Review
Chemistry, Analytical
Zakia Fatima, Maurizio Quinto, John L. Zhou, Donghao Li
Summary: This review discusses and compares the latest advances in extraction and chromatographic methods for analyzing the active forms of fat-soluble vitamins (FSVs) in various matrices. It focuses on newly established extraction and analytical approaches for multi-form vitamin analysis, as well as the suitability and specificity of multi-dimensional chromatography-based methods for FSV substances. Analytical challenges related to mass spectrometry detection of FSV substances are also briefly discussed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Liyun Kong, Jiaqi Wang, Qingpeng Gao, Xiaoqian Li, Wenbin Zhang, Ping Wang, Le Ma, Langchong He
Summary: The determination of fat-soluble vitamins and carotenoids in human serum can be achieved simultaneously using a surface active ionic liquid (SAIL)-based dispersive liquid-liquid microextraction (DLLME) method coupled with high performance liquid chromatography (HPLC). This method provides efficient sample preparation and high enrichment factors.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemical Research Methods
Fei-Fei Qi, Li-Mei Tao, Yi-Ming Dai, Bao-Ming Zhang, Xin Wang, Yan Yu
Summary: A fast, efficient, and high-throughput supported liquid extraction method was developed for simultaneous extraction of FSV and CAR from human serum, showing good recovery and reproducibility. Compared to traditional liquid-phase extraction, this method offers faster extraction, higher recovery, better reproducibility, and lower matrix effect.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Medicine, General & Internal
Qiong Tang, Xiao-Min Ye, Yi-Can Yang, Shi-Bin Zhang, Li-Juan Yan, Dai Gong, Li Zou, Xiang-Lan Wen
Summary: This study investigated the nutritional status of fat-soluble vitamins (vitamin A, 25-hydroxyvitamin D, and vitamin E) in the serum of minors in the Zhuzhou area. It was found that children and adolescents should strengthen their supplementation of fat-soluble vitamins.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Yuqing Zhang, Jing Kong, Xiaohong Jiang, Jiangping Wu, Xiaoli Wu
Summary: This study found that higher serum levels of vitamins A and K in women of childbearing age are significantly associated with an increased likelihood of irregular and long menstrual cycles in a linear dose-response pattern.
Review
Nutrition & Dietetics
Irene Degrassi, Ilaria Leonardi, Elisabetta Di Profio, Chiara Montanari, Gianvincenzo Zuccotti, Elvira Verduci
Summary: This review identifies the current indications and gaps in the management of fat-soluble vitamins in pediatric patients with cholestasis. A comprehensive literature review was conducted, and relevant studies published in the past 20 years were selected. The causes of malabsorption, recommended methods of supplementation, and monitoring complications were discussed. The literature suggests that children with cholestasis are at a higher risk of fat-soluble vitamin deficiency, but there is no uniform validated treatment for vitamin deficiency.
Article
Chemistry, Multidisciplinary
Chiara Dal Bosco, Valerio Di Lisio, Paola D'Angelo, Alessandra Gentili
Summary: An ideal hydrophobic eutectic solvent based on L-menthol and butylated hydroxytoluene in a molar ratio of 3:1 was proposed and confirmed through physicochemical characterization. It showed intrinsic antioxidant activity and was efficient in extracting and preserving easily oxidizable lipophilic compounds. The solvent was successfully utilized for the dispersive liquid-liquid microextraction of carotenoids and fat-soluble vitamins from fruit juices.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Patrick Borel, Olivier Dangles, Rachel E. Kopec
Summary: Metabolites of organic compounds can have protective effects, and consuming diets rich in fruits and vegetables can lower the risk of developing certain degenerative diseases.
PROGRESS IN LIPID RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Jean M. Kerver, Claudia B. Holzman, Yan Tian, Bertha L. Bullen, Rhobert W. Evans, Jamil B. Scott
Summary: The study suggests that higher maternal serum antioxidants may be associated with a reduced risk of medically indicated preterm delivery. Although not statistically significant, elevated levels of antioxidants could potentially lower the risk of small for gestational age births.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Immunology
Sean Hasan, Belal Alshaikh, Kamran Yusuf
Summary: Our study reveals higher levels of sFasL in pregnant women who smoke, potentially reducing the incidence of preeclampsia by inducing apoptosis of immune cells.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Abdelhacib Kihal, Maria Ercilda Rodriguez-Prado, Carles Cristofol, Sergio Calsamiglia
Summary: The study aimed to evaluate the impact of six mycotoxin binders on the bioavailability of fat-soluble vitamins in vitro. The results showed that many of the binders adsorb a significant proportion of vitamin E but not vitamin D, indicating a potential reduction in the bioavailability of vitamin E in the presence of mycotoxin binders.
