Article
Endocrinology & Metabolism
Afnan Mansour, Mira Mousa, Dima Abdelmannan, Guan Tay, Ahmed Hassoun, Habiba Alsafar
Summary: This study conducted an Exome-Wide Association Study (EWAS) on Emirati individuals with type 2 diabetes mellitus (T2DM) to identify susceptibility loci associated with T2DM-related complications. The results showed associations between various genes and each complication category. The study also highlighted the limitations of the current genotyping arrays in representing diverse populations, emphasizing the need for better representation in future studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bato Korac, Andjelika Kalezic, Vanja Pekovic-Vaughan, Aleksandra Korac, Aleksandra Jankovic
Summary: Life is defined as an instantaneous encounter of circulating matter and flowing energy, and the relationship between redox biology and metabolism forms a dynamic balance in health, but disruption can lead to disease. The rising prevalence of metabolic diseases presents challenges in understanding, diagnosing, and treating them, emphasizing the need for research on novel redox-metabolic biomarkers.
Article
Rheumatology
Yu-Jih Su, Pui-Ying Leong, Yu-Hsun Wang, James Cheng-Chung Wei
Summary: This study investigated the cardiovascular risk among diabetic patients with Sjogren syndrome. The results showed that Sjogren syndrome is an unrecognized independent risk factor for cardiovascular events among diabetes patients. Hypertension and hyperlipidemia were also identified as independent risk factors for diabetes vascular complications. Treatment with traditional statins and aspirin may help reduce the risk of developing cardiovascular events.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Endocrinology & Metabolism
Emir Muzurovic, Lvana Kraljevic, Mirsala Solak, Sinisa Dragnic, Dimitri P. Mikhailidis
Summary: Homocysteine’s role in the development of vascular complications in diabetes mellitus is still unclear, with conflicting results from studies. While lowering therapies can effectively reduce homocysteine levels, their impact on reducing cardiovascular disease risk remains uncertain, requiring further investigation, especially in diabetic patients.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Endocrinology & Metabolism
Siyao He, Jinping Wang, Xiaoxing Zhang, Xin Qian, Shuang Yan, Wenjuan Wang, Bo Zhang, Xiaoping Chen, Yali An, Qiuhong Gong, Lihong Zhang, Xiaolin Zhu, Hui Li, Yanyan Chen, Guangwei Li
Summary: The long-term influence of metabolic syndrome on death and vascular complications was examined in this study. Individuals with impaired glucose tolerance plus MetS had a higher incidence of death, macrovascular events, and microvascular complications. The incidence was even higher in participants with type 2 diabetes mellitus plus MetS. The findings highlight the importance of early prevention of diabetes in individuals with impaired glucose tolerance plus MetS, and prompt the need to redefine a subgroup of patients with type 2 diabetes mellitus as having metabolic syndrome.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Nutrition & Dietetics
Rodolfo Deusdara, Amanda de Moura Souza, Moyses Szklo
Summary: This study evaluated the additive and multiplicative interactions between components of Metabolic syndrome (MetS) regarding type 2 diabetes mellitus. The results showed that the joint presence of certain components had a stronger association with the prevalence of type 2 diabetes mellitus in adolescents.
Review
Biochemistry & Molecular Biology
Carla Luis, Pilar Baylina, Raquel Soares, Ruben Fernandes
Summary: This study discusses the significance of metabolic imbalances in the pathophysiological course of type 2 diabetes (T2D) for early-stage prediction, emphasizing the potential value of biomarkers and the role of lifestyle interventions in treatment. Additionally, it highlights the varying responses of individuals to treatment and introduces the concept of novel biomarkers for better treatment outcomes.
Review
Medical Laboratory Technology
Frida Emanuelsson, Marianne Benn
Summary: The causal effect of LDL-cholesterol on peripheral arterial disease and chronic kidney disease is supported by evidence, while glucose has a causal effect on both micro- and macrovascular diseases. Studies on normoglycemic and prediabetic populations are needed for further investigation.
CLINICAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Elise Girard, Mathieu Nacher, John Bukasa-Kakamba, Aniza Fahrasmane, Antoine Adenis, Mickael Massicard, Kinan Drak Alsibai, Bertrand De Toffol, Raissa Bekima, Liliane Thelusme, Diana Okambabelle, Magalie Demar, Jean M. Aurelus, Nadia Sabbah
Summary: The study in French Guiana found a high prevalence of vitamin D deficiency among patients with diabetes, with levels inversely proportional to HbA1c and related to certain complications. Women and patients with a high school education were more likely to have vitamin D deficiency.
