Article
Clinical Neurology
Jianzhao Zhang, Jing Sun, Ping Zheng, Shuo Feng, Xiaoli Yi, Haitao Ren, Qian Chen
Summary: This study retrospectively analyzed the seizure characteristics of 50 children with anti-NMDAR encephalitis. The results showed that 68.0% of the children with anti-NMDAR encephalitis had seizures. Compared to children without seizures, those with seizures were more likely to experience consciousness disturbances and epileptic form discharge on electroencephalograms. Additionally, children with involvement of the limbic system and neocortex were prone to status epilepticus.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Sakiko Taniguchi, Jacob R. Stolz, Geoffrey T. Swanson
Summary: Perampanel (PMP) has been found to inhibit both AMPAR and KARs, suggesting that its clinical actions may arise from selective inhibition of different glutamate receptor signaling pathways.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Medicine, Research & Experimental
Zihuan Shen, Mi Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang, Xiangning Cui
Summary: This article reviews the glutamate-mediated excitotoxicity mechanism in post-ischemic stroke damage, focusing on the pathological changes in glutamate release, reuptake, NMDAR, and cellular signaling pathways. It also discusses new treatment targets and potential neuroprotective drugs for ischemic stroke.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
M. Crespo, D. A. Leon-Navarro, M. Martin
Summary: Febrile seizures in children can lead to epilepsy in adults, with glutamate playing a key role in the development of neurological disorders. In the short term after seizures, GLT-1 levels increase and glutamate concentration decreases, while mGlu(5)R levels remain unchanged. However, in the long term, an increase in mGlu(5)R levels and decreases in GLT-1 and glutamate levels are observed, associated with the development of an anxious phenotype and potentially increased vulnerability to epileptic events in adults.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Chemistry, Medicinal
Shravan Sivakumar, Mehdi Ghasemi, Steven C. Schachter
Summary: This review discusses the pathological role of NMDARs in epilepsy and provides an overview of NMDAR antagonists evaluated as anticonvulsive agents in clinical studies and preclinical seizure models.
Article
Biochemistry & Molecular Biology
Maria Crespo, David Agustin Leon-Navarro, Mairena Martin
Summary: Febrile seizures, classified as short or prolonged, are common in childhood. Prolonged febrile seizures have been linked to temporal lobe epilepsy, and animal models have shown that they can alter neuronal function. Na+/K+-ATPase and Mg2+-ATPase have been suggested to play a role in this process. The study found that hyperthermia-induced seizures increased the activity of Na+/K+-ATPase and Mg2+-ATPase, and also increased the protein level of the AMPA subunit GluR1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ali K. Vibholm, Anne M. Landau, Arne Moller, Jan Jacobsen, Kim Vang, Ole L. Munk, Dariusz Orlowski, Jens C. H. Sorensen, David J. Brooks
Summary: This study demonstrates that positron emission tomography (PET) can visualize increased uptake of [F-18]GE-179 by active NMDAR-ICs, and this uptake can be blocked by the PCP antagonist S-ketamine. Electrical stimulation induces a significant increase in [F-18]GE-179 uptake at the electrode site, which can be maintained at non-stimulated levels with prior injection of S-ketamine. PET is shown to be a useful tool for visualizing in vivo activation of NMDAR-ICs.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Martina Tallarico, Antonio Leo, Emilio Russo, Rita Citraro, Ernesto Palma, Giovambattista De Sarro
Summary: Autism spectrum disorders (ASDs) and epilepsy show a bidirectional link, possibly through common neurobiological pathways. BTBR mice have increased susceptibility to seizures induced by chemoconvulsants impairing GABA(A) neurotransmission, while there is no significant difference for seizures induced by AMPA, NMDA, and Kainate. PTZ-kindling does not affect autistic-like behavior in BTBR mice but can increase anxiety and worsen cognitive performance. This suggests a tight connection between ASD and epilepsy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Neurosciences
Henry Querfurth, Han-Kyu Lee
Summary: mTOR is involved in regulating energy metabolism, neuronal growth, insulin signaling, and autophagy, playing both beneficial and pathogenic roles in neurodegenerative diseases. Balanced actions of mTOR complexes may have implications for Alzheimer's disease, Parkinson's disease, Huntington's disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Beyond rapamycin, rapalogs with improved tolerability and delivery modes hold promise in treating age-related conditions.
MOLECULAR NEURODEGENERATION
(2021)
Article
Medicine, Research & Experimental
Mohamed El-Tanani, Hamdi Nsairat, Alaa A. Aljabali, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Walhan Alshaer, Murtaza M. Tambuwala
Summary: The mammalian target of rapamycin (mTOR), a signalling system, is necessary for various cell proliferation activities. It recognizes PI3KAKT stress signals as a serine-threonine kinase. The abnormal regulation of mTOR pathway has been proven to be crucial in cancer growth and advancement. This review primarily discusses the normal functions of mTOR as well as its abnormal roles in cancer development.
