Article
Neurosciences
Sara Diana Lolansen, Nina Rostgaard, Dagne Barbuskaite, Tenna Capion, Markus Harboe Olsen, Nicolas H. Norager, Frederik Vilhardt, Soren Norge Andreassen, Trine L. Toft-Bertelsen, Fenghui Ye, Marianne Juhler, Richard F. Keep, Nanna MacAulay
Summary: This study aimed to elucidate the molecular coupling between hemorrhagic events and the development of posthemorrhagic hydrocephalus (PHH), as well as the inflammatory profile of PHH pathogenesis. The findings suggest that excessive cerebrospinal fluid (CSF) secretion may contribute to PHH development, likely due to hyperactivity of choroid plexus transporters. Hemorrhage-induced inflammation detected in CSF and choroid plexus tissue may represent the underlying pathology of PHH.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Neurosciences
Zilin Meng, Chunbo Liu, Chao Chen, Fanglin Di, Shuping Zhang, Xue Liang, Meng Li
Summary: This study confirms the induction of ferroptosis in posthemorrhagic hydrocephalus (PHH). The experimental results show that rats with induced PHH exhibit memory and cognition defects, lipid peroxidation, and changes in specific genes. This suggests that ferroptosis may serve as an auxiliary indicator for the diagnosis of PHH.
Article
Clinical Neurology
Sruthi Ramagiri, Shelei Pan, Dakota DeFreitas, Peter H. Yang, Dhvanii K. Raval, David F. Wozniak, Prabagaran Esakky, Jennifer M. Strahle
Summary: Posthemorrhagic hydrocephalus is a common complication of intraventricular hemorrhage in infants. This study develops an animal model of intraventricular hemorrhage and demonstrates that administration of the iron chelator deferoxamine at the time of hemorrhage can prevent hydrocephalus and reduce iron levels in the choroid plexus. This treatment strategy may be clinically relevant for preventing neurological sequelae after intraventricular hemorrhage.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Immunology
Zhaoqi Zhang, Qiang Tan, Peiwen Guo, Suna Huang, Zhengcai Jia, Xin Liu, Hua Feng, Yujie Chen
Summary: The NLRP3 inflammasome plays a crucial role in the pathogenesis of hydrocephalus after intracerebral hemorrhage. Inhibition of NLRP3 decreases CSF secretion and attenuates ventricular dilation and neurological deficits.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Cell Biology
Riley Sevensky, Jessie C. Newville, Ho Lam Tang, Shenandoah Robinson, Lauren L. Jantzie
Summary: Globally, around 11% of newborns are born prematurely, with encephalopathy of prematurity (EoP) being a major cause of morbidity and mortality for very preterm infants. Posthemorrhagic hydrocephalus of prematurity (PHHP) is considered a severe manifestation of EoP, impacting neurodevelopment and potentially leading to permanent consequences. Understanding mechanisms of cell death in the context of PHHP can shed light on therapeutic interventions to prevent and reverse brain remodeling associated with hydrocephalus and EoP.
Review
Pediatrics
Brett A. Whittemore, Dale M. Swift, Jennifer M. Thomas, Lina F. Chalak
Summary: Recent advancements in perinatal care and neuroprotective treatments have significantly improved morbidity and mortality rates in prematurely born infants. Surgical intervention for posthemorrhagic ventricular dilation (PHVD) in premature infants with intraventricular hemorrhage (IVH) can mitigate detrimental effects on neurodevelopmental outcome, but management practices vary widely across institutions. Neuromonitoring techniques have shown potential to optimize surgical timing and technique for improved neurodevelopmental outcomes.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zsolt Fejes, Marianna Pocsi, Jun Takai, Judit Erdei, Andrea Toth, Eniko Balogh, Agnes Rusznyak, Ferenc Fenyvesi, Andrea Nagy, Janos Kappelmayer, Viktoria Jeney, Bela Nagy
Summary: The study revealed a time-dependent increase in Hb derivatives, IL-8, and adhesion molecules in IVH-IV compared to IVH-III, with higher expression of miR-155 and miR-181b at days 41-60. Exposure of HCPEpiCs to IVH CSF samples resulted in increased levels of HMOX1, IL8, and ICAM1 mRNA, along with ROS production via NF-kappa B pathway activation, without causing cell death. Additionally, higher intracellular miR-155 levels and decreased miR-223 and miR-181b expression were observed in HCPEpiCs after treatment with CSF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Deepti Purohit, Dina A. Finkel, Ana Malfa, Yanling Liao, Larisa Ivanova, George M. Kleinman, Furong Hu, Shetal Shah, Carl Thompson, Etlinger Joseph, Michael S. Wolin, Mitchell S. Cairo, Edmund F. La Gamma, Govindaiah Vinukonda
Summary: The study showed that injecting USSCs into the cerebral ventricles of rabbit pups with IVH reduced ventricular size, cellular infiltration, and ependymal wall disruption, restored aquaporin expression, and affected gene expression. USSCs exert anti-inflammatory effects and alleviate the consequences of IVH.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Miguel Saez-Alegre, Rocio Martin, Alexis Palpan, Fernando Carceller, Jesus Saez-Alegre, Guillermo Servera, Rudolf Bauer, Pablo Garcia Feijoo, Javier Saceda
Summary: This study developed a predictive algorithm using artificial intelligence techniques and classical statistics to predict the conversion of an Ommaya reservoir to a permanent shunt, achieving an accuracy of 86%.
