Review
Nutrition & Dietetics
Marina Yazigi Solis, Guilherme Giannini Artioli, Bruno Gualano
Summary: Creatine supplementation can improve power, strength, muscle mass, and performance, and may have potential therapeutic effects on glucose metabolism. Combined with exercise training, creatine supplementation could lead to additional improvements in glucose metabolism.
Article
Physiology
Siana Jones, Therese Tillin, Suzanne Williams, Alicja Rapala, Nishi Chaturvedi, Alun D. Hughes
Summary: Measuring local haemodynamics in skeletal muscle can provide valuable insights into tissue oxygen delivery during high demand situations such as exercise. This study compared the skeletal muscle microvascular response during post-occlusive reactive hyperaemia (PORH) with the response to exercise using near-infrared spectroscopy (NIRS) and examined the associations between muscle measures and exercise capacity or sex. The results showed that these local microvascular NIRS measures are associated with exercise capacity in older adults and can detect differences in microvascular reactivity between men and women in a community-based sample.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Liangzhi Zhang, Hengjun Lin, Xudong Yang, Jipeng Shi, Xiusheng Sheng, Lifeng Wang, Ting Li, Helong Quan, Xia Zhai, Wei Li
Summary: This study found that dapagliflozin monotherapy can improve insulin resistance and maintain mitochondrial quality control in skeletal muscle in rats with T2DM. However, combined aerobic exercise did not provide additional benefits.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Fuyao Yu, Yiping Fan, He Sun, Tianming Li, Yanbin Dong, Shinong Pan
Summary: This systematic review focuses on the role of intermuscular adipose tissue (IMAT) in Type 2 diabetes mellitus (T2DM) and the use of imaging techniques to evaluate IMAT in T2DM patients. By reviewing the cell of origin, definition, and relevant imaging technologies, this article provides important insights into controlling T2DM by targeting IMAT.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Optics
Alexey Glazkov, Ksenia Krasulina, Polina Glazkova, Andrey Tarasov, Denis Lapitan, Yulia Kovaleva, Dmitry Rogatkin
Summary: The aim of this study was to evaluate changes in cutaneous blood flow using incoherent optical fluctuation flowmetry (IOFF) in diabetic patients with microangiopathies. The study included 52 patients with type 2 diabetes mellitus, who were examined using IOFF and functional tests. The results showed that IOFF has the potential to accurately detect blood flow abnormalities associated with diabetic microangiopathies.
Article
Endocrinology & Metabolism
Jin Matsushita, Hiroshi Okada, Yuki Okada, Takashi Sekiyama, Hideto Iida, Atsushi Shindo, Hiroaki Murata, Michiaki Fukui
Summary: This study investigated the effects of physical therapists' exercise instructions on glycemic control in Japanese patients with type 2 diabetes. The results showed that patients who received exercise instructions from physical therapists had reduced HbA1c levels, increased daily steps, energy expenditure, lower extremity muscle strength, and improved transtheoretical model after 8 weeks.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
C. S. C. Trevisan, A. S. Garcia-Araujo, A. C. G. O. Duarte, V. O. Furino, T. L. Russo, A. Fujimoto, H. C. D. Souza, R. B. Jaenisch, R. Arena, A. Borghi-Silva
Summary: This study found that respiratory muscle training (RMT) improved cardiovascular function, respiratory muscle strength, and muscle morphology in streptozotocin-induced diabetic rats by increasing the root mean square of successive differences between adjacent RR intervals (RMSSD).
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Juan Fabregat-Fernandez, Vicente Rodriguez-Perez, Rocio Llamas-Ramos, Ana Felicitas Lopez-Rodriguez, Jesus Seco-Calvo, Ines Llamas-Ramos
Summary: This study aims to analyze the effects of whole-body vibration platforms on individuals with type 2 diabetes. The study design is a double-blind, randomized controlled trial with a 12-week intervention period. The results will provide insights into the potential benefits of whole-body vibration for diabetes management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
David P. McBey, Michelle Dotzert, C. W. J. Melling
Summary: This study investigated glycogen and fat content in skeletal muscle fibres of diabetic rats following exercise training. The results indicate that insulin treatment and exercise training have significant effects on muscle fibre types and lipid content.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Endocrinology & Metabolism
Nan Li, Liang Zhang, Xintang Wang, Yue Zhou, Lijing Gong
Summary: This review provides a comprehensive elucidation of the molecular mechanisms underlying pyroptosis and the potential mechanism of exercise in the treatment of diabetes mellitus (DM) and its complications. Exercise can inhibit pyroptosis through the regulation of inflammasome pathways, offering promising potential for expanding preventive and therapeutic strategies for DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Ulric Sena Abonie, Ama Kissiwaa Ampomah, Vincent Makinyi, Raphael Aseye Addo, Laureen Kumah
Summary: This study explored the relationship between physical activity patterns and quality of life in type 2 diabetes patients from a major tertiary hospital in Ghana. The results suggest that regular walking can improve energy and mobility, sexual functioning, social burden, and disease management, while vigorous-intensity activities are negatively related to anxiety and worry.
