Article
Computer Science, Artificial Intelligence
Yi Wang, Yuan Zhang, Chi Ma, Rui Wang, Zhe Guo, Yu Shen, Miaomiao Wang, Hongying Meng
Summary: Punctate White Matter Damage (PWMD) is a common neonatal brain disease that affects neurological function. The difficulty in diagnosis leads to missed treatment opportunities. This study proposes a new method using T1 MRI and DTI to analyze PWMD, which effectively predicts and analyzes the impact of lesions on fiber tracts through super-resolution and image registration.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2023)
Article
Neurosciences
J. Zhang, K. Xia, M. Ahn, S. C. Jha, R. Blanchett, J. J. Crowley, J. P. Szatkiewicz, F. Zou, H. Zhu, M. Styner, J. H. Gilmore, R. C. Knickmeyer
Summary: This study on genetic influences on early white matter development in neonates identified a latent measure of white matter microstructure and a significant intronic SNP in PSMF1 on chromosome 20 that exceeded the conventional GWAS threshold. Additional loci near genes associated with axon growth and guidance, fasciculation, and myelination were also found.
Article
Neurosciences
Alex Luna, Joel Bernanke, Kakyeong Kim, Natalie Aw, Jordan D. Dworkin, Jiook Cha, Jonathan Posner
Summary: The study compared brain predicted age difference in youth using multimodal MRI and stacked ensemble machine learning. Results showed that combining morphometry and connectomes in the model had better performance, serving as a clinically relevant indicator of psychiatric and cognitive functioning in youth.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Gianpaolo Antonio Basile, Salvatore Bertino, Victor Nozais, Alessia Bramanti, Rosella Ciurleo, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola
Summary: This study used the track-weighted dynamic functional connectivity model to investigate the contribution of structural connectivity to functional connectivity dynamics. The results showed that this model can provide functional information about white matter activity, capturing meaningful features of brain connectivity organization and predicting higher-order cognitive performance.
Article
Anatomy & Morphology
Tory O. Frizzell, Elisha Phull, Mishaa Khan, Xiaowei Song, Lukas A. Grajauskas, Jodie Gawryluk, Ryan C. N. D'Arcy
Summary: This study evaluated white matter neuroplasticity in healthy adults pre-post motor training, specifically focusing on motor learning in the non-dominant hand. Changes in neuroplasticity were observed in the internal capsule and corpus callosum, with significant amplitude reductions in low-frequency oscillations implicating optimized transmission through altered myelination. The findings open new avenues for white matter investigations and advance MRI clinical applications.
BRAIN STRUCTURE & FUNCTION
(2022)
Review
Clinical Neurology
Stefan Stamenkovic, Yuandong Li, Jack Waters, Andy Shih
Summary: The increasing socio-economic burden of Alzheimer disease (AD) and AD-related dementias has created a pressing need to define targets for therapeutic intervention. Animal models that recapitulate features of AD/AD-related dementias may provide mechanistic insight because microvascular pathology can be studied as it develops in vivo. Recent advances in in vivo optical and ultrasound-based imaging of the rodent brain facilitate this goal by providing access to deeper brain structures, including white matter and hippocampus, which are more vulnerable to injury during cerebrovascular disease.
Article
Clinical Neurology
Letizia Squarcina, Susanna Lucini Paioni, Marcella Bellani, Maria Gloria Rossetti, Josselin Houenou, Mircea Polosan, Mary L. Phillips, Michele Wessa, Paolo Brambilla
Summary: In this study, the state of white matter structures in bipolar disorder patients was investigated using TBSS and FD analyses. The results showed diffusion abnormalities primarily located in the temporo-parietal network, while no significant differences were found in the morphological complexity of white matter structures. Individual patients showed localized significant deviations in fractal dimension values.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Computer Science, Interdisciplinary Applications
Temesgen Bihonegn, Sumit Kaushik, Avinash Bansal, Lubomir Vojtisek, Jan Slovak
Summary: The study aims to enhance the effectiveness of geodesic ray-tracing method in white matter fiber reconstruction by adjusting metrics on diffusion tensor spaces. By choosing appropriate metrics, enhancing robustness, and utilizing fourth order tensor data, more satisfactory results are achieved in white matter tract construction.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Neurosciences
David K. Wright, Georgia F. Symons, William T. O'Brien, Stuart J. McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D. Brady, Mujun Sun, Meng Law, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz
Summary: The preliminary study showed that male athletes with SRC reported more severe symptoms compared to female athletes. dMRI revealed white matter differences between SRC athletes and non-concussed athletes at 48 hours post-injury, which persisted at 2 weeks post-injury. Furthermore, male SRC athletes exhibited significantly greater white matter disruption than female SRC athletes. These findings have implications for concussion management, including return-to-play decisions, and enhance our understanding of the role of sex in SRC outcomes.
