Article
Endocrinology & Metabolism
Erfei Song, Daniel Da Eira, Shailee Jani, Diane Sepa-Kishi, Vivian Vu, Howard Hunter, Mi Lai, Michael B. Wheeler, Rolando B. Ceddia, Gary Sweeney
Summary: The study showed that cardiomyocyte-specific autophagy deficiency in mice resulted in metabolic dysfunction, including increased body weight, reduced insulin sensitivity, and altered ambulatory activity. This deficiency also affected myocardial-adipose cross talk by decreasing atrial natriuretic peptide levels, leading to adverse metabolic consequences. Restoring normal ANP levels corrected the metabolic dysfunction in autophagy-deficient mice.
Review
Cell Biology
Michael P. Wiggs, Anna G. Beaudry, Michelle L. Law
Summary: Cancer cachexia is a syndrome that causes progressive weight loss and muscle wasting in advanced cancer patients, leading to impaired quality of life and increased mortality. This review focuses on the cardiac changes occurring in cachexia and discusses the underlying physiological and molecular mechanisms that contribute to cachexia-induced cardiomyopathy. Understanding the specific effects of cachexia on the heart may lead to the identification of unique therapeutic targets and improve clinical management for cancer cachexia patients.
Article
Physiology
Carolina S. Cerrudo, Susana Cavallero, Martin Rodriguez Fermepin, German E. Gonzalez, Martin Donato, Nicolas M. Kouyoumdzian, Ricardo J. Gelpi, Cecilia M. Hertig, Marcelo R. Choi, Belisario E. Fernandez
Summary: The study found that natriuretic peptides play an important role in the hypertrophic remodeling transition caused by chronic hemodynamic overload. Results showed that cardiac hypertrophy and left ventricular ANP gene expression were more pronounced in volume overload model, while BNP gene expression was positively correlated with left ventricular hypertrophy only in pressure overload model. The combined models exhibited intermediate values between those of single groups.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Yoshinori Hayashi, Hirohide Yokokawa, Hiroshi Fukuda, Mizue Saita, Taiju Miyagami, Yuichi Takahashi, Teruhiko Hisaoka, Toshio Naito
Summary: This study found an independent and significant negative correlation between visceral fat area (VFA) and plasma B-type natriuretic peptide (BNP) levels, while the correlation between subcutaneous fat area (SFA) and BNP levels was weaker compared to VFA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Vibhu Parcha, Nirav Patel, Orlando M. Gutierrez, Peng Li, Karen L. Gamble, Kiran Musunuru, Kenneth B. Margulies, Thomas P. Cappola, Thomas J. Wang, Garima Arora, Pankaj Arora
Summary: This clinical trial investigated the diurnal rhythmicity of natriuretic peptides in healthy lean and obese individuals, revealing a misalignment of the NP-BP diurnal rhythm in the obese population.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Hitoshi Nakagawa, Takuya Kumazawa, Kenji Onoue, Yasuki Nakada, Tomoya Nakano, Satomi Ishihara, Naoto Minamino, Hiroshi Hosoda, Nobuhisa Iwata, Tomoya Ueda, Ayako Seno, Taku Nishida, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
Summary: The study showed that overexpression of NEP in cardiomyocytes leads to increased degradation of natriuretic peptides in the heart, resulting in an exaggerated hypertrophic and fibrotic response to pressure overload.
Article
Biochemistry & Molecular Biology
Renata Silverio, Robson Barth, Andrea S. Heimann, Patricia Reckziegel, Gustavo J. dos Santos, Silvana Y. Romero-Zerbo, Francisco J. Bermudez-Silva, Alex Rafacho, Emer S. Ferro
Summary: Oral administration of Pep19 can alleviate high-fat diet-induced obesity and have positive effects on metabolic traits, morphology, and behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Frederik H. Verbrugge, Kazunori Omote, Yogesh N. Reddy, Hidemi Sorimachi, Masaru Obokata, Barry A. Borlaug
Summary: Patients with HFpEF and normal NP levels exhibit mild diastolic dysfunction and preserved cardiac output reserve during exercise, despite marked elevation in filling pressures. These patients have higher morbidity and mortality compared to patients without heart failure, emphasizing the importance of this phenotype.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Manuela Cabiati, Agnese Sgalippa, Giovanni Federico, Silvia Del Ry
Summary: Obesity has been on the rise in both adults and children over the past 30 years. Childhood obesity increases the risk of obesity and cardiovascular diseases in adulthood. Natriuretic peptides, especially C-type natriuretic peptide (CNP), play a crucial role in regulating body weight and energy metabolism in obese individuals.
