Article
Biochemistry & Molecular Biology
Kiyotaka Okada, Naoyuki Kawao, Daisho Nakai, Rei Wakabayashi, Yoshitaka Horiuchi, Katsumi Okumoto, Shinji Kurashimo, Yoshimasa Takafuji, Osamu Matsuo, Hiroshi Kaji
Summary: This study demonstrated that glucocorticoids decrease the number of macrophages at the injured site during early bone repair after femoral bone injury partly through PAI-1 and M-CSF in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Rawan Altalhi, Nikoletta Pechlivani, Ramzi A. Ajjan
Summary: Hypofibrinolysis is a key abnormality in diabetes, with elevated levels of PAI-1 playing a significant role. Strategies to inhibit PAI-1 function may lead to new antithrombotic agents that reduce vascular complications in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Esra Demirel, Reem Sabouni, Neelima Chandra, Ov D. Slayden, David F. Archer
Summary: The study investigates the distribution and concentrations of several receptors and activators within the primate endometrium during artificial menstrual cycles, showing similarities in their expression patterns suggesting overlapping pathways. These findings indicate potential interactions between the plasminogen activator system and steroid receptors in the endometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Hiroki Ehara, Yoshimasa Takafuji, Kohei Tatsumi, Kiyotaka Okada, Yuya Mizukami, Naoyuki Kawao, Osamu Matsuo, Hiroshi Kaji
Summary: The study revealed that PAI-1 deficiency exacerbates grip strength impairment in female mice under diabetic conditions, while not affecting the decrease in muscle mass caused by diabetes.
Review
Endocrinology & Metabolism
Gaber El-Saber Batiha, Hayder M. Al-kuraishy, Thabat J. Al-Maiahy, Ali K. Al-Buhadily, Hebatallah M. Saad, Ali Al-Gareeb, Jesus Simal-Gandara
Summary: GDM triggers the expression and release of PAI-1, which is associated with inflammation, abnormal fibrinolysis, and thrombosis.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Endocrinology & Metabolism
Yongzhuo Yu, Wenxuan Li, Lili Xu, Yangang Wang
Summary: Cardiovascular complications are a common cause of death in type 2 diabetes patients, and Plasminogen-activator Inhibitor 1 (PAI-1) plays a crucial role in their development and progression. Insulin resistance increases PAI-1 production, leading to an environment conducive to thrombosis and severe vascular disease. PAI-1 also exhibits circadian rhythm characteristics, which may explain the higher incidence of cardiovascular events in the morning. PAI-1 is a potential drug target, but currently, no PAI-1 inhibitors have been approved for clinical use. Chronotherapy, based on rhythm, may offer improved treatment for cardiovascular complications in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Seo Young Kwak, Sunhoo Park, Hyewon Kim, Sun-Joo Lee, Won-Suk Jang, Min-Jung Kim, SeungBum Lee, Won Il Jang, Ah Ra Kim, Eun Hye Kim, Sehwan Shim, Hyosun Jang
Summary: The study revealed that atorvastatin mitigates radiation-induced endothelial damage through regulation of PAI-1, thus alleviating radiation-induced enteropathy. These findings support further investigation into atorvastatin as a radio-mitigator in patients receiving radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Joshua A. Levine, Carlota Oleaga, Mesut Eren, Ansel P. Amaral, Meng Shang, Elizabeth Lux, Sadiya S. Khan, Sanjiv J. Shah, Yasuhiro Omura, Nathalie Pamir, Joshua Hay, Grant Barish, Toshio Miyata, Hagai Tavori, Sergio Fazio, Douglas E. Vaughan
Summary: PAI-1 is not only a functional biomarker of the metabolic syndrome, but also a critical regulator of hepatic lipid metabolism. By directly regulating the transcriptional expression of genes involved in lipid balance, PAI-1 plays a key role in ameliorating hyperlipidemia in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Nina C. Teske, Joo-Yeon Engelen-Lee, Susanne Dyckhoff-Shen, Hans-Walter Pfister, Matthias Klein, Diederik van de Beek, Carsten K. Kirschning, Uwe Koedel, Matthijs C. Brouwer
Summary: This study found that PAI-2 levels are elevated in both patients and mice with pneumococcal meningitis. PAI-2 deficiency leads to an imbalance in inflammation, exacerbating brain pathology and increasing mortality.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Yukiko Asano, Takayuki Iwaki, Kazuo Umemura, Naohiro Kanayama, Hiroaki Itoh
Summary: The study showed that fibrin had no effect on mouse blastocysts, but significantly suppressed trophoblast growth in human blastocysts. However, trophoblasts in human blastocysts then switched to growth promotion through increased fibrinolysis with urokinase-type plasminogen activator (uPA) activity.
