Article
Engineering, Biomedical
Mohammad Ariful Islam, Jamie Rice, Emma Reesor, Harshal Zope, Wei Tao, Michael Lim, Jianxun Ding, Yunhan Chen, Dike Aduluso, Bruce R. Zetter, Omid C. Farokhzad, Jinjun Shi
Summary: The study demonstrated that using mRNA vaccine nanoparticles with C16-R848 adjuvant can effectively induce anti-tumor immune response, increase the number of OVA-specific CD8(+) T cells, and significantly inhibit tumor growth.
Article
Nanoscience & Nanotechnology
Yonghui Liu, Zhaoyu Wang, Fan Yu, Mingjing Li, Haomiao Zhu, Kun Wang, Meng Meng, Wei Zhao
Summary: This study aimed to enhance the immune effect of MUC1 glycopeptide antigen-based antitumor vaccines by developing novel adjuvants and carriers. The constructed vaccines showed significant antibody response, specific binding with MUC1 positive cells, and induction of MUC1-specific CTLs. Overall, the use of alpha-GalCer adjuvant and antigen on gold nanoparticles offers a potential strategy to improve antitumor response in cancer immunotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Oncology
Youhuai Li, Mina Wang, Xueqiang Peng, Yingying Yang, Qishuang Chen, Jiaxing Liu, Qing She, Jichao Tan, Chuyuan Lou, Zehuan Liao, Xuexin Li
Summary: Messenger ribonucleic acid (mRNA) vaccines are a promising therapy for infectious diseases and cancer, particularly in the case of SARS-CoV2. Compared to conventional cancer vaccines, mRNA vaccines have advantages such as efficient immune response production, low side effects, and lower acquisition cost. This review discusses the development of cancer vaccines, mRNA cancer vaccines, their potential biological mechanisms, recent progress in tumor treatments, and future challenges and directions in the field.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Hematology
Abraham J. P. Teunissen, Mandy M. T. van Leent, Geoffrey Prevot, Eliane E. S. Brechbuhl, Carlos Perez-Medina, Raphael Duivenvoorden, Zahi A. Fayad, Willem J. M. Mulder
Summary: This article explores the role of trained immunity in atherosclerosis and the progress in utilizing nanobiologics for immune therapy targeting myeloid cells. The research demonstrates that nanobiologics have consistent biocompatibility and in vivo behavior across different species.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Immunology
Zihan Deng, Lisen Lu, Binghui Li, Xiujuan Shi, Honglin Jin, Weidong Hu
Summary: Inflammation is a critical feature in all stages of tumor development. Inflammasomes, as an important component of the inflammatory response and innate immune system, regulate infiltrating immune cell activity by signaling the secretion of different cytokines and chemokines. The expression patterns of inflammasomes vary across tumor types and stages, and understanding their specific effects is crucial for developing inflammasome-targeting drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Anirban Sengupta, Mohammad Azharuddin, Noha Al-Otaibi, Jorma Hinkula
Summary: The use of gold nanoparticles (GNPs) in vaccine development has gained popularity due to their excellent properties in biocompatibility, immune modulation, and antigen delivery. GNPs can effectively combat various pathogens by modulating immune responses of cells and antibodies. Despite their potential toxicity, it is worth further exploring and investing in GNPs for vaccine development.
