Article
Medicine, General & Internal
P. Kotagiri, A. Martin, P. Hughes, G. Becker, K. Nicholls
INTERNAL MEDICINE JOURNAL
(2016)
Article
Immunology
P. Kotagiri, D. Chembolli, J. Ryan, P. D. Hughes, N. D. Toussaint
TRANSPLANTATION PROCEEDINGS
(2017)
Article
Developmental Biology
Prasanti Kotagiri, Steven A. Chance, Francis G. Szele, Margaret M. Esiri
DEVELOPMENTAL NEUROBIOLOGY
(2014)
Review
Surgery
Stephen G. Holt, Prasanti Kotagiri, Chris Hogan, Peter Hughes, Rosemary Masterson
TRANSPLANT INTERNATIONAL
(2020)
Article
Immunology
Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aimee L. Hanson, Prasanti Kotagiri, Benjamin J. Dunmore, Helene Ruffieux, Aloka De Sa, Oisin Huhn, Michael D. Morgan, Pehuen Pereyra Gerber, Mark R. Wills, Stephen Baker, Fernando J. Calero-Nieto, Rainer Doffinger, Gordon Dougan, Anne Elmer, Ian G. Goodfellow, Ravindra K. Gupta, Myra Hosmillo, Kelvin Hunter, Nathalie Kingston, Paul J. Lehner, Nicholas J. Matheson, Jeremy K. Nicholson, Anna M. Petrunkina, Sylvia Richardson, Caroline Saunders, James E. D. Thaventhiran, Erik J. M. Toonen, Michael P. Weekes, Berthold Gottgens, Mark Toshner, Christoph Hess, John R. Bradley, Paul A. Lyons, Kenneth G. C. Smith
Summary: The kinetics of immune changes in COVID-19 across different severity groups show that early bystander CD8(+) T cell immune response is prominent in asymptomatic or mild diseases, while severe cases have persistent cellular abnormalities and immune defects, which may increase clinical risks.
Article
Multidisciplinary Sciences
Dami A. Collier, Isabella A. T. M. Ferreira, Prasanti Kotagiri, Rawlings P. Datir, Eleanor Y. Lim, Emma Touizer, Bo Meng, Adam Abdullahi, Anne Elmer, Nathalie Kingston, Barbara Graves, Emma Le Gresley, Daniela Caputo, Laura Bergamaschi, Kenneth G. C. Smith, John R. Bradley, Lourdes Ceron-Gutierrez, Paulina Cortes-Acevedo, Gabriela Barcenas-Morales, Michelle A. Linterman, Laura E. McCoy, Chris Davis, Emma Thomson, Paul A. Lyons, Eoin McKinney, Rainer Doffinger, Mark Wills, Ravindra K. Gupta
Summary: Elderly individuals, especially those above eighty, show lower immune responses and neutralization abilities against variants of concern after the first vaccine dose, but this improves after the second dose. They have higher frequencies of spike-specific memory B cells but reduced somatic hypermutation of class-switched cells. Production of interferon-gamma and interleukin-2 by SARS-CoV-2 spike-specific T cells is lower in older participants, predominantly by CD4 T cells.
Article
Cell Biology
Prasanti Kotagiri, Federica Mescia, William M. Rae, Laura Bergamaschi, Zewen K. Tuong, Lorinda Turner, Kelvin Hunter, Pehuen P. Gerber, Myra Hosmillo, Christoph Hess, Menna R. Clatworthy, Ian G. Goodfellow, Nicholas J. Matheson, Eoin F. McKinney, Mark R. Wills, Ravindra K. Gupta, John R. Bradley, Rachael J. M. Bashford-Rogers, Paul A. Lyons, Kenneth G. C. Smith
Summary: B cell receptor (BCR) repertoire development differs between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and vaccination, potentially informing vaccine strategies. After infection, there is an increase in immunoglobulin (Ig)G1/3 and IgA1 BCRs, a decrease in somatic hypermutation (SHM), and expansion of IgM and IgA clones in severe disease. In contrast, vaccination leads to an increase in IgD/M BCRs, unchanged SHM, and prominent expansion of IgG clones.
Article
Medicine, General & Internal
Prasanti Kotagiri, Federica Mescia, Aimee L. Hanson, Lorinda Turner, Laura Bergamaschi, Ana Penalver, Nathan Richoz, Stephen D. Moore, Brian M. Ortmann, Benjamin J. Dunmore, Michael D. Morgan, Zewen Kelvin Tuong, Berthold Gottgens, Mark Toshner, Christoph Hess, Patrick H. Maxwell, Menna R. Clatworthy, James A. Nathan, John R. Bradley, Paul A. Lyons, Natalie Burrows, Kenneth G. C. Smith
Summary: Early and persistent defects in B cell subsets in COVID-19 are associated with hypoxia. Early oxygen therapy may be beneficial in correcting these immune deficiencies and improving outcomes.