Review
Cell Biology
Leena P. Bharath, Jack Donato Rockhold, Rachel Conway
Summary: Dysregulation of autophagy plays a key role in the onset and progression of many metabolic diseases, including diabetes. Inability to upregulate autophagy or excessive autophagy can be detrimental to health. Autophagy is crucial for the development of vascular complications in diabetic patients.
Article
Endocrinology & Metabolism
Charles D. Nicoli, April P. Carson, Timothy B. Plante, D. Leann Long, Leslie A. McClure, Janin Schulte, Mary Cushman
Summary: The stable precursor pro-neurotensin/neuromedin N (pro-NT/NMN) is associated with metabolic syndrome and diabetes mellitus, likely explained by insulin resistance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Qianwen Huang, Daizhi Yang, Hongrong Deng, Hua Liang, Xueying Zheng, Jinhua Yan, Wen Xu, Xiangwen Liu, Bin Yao, Sihui Luo, Jianping Weng
Summary: This study investigated the prevalence of MetS among adult patients with T1DM in China and found that patients with MetS were more likely to have DKD and DR. Female gender, longer diabetes duration, higher body mass index, and higher HbA1c were identified as risk factors associated with MetS.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Critical Care Medicine
Guochen Li, Matthew D. Jankowich, Luying Wu, Yanqiang Lu, Liping Shao, Xujia Lu, Yulong Fan, Chen-Wei Pan, Ying Wu, Chaofu Ke
Summary: There is an association between preserved ratio impaired spirometry (PRISm) and adverse complications and mortality in individuals with type 2 diabetes (T2D). PRISm can enhance the prediction ability of an established risk score.
Article
Endocrinology & Metabolism
Yuchen Cao, Hejia Zhao, Fanke Meng, Qixin Deng, Liyang Cai, Xi Guo, Yanxia Chen, Xiongyi Yang, Zhuohang Xie, Guoguo Yi, Min Fu
Summary: The microvascular and macrovascular complications of diabetes, such as diabetic retinopathy and diabetic nephropathy, are major complications of diabetes. Through gene expression profiling, this study identified inflammation-oxidative stress and immune regulation pathways as important mechanisms underlying these complications. The findings have significant implications for prolonging the lifespan of diabetes patients and improving their quality of life.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Charles D. Nicoli, April P. Carson, Timothy B. Plante, D. Leann Long, Leslie A. McClure, Janin Schulte, Mary Cushman
Summary: The study demonstrates an association between the peptide neurotensin's stable precursor, pro-neurotensin/neuromedin N (pro-NT/NMN), and metabolic syndrome, specifically with dysglycemia and low density lipoprotein, likely attributable to insulin resistance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Psychology, Clinical
Seon-Kyeong Jang, Gretchen Saunders, MengZhen Liu, Yu Jiang, Dajiang J. Liu, Scott Vrieze
Summary: This study uses genetically informative methods to investigate the genetic etiology of substance use and psychiatric disorders. The findings suggest that there is a high degree of pleiotropy and shared neurodevelopmental pathways, neurotransmission, and intracellular trafficking involved in these conditions.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Statistics & Probability
Jian Huang, Yuling Jiao, Lican Kang, Jin Liu, Yanyan Liu, Xiliang Lu
Summary: The paper introduces a GSDAR algorithm for l(0) regularized high-dimensional generalized linear models, which employs support detection and root finding for a fast Newton algorithm. Under certain conditions, GSDAR can achieve optimal error in finite iterations with high probability. Additionally, the algorithm can recover the Oracle estimator with high probability.
