Article
Medicine, General & Internal
Milad Nazarzadeh, Zeinab Bidel, Dexter Canoy, Emma Copland, Malgorzata Wamil, Jeannette Majert, Karl Smith Byrne, Johan Sundstrom, Koon Teo, Barry R. Davis, John Chalmers, Carl J. Pepine, Abbas Dehghan, Derrick A. Bennett, George Davey Smith, Kazem Rahimi
Summary: Lowering blood pressure is an effective strategy for preventing new-onset type 2 diabetes. Different classes of antihypertensive drugs have varying effects on diabetes, with ACE inhibitors and ARBs showing the most favorable outcomes. Selective use of antihypertensive drugs can help prevent diabetes.
Article
Medicine, General & Internal
Paul M. Ridker, Matt Devalaraja, Florian M. M. Baeres, Mads D. M. Engelmann, G. Kees Hovingh, Milana Ivkovic, Larry Lo, Douglas Kling, Pablo Pergola, Dominic Raj, Peter Libby, Michael Davidson
Summary: This study investigated the safety and efficacy of IL-6 inhibition treatment in high cardiovascular risk individuals. Results showed that ziltivekimab effectively reduced biomarkers of inflammation and thrombosis, with promising effects observed in patients with chronic kidney disease.
Article
Medicine, General & Internal
Marios K. Georgakis, Rainer Malik, Tom G. Richardson, Joanna M. M. Howson, Christopher D. Anderson, Stephen Burgess, G. Kees Hovingh, Martin Dichgans, Dipender Gill
Summary: The study found that genetically predicted IL-6 signaling is positively associated with CVD risk, and the increase in CVD risk is linearly related to baseline hsCRP levels. There is no heterogeneity in the association of genetically predicted IL-6 signaling with CVD risk when stratifying the population by sex, age, body mass index, estimated glomerular filtration rate, or systolic blood pressure, but there is evidence of greater associations in individuals with low-density lipoprotein cholesterol >= 160 mg/dL.
Article
Biochemistry & Molecular Biology
Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido
Summary: This study investigated the involvement of IL-6 trans-signaling in DVT and found a strong correlation between the Asp358Ala variant and sIL6-R levels. The high frequency of the Asp358Ala mutation and elevated IL-6 levels in DVT patients may explain the association between IL-6 overactivation and DVT outcome. These findings provide a proof of concept for targeting IL-6 trans-signaling as a new strategy for DVT adjuvant therapy.
Article
Immunology
Paraic S. O'Suilleabhain, Nicholas A. Turiano, Denis Gerstorf, Martina Luchetti, Stephen Gallagher, Amanda A. Sesker, Antonio Terracciano, Angelina R. Sutin
Summary: Higher conscientiousness is associated with lower mortality risk, partially due to lower IL-6 levels. While there is initial evidence that biomarkers mediate the relationship between personality traits and mortality risk, the association is not significant when controlling for sociodemographic variables.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Medicine, General & Internal
Eun-Hwa Lee, Kyoung-Hwa Lee, Young-Goo Song, Sang-Hoon Han
Summary: C-reactive protein (CRP) or procalcitonin (PCT) alone have limitations in the early detection of infection or inflammation. Interleukin (IL)-6 has been assessed recently, and this study reveals considerable discrepancies among CRP, PCT, and IL-6 levels. Relying solely on CRP tests may lead to misinterpretation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Sanggap Indra Sitompul, Budi Susetyo Pikir, Aryati, Citrawati Dyah Kencono Wungu, Shafira Kurnia Supandi, Monika Estherlita Sinta
Summary: This study investigated the role of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms in chronic periodontitis with CAD, and evaluated the impact of IL-6 and CRP levels on the severity of periodontitis in Indonesian CAD patients. The results showed no significant effects of IL-6 and CRP gene polymorphisms on IL-6 and CRP levels, but IL-6 levels had a significant impact on CRP levels in CAD patients.
Article
Oncology
Victor M. Schuettfort, Benjamin Pradere, Quoc-Dien Trinh, David D'Andrea, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Michael Rink, Pierre Karakiewicz, Piotr Chlosta, Jeremy Yuen-Chun Teoh, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Marco Moschini, Shahrokh F. Shariat
Summary: The study confirmed that elevated preoperative plasma levels of IL6 and IL6sR are associated with worse oncological disease survival in patients treated with RC for UCB in a large multicenter study. Both biomarkers have the potential to identify patients with adverse pathological features, improve the predictive accuracy of prognostic models, and guide clinical decision making.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Anu Kataja, Tuukka Tarvasmaki, Johan Lassus, Alessandro Sionis, Alexandre Mebazaa, Kari Pulkki, Marek Banaszewski, Valentina Carubelli, Mari Hongisto, Ewa Jankowska, Raija Jurkko, Toni Jantti, Monika Kasztura, John Parissis, Tuija Sabell, Jose Silva-Cardoso, Jindrich Spinar, Heli Tolppanen, Veli-Pekka Harjola
Summary: Inflammatory markers, particularly PCT and IL-6, are strongly associated with signs of systemic hypoperfusion in cardiogenic shock (CS) and predict poor prognosis. High levels of PCT and IL-6 are linked to increased 90-day mortality rates, while CRP levels do not show significant prognostic value.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Immunology
Marijne Vandebergh, Sara Becelaere, Benedicte Dubois, An Goris, CHARGE Inflammation Working Grp
Summary: This study identified IL-6 signaling as a major mediator of the association between BMI and risk of MS. The proportion of the effect of BMI on MS mediated by IL-6 signaling corresponded to 43%. In contrast to IL-6 signaling, there was little evidence for an effect of serum IL-6 levels or CRP levels on the risk of MS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Marcio Mossmann, Marco Vugman Wainstein, Stefani Mariani, Guilherme Pinheiro Machado, Gustavo Neves de Araujo, Michael Andrades, Sandro Cadaval Goncalves, Marcello Casaccia Bertoluci
Summary: The study found that in high-risk patients, IL-6 levels exceeding 0.44 pg/mL before elective coronary angiography were associated with a poorer prognosis.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Peng-Peng Niu, Xue Wang, Yu-Ming Xu
Summary: Two-sample Mendelian randomization analyses showed no evidence of association between circulating sIL6R and CRP levels and the risk of IA. A positive genetic correlation between CRP levels and IA risk was found, mainly driven by the shared genetic background of blood pressure and smoking.
FRONTIERS IN GENETICS
(2021)
Article
Health Care Sciences & Services
Jihyun Baek, Hyeyeon Lee, Taeyoung Yang, So-Young Lee, Yang Gyun Kim, Jin Sug Kim, ShinYoung Ahn, Kipyo Kim, Seok Hui Kang, Min-Jeong Lee, Dong-Young Lee, Hye Yun Jeong, Yu Ho Lee
Summary: In this study, researchers aimed to identify circulating inflammatory biomarkers that could predict future arteriovenous fistula dysfunction in hemodialysis patients. They found that plasma interleukin-6 (IL-6) levels were positively associated with the occurrence of AVF dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Arpita Basu, Du Feng, Petar Planinic, Jeffrey L. Ebersole, Timothy J. Lyons, James M. Alexander
Summary: This study suggests that supplementation with whole blueberry and soluble fiber may help prevent excessive gestational weight gain and improve glycemic control and inflammation in women at high risk of developing GDM.
JOURNAL OF NUTRITION
(2021)