Article
Multidisciplinary Sciences
Alexandrina Mateeva, Magdalena Kondeva-Burdina, Lily Peikova, Silvia Guncheva, Alexander Zlatkov, Maya Georgieva
Summary: The current study focused on investigating and quantifying seven commercially available food supplements in the Bulgarian market, which contained a mixture of water-soluble and fat-soluble vitamins. Additionally, brewer's yeast from secondary fermentation was also analyzed. The analytical procedures were performed using RP-HPLC/DAD with specific columns and wavelengths for different vitamins. Two methods, gradient elution and isocratic elution, were developed and both were able to confirm the labeled amounts of vitamins as stated by the manufacturer. These methods are applicable for routine analysis of vitamin contents in both multivitamin preparations and brewer's yeast.
Article
Multidisciplinary Sciences
Pawel Gutaj, Jan Matysiak, Eliza Matuszewska, Katarzyna Jaskiewicz, Dorota Kaminska, Agata Swiatly-Blaszkiewicz, Tomasz Szczapa, Anastasia Kalantarova, Marzena Gajecka, Ewa Wender-Ozegowska
Summary: This study analyzed serum proteomic profiling in pregnant women with T1DM in the late third trimester and identified distinct protein differences in the coagulation and inflammatory pathways. However, further investigation is needed to determine the utility of these differential proteins as biomarkers for pregnancy complications in women with T1DM.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Ryszard Tomasiuk, Igor Z. Zubrzycki, Magdalena Wiacek
Summary: Aging is an independent risk factor for diseases associated with detrimental blood levels of fat- and water-soluble vitamins. This study investigated age-related changes in blood levels of vitamin A, B12, C, D, and E. The results showed a continuous increase in vitamin A, B12, D, and E levels with age, while vitamin C concentration remained constant. There was no correlation between lipid and water-soluble vitamin levels and blood pressure and bone health.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Noha Mousaad Elemam, Hind Hasswan, Hayat Aljaibeji, Nabil Sulaiman
Summary: The study revealed a decrease in circulating serum levels of sACE2 in T2DM patients, influenced by age, gender, and obesity level, and identified 4 novel miRNAs associated with T2DM that are affected by various clinical and demographic factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Endocrinology & Metabolism
Steven James, Alison Pryke, Janine Cusumano, Alicia Jenkins, Paul Benitez-Aguirre, Maria Craig, Andrew Biggin, Samantha Lain, Albert Chan, Natasha Nassar, Kim Donaghue
Article
Nursing
Sharon Atkinson-Briggs, Alicia Jenkins, Anthony Keech, Christopher Ryan, Laima Brazionis
Summary: The study aims to improve diabetes management in Indigenous Australians by integrating nurse-led diabetes education and eye screening. Nurses will conduct retinal photography for diabetic retinopathy screening, administer lifestyle surveys, and provide personalized diabetes education. The study seeks to enhance adherence to eye screening recommendations, population screening coverage, health literacy, and diabetes self-care.
JOURNAL OF ADVANCED NURSING
(2021)
Review
Endocrinology & Metabolism
Nicola Quinn, Alicia Jenkins, Chris Ryan, Andrzej Januszewski, Tunde Peto, Laima Brazionis
Summary: Diabetes is a major cause of global vision loss, with early detection and treatment of diabetic retinopathy necessitating eye screening. Ocular imaging is widely used clinically, revealing common eye conditions and signs of systemic conditions. Non-ophthalmic clinicians can also carry out diabetic eye screening, with emerging grading methods incorporating artificial intelligence. Additionally, retinal vessel analyses and corneal confocal microscopy are showing associations with diabetes complications.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Joseph G. Timmons, Nicola Greenlaw, James G. Boyle, Nish Chaturvedi, Ian Ford, Martijn C. G. J. Brouwers, Therese Tillin, Irene Hramiak, Alun D. Hughes, Alicia J. Jenkins, Barbara E. K. Klein, Ron Klein, Teik C. Ooi, Peter Rossing, Coen D. A. Stehouwer, Naveed Sattar, Helen M. Colhoun, John R. Petrie
Summary: Metformin has a reduction effect on carotid artery intima-media thickness in type 1 diabetes patients, especially in individuals who have never smoked cigarettes. Smoking status may influence the effectiveness of metformin in cardiovascular risk management for type 1 diabetes.