WORLD NEUROSURGERY
(2022)
Review
Obstetrics & Gynecology
Shenandoah Robinson, Lauren L. Jantzie
Summary: This study investigates the pathogenesis of posthemorrhagic hydrocephalus in premature infants and its impact on CSF dynamics. It highlights the importance of distinguishing ventricular volume from brain health and function. The study reviews the influence of pathogenesis on current interventions and discusses emerging interventions.
SEMINARS IN PERINATOLOGY
(2022)
Review
Clinical Neurology
Atsuko Harada
Summary: In recent years, there has been an increasing trend in performing endoscopic third ventriculostomy with or without choroid plexus cauterization as a permanent treatment for posthemorrhagic hydrocephalus (PHH). This paper provides a review of the latest evidence on the permanent treatment options for PHH.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Critical Care Medicine
Ying Li, Ding Nan, Ran Liu, Jieyu Li, Zhuangzhuang Zhang, Jianwen Deng, Yang Zhang, Ziguang Yan, Chao Hou, Ensheng Yao, Weiping Sun, Zhaoxia Wang, Yining Huang
Summary: This study investigated the role of Aquaporin 4 (AQP4) in hydrocephalus caused by iron overload after intraventricular hemorrhage (IVH). The results showed that iron overload contributed to the development of hydrocephalus, and AQP4 played an important role in this process.
NEUROCRITICAL CARE
(2023)
Article
Neurosciences
Trine Lisberg Toft-Bertelsen, Dagne Barbuskaite, Eva Kjer Heerfordt, Sara Diana Lolansen, Soren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H. Norager, Tenna Capion, Martin Fredensborg Rath, Marianne Juhler, Nanna MacAulay
Summary: The study reveals that a serum lipid can promote excessive CSF secretion and subsequent brain water accumulation by acting on TRPV4, which may be a potential pharmacological target for pathologies involving brain water accumulation.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Clinical Neurology
Kelly B. Mahaney, Chandana Buddhala, Mounica Paturu, Diego M. Morales, Christopher D. Smyser, David D. Limbrick, Santosh E. Gummidipundi, Summer S. Han, Jennifer M. Strahle
Summary: This study found that neonates with severe initial ventriculomegaly had higher initial levels and prolonged clearance of cerebrospinal fluid hemoglobin and hemoglobin degradation products compared to those with moderate initial ventriculomegaly, indicating a more severe early ventricular enlargement.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2022)
Article
Pediatrics
Min Sheng, Ting Guo, Connor Mabbott, Vann Chau, Anne Synnes, Linda S. de Vries, Ruth E. Grunau, Steven P. Miller
Summary: This study evaluated the relationship between ventricular volume and neurodevelopmental outcomes in children born very preterm. The results showed that ventricular size at birth was associated with cognitive and motor outcomes at 4.5 years, suggesting abnormal white matter maturation in the setting of enlarged ventricular size.