Article
Cell Biology
Yun-Qing Luo, Rong-Bin Liang, San-Hua Xu, Yi-Cong Pan, Qiu-Yu Li, Hui-Ye Shu, Min Kang, Pin Yin, Li-Juan Zhang, Yi Shao
Summary: This study investigated regional changes in brain white matter in dry eye patients using DTI and NODDI. The results showed significant differences in FA, MD, and ODI between dry eye patients and healthy controls, suggesting potential pathological mechanisms underlying dry eye.
Article
Clinical Neurology
Melanie A. Matyi, Jeffrey M. Spielberg
Summary: Deficits in negative emotion differentiation are associated with mental health outcomes, but the processes underlying individual differences in negative emotion differentiation are poorly understood. This study examines the relationship between white matter microstructure and negative emotion differentiation, providing insights into its component processes and its link to brain structure.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Liu Yang, Xuefei Yu, Yajun Zhang, Na Liu, Danni Li, Xindong Xue, Jianhua Fu
Summary: Caffeine has neuroprotective effects on hypoxic-ischemic white matter damage by modulating proteins related to myelin development and synapse formation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Zhi-gang Min, Hai-rong Shan, Long Xu, Dai-hai Yuan, Xue-xia Sheng, Wen-chao Xie, Ming Zhang, Chen Niu, Tahir Mehmood Shakir, Zhi-hong Cao
Summary: Research suggests that distinct pathological processes can be identified between frontal periventricular WMH and other regions, indicating potential severe demyelination effects within the frontal periventricular WMH.
Article
Neurosciences
Natalia Del Campo, Owen Phillips, Francoise Ory-Magne, Christine Brefel-Courbon, Monique Galitzky, Claire Thalamas, Katherine L. Narr, Shantanu Joshi, Manpreet K. Singh, Patrice Peran, Anne Pavy-LeTraon, Olivier Rascol
Summary: Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterized by widespread accumulation of alpha-synuclein, primarily in oligodendrocytes. Whole brain deep and superficial white matter diffusivity abnormalities were observed in MSA patients but not in Parkinson's disease (PD) patients. These abnormalities were associated with motor and cognitive functions in MSA patients.
HUMAN BRAIN MAPPING
(2021)
Article
Biochemistry & Molecular Biology
Amanda C. Welch, Jie Zhang, Jinrui Lyu, Matthew S. McMurray, Jonathan A. Javitch, Christoph Kellendonk, Stephanie C. Dulawa
Summary: D2R-OENAc alters glucose metabolism in both sexes but drives robust weight loss only in females during scheduled fasting, implicating metabolic mechanisms in this sexually dimorphic effect.
MOLECULAR PSYCHIATRY
(2021)
Correction
Neurosciences
Adam T. Eggebrecht, Jed T. Elison, Eric Feczko, Alexandre Todorov, Jason J. Wolff, Sridhar Kandala, Chloe M. Adams, Abraham Z. Snyder, John D. Lewis, Annette M. Estes, Lonnie Zwaigenbaum, Kelly N. Botteron, Robert C. McKinstry, John N. Constantino, Alan Evans, Heather C. Hazlett, Stephen Dager, Sarah J. Paterson, Robert T. Schultz, Martin A. Styner, Guido Gerig, Samir Das, Penelope Kostopoulos, Bradley L. Schlaggar, Steven E. Petersen, Joseph Piven, John R. Pruett
Article
Endocrinology & Metabolism
Katherine M. Reding, Martin M. Styner, Mark E. Wilson, Donna Toufexis, Mar M. Sanchez
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Jessica Raper, Zsofia Kovacs-Balint, Maud Mavigner, Sanjeev Gumber, Mark W. Burke, Jakob Habib, Cameron Mattingly, Damien Fair, Eric Earl, Eric Feczko, Martin Styner, Sherrie M. Jean, Joyce K. Cohen, Mehul S. Suthar, Mar M. Sanchez, Maria C. Alvarado, Ann Chahroudi
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Yilin Liu, Brendon M. Nacewicz, Gengyan Zhao, Nagesh Adluru, Gregory R. Kirk, Peter A. Ferrazzano, Martin A. Styner, Andrew L. Alexander
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Neurosciences
Astrid Schmied, Takahiro Soda, Guido Gerig, Martin Styner, Meghan R. Swanson, Jed T. Elison, Mark D. Shen, Robert C. McKinstry, John R. Pruett, Kelly N. Botteron, Annette M. Estes, Stephen R. Dager, Heather C. Hazlett, Robert T. Schultz, Joseph Piven, Jason J. Wolff
Article
Computer Science, Interdisciplinary Applications
Jiazhou Chen, Guoqiang Han, Hongmin Cai, Defu Yang, Paul J. Laurienti, Martin Styner, Guorong Wu
Summary: The spatial patterns of disease-relevant brain alterations follow large-scale brain networks rather than occurring randomly. A novel connectome harmonic analysis framework is proposed to provide enhanced mathematical insights into disease progression by detecting frequency-based alterations relevant to brain disorders. This approach outperforms Euclidean methods in identifying significant and reproducible network dysfunction patterns related to Alzheimer's disease.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Endocrinology & Metabolism
Rebecca C. Knickmeyer, Crystal T. Nguyen, Jeffrey T. Young, Anne Haunton, Michael R. Kosorok, John H. Gilmore, Martin Styner, Debora A. Rothmond, Pamela L. Noble, Rhoshel Lenroot, Cynthia Shannon Weickert
Summary: The study found that prepubertal gonadectomy alters the developmental trajectory of prefrontal gray matter in male rhesus macaques, suggesting that the prefrontal cortex is more vulnerable to gonadectomy compared to other brain regions.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Danielle N. Rendina, Gabriele R. Lubach, Mark Lyte, Gregory J. Phillips, Ankush Gosain, Joseph F. Pierre, Roza M. Vlasova, Martin A. Styner, Christopher L. Coe
Summary: This study tracked the assembly of gut microbiota during the initial nursing period and transition to solid food in infant monkeys. The dynamic bacterial community structure reflected different maturational phases, influenced early by breast milk and later by solid foods. Higher abundance of certain microbial taxa during nursing was associated with slower growth trajectories and smaller brain volumes at one year of age.