Article
Chemistry, Multidisciplinary
Qiang Zeng, Zhigang Liu, Ting Niu, Chuan He, Ying Qu, Zhiyong Qian
Summary: Cellular immunotherapy involves reinjecting in vitro modified immunocytes into patients to target and kill tumor cells. Chimeric antigen receptor T cell (CAR-T) therapy, as a successful representative of tumor cellular immunotherapy, has shown promising results in treating relapsed/refractory hematological tumors. However, challenges such as the limited effectiveness in solid tumors, cytokine release syndrome (CRS) or CAR-T-related encephalopathy syndrome (CRES), off-target effects, and high costs remain. Nanotechnology offers advantages in CAR construction, T cell transfection, expansion, delivery, antitumor effects, and reducing toxicities. This review summarizes the nanotechnologies used in CAR-T immunotherapy and discusses the future directions and challenges of combining nanotechnologies with CAR-T immunotherapy.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Physical
Florent Voisin, Gerald Lelong, Jean Michel Guigner, Thomas Bizien, Jean Maurice Mallet, Florent Carn
Summary: This article demonstrates the stabilizing effect of polyelectrolyte chains on globally neutral aggregates formed through electrostatic complexation. These stabilized complexes, composed of citrate-stabilized gold particles and quater-nized chitosan, are able to retain their nanometric size and stability in saline environment and cell culture media. The plasmonic coupling in these complexes allows for maximized optical absorption.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Immunology
Marian Ackun-Farmmer, Christopher M. Jewell
Summary: Multiple sclerosis (MS) is an autoimmune disease where autoreactive lymphocytes attack the myelin sheath in the central nervous system. Treatments for MS are limited and often have side effects. This study presents a method using immune polyelectrolyte multilayer (iPEM) complexes to deliver immunomodulatory signals and antigens to immune cells, potentially treating MS. Glutaraldehyde-mediated cross-linking allows for the integration of multiple therapeutic drugs into the iPEM complexes, including mTOR inhibitors which induce regulatory T cells. This research demonstrates a precise technology for modulating innate and adaptive immunity in antigen-specific immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Engineering, Biomedical
Xinyi Zhang, Hengqing Cui, Wenjun Zhang, Zhaoshen Li, Jie Gao
Summary: Tumor vaccination is a promising approach for tumor immunotherapy. Whole tumor cells, extracellular vesicles, and cell membrane-encapsulated nanoparticles can be used as tumor cell-derived vaccines to trigger comprehensive tumor-specific immune responses. However, engineering improvements are needed to enhance their immunogenicity and targeting. Further research and advances in materials science, biomedicine, and oncology can facilitate the clinical translation of tumor cell-derived vaccines.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Ting Su, Shurong Zhou, Suling Yang, Nicholas Humble, Fuwu Zhang, Guocan Yu, Paula D. Bos, Furong Cheng, Kristoffer Valerie, Guizhi Zhu
Summary: This study reports a radioimmunotherapy for adult brain cancer that combines radiotherapy, immune checkpoint blockade, and lymph-node-targeting vaccines. The vaccines induced anti-cancer immune responses in mice and enhanced therapeutic efficacy in orthotopic brain cancer mice. However, radioimmunotherapy only showed a trend towards improved efficacy compared to radiotherapy alone.
Article
Oncology
Courtney T. Stump, Gregory Ho, Chenkai Mao, Frank A. Veliz, Veronique Beiss, Jennifer Fields, Nicole F. Steinmetz, Steven Fiering
Summary: Ovarian cancer has poor survival rates, with a significant need for treatments that prevent relapse. Research suggests that using personalized vaccines during remission could be an effective strategy. This study demonstrates the potential of using irradiated tumor tissue and immune adjuvants as a feasible treatment option for ovarian cancer.
Article
Chemistry, Multidisciplinary
Matthew D. Gallovic, Robert D. Junkins, Adam M. Sandor, Erik S. Pena, Christopher J. Sample, Ariel K. Mason, Leslee C. Arwood, Rebecca A. Sahm, Eric M. Bachelder, Kristy M. Ainslie, Gregory D. Sempowski, Jenny P. -Y. Ting
Summary: The current pandemic emphasizes the importance of effective vaccines against respiratory viruses. This study presents a vaccine strategy using a scalable microparticle platform containing a STING agonist as an adjuvant, which provides durable protection against the influenza virus. Animal studies demonstrate that this vaccine-adjuvant combination can reduce viral shedding, improve vaccine outcomes, and provide sustained protection even a year after a single dose.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Yudi Xu, Sheng Ma, Jiayu Zhao, Hongyu Chen, Xinghui Si, Zichao Huang, Zhentao Yu, Wantong Song, Zhaohui Tang, Xuesi Chen
Summary: Using nanotechnology for cancer vaccine design holds great promise, but there are still obstacles to achieving efficient tumor therapeutic effects. This study reports the use of mannan-decorated polymeric nanoparticles as a protein vaccine carrier to elicit robust anticancer immunity. The nanovaccine showed enhanced lymph node draining ability and capturing by dendritic cells, as well as antigen endosome escape and antigen cross-presentation. Excitingly, the nanovaccine alone showed superior anti-tumor effects in murine tumor models.