JOURNAL OF PEDIATRICS
(2022)
Article
Biochemical Research Methods
Jenny Hult, Aboma Merdasa, Agnes Pekar-Lukacs, Magne Tordengren Stridh, Azin Khodaverdi, John Albinsson, Bodil Gesslein, Ulf Dahlstrand, Linn Engqvist, Yousef Hamid, Douglas Larsson Alber, Bertil Persson, Tobias Erlov, Rafi Sheikh, Magnus Cinthio, Malin Malmsjo
Summary: Photoacoustic imaging, a novel technology combining optical and ultrasound imaging, has shown promising results in diagnosing melanoma by providing detailed maps of tumor borders with high contrast. It has the potential to improve tumor localization and diagnosis, offering a non-invasive alternative to surgical excision in the future.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Hematology
Sara E. Sjogren, Jun Chen, Alexander Mattebo, Abdul G. Alattar, Helena Karlsson, Kavitha Siva, Shamit Soneji, Ulf Tedgard, Jane-Jane Chen, Magnus Gram, Johan Flygare
Summary: Diamond-Blackfan anemia is a rare genetic disorder characterized by a scarcity of erythroid precursors in the bone marrow, with most patients carrying mutations in ribosomal proteins. Targeting elevated heme levels may be a promising new treatment strategy for DBA, as it improves disease symptoms and provides insights for future therapies.
EXPERIMENTAL HEMATOLOGY
(2022)
Article
Acoustics
Sandra Sjostrand, Maria Evertsson, Esayas Atile, Roger Andersson, Ingrid Svensson, Magnus Cinthio, Tomas Jansson
Summary: Magnetomotive ultrasound is a promising technique for detecting magnetic nanoparticles and imaging molecular structures, with observed displacements influenced by mechanical coupling and mass conservation principles. The importance of considering vector-valued magnetic forces in magnetomotive ultrasound is highlighted, as a simple scalar representation may underestimate vertical force components. Using a finite element model, simulations show the influence of boundary conditions, compressibility, and stiffness on nanoparticle motion, contributing to accurate analysis of magnetomotive ultrasound imaging.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemical Research Methods
Magne Tordengren Stridh, Jenny Hult, Aboma Merdasa, John Albinsson, Agnes Pekar-Lukacs, Bodil Gesslein, Ulf Dahlstrand, Karl Engelsberg, Johanna Berggren, Magnus Cinthio, Rafi Sheikh, Malin Malmsjo
Summary: This study assesses the feasibility of photoacoustic (PA) imaging for the detection of periocular skin cancer. The results show that PA imaging can differentiate different types of periocular skin tumors by analyzing the chromophore composition of the tumors and healthy eyelid tissue.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Medicine, General & Internal
Asa Jungner, Suvi Vallius, Magnus Gram, David Ley
Summary: During neonatal cardiopulmonary bypass, there is an increase in plasma concentrations of cell-free hemoglobin and a decrease in scavenger protein supplies. The concentration of cell-free hemoglobin in blood prime solution is a major predictor of cell-free hemoglobin exposure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Robert Greite, Li Wang, Lukas Gohlke, Sebastian Schott, Kirill Kreimann, Julian Doricic, Andreas Leffler, Igor Tudorache, Jawad Salman, Ruslan Natanov, Fabio Ius, Christine Fegbeutel, Axel Haverich, Ralf Lichtinghagen, Rongjun Chen, Song Rong, Hermann Haller, Vijith Vijayan, Magnus Gram, Irina Scheffner, Faikah Gueler, Wilfried Gwinner, Stephan Immenschuh
Summary: This study investigated the levels of CFH and CFH-binding hemoglobin in LuTx patients and found that CFH may be associated with postoperative AKI. Moreover, experimental studies on a mouse model of mild renal ischemia reperfusion injury confirmed the role of CFH in promoting AKI. Targeting CFH may be a therapeutic option to prevent AKI after LuTx.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Acoustics
Magdalena Naumovska, Aboma Merdasa, Bjorn Hammar, John Albinsson, Ulf Dahlstrand, Magnus Cinthio, Rafi Sheikh, Malin Malmsjo
Summary: Photoacoustic (PA) imaging is a promising clinical diagnostic tool, with one application being imaging of vascular networks in humans. We propose a method using multispectral PA imaging to image the temporal artery, allowing for clear differentiation of the artery wall and lumen, as well as distinguishing between patients diagnosed as GCA- and GCA+ based on biopsies.
Article
Pediatrics
Christina Graneli, Sofia Patarroyo, Rodrigo Munoz Mitev, David Gisselsson, Emilia Gottberg, Tobias Erlov, Tomas Jansson, Kristine Hagelsteen, Magnus Cinthio, Pernilla Stenstrom
Summary: This study explored the differences in histoanatomical layers of bowel walls between ganglionic and aganglionic bowel walls in children with HSCR. The findings suggest that the thicknesses of the bowel wall's muscle layers differ between aganglionic and ganglionic bowel walls. These findings support the development of a diagnostic index that could be used for instant diagnostic imaging techniques.