COMPUTATIONAL STATISTICS
(2022)
Article
Statistics & Probability
Wei Liu, Huazhen Lin, Shurong Zheng, Jin Liu
Summary: This article introduces a generalized factor model, algorithm, and theory for ultra-high dimensional mixed types of variables. The proposed method demonstrates advantages over existing factor models in terms of predictive and interpretable estimators for loadings and factors.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Statistics & Probability
Xingyu Zhou, Yuling Jiao, Jin Liu, Jian Huang
Summary: We propose a deep generative approach to sampling from a conditional distribution, using neural networks for nonparametric estimation. Our method has advantages in handling high-dimensional and continuous/discrete variables, and achieves good results in numerical experiments.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Resham Lal Gurung, M. Yiamunaa, Jian-Jun Liu, Rajkumar Dorajoo, Jiexun Wang, Ling Wang, Sylvia Liu, Clara Chan, Keven Ang, Yi-Ming Shao, Tavintharan Subramaniam, Wern E. Tang, Chee Fang Sum, Su Chi Lim
Summary: This study found that elevated plasma UA is associated with incident CKD and potentially has a causal role in early eGFR loss in patients with type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Peipei Han, Hairui Yu, Fandi Xie, Ming Li, Xiaoyu Chen, Xing Yu, Jing Li, Xiangjing Liu, Bohan Shao, Jianjun Liu, Yaping Liu, Zhigang Liu, Xiaocheng Liu, Qi Guo
Summary: This study evaluated the effectiveness, feasibility, and safety of early rehabilitation for patients after coronary artery bypass graft (CABG) surgery. The results showed that early rehabilitation significantly improved patients' functional independence and did not increase the risk of post-operative complications.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wei Liu, Xu Liao, Yi Yang, Huazhen Lin, Joe Yeong, Xiang Zhou, Xingjie Shi, Jin Liu
Summary: Researchers have developed a unified computational method, DR-SC, which can simultaneously perform dimension reduction and spatial clustering, leading to the extraction of biologically informative low-dimensional features and improved clustering performance and trajectory inference analysis.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Microbiology
Caiqin Yang, Xin Guo, Jianjie Li, Jingwan Han, Lei Jia, Hong-Ling Wen, Chengxi Sun, Xiaolin Wang, Bohan Zhang, Jingyun Li, Yujia Chi, Tongtong An, Yuyan Wang, Ziping Wang, Hanping Li, Lin Li
Summary: This study found that the transcription levels of HERV-K (HML-2) genes were significantly higher in lung cancer cells and blood samples from lung cancer patients compared to healthy controls. These findings suggest that HERV-K (HML-2) genes may serve as potential biomarkers for the diagnosis of lung cancer. Additionally, there was a correlation between the abnormal transcription levels of HERV-K (HML-2) genes in lung cancer patients and the clinicopathological parameters of lung cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sen Yang, Shidan Wang, Yiqing Wang, Ruichen Rong, Jiwoong Kim, Bo Li, Andrew Y. Koh, Guanghua Xiao, Qiwei Li, Dajiang J. Liu, Xiaowei Zhan
Summary: The human microbiome, consisting of trillions of microorganisms, can modulate host physiology through interactions with molecules and metabolites. This study proposes a novel modeling framework that integrates microbiome and metabolome data to improve prediction accuracy in datasets that only measure microbiome data. The framework, called MB-SupCon, outperformed existing prediction methods in predicting insulin resistance status, sex, and race in type 2 diabetes patients. The study also observed similar advantages in a large inflammatory bowel disease study.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biology
Chenlin Zhang, Huazhen Lin, Li Liu, Jin Liu, Yi Li
Summary: This article proposes a new functional regression model that links the covariance structures of response curves to external covariates. By allowing the variances of random scores to be dependent on covariates, it identifies eigenfunctions for each individual, resulting in improved interpretability and prediction power. The utility of the developed method is demonstrated through simulations and an analysis of real data concerning parental effects on offspring growth curves, yielding biologically interesting results.