Article
Cardiac & Cardiovascular Systems
Senthil Selvaraj, Jessica Kim, Bilal A. Ansari, Lei Zhao, Mary Ellen Cvijic, Matthew Fronheiser, Jagan Mohan-Rao Vanjarapu, Anupam A. Kumar, Arpita Suri, Sowjanya Yenigalla, Vaibhav Satija, Armghan Haider Ans, Offdan Narvaez-Guerra, Karela Herrera-Enriquez, Mary Jo Obeid, Jonathan J. Lee, Qasim Jehangir, Dietmar A. Seiffert, Bruce D. Car, David A. Gordon, Julio A. Chirinos
Summary: This study found distinct abnormalities in body composition between HFpEF and HFrEF, with reduced axial SM, not fat, independently predicting mortality in HF patients. NT-proBNP levels were more closely related to axial SM mass than fat distribution or BMI. Lower NT-proBNP levels in HFpEF compared with HFrEF relate more closely to muscle mass than obesity.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Hematology
Marco Basset, Paolo Milani, Andrea Foli, Mario Nuvolone, Pietro Benvenuti, Martina Nanci, Francesca Fabris, Claudia Bellofiore, Giampaolo Merlini, Giovanni Palladini
Summary: This study evaluated the impact of early cardiac response on the outcome of patients with newly diagnosed stage IIIb cardiac AL amyloidosis, and found that early cardiac response resulted in longer survival.
Article
Cardiac & Cardiovascular Systems
Vibhu Parcha, Nirav Patel, Rajat Kalra, Sarabjeet S. Suri, Garima Arora, Thomas J. Wang, Pankaj Arora
Summary: This study evaluated the impact of obesity on NT-proBNP levels and cardiovascular event risk in HF patients, and found that NT-proBNP was the strongest predictor of cardiovascular events regardless of obesity status.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Jawad H. Butt, William T. Abraham, Inder S. Anand, Akshay S. Desai, Lars Kober, Milton Packer, Marc A. Pfeffer, Jean L. Rouleau, Marc S. Sabatine, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, John J. McMurray
Summary: Patients with heart failure who have a history of stroke are at a high risk of subsequent cardiovascular events, regardless of ejection fraction. This study investigated the prevalence of stroke history in patients with heart failure and found that they had more vascular comorbidity and worse heart failure compared to those without stroke history. Targeting underutilization of guideline-recommended treatments might improve outcomes in this high-risk population.
EUROPEAN HEART JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Riccardo Sarzani, Massimiliano Allevi, Chiara Di Pentima, Paola Schiavi, Francesco Spannella, Federico Giulietti
Summary: Cardiac natriuretic peptides are true hormones produced by cardiomyocytes, exerting systemic effects and contributing to cardiovascular health. They also have paracrine and autocrine activities on the heart, preventing cardiac dysfunction and promoting heart protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Natalia Lucia Rukavina Mikusic, Nicolas Martin Kouyoumdzian, Ana Maria Puyo, Belisario Enrique Fernandez, Marcelo Roberto Choi
Summary: Natriuretic peptides play a crucial role in cardiovascular function, energy metabolism, lipid metabolism, and insulin sensitivity. Dysfunction in the natriuretic peptide system may contribute to the development of obesity, type 2 diabetes mellitus, and cardiometabolic complications, although the causal relationship is not fully understood. Targeting the natriuretic peptide pathway could potentially improve metabolic health in obesity and type 2 diabetes mellitus, and alterations in the natriuretic peptide system could be a linking mechanism between adipose tissue dysfunction and cardiovascular disease.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)