Article
Physiology
Asa Ryden Ahlgren, Tobias Erlov, Magnus Cinthio
Summary: This study aimed to investigate the longitudinal motion of the carotid artery wall during physical activity in healthy humans. The results showed that physical activity significantly influenced the longitudinal motion of the carotid artery wall, even at low workload. This increase in longitudinal motion was correlated with an increase in blood pressure.
PHYSIOLOGICAL REPORTS
(2023)
Article
Multidisciplinary Sciences
Nishte Rassol, Charlotte Andersson, Daniella Pettersson, Amin Al-Awar, Emman Shubbar, Aniko Kovacs, Bo Akerstrom, Magnus Gram, Khalil Helou, Eva Forssell-Aronsson
Summary: The aim of this study was to investigate the regulation of apoptosis-related genes in GOT1 tumors after administration of Lu-177-octreotate with or without A1M. The results showed that co-administration of A1M did not negatively affect the apoptotic response of Lu-177-octreotate in GOT1 tumors.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Abdul Ghani Alattar, Amanda Kristiansson, Helena Karlsson, Suvi Vallius, Jonas Ahlstedt, Eva Forssell-Aronsson, Bo Akerstrom, Sven-Erik Strand, Johan Flygare, Magnus Gram
Summary: Lu-177-DOTATATE PRRT is an effective therapy for neuroendocrine tumors, but it can cause bone marrow suppression and renal toxicity. A1M, a recombinant antioxidant, has been shown to protect the kidneys in preclinical models. In this study, intravenous administration of rA1M reduced albuminuria levels and oxidative stress-related protein FGF-21 in mice treated with Lu-177-DOTATATE. Dual injections of rA1M preserved bone marrow cellularity and peripheral blood reticulocytes. This suggests that rA1M, when administered with Lu-177-DOTATATE, may reduce hematopoietic and kidney toxicity.
Article
Medicine, General & Internal
Tebin Hawez, Christina Graneli, Tobias Erloev, Emilia Gottberg, Rodrigo Munoz Mitev, Kristine Hagelsteen, Maria Evertsson, Tomas Jansson, Magnus Cinthio, Pernilla Stenstroem
Summary: This study validates the accuracy of UHFUS imaging in children with Hirschsprung's disease by investigating the correlation and systematic differences between UHFUS and histopathology.
Article
Medicine, General & Internal
Maria Evertsson, Christina Graneli, Alvina Vernersson, Olivia Wiaczek, Kristine Hagelsteen, Tobias Erlov, Magnus Cinthio, Pernilla Stenstrom
Summary: It has been shown that using ultra-high frequency (UHF) ultrasound on the external bowel wall can accurately differentiate between normal bowel and aganglionosis, which could potentially eliminate the need for biopsies in diagnosing Hirschsprung's disease. However, there are currently no suitable rectal probes available for this purpose. This study aimed to define the specifications of a new UHF transrectal ultrasound probe that would be suitable for use in infants, and two prototypes were created and tested by pediatric surgeons, with the larger and straight probe being preferred.
Article
Physiology
Sandra Sjostrand, Alice Widerstrom, Ingrid Svensson, Patrick Segers, Tobias Erlov, Asa Ryden Ahlgren, Magnus Cinthio
Summary: Longitudinal motion of the carotid arterial wall, as measured with ultrasound, is a promising indicator of vascular health, but its underlying mechanisms are not fully understood. Blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Tapered geometry and intramural friction between two parts of a vessel wall also influence the longitudinal displacement.
PHYSIOLOGICAL REPORTS
(2023)
Article
Medicine, General & Internal
Tobias Erlov, Tebin Hawez, Christina Graneli, Maria Evertsson, Tomas Jansson, Pernilla Stenstrom, Magnus Cinthio
Summary: Ultra-high-frequency ultrasound (UHFUS) has the potential to differentiate between different types of bowel wall based on histoanatomical differences. A computer program was developed to objectively and accurately assess and calculate the histoanatomical morphometrics of the bowel wall in UHFUS images. The program showed excellent agreement between observers and can be used for various bowel wall conditions.