Article
Chemistry, Multidisciplinary
Alireza Hassani Najafabadi, Zeynab Izadi Najaf Abadi, Marisa E. Aikins, Kathryn E. Foulds, Mitzi M. Donaldson, Wenmin Yuan, Emeka B. Okeke, Jutaek Nam, Yao Xu, Priyan Weerappuli, Taryn Hetrick, David Adams, Patrick A. Lester, Andres M. Salazar, Dan H. Barouch, Anna Schwendeman, Robert A. Seder, James J. Moon
Summary: This study confirmed that sHDL combined with polyICLC is a strong vaccine platform for inducing CD8+ T cell responses. While the CpG B and CpG C classes generated strong responses in mice, their efficacy was mixed in non-human primates.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Zaoqu Liu, Hui Xu, Siyuan Weng, Chunguang Guo, Qin Dang, Yuyuan Zhang, Yuqing Ren, Long Liu, Libo Wang, Xiaoyong Ge, Zhe Xing, Jian Zhang, Peng Luo, Xinwei Han
Summary: A machine learning-based prognostic signature (MLPS) has been developed to predict the prognosis of melanoma patients, showing superior predictive performance compared to clinical traits and other collected signatures.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Tianqi Gu, Aimin Jiang, Chaozheng Zhou, Anqi Lin, Quan Cheng, Zaoqu Liu, Jian Zhang, Peng Luo
Summary: This study aims to determine the safety of immune checkpoint inhibitors combined with the anti-angiogenesis drug bevacizumab through a large-scale retrospective analysis of adverse drug reactions (ADRs). The risk of ADRs such as interstitial lung disease, hypertension, and gastrointestinal bleeding was found to be elevated in patients receiving combination therapy.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Materials Science, Multidisciplinary
Yanan Zhao, Yiming Liu, Chuan Tian, Zaoqu Liu, Kunpeng Wu, Chengzhi Zhang, Xinwei Han
Summary: This study constructed a nanofiber material with antibacterial and pro-angiogenic effects, which can accelerate wound healing and reduce the occurrence of infection by adding nanosilvers and black phosphorus.
MATERIALS & DESIGN
(2023)
Article
Engineering, Biomedical
Yanan Zhao, Chuan Tian, Yiming Liu, Zaoqu Liu, Jing Li, Zijian Wang, Xinwei Han
Summary: This study presents a comprehensive strategy to remodel the harsh hypoxic microenvironment of diabetic wound healing using NIR-assisted oxygen delivery and the bioactive properties of biopolymers. The strategy involves the self-assembly of black phosphorus nanosheets and hemoglobin onto electrospun nanofibers, utilizing charged quaternized chitosan and hyaluronic acid. The composite wound dressings fabricated through this strategy showed great potential in diabetic wound healing and expanding biomedical engineering fields.
Review
Cell Biology
Hong Luo, Hao Zhang, Jinning Mao, Hui Cao, Yihao Tao, Guanjian Zhao, Zhiwen Zhang, Nan Zhang, Zaoqu Liu, Jian Zhang, Peng Luo, Yuguo Xia, Yuan Cheng, Zongyi Xie, Quan Cheng, Guodong Liu
Summary: Exosomes play a crucial role in cell-to-cell communication by transporting DNA, RNA, bioactive proteins, glucose chains, and metabolites. They have great potential as targeted drug carriers, cancer vaccines, and noninvasive biomarkers. Being highly versatile, exosomes have advantages such as high drug loading capacity, adjustable drug release, enhanced permeation and retention effect, biodegradability, biocompatibility, and low toxicity. With the growing interest in exosome-based therapeutics, this review focuses on the potential use of exosomes in immunotherapy targeting tumor-associated macrophages (TAMs) in glioma, a challenging brain tumor. TAMs contribute to the immunosuppressive microenvironment and strongly influence glioma progression, making them an attractive therapeutic target. Exosomes can serve as both drug delivery vehicles and liquid biopsy biomarkers for TAMs-centered treatment. This review also summarizes recent investigations into the molecular signaling events by TAMs that promote glioma progression.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Siyuan Weng, Minghao Li, Jinhai Deng, Hui Xu, Yuqing Ren, Zhaokai Zhou, Libo Wang, Yuyuan Zhang, Zhe Xing, Lifeng Li, Zaoqu Liu, Xinwei Han
Summary: This study identified and validated four molecular subtypes of gastric cancer based on the analysis of MIRcor and METcor genes, and investigated their impact on prognosis, immune microenvironment, and potential treatment.
