefits of glucose monitoring with this system.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Kageumi Takeno, Yoshifumi Tamura, Saori Kakehi, Hideyoshi Kaga, Ryuzo Kawamori, Hirotaka Watada
Summary: The study found that individuals carrying the ALDH2 rs671 G/G genotype had higher alcohol consumption, elevated fasting plasma glucose, lower hepatic insulin sensitivity, and reduced fasting glucose clearance compared to those carrying the non-risk alleles. These results suggest that high alcohol intake may lead to hepatic insulin resistance and reduced fasting glucose clearance in carriers of the ALDH2 rs671 G/G genotype.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