Article
Multidisciplinary Sciences
Alexander L. Carlson, Kai Xia, M. Andrea Azcarate-Peril, Samuel P. Rosin, Jason P. Fine, Wancen Mu, Jared B. Zopp, Mary C. Kimmel, Martin A. Styner, Amanda L. Thompson, Cathi B. Propper, Rebecca C. Knickmeyer
Summary: Experimental manipulation of the gut microbiome in animal models impacts fear behaviors. This pilot study suggests associations between features of the human infant gut microbiome and non-social fear behaviors. Understanding the role of the gut microbiome in human fear behavior development requires further validation with a larger sample size.
NATURE COMMUNICATIONS
(2021)
Article
Psychology, Experimental
Max Teaford, William Berg, Vincent A. Billock, Matthew S. McMurray, Robin Thomas, L. James Smart
Summary: The rubber hand illusion is a perceptual illusion where people feel a hand-shaped object is part of their body. This study explores the relationship between muscle activity and experiencing the illusion, and finds that muscle fatigue is positively associated with proprioceptive drift when the stimulation is synchronous or visual movement only.
PSYCHOLOGICAL RESEARCH-PSYCHOLOGISCHE FORSCHUNG
(2023)
Article
Genetics & Heredity
Kai Xia, Andrey A. Shabalin, Zhaoyu Yin, Wonil Chung, Patrick F. Sullivan, Fred A. Wright, Martin Styner, John H. Gilmore, Rebecca C. Santelli, Fei Zou
Summary: We developed an efficient alternative called TwinEQTL to the linear mixed-effects model for twin genome-wide association study data. TwinEQTL splits twin samples into two independent groups and combines the test results using a meta-analysis-like approach. Mathematical derivations and simulations show that TwinEQTL is valid and has comparable power to the gold-standard linear mixed-effects models.
Article
Behavioral Sciences
Brianna F. Roberts, Alexia L. Zylko, Courtney E. Waters, Jessica D. Crowder, William J. Gibbons Jr, Abhishek K. Sen, J. Andrew Jones, Matthew S. McMurray
Summary: This study investigated the effects of psilocybin on decision-making and motivation in rats. The results showed that psilocybin did not affect decision-making and motivation, but it did cause head twitch responses. Therefore, the study suggests that psilocybin may not impair or improve decision-making and motivation.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Alexandra M. Adams, Nicholas A. Anas, Abhishek K. Sen, Jordan D. Hinegardner-Hendricks, Philip J. O'Dell, William J. Gibbons, Jessica E. Flower, Matthew S. McMurray, J. Andrew Jones
Summary: Interest in the potential therapeutic efficacy of psilocybin and other psychedelic compounds has increased significantly. In this study, a novel E. coli platform was developed for the production of norbaeocystin, an intermediate compound in the psilocybin pathway. In vivo measurements showed that psilocybin had a dose response, while norbaeocystin did not elicit any pharmacological response, suggesting a weak affinity of norbaeocystin and its metabolites for the serotonin 2A receptor. This research provides a mechanism to source norbaeocystin for future studies and supports the safety of cell broth as a drug delivery vehicle.
METABOLIC ENGINEERING COMMUNICATIONS
(2022)
Review
Psychology, Clinical
Max Teaford, Matthew S. McMurray, Vincent Billock, Madison Filipkowski, L. James Smart
Summary: Individuals with anorexia nervosa show abnormalities in multisensory integration, reduced discrimination ability for complex haptic and tactile stimuli, and decreased sensitivity to nociceptive stimuli, indicating potential avenues for future research.
JOURNAL OF EXPERIMENTAL PSYCHOPATHOLOGY
(2021)