DIABETES OBESITY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Feifei Cheng, Luke Carroll, Mugdha Joglekar, Andrzej S. Januszewski, Kwun Kiu Wong, Anandwardhan A. Hardikar, Alicia J. Jenkins, Ronald C. W. Ma
Summary: Telomeres, repetitive nucleotide sequences at chromosome ends, serve as markers for DNA damage and biological ageing, associated with cardiovascular disease, diabetes, and cancer. Studies focus on genetic and environmental influences on telomere length regulation, emphasizing the need for further research to understand the link between diabetes and telomere length.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Nursing
Sharon Atkinson-Briggs, Alicia Jenkins, Christopher Ryan, Laima Brazionis
Summary: The study aims to assess the prevalence of modifiable health-risk behaviors among Indigenous Australian adults with diabetes. The results indicate that suboptimal health behaviors and depressive symptoms are common in this population.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Nursing
Sharon Atkinson-Briggs, Christopher Ryan, Anthony Keech, Alicia Jenkins, Laima Brazionis
Summary: This study aimed to describe vascular risk factors in Australian adults with diabetes attending an Indigenous primary care nurse-led diabetes clinic. The findings revealed suboptimal levels of clinical risk factor control in this population. Integrating clinical risk factor assessment into a diabetes education service led by nurses is achievable and important for avoiding diabetes complications.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Medicine, General & Internal
Callum J. Hensman, Judith L. Gooley, Andrzej S. Januszewski, Melissa H. Lee, Richard J. Maclsaac, Raymond C. Boston, Glenn M. Ward, Alicia J. Jenkins
Summary: Insulin antibody levels are higher in adults with type 1 diabetes compared to those without diabetes. The levels are also found to be decreasing after islet cell transplantation.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Endocrinology & Metabolism
David N. O'Neal, Ohad Cohen, Sara Vogrin, Robert A. Vigersky, Alicia J. Jenkins
Summary: This study aimed to evaluate the relationships between continuous glucose monitoring (CGM) time in range (TIR), time below range (TBR), time above range (TAR), and glucose coefficient of variation (CV) in older people with type 1 diabetes. The results showed strong correlations between TIR and TAR, weak correlation between TBR and TIR, and no significant correlation between CV and glucose variability. It is recommended to prioritize TBR targets to reduce hypoglycemic risk in older individuals and address TBR independently of TIR.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Gerard Boix-Lemonche, Richard M. Nagymihaly, Essi M. Niemi, Natasha Josifovska, Stian Johansen, Morten C. Moe, Hanne Scholz, Goran Petrovski
Summary: Injury of the cornea is a complex biological process that can be facilitated by mesenchymal stromal cells (MSCs) and tissue equivalents. This study presents a new tissue-engineering strategy for corneal stroma regeneration using cellularized 3D bioprinted hydrogel constructs implanted into cultured porcine corneas. The experiment successfully combines laboratory-based methods with patient-care practice to produce a cell-laden tissue equivalent for corneal implantation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Endocrinology & Metabolism
Angela Sheu, Rachel L. O'Connell, Alicia J. Jenkins, Thach Tran, Paul L. Drury, David R. Sullivan, LiPing Li, Peter Colman, Richard O'Brien, Y. Antero Kesaniemi, Jacqueline R. Center, Christopher P. White, Anthony C. Keech
Summary: This study aimed to investigate the fracture risk in patients with type 2 diabetes and the diabetes-related characteristics associated with fracture risk. The analysis of fracture data from the FIELD trial showed that in men, fracture risk was independently associated with macrovascular disease and insulin use, while in women, fracture risk was independently associated with peripheral neuropathy and insulin use.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Ophthalmology
Laima Brazionis, Nicola Quinn, Sami Dabbah, Chris D. Ryan, Dennis M. Moller, Hilary Richardson, Anthony C. Keech, Andrzej S. Januszewski, Jakob Grauslund, Malin Lundberg Rasmussen, Tunde Peto, Alicia J. Jenkins
Summary: Advancements in retinal imaging technology have made it possible to quantitatively evaluate the retinal vasculature. Changes in retinal vessel caliber and geometry have been observed in various systemic diseases and neurodegenerative diseases. Several retinal vessel analysis softwares are available, some specific to certain diseases and others for a broader context. In research studies, semi-automated software has identified associations between retinal vessel caliber and geometry and the presence or risk of diseases such as diabetes mellitus, cardiovascular disease, and dementia. This article reviews and compares widely used semi-automated retinal vessel analysis softwares and their associations with ocular imaging findings in common systemic diseases. Original data comparing retinal caliber grading in individuals with Type 1 diabetes using two softwares is also provided, showing good agreement.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Endocrinology & Metabolism
Nick S. R. Lan, Regina S. Y. Hong, Christopher Ryan, Alicia J. Jenkins, P. Gerry Fegan
Summary: There are barriers to lipid management in type 1 diabetes, including lack of awareness of cardiovascular risk and cholesterol levels, preference for managing glycaemia over lipids, preference for lifestyle modification over pharmacotherapy, and statin side-effect concerns.
PRIMARY CARE DIABETES
(2023)
Article
Cell & Tissue Engineering
Ekaterine Berishvili, Laurent Kaiser, Marie Cohen, Thierry Berney, Hanne Scholz, Yngvar Floisand, Jonas Mattsson
Summary: Global COVID-19 pandemic has led to nearly 500,000 deaths, with most fatalities attributed to ARDS caused by an excessive immune response. Current antiviral and anti-inflammatory therapies have shown limited efficacy, prompting the consideration of placenta-derived cells as a potential cell-based therapy for severe cases.
STEM CELL REVIEWS AND REPORTS
(2021)
Article
Endocrinology & Metabolism
Rebecca Helen McLeese, Jiawu Zhao, Dongxu Fu, Jeremy Y. Yu, Derek P. Brazil, Timothy J. Lyons
Summary: Diabetes increases the risk of pre-eclampsia, possibly by affecting the release of antiangiogenic factors by trophoblast cells. Potential therapies targeting placental barrier function may help reduce this risk.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)