Article
Cardiac & Cardiovascular Systems
Francesco Gentile, Vincenzo Castiglione, Raffaele De Caterinao
Summary: CAAs are a group of congenital conditions characterized by abnormal origin or course of the 3 main epicardial coronary arteries. While they have been identified as a common underlying condition in young athletes, their recognition among adults has increased with the widespread use of invasive and noninvasive coronary imaging. The clinical correlates and therapeutic choices for CAAs remain poorly understood, with studies suggesting that multimodality imaging may play a key role in management.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yarong Yu, Wenli Yang, Xu Dai, Lihua Yu, Ziting Lan, Xiaoying Ding, Jiayin Zhang
Summary: This study investigated the incidence of microvascular myocardial ischemia in diabetic patients without obstructive coronary artery disease (CAD) and its relationship with angina. Dynamic computed tomography-myocardial perfusion imaging and coronary computed tomography angiography were used to assess coronary stenosis, myocardial blood flow, and extracellular volume. The results showed a high incidence of microvascular myocardial ischemia in diabetic patients without obstructive CAD, which was strongly associated with angina.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ho Young Hwang, Jin Chul Paeng, Jeehoon Kang, Myoung-jin Jang, Ki-Bong Kim
Summary: The study found that graft occlusion during the 5 years after coronary artery bypass grafting was associated with the functional significance of coronary artery stenosis, particularly when the stenosis degree was not severe.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Paul Valensi, Narimane Berkane, Sara Pinto, Nicolas Sellier, Michael Soussan, Minh Tuan Nguyen, Emmanuel Cosson
Summary: The study aimed to test the validity of the 2019 guidelines for cardiovascular risk stratification by the ESC-EASD. The most effective strategy for screening silent myocardial ischemia (SMI) in asymptomatic patients was found to be performing stress myocardial scintigraphy in patients with severe target organ damage and in those without severe damage but with high coronary artery calcium (CAC) score.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Gilles Lemesle, Etienne Puymirat, Laurent Bonello, Tabassome Simon, Philippe-Gabriel Steg, Jean Ferrieres, Francois Schiele, Laurent Fauchier, Patrick Henry, Guillaume Schurtz, Sandro Ninni, Nicolas Lamblin, Christophe Bauters, Nicolas Danchin
Summary: This study aimed to investigate the relationship between diabetes mellitus (DM) status and the risk of heart failure (HF) occurrence in patients with coronary artery disease (CAD). The results showed that patients with DM had a significantly higher risk of HF, whether in the acute myocardial infarction (MI) phase or the chronic stable phase. Therefore, it is crucial to prevent HF occurrence in CAD patients with DM.
DIABETES & METABOLISM
(2022)
Article
Medicine, General & Internal
Yves Cottin, Rany Issa, Mourad Benalia, Basile Mouhat, Alexandre Meloux, Laura Tribouillard, Florence Bichat, Luc Rochette, Catherine Vergely, Marianne Zeller
Summary: The study found an association between serum OPG levels and coronary lesion complexity in patients with acute myocardial infarction, which was not influenced by factors such as hypercholesterolemia, cardiovascular history, and reduced glomerular filtration rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Asthildur Arnadottir, Sune Pedersen, Rasmus Bo Hasselbalch, Jens P. Goetze, Lennart J. Friis-Hansen, Anna-Marie Bloch-Munster, Jan Skov Jensen, Henning Bundgaard, Kasper Iversen
Summary: This study is the first to report the early-release kinetics of cTn concentrations after different durations of experimental coronary balloon occlusion in humans. All assays detected a cTn increase after only 30 s of ischemia. hs-cTnI (Siemens) rose faster and reached a higher peak. Copeptin levels did not change significantly.
Article
Medical Laboratory Technology
Yisi Liu, Fangqin Wu, Ying Wu, Malcolm Elliott, Wei Zhou, Ying Deng, Dianxu Ren, Haibo Zhao
Summary: Clinical observation and ex vivo studies have shown a strong association between inflammation and POAF. IL-6 plays a mechanistic role in sPOAF by inducing early fibrosis in the left atrium, leading to an increased susceptibility to POAF. Identifying IL-6 in pericardial drainage could serve as a potential noninvasive biomarker for predicting POAF.
TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Jia-Wei Wu, Hao Hu, Dan Li, Li-Kun Ma
Summary: HIF2 alpha transcriptionally regulates IL-6 expression in cardiomyocytes to provide cardioprotection, and treatment with recombinant IL-6 can rescue mice with HIF2 alpha knockdown, activating the PI3K/Akt and STAT3 signaling pathways.
Article
Endocrinology & Metabolism
Xunxun Feng, Guangyao Zhai, Jiaqi Yang, Yang Liu, Yujie Zhou, Qianyun Guo
Summary: In menopausal women, the study found a negative correlation between TBA levels and CAD and MI in patients with T2DM, while low TBA levels were positively associated with the occurrence of CAD combined with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Abdurrahim Yilmaz, Mert Ilker Hayiroglu, Serkan Salturk, Levent Pay, Ali Anil Demircali, Cahit Coskun, Rahmetullah Varol, Ozan Tezen, Semih Eren, Tugba Cetin, Ahmet Ilker Tekkesin, Huseyin Uvet
Summary: Machine learning models can optimize the performance of Treadmill Exercise Test (TET) by analyzing ECG wave characteristics and signals, reducing unnecessary invasive Coronary Angiography (CAG). In a study involving 294 patients who underwent CAG following high risk TET, the performance of 5 machine learning algorithms surpassed that of cardiologists. The XGBoost model achieved the highest accuracy and area under the curve (AUC).
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, Leslee J. Shaw, James K. Min, Courtney B. Page, Daniel S. Berman, Bernard R. Chaitman, Michael H. Picard, Raymond Y. Kwong, Sean M. O'Brien, Zhen Huang, Daniel B. Mark, Ranjit K. Nath, Sudhanshu K. Dwivedi, Paola E. P. Smanio, Peter H. Stone, Claes Held, Matyas Keltai, Sripal Bangalore, Jonathan D. Newman, John A. Spertus, Gregg W. Stone, David J. Maron, Judith S. Hochman
Summary: The ISCHEMIA trial found that the severity of ischemia was not associated with increased risk after adjustment for CAD severity. More severe CAD was related to increased risk. Invasive management did not lower all-cause mortality at 4 years in any ischemia or CAD subgroup.
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Michael Maeng, Lars Kjoller-Hansen, Akiko Maehara, Zhipeng Zhou, Ori Ben-Yehuda, Hans Erik Botker, Thomas Engstrom, Mitsuaki Matsumura, Gary S. Mintz, Ole Froebert, Jonas Persson, Rune Wiseth, Alf I. Larsen, Lisette O. Jensen, Jan E. Nordrehaug, Oyvind Bleie, Elmir Omerovic, Claes Held, Stefan K. James, Ziad A. Ali, Hans C. Rosen, Gregg W. Stone, David Erlinge
Summary: Patients with diabetes have a higher risk of major adverse cardiac events due to both treated culprit lesions and untreated nonculprit lesions. However, this study did not identify diabetes-related high-risk plaque characteristics using multimodality imaging.
Article
Cardiac & Cardiovascular Systems
Andrew E. Arai, Jeanette Schulz-Menger, Dipan J. Shah, Yuchi Han, W. Patricia Bandettini, Arun Abraham, Pamela K. Woodard, Joseph B. Selvanayagam, Christian Hamilton-Craig, Ru-San Tan, James Carr, Lynette Teo, Christopher M. Kramer, Bernd J. Wintersperger, Mukesh G. Harisinghani, Scott D. Flamm, Matthias G. Friedrich, Igor Klem, Subha Raman, Daniel Haverstock, Zheyu Liu, Guenther Brueggenwerth, Marta Santiuste, Daniel S. Berman, Dudley J. Pennell
Summary: The study demonstrates that vasodilator stress perfusion cardiovascular magnetic resonance (CMR) performed with gadobutrol has superior diagnostic accuracy for the diagnosis and exclusion of significant coronary artery disease (CAD) compared to gated single-photon emission computed tomography (SPECT).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Mirthe Dekker, Farahnaz Waissi, Max J. M. Silvis, Joelle Bennekom, Arjan H. Schoneveld, Robbert J. de Winter, Ivana Isgum, Nikolas Lessmann, Birgitta K. Velthuis, Gerard Pasterkamp, Arend Mosterd, Leo Timmers, Dominique P. de Kleijn
Summary: This study investigated the association between plasma OPG and its derived EVs with coronary artery calcification, showing that high levels of OPG were associated with VC.
SCIENTIFIC REPORTS
(2021)