Article
Multidisciplinary Sciences
Jun Wang, Prasanti Kotagiri, Paul A. Lyons, Rafia S. Al-Lamki, Federica Mescia, Laura Bergamaschi, Lorinda Turner, Michael D. Morgan, Fernando J. Calero-Nieto, Karsten Bach, Nicole Mende, Nicola K. Wilson, Emily R. Watts, Patrick H. Maxwell, Patrick F. Chinnery, Nathalie Kingston, Sofia Papadia, Kathleen E. Stirrups, Neil Walker, Ravindra K. Gupta, David K. Menon, Kieren Allinson, Sarah J. Aitken, Mark Toshner, Michael P. Weekes, James A. Nathan, Sarah R. Walmsley, Willem H. Ouwehand, Mary Kasanicki, Berthold Gottgens, John C. Marioni, Kenneth G. C. Smith, Jordan S. Pober, John R. Bradley
Summary: The increased expression of Factor V in leukocytes correlates with severe COVID-19 and T-cell lymphopenia. Anticoagulants may suppress the adaptive immune system.
Article
Immunology
William Rae, John M. Sowerby, Dorit Verhoeven, Mariam Youssef, Prasanti Kotagiri, Natalia Savinykh, Eve L. Coomber, Alexis Boneparth, Angela Chan, Chun Gong, Machiel H. Jansen, Romy du Long, Giorgia Santilli, Ilenia Simeoni, Jonathan Stephens, Kejia Wu, Marta Zinicola, Hana Lango Allen, Helen Baxendale, Dinakantha Kumararatne, Effrossyni Gkrania-Klotsas, Selma C. Scheffler Mendoza, Marco Antonio Yamazaki-Nakashimada, Laura Berron Ruiz, Cesar Mauricio Rojas-Maruri, Saul O. Lugo Reyes, Paul A. Lyons, Anthony P. Williams, Daniel J. Hodson, Gail A. Bishop, Adrian J. Thrasher, David C. Thomas, Michael P. Murphy, Timothy J. Vyse, Joshua D. Milner, Taco W. Kuijpers, Kenneth G. C. Smith
Summary: This study identifies a syndrome of immune dysregulation that is associated with recurrent bacterial infections, autoimmunity, systemic inflammation, B cell lymphoproliferation, and high levels of immunoglobulin. The mutations in the TRAF3 gene and common genetic variants associated with reduced TRAF3 expression both contribute to the development of this syndrome. These findings shed light on the role of TRAF3 in human immunity and its impact on various diseases.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M. C. Boehner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Roesen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
Summary: The study identifies abnormal DNA recognition and IFN-I production as drivers of severe ANCA-associated vasculitis, and demonstrates that blocking this pathway can ameliorate the disease and accelerate recovery, suggesting potential therapeutic targets for patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Helene Ruffieux, Aimee L. Hanson, Samantha Lodge, Nathan G. Lawler, Luke Whiley, Nicola Gray, Tui H. Nolan, Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aloka de Sa, Victoria S. Pelly, Prasanti Kotagiri, Nathalie R. Kingston, John Bradley, Elaine Holmes, Julien K. Wist, Jeremy A. Nicholson, Paul Lyons, Kenneth G. C. Smith, Sylvia Richardson, Glenn Bantug, Christoph Hess
Summary: We analyzed detailed longitudinal phenotyping data from 215 individuals with varying disease severities to understand the biology behind individual patient responses to SARS-CoV-2 infection. Our findings revealed distinct profiles of 'systemic recovery', including the progression and resolution of inflammatory, immune cell, metabolic, and clinical responses. We identified strong correlations between innate immune cell numbers, kynurenine metabolites, and lipid metabolites, which have implications for homeostasis restoration, risk of death, and long COVID.
Article
Gastroenterology & Hepatology
Victoria Mulcahy, Evaggelia Liaskou, Jose-Ezequiel Martin, Prasanti Kotagiri, Jonathan Badrock, Rebecca L. Jones, Simon M. Rushbrook, Stephen D. Ryder, Douglas Thorburn, Simon D. Taylor-Robinson, Graeme Clark, Heather J. Cordell, Richard N. Sandford, David E. Jones, Gideon M. Hirschfield, George F. Mells
Summary: This study characterized the immunobiology of the UDCA response in patients with primary biliary cholangitis (PBC). The results showed that adaptive immune responses are better regulated in patients with PBC with adequate UDCA response.
HEPATOLOGY COMMUNICATIONS
(2023)
Meeting Abstract
Urology & Nephrology
P. Kotagiri, R. Masteron, P. Hughes, M. Haeusler, S. Holt, C. Hogan