HUMAN REPRODUCTION
(2021)
Article
Hematology
Makiko Yamasaki-Morita, Yasuyuki Arai, Takashi Ishihara, Tomoko Onishi, Hanako Shimo, Kayoko Nakanishi, Yukiko Nishiyama, Tomoyasu Jo, Hidefumi Hiramatsu, Takaya Mitsuyoshi, Chisaki Mizumoto, Junya Kanda, Momoko Nishikori, Toshio Kitawaki, Keiji Nogami, Akifumi Takaori-Kondo, Miki Nagao, Souichi Adachi
Summary: This study analyzed the coagulation/fibrinolysis parameters in DLBCL patients treated with tisagenlecleucel and found a hypofibrinolytic and relatively hypercoagulable state concomitant with elevated PAI-1 levels at the onset of CRS, which gradually resolved after CRS remission. These results contribute to the understanding of CRS-related coagulopathy and highlight the importance of monitoring coagulation/fibrinolysis parameters during CAR-T therapy.
Article
Pharmacology & Pharmacy
Iffat Ara Aziz, Asher Fawwad, Iftikhar Ahmed Siddiqui, Kahkashan Perveen, Ruqaya Nangrejo, Nazish Waris, Abdul Basit
Summary: The aim of this study was to investigate the relationship between type of diabetes and plasma fibrinogen and plasminogen activator inhibitor-1 levels. The results showed that diabetes patients had higher levels of fibrinogen and plasminogen activator inhibitor-1, which increased their risk of coronary artery disease.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ziran Wang, Jintu Chen, Jingjing Song, Lingjun Kong, Xuanzhi Wang, Tengda Xu, Songbai Lin, Yaling Dou
Summary: This study used a robust detection method to determine the PAI-1 4G/5G genotype and investigated its association with diabetes mellitus, hypertension, and clinical characteristics. The results showed high concordance between the RT-PCR method and sequencing method for detecting PAI-1 4G/5G polymorphism. However, no association was found between the PAI-1 4G/5G polymorphism and genetic susceptibility to diabetes mellitus, hypertension, and diabetes mellitus combined with hypertension. Nevertheless, there were differences in clinical characteristics among individuals with different genotypes, which may provide reference for disease assessment and personalized treatment.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Endocrinology & Metabolism
Yukinori Tamura, Naoyuki Kawao, Takeshi Shimoide, Kiyotaka Okada, Osamu Matsuo, Hiroshi Kaji
JOURNAL OF BONE AND MINERAL METABOLISM
(2018)
Article
Cell Biology
Naoyuki Kawao, Hironobu Morita, Koji Obata, Kohei Tatsumi, Hiroshi Kaji
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Physiology
Naoyuki Kawao, Hironobu Morita, Kazuaki Nishida, Koji Obata, Kohei Tatsumi, Hiroshi Kaji
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2018)
Article
Rheumatology
Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Masayoshi Ishida, Kohei Tatsumi, Osamu Matsuo, Masao Akagi, Hiroshi Kaji
MODERN RHEUMATOLOGY
(2019)
Article
Cell Biology
Yoshimasa Takafuji, Kohei Tatsumi, Masayoshi Ishida, Naoyuki Kawao, Kiyotaka Okada, Osamu Matsuo, Hiroshi Kaji
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Shunki Iemura, Naoyuki Kawao, Katsumi Okumoto, Masao Akagi, Hiroshi Kaji
JOURNAL OF BONE AND MINERAL METABOLISM
(2020)
Article
Multidisciplinary Sciences
Naoyuki Kawao, Masayoshi Ishida, Hiroshi Kaji
Article
Multidisciplinary Sciences
Yasuyuki Shiraishi, Atsushi Kimura, Osamu Matsuo, Yoichi Sakata, Katsushi Takeshita, Tsukasa Ohmori
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Yoshimasa Takafuji, Kohei Tatsumi, Masayoshi Ishida, Naoyuki Kawao, Kiyotaka Okada, Hiroshi Kaji
Article
Endocrinology & Metabolism
Kiyotaka Okada, Takahiro Okamoto, Katsumi Okumoto, Yoshimasa Takafuji, Masayoshi Ishida, Naoyuki Kawao, Osamu Matsuo, Hiroshi Kaji
Article
Multidisciplinary Sciences
Naoyuki Kawao, Yoshimasa Takafuji, Masayoshi Ishida, Katsumi Okumoto, Hironobu Morita, Masafumi Muratani, Hiroshi Kaji
Article
Endocrinology & Metabolism
Masayoshi Ishida, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Kazuko Sakai, Kazuto Nishio, Hiroshi Kaji