Article
Endocrinology & Metabolism
Amin Nozari, Remi Gagne, Chunyu Lu, Carole Yauk, Vance L. Trudeau
Summary: The study investigated the long-lasting effects of developmental daily exposure to Fluoxetine (FLX) on the transcriptomic profile of brain tissues in zebrafish. The results revealed dysregulation of genes involved in neuroendocrine signaling, stress response, and the circadian rhythm, which are all implicated in the development of depressive disorders in humans. The findings raise concerns about the potential endocrine-disrupting effects of brief antidepressant exposure during embryonic development.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Helen E. Vuong, Elena J. L. Coley, Maria Kazantsev, Michaela E. Cooke, Tomiko K. Rendon, Jorge Paramo, Elaine Y. Hsiao
Summary: This study demonstrates that maternal treatment with the SSRI fluoxetine can induce widespread alterations in the fetal brain transcriptome during midgestation, affecting genes related to synaptic organization, neuronal signaling, DNA replication, and mitosis. Furthermore, the maternal gut microbiome plays a significant role in modulating the fetal brain's transcriptional responses to maternal fluoxetine treatment, as shown by the elevation of certain gene expression in specific brain regions and the prevention of this effect by maternal antibiotic treatment.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Nadeem, Shumaila Usman, Rehan Imad, Uzair Nisar, Irfan Khan, Ghulam Abbas
Summary: Perinatal depression can have long-term impacts on the mental wellbeing of newborns. A study found that pre-weaning fluoxetine exposure can decrease depression-like behavior in adult offspring by perturbing tryptophan metabolism.
METABOLIC BRAIN DISEASE
(2022)
Article
Neurosciences
Binliang Tang, Kailin Li, Yuan Cheng, Guimin Zhang, Pengying An, Yutian Sun, Yue Fang, Hui Liu, Yang Shen, Yifan Zhang, Ye Shan, Etienne De Villers-Sidani, Xiaoming Zhou
Summary: Exposure to BPA during development affects auditory cortical processing and auditory discrimination, particularly in the temporal domain.
NEUROSCIENCE BULLETIN
(2022)
Article
Physiology
Hannah P. Fricke, Chandler J. Krajco, Molly J. Perry, Katelyn M. Desorcy-Scherer, Lella A. Wake, Julia F. Charles, Laura L. Hernandez
Summary: At the end of gestation, fetal skeleton rapidly accumulates calcium, and bone development continues in offspring postnatally. Maternal skeletal physiology is modulated in a serotonin-dependent manner to accommodate this. Selective serotonin reuptake inhibitors (SSRIs), commonly used to treat major depressive disorder, postpartum depression, and other psychiatric illnesses, are associated with decreased bone mass due to their impact on serotonin, but their effects on fetal and postnatal development have not been fully studied. This study investigated the impact of developmental fluoxetine exposure on offspring skeleton and found that a low dose during lactation caused more damage to offspring bone than a low dose during fetal and postpartum development or a high dose during lactation only. Furthermore, lasting impacts of developmental fluoxetine exposure, especially during lactation only, on adult bone and body composition were discovered. This study provides evidence that early developmental fluoxetine exposure may have detrimental effects on the skeleton of offspring at weaning and into adulthood.
PHYSIOLOGICAL REPORTS
(2023)
Article
Environmental Sciences
Yuese Yuan, Xiaoyun Wang, Jianhong Ge, Wanyu Jiang, Zekang Li, Zhenyu Wang, Qianqian Xiao, Qinghe Meng, Jianjun Jiang, Weidong Hao, Xuetao Wei
Summary: This study reveals the potential developmental immunotoxicity of yttrium nitrate, particularly in female offspring. It inhibits humoral and cellular immune responses and affects the development of the immune system. The toxic effects on cellular immunity can persist into adulthood.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Tingting Chai, Feng Cui, Shanshan Di, Shenggan Wu, Yiming Zhang, Xinquan Wang
Summary: The study showed that exposure to fluoxetine had cardiotoxic effects on developmental zebrafish, with differences in toxicity between the enantiomers. The accumulation of fluoxetine and its biotransformation to norfluoxetine contributed to the observed adverse effects, highlighting the need to assess the environmental risk posed by these substances.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nutrition & Dietetics
Jessica A. Baker, Kristen R. Breit, Tamara S. Bodnar, Joanne Weinberg, Jennifer D. Thomas
Summary: Prenatal alcohol exposure can disrupt the development of the immune system, but choline supplementation can mitigate these effects. The study found that early choline supplementation can reduce the impact of alcohol exposure on hippocampal inflammation and improve hippocampal function.
Article
Environmental Sciences
Xi Su, Wenqiang Li, Zhen Li, Kang Liu, Meng Song, Minglong Shao, Luxian Lv, Xulu Chang
Summary: Chronic exposure to low-dose 1-octyl3-methylimidazolium hexafluorophosphate induced neurotoxicity in rats, resulting in behavioral abnormalities and damage to glutamatergic excitatory synapses.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Neurosciences
Hayley N. Manke, Kenner C. Rice, Anthony L. Riley
Summary: Previous studies have found that the aversive effects of a drug are weakened when the pre-exposure and conditioning drugs are the same or different. Cross-drug pre-exposure, which involves different drugs, has been used to assess the mechanisms underlying drug aversive effects. This study examined the impact of methylone pre-exposure on taste avoidance induced by the serotonin reuptake inhibitor fluoxetine.
