Article
Agriculture, Dairy & Animal Science
Beatriz Fuentes-Romero, Alberto Munoz-Prieto, Jose J. Ceron, Maria Martin-Cuervo, Manuel Iglesias-Garcia, Escolastico Aguilera-Tejero, Elisa Diez-Castro
Summary: Obesity and its associated complications are increasing problems in humans and horses. This study found that plasma resistin concentrations in horses are predominantly related to inflammatory conditions and not to insulin dysregulation, similar to humans.
Article
Medicine, Research & Experimental
Ali Taylan, Baris Akinci, Burak Toprak, Merih Birlik, Fatma Demet Arslan, Hasan Ekerbicer, Baris Gundogdu, Ayfer Colak, Bahar Engin
Summary: This study investigated the relationship between disease activity and adipocytokine levels in early rheumatoid arthritis patients, finding that those with high disease activity had higher BMI and leptin levels, which decreased after treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Immunology
Huimin Beng, Junhua Hu, Shanping Wang, Xinglong Liang, Haolong Qin, Wen Tan
Summary: This study investigated the effects of R-salbutamol, S-salbutamol, and their racemic mixture on a mouse model of lipopolysaccharide-induced endotoxemia. The results showed that R-salbutamol significantly improved the 7-day survival rate of endotoxic mice. It also effectively inhibited lung damage and reduced inflammatory responses, suggesting its potential benefits in regulating endotoxemia and endotoxin-induced lung injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C. Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Summary: This study reveals that suppression of Akt activity in skeletal muscle of mammals associated with insulin resistance and aging could accelerate sarcopenia and reduce lifespan.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Absalon D. Gutierrez, Carlos A. Flores, Sapna Naik, MinJae Lee, Parisa Asgarisabet, Masha Resman, Miryoung Lee, Joseph B. McCormick, Susan P. Fisher-Hoch
Summary: Resistin decreased as glucose tolerance deteriorated, positively associated with IL-1 beta and IL-8, inversely associated with TNF-alpha, and not significantly associated with IL-6. There are complex relationships between resistin, adipokines, and demographic variables.
Review
Endocrinology & Metabolism
Mona Mohamed Ibrahim Abdalla
Summary: The increasing global burden of type 2 diabetes highlights the need for more reliable and quicker strategies to improve early identification of insulin resistance in high-risk groups. Salivary biomarkers offer a promising alternative to serum collection, with adipocytokines like leptin being potential biomarkers for insulin resistance. Studies on salivary resistin as a biomarker for IR show conflicting findings on its potential role in linking obesity and IR.
WORLD JOURNAL OF DIABETES
(2021)
Article
Surgery
Rui Xu, Chenyu Zhu, Yuxin Li, Michael Andrade, Deng Ping Yin
Summary: Roux-en-Y gastric bypass surgery has been shown to improve obesity and insulin resistance through the regulation of early inflammatory responses in the liver and adipose tissue.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mohammed Baqur S. Al-Shuhaib, Sarfaraz Alam, Salman Ali Khan, Hayder O. Hashim, Daniel H. Obayes, Jafar M. B. Al-Shuhaib
Summary: Resistin is a hormone that induces insulin resistance and is associated with diabetes and metabolic disorders. This study identified masoprocol as the most potent drug to inhibit resistin.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Emily A. Day, Logan K. Townsend, Sonia Rehal, Battsetseg Batchuluun, Dongdong Wang, Marisa R. Morrow, Rachel Lu, Lucie Lundenberg, Jessie H. Lu, Eric M. Desjardins, Tyler K. T. Smith, Amogelang R. Raphenya, Andrew G. McArthur, Morgan D. Fullerton, Gregory R. Steinberg
Summary: This study found that pharmacological activation of AMP-activated protein kinase (AMPK) with PF-06409577 reduced atherosclerosis by suppressing lipid and cholesterol synthesis, reducing inflammation, and promoting autophagy.
Review
Gastroenterology & Hepatology
Mona Mohamed Ibrahim Abdalla
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. Diabetes has been identified as a significant risk factor for HCC, with resistin hormone playing a potential role in its development and progression. Increased levels of resistin in HCC patients may be associated with more advanced disease stages and poorer prognoses.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Luis Crisostomo, Ivana Jarak, Luis P. Rato, Joao F. Raposo, Rachel L. Batterham, Pedro F. Oliveira, Marco G. Alves
Summary: The consumption of energy-dense diets has led to an increase in obesity and its associated comorbidities worldwide. Unhealthy feeding habits can start at an early age, leading to early onset of metabolic diseases with potential unknown consequences on reproductive function. Recent evidence suggests intergenerational and transgenerational effects of high-fat diets on sperm parameters and testicular metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Wafaa A. Shehata, Alaa Maraee, Tagreed A. A. Wahab, Rania Azmy
Summary: The study found a correlation between RETN gene rs1862513 GG and G allele and the development and severity of acne vulgaris in a sample of the Egyptian population.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Neurosciences
Akira Mizoguchi, Ryoichi Banno, Runan Sun, Hiroshi Yaginuma, Keigo Taki, Tomoko Kobayashi, Mariko Sugiyama, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Hiroshi Arima
Summary: This study found that high-fat diet induced inflammation in the VTA area, leading to insulin resistance and increased microglial activation. Subsequent research revealed that the inflammation induced by HFD in the VTA is associated with dysfunction of the reward system and insulin resistance.
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Article
Plant Sciences
Rasidat O. Tijani, Jose Alberto Molina-Tijeras, Teresa Vezza, Antonio Jesus Ruiz-Malagon, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Oyindamola O. Abiodun, Julio Galvez
Summary: The methanol extract of Myrianthus arboreus leaf showed significant therapeutic effects in a mice model of metabolic syndrome induced by a high-fat diet, including reducing weight gain, improving blood sugar and insulin resistance, and enhancing lipid profile. Additionally, the extract demonstrated potential in treating metabolic disorders through modulation of inflammatory status and gene expression related to obesity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)