Article
Endocrinology & Metabolism
Anne-Sophie Sejling, Peili Wang, Wanling Zhu, Rawad Farhat, Nicholas Knight, Daniel Appadurai, Owen Chan
Summary: Repeated activation of noradrenergic receptors in the ventromedial hypothalamus increases local lactate levels, leading to a blunted counterregulatory hormone response to hypoglycemia.
Article
Biochemistry & Molecular Biology
Ruxu Zhai, Erika L. Varner, Ajay Rao, Sunil Karhadkar, Antonio Di Carlo, Nathaniel W. Snyder, Priscila Y. Sato
Summary: GRK2 is upregulated in heart failure and cardiac disease models, which reduces mitochondrial respiratory function and responses to beta-AR activation. Upregulation of GRK2 promotes palmitate-induced cell death and impairs ISO-mediated mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Caroline C. Ohrstrom, Dorte L. Hansen, Urd Lynge Kielgast, Marianne Lerbok Bergmann, Simon Veedfald, Jens Juul Holst, Dorte Worm
Summary: This study evaluated counterregulatory responses during postprandial hypoglycemia in patients with postbariatric hypoglycemia who underwent Rouxen-Y gastric bypass surgery. The findings showed that individuals with postbariatric hypoglycemia had minor increases in counterregulatory hormones during postprandial hypoglycemia, but larger hormone responses occurred when glucose levels were lowered during treatment with sitagliptin.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Davia Prischich, Alexandre M. J. Gomila, Santiago Milla-Navarro, Gemma Sanguesa, Rebeca Diez-Alarcia, Beatrice Preda, Carlo Matera, Montserrat Batlle, Laura Ramirez, Ernest Giralt, Jordi Hernando, Eduard Guasch, J. Javier Meana, Pedro de la Villa, Pau Gorostiza
Summary: The paper introduces a first generation of photochromic ligands that can modulate physiological processes by manipulating adrenergic neurotransmission, demonstrating their control effects in zebrafish and mice.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Neurosciences
Lucia Mendoza-Viveros, Clarisa Marmolejo-Gutierrez, Carolina Cid-Castro, Quetzalcoatl Escalante-Covarrubias, Emilie Montellier, Erick Carreno-Vazquez, Lilia G. Noriega, Laura A. Velazquez-Villegas, Armando R. Tovar, Paolo Sassone-Corsi, Lorena Aguilar-Arnal, Ricardo Orozco-Solis
Summary: Hypothalamic circuits control metabolism and astrocytes play a role in integrating metabolic information. The role of the astrocytic circadian clock in energy balance regulation is unclear. A study on mice reveals that the circadian clock in astrocytes modulates energy balance through regulation of cellular stress responses.
Article
Multidisciplinary Sciences
Khaggeswar Bheemanapally, Prabhat R. Napit, Mostafa M. H. Ibrahim, Karen P. Briski
Summary: The research demonstrates the effects of decreased glycogen breakdown in astrocytes on amino acid homeostasis in neurons and astrocytes. The reversible up-regulation of metabolic-sensory neuron GABA signaling by lactate may indicate compensatory nerve cell energy stabilization. The study highlights the importance of LC-ESI-MS sensitivity for measuring GAA in specific brain cell populations.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Jinhee H. Hwang, Michael E. Spurlock, John C. Kube, Xiang Z. Li, Stephen B. Smith
Summary: The study revealed that lubabegron fumarate is highly selective for the beta(3)-adrenergic receptor subtype and has minimal agonistic activity at the beta(2)-adrenergic receptor. Differences in mRNA expression levels of beta(1)-, beta(2)-, and beta(3)-AR were observed between subcutaneous and intramuscular adipose tissues. The response to beta-adrenergic ligands, especially agonists for the beta(1)- and beta(3)-receptor subtypes, was found to be lower in intramuscular adipose tissue compared to subcutaneous adipose tissue.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Cell Biology
Jin-Sook Kwon, Eric W. Barr, J. Kurt Chuprun, Walter J. Koch
Summary: Stimulation of alpha- or beta-adrenergic receptors in mice led to changes in the content of circulating blood EVs, with differential expression patterns of miRs. Pathway analysis revealed common and distinct pathways affected by PE and ISO treatment, indicating regulation of specific pathways by alpha- or beta-AR agonists. This study suggests that chronic sympathetic nervous system activation in heart failure may alter the content of EVs secreted from the heart and other organs, potentially impacting pathological remodeling.