Article
Multidisciplinary Sciences
Noortje Van der Knaap, Dirk Wiedermann, Dirk Schubert, Mathias Hoehn, Judith R. Homberg
Summary: The use of SSRIs during pregnancy may increase the risk of neurodevelopmental disorders such as autism in offspring, likely due to developmental changes in brain function. Studies in rats lacking the serotonin transporter have shown that alterations in serotonin levels can affect brain activity related to whisker stimulation. Results from functional MRI studies on offspring exposed to perinatal SSRI suggest complex changes in brain networks involved in sensory perception and processing.
SCIENTIFIC REPORTS
(2021)
Article
Toxicology
AtLee T. D. Watson, Victor J. Johnson, Michael Luster, Gary R. Burleson, Dawn M. Fallacara, Barney R. Sparrow, Mark F. Cesta, Michelle C. Cora, Keith R. Shockley, Matt D. Stout, Chad R. Blystone, Dori R. Germolec
Summary: The study investigated the impact of oral exposure to Sulfolane on the immune system using rodent models. Results showed minimal effects on the immune system in rodents, with decreased NK cell activity observed in female F1 rats following developmental exposure.
JOURNAL OF IMMUNOTOXICOLOGY
(2021)
Article
Neurosciences
Edenia C. Menezes, Relish Shah, Lindsay Laughlin, K. Yaragudri Vinod, John F. Smiley, Catarina Cunha, Andrea Balla, Henry Sershen, Francisco X. Castellanos, Andre Corvelo, Catia M. Teixeira
Summary: Early life is a critical period where enhanced neural plasticity allows the developing brain to adapt to its environment. Exposure to fluoxetine in early postnatal period can lead to reduced effort-related motivation and blunted dopaminergic activation in reward tasks in adulthood. Administering bupropion in adulthood can rescue the reduction in motivation, highlighting the involvement of the dopaminergic system in this process.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Environmental Sciences
Louise Ramhoj, Caroline Fraedrich, Terje Svingen, Martin Scholze, Eva K. Wirth, Eddy Rijntjes, Josef Koehrle, Andreas Kortenkamp, Marta Axelstad
Summary: This study demonstrates that certain environmental chemicals can alter brain development through impacting the synthesis and action mechanisms of thyroid hormones, leading to brain malformations.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Giovanni Luca Romano, Lucia Gozzo, Oriana Maria Maurel, Serena Di Martino, Valentina Riolo, Vincenzo Micale, Filippo Drago, Claudio Bucolo
Summary: The topical ocular administration of FLX was found to have a neuroprotective effect in a mouse model of acute retinal damage, as it counteracted the damage of retinal ganglion cells and preserved retinal function. FLX treatment also reduced the production of pro-inflammatory molecules elicited by retinal injury. Further studies are needed to support the use of FLX as a neuroprotective agent in retinal degenerative diseases.
Article
Behavioral Sciences
Brendan B. McAllister, Simon C. Spanswick, Payal P. Patel, Alison A. Barneto, Richard H. Dyck
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Pediatrics
Taryn B. Bemister, Brian L. Brooks, Richard H. Dyck, Adam Kirton
Article
Neurosciences
V. Kiryanova, S. J. Meunier, H. A. Vecchiarelli, M. N. Hill, R. H. Dyck
Article
Neurosciences
Veronika Kiryanova, Victoria M. Smith, Richard H. Dyck, Michael C. Antle
PSYCHOPHARMACOLOGY
(2017)
Review
Behavioral Sciences
Brendan B. McAllister, Richard H. Dyck
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2017)
Article
Multidisciplinary Sciences
Daniel J. Dennis, Grey Wilkinson, Saiqun Li, Rajiv Dixit, Lata Adnani, Anjali Balakrishnan, Sisu Han, Christopher Kovach, Nicole Gruenig, Deborah M. Kurrasch, Richard H. Dyck, Carol Schuurmans
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Editorial Material
Biology
Brendan B. McAllister, Richard H. Dyck
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Neurosciences
H. -P. Patrick Wu, Richard H. Dyck
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Neurosciences
Veronika Kiryanova, Victoria M. Smith, Michael C. Antle, Richard H. DycK
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Neurosciences
Brendan B. McAllister, Angela Pochakom, Selena Fu, Richard H. Dyck
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Neurosciences
Brendan B. McAllister, Nicoline Bihelek, Richelle Mychasiuk, Richard H. Dyck
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Neurosciences
Mahtab Moshirpour, Amy S. Nakashima, Nicole Sehn, Victoria M. Smith, Sarah E. Thackray, Richard H. Dyck, Michael C. Antle
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Neurosciences
Brendan B. McAllister, David K. Wright, Ryan C. Wortman, Sandy R. Shultz, Richard H. Dyck
NEUROBIOLOGY OF STRESS
(2018)
Article
Behavioral Sciences
Veronika Kiryanova, Sara J. Meunier, Richard H. Dyck
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Behavioral Sciences
Sarah E. Thackray, Brendan B. McAllister, Richard H. Dyck
BEHAVIOURAL BRAIN RESEARCH
(2017)