Article
Engineering, Multidisciplinary
Abhijit Paul, Phonindra Nath Das, Samrat Chatterjee
Summary: Type 2 diabetes is a global health problem caused by the gradual loss of pancreatic beta-cell function. Impaired glucose-stimulated insulin secretion is one of the major causes of beta-cell dysfunction and the development of type 2 diabetes. This study analyzed the potential factors responsible for impaired insulin secretion in insulin resistance and proposed therapeutic strategies for preventing disease progression.
APPLIED MATHEMATICAL MODELLING
(2022)
Article
Endocrinology & Metabolism
Laura del Bosque-Plata, Eduardo Martinez-Martinez, Miguel Angel Espinoza-Camacho, Claudia Gragnoli
Summary: TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and is consistently associated with the disease across diverse populations with different genetic origins. The exact mechanisms by which TCF7L2 affects T2D are still not well understood.
Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Xiaoyu Duan, Weijie Sun, Hongwen Sun, Lianying Zhang
Summary: The study revealed that PFASs adversely affect insulin secretion, with exposure to PFOS inhibiting SIRT1 activity and leading to impairment of GSIS.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biology
Yaser Albadr, Andrew Crowe, Rima Caccetta
Summary: This paper discusses the key compounds found in Golden Germander that may be valuable for developing a new medication for type 2 diabetes. Despite some issues with the research conducted on Golden Germander, it is still considered to have potential as an anti-diabetic agent.
Article
Multidisciplinary Sciences
Ming-Jun Chen, Jing Leng, Jian-Ping Ni, Ai-Ling Xiong, Man-Yun Hu
Summary: This study examined the association between fasting plasma C-peptide levels and sarcopenia, revealing a U-shaped relationship with lower risk in the range of 774-939 pmol/L.
Review
Endocrinology & Metabolism
Markku Laakso, Lilian Fernandes Silva
Summary: Statins are commonly used to prevent cardiovascular disease events, but they also increase the risk of type 2 diabetes. These two diseases share common genetic and environmental factors. Studies have confirmed the association between statin treatment and type 2 diabetes, and the purpose of this review is to summarize the important findings and describe the mechanisms behind the increased risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dan Luo, Taihua Mu, Hongnan Sun
Summary: Sweet potato leaf polyphenols (SPLP) have significant hypoglycemic effects on type 2 diabetes, improving blood glucose levels, insulin resistance, hepatic and muscle glycogen levels, and reversing dyslipidemia. Additionally, SPLP can enhance glucose metabolism and transport through signaling pathways regulation.
Article
Endocrinology & Metabolism
Daniel C. Parker, Ma Wan, Kurt Lohman, Li Hou, Anh Tram Nguyen, Jingzhong Ding, Alain Bertoni, Steve Shea, Gregory L. Burke, David R. Jacobs, Wendy Post, David Corcoran, Ina Hoeschele, John S. Parks, Yongmei Liu
Summary: miRNAs play a role in the occurrence and development of type 2 diabetes (T2D) and are also associated with lipid levels.
Article
Biochemistry & Molecular Biology
Siresha Bathina, Tumininu S. Faniyan, Lauren Bainbridge, Autumn Davis, Kavaljit H. Chhabra
Summary: The role of beta-cell Glut2 in regulating insulin secretion and blood glucose levels in mice was investigated in this study. Knocking down Glut2 specifically in beta-cells did not affect glucose-stimulated insulin secretion and systemic glucose homeostasis in mice.
Article
Medicine, Research & Experimental
Feiye Zhou, Linlin Zhang, Kecheng Zhu, Mengyao Bai, Yuqing Zhang, Qin Zhu, Shushu Wang, Chunxiang Sheng, Miaomiao Yuan, Yun Liu, Jieli Lu, Li Shao, Xiao Wang, Libin Zhou
Summary: SIRT2 plays a crucial role in glucose homeostasis by regulating insulin secretion and glucose tolerance; its deficiency inhibits GSIS by affecting the degradation of GKRP and ALDOA proteins; SIRT2 overexpression enhances insulin secretion through deacetylation of GKRP in beta-cells and promoting its degradation.