Article
Medicine, Research & Experimental
Rasha M. S. M. Mohamed, Enssaf Ahmad Ahmad, Bothina H. F. Omran, Amr T. Sakr, Islam A. A. E-H Ibrahim, Mona F. Mahmoud, Mostafa E. El-Naggar
Summary: This study investigated the role of a and 13-adrenergic receptors (13ARs) in the dexamethasone-induced nephrotoxicity and found that blocking either a1ARs or 13ARs can effectively protect against the nephrotoxicity. However, the combined blocking of a1ARs and 13ARs does not enhance the renal protective effects.
Article
Chemistry, Multidisciplinary
Chao Yang, Yi He, Fangman Chen, Fan Zhang, Dan Shao, Zheng Wang
Summary: A tumor membrane-coated nanovaccine was designed to address the issues of insufficient T cell priming and immunosuppressive tumor microenvironment in cancer immunotherapy by delivering adjuvant CpG and the beta-adrenergic receptor inhibitor propranolol.
Article
Multidisciplinary Sciences
Marc Bathe-Peters, Philipp Gmach, Horst-Holger Boltz, Jurgen Einsiedel, Michael Gotthardt, Harald Huebner, Peter Gmeiner, Martin J. Lohse, Paolo Annibale
Summary: Two beta-adrenergic receptor subtypes, beta(1) and beta(2), show different localizations and diffusions in cardiomyocytes, with the segregation depending on the development of the T-tubular network, leading to distinct signaling and functional effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Gennaro Bruno, Francesco De Logu, Daniel Souza Monteiro de Araujo, Angela Subbiani, Federica Lunardi, Sofia Rettori, Romina Nassini, Claudio Favre, Maura Calvani
Summary: The study found that beta-ARs play a role in cancer pain, with antagonists for beta 2-and beta 3-ARs slowing down mechanical allodynia and the development of macrophages, while also reducing the accumulation of oxidative stress byproducts.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Michael W. Rudokas, John P. Post, Alejandra Sataray-Rodriguez, Rinzhin T. Sherpa, Karni S. Moshal, Shailesh R. Agarwal, Robert D. Harvey
Summary: This study revealed that cAMP produced by stimulation of beta(2)-adrenoceptors was unable to reach the SERCA2 pump location, and this compartmentalized response is partly due to PDE2 and PDE3 activity.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Xiaoyu Tian, Ziwei Huang, Yuanping Wang, Xiaoxiao Qi, Dawei Wang, Zhongqiu Liu, Yuanyuan Cheng
Summary: This study revealed that Xinbao Pill (XBP) improved cardiac function against chronic heart failure (CHF) by suppressing the ubiquitination of ll1-AR and ll2-AR mediated by USP18 and MDM2/ll-arrestin2/Nedd4.
Article
Multidisciplinary Sciences
Anna Duran-Corbera, Joan Font, Melissa Faria, Eva Prats, Marta Consegal, Juanlo Catena, Lourdes Munoz, Demetrio Raldua, Antonio Rodriguez-Sinovas, Amadeu Llebaria, Xavier Rovira
Summary: This study presents a new photopharmacological tool that allows the control of adrenoceptor activity through light-induced release. The tool effectively modulates various physiological systems, providing potential for the development of precise therapies in the future.