CLINICAL EPIGENETICS
(2023)
Article
Immunology
Zeyu Wang, Ziyu Dai, Hao Zhang, Xisong Liang, Xun Zhang, Zhipeng Wen, Peng Luo, Jian Zhang, Zaoqu Liu, Mingyu Zhang, Quan Cheng
Summary: In this study, lactate was found to contribute to the immune suppressive microenvironment in glioblastoma through RNA sequencing and machine learning algorithms. High levels of lactate can affect the migration and infiltration of CD8 T cells in glioblastoma.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Oncology
Zaoqu Liu, Yuyuan Zhang, Siyuan Weng, Hui Xu, Xinwei Han
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Letter
Oncology
Hui Xu, Zaoqu Liu, Siyuan Weng, Yuqing Ren, Jianzhuang Ren, Xinwei Han
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Anqi Lin, Jiarong Yao, Quan Cheng, Zaoqu Liu, Peng Luo, Jian Zhang
Summary: This study found that the status of NOTCH pathway mutation is closely associated with the efficacy of immunotherapy in colorectal cancer (CRC) patients, and it may serve as a novel biomarker and therapeutic target for CRC.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Yuyuan Zhang, Zaoqu Liu, Jie Li, Xin Li, Mengjie Duo, Siyuan Weng, Peijie Lv, Guozhong Jiang, Caihong Wang, Yan Li, Shichao Liu, Zhen Li
Summary: This study explores the mutation patterns in hepatocellular carcinoma (HCC) and identifies two distinct mutation signature clusters. A high-risk prognosis cluster, MSC1, is characterized by activated anti-tumor immune and metabolism dysfunctional states, high genomic instability, and poor prognosis. Additionally, afatinib and canertinib drugs are found to have potential therapeutic implications in MSC1.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Medicine, General & Internal
Chaozheng Zhou, Shengkun Peng, Anqi Lin, Aimin Jiang, Yuanxi Peng, Tianqi Gu, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo
Summary: With the increasing use of immune checkpoint inhibitors (ICIs) for tumour immunotherapy, psychiatric adverse events associated with ICIs have become a significant concern. This study aims to provide a comprehensive study and summary of psychiatric adverse events associated with ICIs.
Review
Oncology
Zaoqu Liu, Tian Duan, Yuyuan Zhang, Siyuan Weng, Hui Xu, Yuqing Ren, Zhenyu Zhang, Xinwei Han
Summary: Radiogenomics, a field that explores the relationship between genomics and imaging phenotypes, has been widely used to address tumor heterogeneity, predict immune response and progression. It offers a lower-cost alternative to traditional genetic sequencing and provides access to whole-tumor information. By providing voxel-by-voxel genetic information, radiogenomics enables tailored therapy for heterogeneous tumors and better stratifies patients for more precise imaging and screening.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Jinhai Deng, Teng Pan, Zaoqu Liu, Caitlin McCarthy, Jose M. Vicencio, Lulu Cao, Giovanna Alfano, Ali Abdulnabi Suwaidan, Mingzhu Yin, Richard Beatson, Tony Ng
Summary: TXNIP is a master regulator of cellular oxidation, and recent studies have revealed its additional roles in metabolism, cell cycle, and inflammation. It is extensively studied in cancers, particularly in modulating signaling between different cell types within the tumor microenvironment. Further understanding of TXNIP's functions and mechanisms in cancer may enhance its potential as a therapeutic target.
BRITISH JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Zaoqu Liu, Qimeng Liang, Yuqing Ren, Chunguang Guo, Xiaoyong Ge, Libo Wang, Quan Cheng, Peng Luo, Yi Zhang, Xinwei Han
Summary: Aging is associated with immune dysfunction, chronic inflammation (inflammaging), and increased risk of age-related diseases. Senescent T cells and inflammaging are major drivers of immunosenescence. Investigating the role of immunosenescence in cancer and other age-related diseases is necessary.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)