Article
Endocrinology & Metabolism
Shiau Chin Chong, Norlela Sukor, Sarah Anne Robert, Kim Fong Ng, Nor Azmi Kamaruddin
Summary: This study aimed to resolve conflicting findings about GLP-1 levels in different glucose tolerance states among Malay, Chinese, and Indian ethnicities. The results showed that GLP-1 levels were higher in T2DM and pre-DM compared to NGT, suggesting a possible adaptive compensatory response. Among the three ethnic groups, Indians had the highest levels of GLP-1 and insulin resistance, supporting the notion of an adaptive compensatory secretion of GLP-1.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
S. Abdelgani, C. Puckett, J. Adams, C. Triplitt, R. A. DeFronzo, M. Abdul-Ghani
Summary: The study demonstrated that beta cell function plays a vital role in predicting response to glucose lowering medications in newly diagnosed T2DM patients. The C-Pep(120)/C-Pep(0) ratio is a practical tool for guiding the choice of glucose lowering agent.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Guillaume Bastin, Lemieux Luu, Battsetseg Batchuluun, Alexandra Mighiu, Stephanie Beadman, Hangjung Zhang, Changhao He, Dana Al Rijjal, Michael B. Wheeler, Scott P. Heximer
Summary: RGS4 protein plays a crucial role in regulating insulin secretion in response to glucose stimulation, with its deficiency leading to impaired insulin secretion, reduced cAMP/PKA activity, and abnormal calcium oscillations in pancreatic beta-cells. These findings highlight the significance of maintaining normal levels of RGS4 function for proper insulin secretion in healthy pancreatic tissues.
Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Ichiro Hirayama, Kent Doi, Miyuki Yamamoto, Chiaki Toida, Naoto Morimura
Summary: This study evaluated the frequency of autonomous actions by citizens and their impact on bystander-initiated CPR and AED application among patients who suffered OHCA in Tokyo from 2013 to 2017. The findings showed a significant association between autonomous locations of resuscitation and the rates of bystander-initiated CPR and AED application, highlighting the need for enhanced education and training of citizens in autonomous CPR.
INTERNATIONAL HEART JOURNAL
(2021)
Article
Urology & Nephrology
Rikako Oki, Yoshifumi Hamasaki, Yohei Komaru, Yoshihisa Miyamoto, Ryo Matsuura, Seigo Akari, Takashi Nakamura, Takayo Murase, Kent Doi, Masaomi Nangaku
Summary: Plasma XOR activity is independently associated with atherosclerotic changes in the carotid artery of stable post-KT patients, with age and plasma XOR activity being independent predictors of CCA/ICA plaque or max-CIMT >0.9 mm. The cutoff value of plasma XOR activity for the diagnosis of CCA/ICA plaque or CCA-IMT > 0.9 mm was found to be 16.3 pmol/h/ml through receiver operator characteristic curve analyses.
Article
Urology & Nephrology
Yoshihisa Miyamoto, Masao Iwagami, Shotaro Aso, Kazuaki Uda, Kiyohide Fushimi, Yoshifumi Hamasaki, Masaomi Nangaku, Hideo Yasunaga, Kent Doi
Summary: Patients with kidney failure and dialysis therapy (KFDT) had higher rates of postoperative complications and 30-day mortality in cancer surgery, but the risk differences varied among different types of cancer. The higher rates of postoperative complications in patients with KFDT were mainly attributable to cardiovascular complications.
CLINICAL KIDNEY JOURNAL
(2022)
Letter
Endocrinology & Metabolism
Rajiv Agarwal, Sibylle Jenny Hauske, David C. Wheeler, Kent Doi, Amelie Elsaesser, Ivana Ritter, Dominik Steubl, Christoph Wanner
DIABETES OBESITY & METABOLISM
(2022)
Letter
Urology & Nephrology
Ryo Matsuura, Kenjiro Honda, Rikako Oki, Yoshifumi Hamasaki, Kent Doi, Masaomi Nangaku
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Rikako Oki, Yoshifumi Hamasaki, Shiho Tsuji, Kana Suzuki, Sayaka Tsuneishi, Mikie Imafuku, Yohei Komaru, Yoshihisa Miyamoto, Ryo Matsuura, Kent Doi, Masaomi Nangaku
Summary: Frailty as assessed by the clinical frailty scale (CFS) at dialysis initiation was found to be associated with lower survival rates and higher hospitalization rates within 2 years in maintenance dialysis patients. The CFS score was independently associated with the occurrence of adverse outcomes, regardless of age. This suggests that frailty assessment using CFS may predict outcomes in dialysis-initiated patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Makoto Kurano, Koh Okamoto, Daisuke Jubishi, Hideki Hashimoto, Eri Sakai, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Sohei Harada, Shu Okugawa, Kent Doi, Kyoji Moriya, Yutaka Yatomi
Summary: This study investigated the modulations of sphingolipids and glycerophospholipids in COVID-19 patients, revealing their dynamic changes depending on the time course and severity of the disease. Several species of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin may serve as better biomarkers for predicting severe COVID-19 during the early phase compared to traditional markers such as CRP and D-dimer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Urology & Nephrology
Masanori Abe, Hidetoshi Shiga, Hiroomi Tatsumi, Yoshihiro Endo, Yoshihiko Kikuchi, Yasushi Suzuki, Kent Doi, Taka-Aki Nakada, Hiroyuki Nagafuchi, Noriyuki Hattori, Nobuyuki Hirohashi, Takeshi Moriguchi, Osamu Yamaga, Osamu Nishida
Summary: This cohort study examined the current status of blood purification therapy for critically ill patients in Japan. The study found that continuous renal replacement therapy (CRRT) was the most frequently used mode of treatment, and patients with multiple organ failure (MOF) or sepsis had lower survival rates.
