Article
Nutrition & Dietetics
Briana M. Nosal, Junichi R. Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George Weinstock, Elaine Choung-Hee Lee, Ock K. Chun
Summary: This study aimed to examine the dose-dependent effects of blackcurrant supplementation on preventing bone loss in adult women. The results showed that blackcurrant supplementation decreased the loss of whole-body bone mineral density and increased the marker of bone formation, P1NP. Further studies with larger samples and different skeletal conditions are needed to confirm these findings.
Article
Public, Environmental & Occupational Health
Ludovico Gennaro Cobuccio, Marie Laurent, Celine Gardiol, Rahel Wampfler, Sven Poppert, Nicolas Senn, Gilles Eperon, Blaise Genton, Isabella Locatelli, Serge de Valliere
Summary: This study aimed to evaluate the effectiveness of metronidazole in patients with gastrointestinal symptoms caused by Blastocystis sp. and determine if Blastocystis subtype or concomitant parasitic infection influenced treatment outcomes. The results showed that metronidazole was not superior to placebo in improving gastrointestinal symptoms, regardless of Blastocystis subtype or microscopically undetected coinfection with other protozoa.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Min P. Tew, Peng C. Tan, Rahmah Saaid, Jesrine G. S. Hong, Siti Z. Omar
Summary: The preemptive use of metformin did not effectively control the level of HbA1c at 36 weeks of pregnancy in women with gestational diabetes mellitus. The mean birth weight was significantly lower in the metformin group without a significant decrease in rates of macrosomia or low birth weight.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Biochemistry & Molecular Biology
Dalong Zhu, Xiaoying Li, Jianhua Ma, Jiao'e Zeng, Shenglian Gan, Xiaolin Dong, Jing Yang, Xiaohong Lin, Hanqing Cai, Weihong Song, Xuefeng Li, Keqin Zhang, Qiu Zhang, Yibing Lu, Ruifang Bu, Huige Shao, Guixia Wang, Guoyue Yuan, Xingwu Ran, Lin Liao, Wenjuan Zhao, Ping Li, Li Sun, Lixin Shi, Zhaoshun Jiang, Yaoming Xue, Hongwei Jiang, Quanmin Li, Zongbao Li, Maoxiong Fu, Zerong Liang, Lian Guo, Ming Liu, Chun Xu, Wenhui Li, Xuefeng Yu, Guijun Qin, Zhou Yang, Benli Su, Longyi Zeng, Houfa Geng, Yongquan Shi, Yu Zhao, Yi Zhang, Wenying Yang, Li Chen
Summary: Dorzagliatin is a drug that improves insulin secretion and glycemic control in drug-naive patients with type 2 diabetes, showing good efficacy and safety.
Article
Endocrinology & Metabolism
Johnny Ludvigsson, Zdenek Sumnik, Terezie Pelikanova, Lia Nattero Chavez, Elena Lundberg, Itxaso Rica, Maria A. Martinez-Brocca, Marisol Ruiz de Adana, Jeanette Wahlberg, Anastasia Katsarou, Ragnar Hanas, Cristina Hernandez, Maria Clemente Leon, Ana Gomez-Gila, Marcus Lind, Marta Ferrer Lozano, Theo Sas, Ulf Samuelsson, Stepanka Pruhova, Fabricia Dietrich, Sara Puente Marin, Anders Nordlund, Ulf Hannelius, Rosaura Casas
Summary: Intralymphatic administration of GAD-alum combined with vitamin D supplementation did not meet the primary endpoint in all patients with T1D, but showed greater preservation of C-peptide in patients with the HLA DR3-DQ2 genotype. This treatment was well-tolerated and may be considered a disease-modifying approach for T1D patients with the specific genetic background.
Article
Clinical Neurology
Chung-Yao Chen, Chia-Ling Chen, Chung-Chieh Yu
Summary: This study found that trazodone treatment significantly improved sleep quality and severity of OSA in post-stroke patients, especially during rapid eye movement sleep. Patients who responded well to the treatment showed a significant reduction in apnea-hypopnea index after the therapy.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephen A. Harrison, Federico Perez Manghi, William B. Smith, Diana Alpenidze, Diego Aizenberg, Naomi Klarenbeek, Chi-Yi Chen, Eli Zuckerman, Eric Ravussin, Phunchai Charatcharoenwitthaya, Pin-Nan Cheng, Helena Katchman, Samuel Klein, Ziv Ben-Ari, Anisha E. Mendonza, Yiming Zhang, Miljen Martic, Shenglin Ma, Sheena Kao, Sandra Tanner, Alok Pachori, Michael K. Badman, YanLing He, Chinweike Ukomadu, Eric Sicard
Summary: In patients with nonalcoholic steatohepatitis (NASH), the use of licogliflozin led to reductions in serum alanine aminotransferase levels, suggesting it could be a potential therapeutic option. However, further studies are needed to validate these findings and evaluate its combination with other drugs.