Article
Immunology
Mengying Liu, Lei Jia, Xing Guo, Xiuli Zhai, Hanping Li, Yongjian Liu, Jingwan Han, Bohan Zhang, Xiaolin Wang, Tianyi Li, Yanglan Wang, Jingyun Li, Changyuan Yu, Lin Li
Summary: This study provides a comprehensive analysis of the presence and distribution of HERV-K HML-8 sequences within the human genome and hominoids, as well as the characterization of their structure and evolution. The results show that HML-8 elements were integrated into the primate lineage around 35 to 42 million years ago during primates evolutionary speciation. These findings offer a detailed background for future functional studies.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2023)
Article
Genetics & Heredity
Fang Chen, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D. D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, R. Graham Barr, Diane M. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Meher Preethi Boorgula, Daniel Chasman, Sameer Chavan, Yii-Der Chen, Lee-Ming Chuang, Adolfo Correa, Joanne E. Curran, Sean P. David, Lisa de Las Fuentes, Ranjan Deka, Ravindranath Duggirala, Jessica D. Faul, Melanie E. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, Nicola L. Hawley, Jiang He, Brian D. Hobbs, John E. Hokanson, Chao A. Hsiung, Shih-Jen Hwang, Thomas M. Hyde, Marguerite R. Irvin, Andrew E. Jaffe, Eric O. Johnson, Robert Kaplan, Sharon L. R. Kardia, Joel D. Kaufman, Tanika N. Kelly, Joel E. Kleinman, Charles Kooperberg, I-Te Lee, Daniel Levy, Sharon M. Lutz, Ani W. Manichaikul, Lisa W. Martin, Olivia Marx, Stephen T. McGarvey, Ryan L. Minster, Matthew Moll, Karine A. Moussa, Take Naseri, Kari E. North, Elizabeth C. Oelsner, Juan M. Peralta, Patricia A. Peyser, Bruce M. Psaty, Nicholas Rafaels, Laura M. Raffield, Muagututi'a Sefuiva Reupena, Stephen S. Rich, Jerome Rotter, David A. Schwartz, Aladdin H. Shadyab, Wayne H-H Sheu, Mario Sims, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Marilyn J. Telen, Harold Watson, Daniel E. Weeks, David R. Weir, Lisa R. Yanek, Kendra A. Young, Kristin L. Young, Wei Zhao, Dana B. Hancock, Bibo Jiang, Scott Vrieze, Dajiang J. Liu
Summary: Most TWASs conducted so far have focused on European ancestry and lacked diversity. To address this limitation, researchers aggregated GWAS summary statistics, whole-genome sequences, and eQTL data from diverse ancestries. They developed a new approach called TESLA, which integrates eQTL datasets with multi-ancestry GWAS, improving power and identifying more genes associated with tobacco use phenotypes compared to alternative TWAS methods. The study also suggests potential drug repurposing options for treating nicotine addiction.
Article
Endocrinology & Metabolism
Xuling Chang, Kevin Yiqiang Chua, Fang Lin Ng, Ling Wang, Jianjun Liu, Jian-Min Yuan, Chiea-Chuen Khor, Chew-Kiat Heng, Rajkumar Dorajoo, Woon-Puay Koh
Summary: This study investigated the relationship between body mass index (BMI) in midlife and functional mobility in late life. The results showed a causal effect of obesity on mobility dysfunction, with high BMI leading to poorer performance in the Timed Up-and-Go test (TUG). Genetic analyses also indicated potential neuronal dysfunctions in regulating the link between obesity and mobility dysfunction.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Chemistry, Multidisciplinary
Jinbang Zhang, Jingwan Han, Hui Li, Zhengyang Li, Pengfei Zou, Jiaxin Li, Te Zhao, Junwei Che, Yang Yang, Meiyan Yang, Yuli Wang, Wei Gong, Zhiping Li, Lin Li, Chunsheng Gao, Haihua Xiao
Summary: A new system is constructed by functionalizing siRNA delivery lipid nanoparticles with the lymphocyte membrane and 12p1, which can escape immune recognition, has HIV-1 neutralizing capacity, and the ability to deliver siRNA specifically into HIV-1-infected cells. This system can escape uptake by the mononuclear phagocyte system, exhibits strong binding ability with gp120, and shows significant gene silencing effect on HIV-1-infected cells.
Article
Medicine, Research & Experimental
Neslihan A. Kaya, Jianbin Chen, Hannah Lai, Hechuan Yang, Liang Ma, Xiaodong Liu, Jacob Santiago Alvarez, Jin Liu, Axel M. Hillmer, David Tai, Joe Yeong Poh Sheng, Zheng Hu, Yun Shen Chan, Pierce K. H. Chow, Yuguang Mu, Torsten Wuestefeld, Weiwei Zhai
Summary: This study integrated HCC genomes from different countries and compared the genomic differences between Asians and Europeans. The study identified new candidate driver genes and found higher genomic instability in Asians. Furthermore, survival models were more accurate in predicting patient prognosis in Asians, suggesting a higher potential for precision medicine applications in Asia.