RENAL REPLACEMENT THERAPY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Itsuki Osawa, Ichiro Hirayama, Mineji Hayakawa, Yuichi J. Shimada, Kent Doi
Article
Cell Biology
Makoto Kurano, Daisuke Jubishi, Koh Okamoto, Hideki Hashimoto, Eri Sakai, Yoshifumi Morita, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Sohei Harada, Shu Okugawa, Kent Doi, Kyoji Moriya, Yutaka Yatomi
Summary: This study investigated the urinary modulations of sphingolipids and glycerophospholipids in COVID-19 patients with kidney injuries. The results showed significant changes in the levels of certain compounds in the urine, which may reflect the direct effects of viral infection.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Kazuma Yamakawa, Ryo Yamamoto, Takero Terayama, Hideki Hashimoto, Tadashi Ishihara, Go Ishimaru, Haruki Imura, Hiromu Okano, Chihiro Narita, Takuya Mayumi, Hideto Yasuda, Kohei Yamada, Hiroyuki Yamada, Tatsuya Kawasaki, Nobuaki Shime, Kent Doi, Moritoki Egi, Hiroshi Ogura, Morio Aihara, Shigeki Kushimoto, Osamu Nishida
Summary: This study provides recommendations for drug management of COVID-19 based on the Japanese Clinical Practice Guidelines. The study used the GRADE approach to assess the certainty of evidence and strength of recommendations. Different drugs are recommended for COVID-19 patients with different conditions to assist clinical decision-making.
ACUTE MEDICINE & SURGERY
(2022)
Article
Critical Care Medicine
Naoko Ohashi-Fukuda, Tatsuma Fukuda, Kent Doi
Summary: This study found that delayed advanced airway management in pediatric out-of-hospital cardiac arrest patients is associated with a decreased chance of survival.
RESUSCITATION PLUS
(2022)
Meeting Abstract
Critical Care Medicine
Itsuki Osawa, Tadahiro Goto, Daisuke Kudo, Toshikazu Abe, Mineji Hayakawa, Atsushi Shiraishi, Ryo Uchimido, Kazuma Yamakawa, Kent Doi, Shigeki Kushimoto
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Ichiro Hirayama, Toshifumi Asada, Miyuki Yamamoto, Naoki Hayase, Takahiro Hiruma, Kent Doi
Summary: This study found that temporal changes in VCO2 and VO2, as well as their association with lactate levels, may be predictive of prognosis in patients with sepsis. Patients with negative slopes of VCO2 and VO2 changes were more likely to survive.
Article
Medicine, General & Internal
Kazuma Yamakawa, Ryo Yamamoto, Takero Terayama, Hideki Hashimoto, Tadashi Ishihara, Go Ishimaru, Haruki Imura, Hiromu Okano, Chihiro Narita, Takuya Mayumi, Hideto Yasuda, Kohei Yamada, Hiroyuki Yamada, Tatsuya Kawasaki, Nobuaki Shime, Kent Doi, Moritoki Egi, Hiroshi Ogura, Morio Aihara, Shigeki Kushimoto, Osamu Nishida
Summary: The Japanese guidelines provide recommendations on drug management for COVID-19, including the use of various drugs such as favipiravir, remdesivir, corticosteroids, tocilizumab, anticoagulants, baricitinib, and casirivimab/imdevimab. It is hoped that these guidelines will assist healthcare professionals in the care of patients with COVID-19.
ACUTE MEDICINE & SURGERY
(2021)