Article
Clinical Neurology
Jocelyn Fotso Soh, Serge Beaulieu, Francesco Trepiccione, Outi Linnaranta, Gabriela Torres-Platas, Robert W. Platt, Suzane Renaud, Chien-Lin Su, Istvan Mucsi, Luciano D'Apolito, Benoit H. Mulsant, Andrea Levinson, Sybille Saury, Daniel Muller, Ayal Schaffer, Annemiek Dols, Nancy Low, Pablo Cervantes, Birgitte M. Christensen, Nathan Herrmann, Tarek Rajji, Soham Rej
Summary: Among chronic lithium users with NDI, 20 mg/d atorvastatin did not significantly improve urinary osmolality compared to placebo after a 12-week period. Larger confirmatory trials with longer follow-up periods are needed to further assess the effects of statins on NDI.
Article
Medicine, General & Internal
Hossein Pakdaman, Koroush Gharagozli, Faezeh Karamiani, Maryam Shamsi Goushki, Saman Moini, Ali Sobhanian, Faeze Maghsoudlu, Akram Esfandani, Mohammad Hossein Hosseini, Ali Amini Harandi
Summary: This study aimed to analyze the efficacy of traditional Chinese medicine MLC901 in patients with hypoxic-ischemic brain injury (HIBI). Results showed that compared to placebo, MLC901 significantly improved neurological functions after 6 months.
Article
Medicine, General & Internal
Athimalaipet Ramanan, Pierre Quartier, Nami Okamoto, Ivan Foeldvari, Alberto Spindler, Sarka Fingerhutova, Jordi Anton, Zhongkai Wang, Gabriella Meszaros, Joana Araujo, Ran Liao, Stuart Keller
Summary: Baricitinib demonstrated good efficacy and acceptable safety in the treatment of polyarticular juvenile idiopathic arthritis, extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, and juvenile psoriatic arthritis.
Article
Cardiac & Cardiovascular Systems
Ole Frobert, Matthias Gotberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Jorg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: This study found that early influenza vaccination after myocardial infarction or in patients with high-risk coronary heart disease significantly reduced the risk of death, myocardial infarction, or stent thrombosis, and also decreased the risk of all-cause death and cardiovascular death within 12 months compared to placebo.
Article
Clinical Neurology
Asako Yoritaka, Yasuko Kobayashi, Tetsuo Hayashi, Shinji Saiki, Nobutaka Hattori
Summary: This pilot study showed that inhalation of molecular hydrogen gas was safe, but did not demonstrate any beneficial effects in patients with PD. Compliance to the protocol-based duration of inhalation decreased with factors such as age, levodopa dose, and emotional symptoms on PDQ-39 in elderly participants.
NEUROLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Lotta Ulander, Heli Tolppanen, Otto Hartman, Tuomas T. Rissanen, Riitta Paakkanen, Jouni Kuusisto, Olli Anttonen, Tuomo Nieminen, Jaana Yrjola, Ransu Ryysy, Teemu Drews, Seppo Utriainen, Pasi Karjalainen, Ismo Anttila, Katariina Nurmi, Kristiina Silventoinen, Miika Koskinen, Petri T. Kovanen, Jukka Lehtonen, Kari K. Eklund, Juha Sinisalo
Summary: Hydroxychloroquine significantly reduces IL-6 levels in myocardial infarction patients without causing clinically significant adverse events. Larger randomized clinical trials are needed to confirm the potential impact on cardiovascular endpoints after myocardial infarction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maja Di Rocco, Eduardo Forleo-Neto, Robert J. Pignolo, Richard Keen, Philippe Orcel, Thomas Funck-Brentano, Christian Roux, Sami Kolta, Annalisa Madeo, Judith S. Bubbear, Jacek Tabarkiewicz, Malgorzata Szczepanek, Javier Bachiller-Corral, Angela M. Cheung, Kathryn M. Dahir, Esmee Botman, Pieter G. Raijmakers, Mona Al Mukaddam, Lianne Tile, Cynthia Portal-Celhay, Neena Sarkar, Peijie Hou, Bret J. Musser, Anita Boyapati, Kusha Mohammadi, Scott J. Mellis, Andrew J. Rankin, Aris N. Economides, Dinko Gonzalez Trotter, Gary A. Herman, Sarah J. O'Meara, Richard Delgizzi, David M. Weinreich, George D. Yancopoulos, E. Marelise W. Eekhoff, Frederick S. Kaplan
Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by abnormal bone formation in connective tissues and painful flare-ups. Garetosmab, an activin A-blocking antibody, can prevent the formation of new lesions but does not significantly impact the activity of pre-existing lesions.
Article
Immunology
Seyed Mehran Marashian, Mohammadreza Hashemian, Mihan Pourabdollah, Mansour Nasseri, Saeed Mahmoudian, Florian Reinhart, Alireza Eslaminejad
Summary: This study suggests that photobiomodulation (PBM) therapy may be effective in inhibiting the release of pro-inflammatory cytokines in COVID-19 patients, reducing organ damage and preventing severe disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