Article
Cardiac & Cardiovascular Systems
Yitschak Biton, Ilan Goldenberg, Valentina Kutyifa, Wojciech Zareba, Barbara Szepietowska, Scott Mcnitt, Bronislava Polonsky, Alon Barsheshet, Arthur J. Moss
AMERICAN JOURNAL OF CARDIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Barbara Szepietowska, Valentina Kutyifa, Martin H. Ruwald, Scott D. Solomon, Anne C. Ruwald, Scott McNitt, Bronislava Polonsky, Sabu Thomas, Arthur J. Moss, Wojciech Zareba
AMERICAN JOURNAL OF CARDIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Barbara Szepietowska, Scott McNitt, Valentina Kutyifa, Dan Ryan, James Corsetti, Charles Sparks, Arthur J. Moss, Wojciech Zareba
CARDIOLOGY JOURNAL
(2015)
Article
Cardiac & Cardiovascular Systems
Xiaojuan Xia, Anne-Christine Ruwald, Martin H. Ruwald, Nene Ugoeke, Barbara Szepietowska, Valentina Kutyifa, Mehmet K. Aktas, Poul Erik B. Thomsen, Wojciech Zareba, Arthur J. Moss, Jean-Philippe Couderc
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Barbara Szepietowska, Scott McNitt, Bronislava Polonsky, Saadia Sherazi, Yitschak Biton, Valentina Kutyifa, Mehmet K. Aktas, Arthur J. Moss, Wojciech Zareba
CARDIOLOGY JOURNAL
(2016)
Letter
Cardiac & Cardiovascular Systems
Barbara Szepietowska, Wojciech Zareba
CARDIOLOGY JOURNAL
(2016)
Article
Cardiac & Cardiovascular Systems
Barbara Szepietowska, Bronislava Polonsky, Saadia Sherazi, Yitschak Biton, Valentina Kutyifa, Scott McNitt, Mehmet Aktas, Arthur J. Moss, Wojciech Zareba
CARDIOVASCULAR DIABETOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Yitschak Biton, Ilan Goldenberg, Valentina Kutyifa, Jayson R. Baman, Scott Solomon, Arthur J. Moss, Barbara Szepietowska, Scott McNitt, Bronislava Polonsky, Wojciech Zareba, Alon Barsheshet
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Usama A. Daimee, Yitschak Biton, Mehmet K. Aktas, Faiez Zannad, Helmut Klein, Barbara Szepietowska, Scott Mcnitt, Bronislava Polonsky, Paul J. Wang, Wojciech Zareba, Arthur J. Moss, Valentina Kutyifa
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Jonathan S. Steinberg, Yash Shah, Barbara Szepietowska
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Meng Wang, Barbara Szepietowska, Bronislava Polonsky, Scott McNitt, Arthur J. Moss, Wojciech Zareba, David S. Auerbach
AMERICAN JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Chinenye O. Usoh, Saadia Sherazi, Barbara Szepietowska, Valentina Kutyifa, Scott McNitt, Anna Papernov, Meng Wang, Jeffrey D. Alexis
ANNALS OF THORACIC SURGERY
(2018)
Article
Cardiac & Cardiovascular Systems
Mariusz Klopotowski, Aleksandra Kwapiszewska, Krzysztof Kukula, Jacek Jamiolkowski, Maciej Dabrowski, Pawel Derejko, Artur Oreziak, Rafal Baranowski, Mateusz Spiewak, Magdalena Marczak, Anna Klisiewicz, Barbara Szepietowska, Zbigniew Chmielak, Adam Witkowski
CLINICAL CARDIOLOGY
(2018)
Letter
Cardiac & Cardiovascular Systems
Jonathan S. Steinberg, Yash Shah, Barbara Szepietowska
CLINICAL RESEARCH IN CARDIOLOGY
(2018)
Article
Endocrinology & Metabolism
Sarita Naik, Renata Belfort-DeAguiar, Anne-Sophie Sejling, Barbara Szepietowska, Robert S. Sherwin
DIABETES OBESITY & METABOLISM
(2017)