Article
Rehabilitation
Nathalia Cristina de Souza Borges, Ariane Hidalgo Mansano Pletsch, Mariana Barbosa Buzato, Natalia Akemi Yamada Terada, Fernanda Maria Ferreira da Cruz, Rinaldo Roberto de Jesus Guirro
Summary: Both supervised and home proprioceptive training did not lead to significant improvements in postural control, gait, or performance on functional tests in patients with type 2 diabetes mellitus.
CLINICAL REHABILITATION
(2021)
Article
Endocrinology & Metabolism
Jiho Park, Ji Hyun Yoon, Hyun Kyun Ki, Kyungdo Han, Hyungjin Kim
Summary: This study found that lifestyle changes, including smoking, alcohol intake, and exercise, were associated with the development of tuberculosis in patients with type 2 diabetes mellitus, highlighting the potential importance of lifestyle management in controlling tuberculosis in Korea.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Yuanlong Shen, Lina Yu, Zhen Hua, Ningxin Jia, Yanan Zhou, Xiaosheng Dong, Meng Ding
Summary: This study aims to compare the effects and acceptability of different exercise modes on glycemic control in type 2 diabetes patients through systematic review and network meta-analysis. The findings will provide guidance for clinicians and patients in selecting more effective exercise methods.
Article
Ophthalmology
Anchal Lal, Neha Dave, Michael Anthony Barry, Annika Sood, Paul Mitchell, Aravinda Thiagalingam
Summary: This study is the first to determine the correlation between impaired digital reactive hyperaemia and flicker-stimulated retinal vascular response with diabetes mellitus. Comparing two different devices, it was found that flicker-stimulated retinal arteriolar calibre change from baseline is more highly correlated with diabetes mellitus than a reduced reactive hyperaemia index.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Letter
Physiology
Christopher D. Askew, Simon Green
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Sport Sciences
Mikel Egana, Larry Jordan, Tommy Moriarty
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2019)
Article
Physiology
Joel Rocha, Norita Gildea, Donal O'Shea, Simon Green, Mikel Egana
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Nutrition & Dietetics
Simon Green, Catherine Kiely, Eamonn O'Connor, Norita Gildea, Donal O'Shea, Mikel Egana
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2020)
Letter
Physiology
Joel Rocha, Norita Gildea, Donal O'Shea, Simon Green, Mikel Egana
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Editorial Material
Respiratory System
Simon Green, Deidre Stuart
Article
Physiology
Norita Gildea, Joel Rocha, Donal O'Shea, Simon Green, Mikel Egana
Summary: This study found that high-intensity priming exercise can accelerate the pulmonary oxygen uptake kinetics time constant in type 2 diabetes patients, likely by eliminating the oxygen delivery limitation present in the unprimed condition, and reducing the oxygen uptake slow component possibly due to changes in muscle fiber activation.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Norita Gildea, Adam McDermott, Joel Rocha, Donal O'Shea, Simon Green, Mikel Egana
Summary: Both low-volume high-intensity interval training (HIIT) and moderate-intensity continuous endurance training (MICT) improved peak oxygen uptake (V O2peak) in adults with uncomplicated type 2 diabetes in a similar time course, with likely improvements due to enhanced microvascular oxygen delivery.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Physiology
Norita Gildea, Adam McDermott, Joel Rocha, Donal O'Shea, Simon Green, Mikel Egana
Summary: This study compared the effects of low-volume high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on oxygen uptake and muscle deoxygenation kinetics in patients with type 2 diabetes. The results showed that both training methods improved oxygen uptake kinetics, but had no significant effect on muscle deoxygenation kinetics.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Simon Green, Catherine Kiely, Eamonn O'Connor, Norita Gildea, Donal O'Shea, Mikel Egana
Summary: Exercise training was found to improve leg vascular conductance in males and females with type 2 diabetes, increasing peak vasodilatory response. Additionally, dynamic response of vasodilation was improved in females but not in males after training.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Physiology
Norita Gildea, Adam McDermott, Joel Rocha, Domenico Crognale, Aaron Nevin, Donal O'Shea, Simon Green, Mikel Egana
Summary: This study assessed the rates of adjustment in oxygen uptake and muscle deoxygenation during high-intensity cycling in type 2 diabetes patients. The results showed that low-volume high-intensity interval training and moderate-intensity continuous training both resulted in similar improvements in oxygen uptake kinetics without changes in muscle deoxygenation kinetics.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Sport Sciences
Mikel Egana, Lynn Allen, Kate Gleeson, Norita Gildea, Stuart Warmington
Summary: Cold water immersion does not impact subsequent 4-km time trial performance, but helps reduce thermal strain.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2021)
Review
Cardiac & Cardiovascular Systems
Simon Green, Deidre Stuart
Summary: Oxygen acts as a pulmonary vasodilator in patients with pulmonary arterial hypertension (PAH), potentially through alveolar and blood-borne mechanisms, regardless of arterial oxygen levels. Current clinical guidelines and practices related to oxygen therapy for PAH patients need to be reevaluated, as recent evidence challenges the previous view that its benefits arise only from correcting hypoxemia. Further research is needed to better understand the therapeutic potential of oxygen in PAH.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Simon Green, Deidre Stuart
PULMONARY CIRCULATION
(2019)
