Article
Multidisciplinary Sciences
Celia Lacaux, Thomas Andrillon, Celeste Bastoul, Yannis Idir, Alexandrine Fonteix-Galet, Isabelle Arnulf, Delphine Oudiette
Summary: This study demonstrates that brain activity during the transition period from sleep to wakefulness can ignite creativity; there is a creative "sweet spot" in the onset of sleep that requires individuals to balance easily falling asleep against falling asleep too deeply.
News Item
Chemistry, Multidisciplinary
Sheena E. Radford, Theodoros K. Karamanos
Summary: Research has revealed the significant impact of O-GlcNAcylation on chaperone activity and inhibition of amyloid fibril formation, potentially offering new avenues for combating neurodegenerative diseases.
Review
Pharmacology & Pharmacy
Depeng Yang, Lijun Yang, Jialing Cai, Xibo Hu, Huaxin Li, Xiaoqing Zhang, Xiaohan Zhang, Xinghe Chen, Haiyang Dong, Huan Nie, Yu Li
Summary: Macrophages are functionally plastic cells that regulate immunity and inflammatory responses by producing various bioactive molecules. They can adopt different phenotypes in response to signals, and glycobiology is closely associated with this process.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Eunjin Cheon, Evan J. Reister, Stephanie R. Hunter, Richard D. Mattes
Summary: Sweetness is a major factor contributing to the appeal of foods, and understanding how to measure and modify the appeal of sweetness is crucial for promoting healthy eating habits. The appeal of sweetness is multifaceted, including elements such as liking, preference, and consumption intent. Research shows that the appeal of sweet foods is influenced by both innate and learned factors, and intake can be modified accordingly.
ADVANCES IN NUTRITION
(2021)
Editorial Material
Multidisciplinary Sciences
Sebastian Will, Tanya Zelevinsky
Summary: Manipulating the energy of ultracold molecules can increase the likelihood of complex formation, offering exciting possibilities for controlled chemistry.
Article
Telecommunications
Jose Saldana, Omer Topal, Jose Ruiz-Mas, Julian Fernandez-Navajas
Summary: The proposed algorithm aims to find the optimal balance between throughput and latency in 802.11 WLANs, accommodating both traditional services and real-time requirements.
IEEE COMMUNICATIONS LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Sophie Thalmayr, Melina Grau, Lun Peng, Jana Poehmerer, Ulrich Wilk, Paul Folda, Mina Yazdi, Eric Weidinger, Tobias Burghardt, Miriam Hoehn, Ernst Wagner, Simone Berger
Summary: By combining cationizable lipids and polymers, we have developed highly potent pH-responsive nucleic acid carriers for efficient intracellular delivery. These carriers exhibit tunable polarity and structural changes in response to pH, allowing for dynamic nucleic acid delivery. Through optimization of topologies, LAF types, and LAF/aminoethylene ratios, we have identified carriers that are up to several 100-fold more efficient than previous generations and maintain activity in the presence of serum. Importantly, these carriers show excellent in vivo performance, particularly in the spleen, tumor, lungs, and liver.
ADVANCED MATERIALS
(2023)
Review
Immunology
Shuting Tong, Peiyu Zhang, Qi Cheng, Mo Chen, Xin Chen, Zitao Wang, Xiaoyong Lu, Huaxiang Wu
Summary: This article summarizes the role of gut microbiota in the onset and progression of gout, discusses its importance in the diagnosis and treatment of gout, and explores potential therapeutic approaches targeting the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Alexandra Jones, Jason H. Y. Wu, Kent Buse
Summary: The consumption of sugar in soft drinks has decreased within a year.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Oncology
Katelyn Tondo-Steele, Karen McLean
Summary: Ovarian cancer is a highly lethal gynecologic malignancy with chemoresistance being a major challenge. This review highlights the altered metabolism and signaling pathways in ovarian cancer, as well as potential therapeutic strategies to overcome chemoresistance.
Article
Computer Science, Information Systems
Abdelrahman Eldosouky, Tapadhir Das, Anuraag Kotra, Shamik Sengupta
Summary: This paper proposes a two-tier mathematical framework for analyzing and mitigating de-anonymization attacks in data sharing. A game-theoretic model is used to guide sharing organizations in selecting optimal anonymization levels, while a contract-theoretic model is used to guide the data collector in providing optimal rewards for the organizations. Simulation results demonstrate the effectiveness of the proposed models.
Review
Immunology
Guillem Montamat, Cathy Leonard, Aurelie Poli, Ludger Klimek, Markus Ollert
Summary: The prevalence and incidence of IgE-mediated allergic diseases have increased in developed and developing countries in recent years. Allergen-specific immunotherapy (AIT) is currently the only curative treatment available for allergic diseases, but it still faces unmet needs and challenges. The use of adjuvants and immune modulators to boost the effects and safety of AIT is a common strategy, with CpG oligodeoxynucleotide (CpG-ODN) showing potential as an immune modulator for the treatment of allergic diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jennifer C. Brazil, Charles A. Parkos
Summary: Glycans are crucial for cellular functions related to tissue development and mucosal homeostasis, while alterations in glycosylation play key roles in cancer and intestinal pathobiology.
MUCOSAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ting Chen, Yufeng Qin, Minjian Chen, Yuqing Zhang, Xu Wang, Tianyu Dong, Guanglin Chen, Xian Sun, Ting Lu, Richard Allen White, Peng Ye, Hein M. Tun, Yankai Xia
Summary: This study revealed significant changes in the meconium microbiota of neonates born to mothers with gestational diabetes mellitus (GDM), with a reduction in alpha diversity and alterations in the abundance of Firmicutes and Proteobacteria. Metabolomic analysis showed changes in metabolic pathways such as taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis in GDM subjects. The findings highlight the impact of maternal factors on early-life metabolism.
Review
Spectroscopy
Yuanwei Xu, Yuefan Wang, Naseruddin Hoti, David J. Clark, Shao-Yung Chen, Hui Zhang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a common and highly lethal malignancy of the pancreas. Early detection of PDAC is challenging, but recent advancements in mass spectrometry, particularly in the study of protein glycosylation, offer promise for early detection.
MASS SPECTROMETRY REVIEWS
(2023)