Article
Neurosciences
Supriya Sharma, Anil Kumar Rana, Aditi Sharma, Damanpreet Singh
Summary: This study found that rapamycin reduces seizures and associated cardiac damage by inhibiting mTOR activation in the zebrafish kindling model.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Neda Valian, Marziyeh Sorayya, Sareh Asadi, Fatemeh Sherafati, Ali Ershad, Sara Savaheli, Abolhassan Ahmadiani
Summary: The study suggests that preconditioning with ultra-low dose of tramadol can reduce seizures induced by high dose tramadol, potentially through upregulation of Norbin and downregulation of NR1 and GluR1.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Teng Zhao, Rui Zhong, Xinyue Zhang, Guangjian Li, Chunkui Zhou, Shaokuan Fang, Ying Ding, Weihong Lin
Summary: In this study, a mouse model of hyperthermic seizure was constructed, and in vitro and in vivo electrophysiological and behavioral studies were conducted to elucidate the pathogenic characteristics and mechanism of the GluN2A/GRIN2A-V685G mutation. The mutant mice showed no significant change in the expression of NMDAR compared to the wild type mice. The mutation resulted in altered excitatory/inhibitory balance of neural networks and increased susceptibility to seizures, which could be reversed by treatment with EFV.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Lara Senn, Anna-Maria Costa, Rossella Avallone, Katarzyna Socala, Piotr Wlaz, Giuseppe Biagini
Summary: The peroxisome proliferator-activated receptor gamma (PPAR gamma), known for its role in metabolic disorders, has been increasingly investigated for its potential involvement in neurological diseases, particularly in epilepsy. Epilepsy, a chronic neurological disorder, has a significant impact on patients' psychological, social, and economic well-being. With a global prevalence of 0.5%-1.0%, epilepsy ranks fourth in importance among neurological disorders. This review focuses on recent findings regarding the intracellular processes dependent on PPAR gamma and their potential anti-seizure effects, as well as promising results from clinical investigations involving PPAR gamma agonists and the ketogenic diet in epilepsy rodent models.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Environmental Sciences
Najm Alsadat Madani, David O. Carpenter
Summary: Glyphosate and glyphosate-based herbicides have adverse effects on nervous system function, including increased risk of Parkinson's disease and autism, impaired synaptic transmission through mechanisms such as oxidative stress and mitochondrial dysfunction. In addition, glyphosate-based herbicides alter the gut microbiome, which in turn affects susceptibility to neurological diseases.
ENVIRONMENTAL RESEARCH
(2022)
Article
Clinical Neurology
Lena H. Nguyen, Amy L. Brewster, Madeline E. Clark, Angelique Regnier-Golanov, C. Nicole Sunnen, Vinit V. Patil, Gabriella D'Arcangelo, Anne E. Anderson
Article
Critical Care Medicine
Ina Nikolaeva, Beth Crowell, Julia Valenziano, David Meaney, Gabriella D'Arcangelo
JOURNAL OF NEUROTRAUMA
(2016)
Review
Clinical Neurology
Mustafa Sahin, Elizabeth P. Henske, Brendan D. Manning, Kevin C. Ess, John J. Bissler, Eric Klann, David J. Kwiatkowski, Steven L. Roberds, Alcino J. Silva, Coryse St Hillaire-Clarke, Lisa R. Young, Mark Zervas, Laura A. Mamounas
PEDIATRIC NEUROLOGY
(2016)
Review
Neurosciences
Gum Hwa Lee, Gabriella D'Arcangelo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2016)
Article
Neurosciences
Ina Nikolaeva, Tatiana M. Kazdoba, Beth Crowell, Gabriella D'Arcangelo
Editorial Material
Neurosciences
Gabriella D'Arcangelo, Laura Lossi, Adalberto Merighi
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Przemyslaw Swiatkowski, Ina Nikolaeva, Gaurav Kumar, Avery Zucco, Barbara F. Akum, Mihir V. Patel, Gabriella D'Arcangelo, Bonnie L. Firestein
SCIENTIFIC REPORTS
(2017)
Review
Pharmacology & Pharmacy
Aruni S. Arachchige Don, Chi Kwan Tsang, Tatiana M. Kazdoba, Gabriella D'Arcangelo, Wise Young, X. F. Steven Zheng
DRUG DISCOVERY TODAY
(2012)
Article
Biochemistry & Molecular Biology
Gum Hwa Lee, Zinal Chhangawala, Sventja von Daake, Jeffrey N. Savas, John R. Yates, Davide Comoletti, Gabriella D'Arcangelo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Neurosciences
Justin Trotter, Gum Hwa Lee, Tatiana M. Kazdoba, Beth Crowell, Jason Domogauer, Heather M. Mahoney, Santos J. Franco, Ulrich Mueller, Edwin J. Weeber, Gabriella D'Arcangelo
JOURNAL OF NEUROSCIENCE
(2013)
Article
Clinical Neurology
Justin T. Rogers, Lisa Zhao, Justin H. Trotter, Ian Rusiana, Melinda M. Peters, Qingyou Li, Erika Donaldson, Jessica L. Banko, Kathleen E. Keenoy, G. William Rebeck, Hyang-Sook Hoe, Gabriella D'Arcangelo, Edwin J. Weeber
JOURNAL OF PSYCHOPHARMACOLOGY
(2013)
Article
Neurosciences
Avery J. Zucco, Valentina Dal Pozzo, Alina Afinogenova, Ronald P. Hart, Orrin Devinsky, Gabriella D'Arcangelo
MOLECULAR AND CELLULAR NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Gum Hwa Lee, Sun Hong Kim, Ramin Homayouni, Gabriella D'Arcangelo
Article
Neurosciences
Beth Crowell, Gum Hwa Lee, Ina Nikolaeva, Valentina Dal Pozzo, Gabriella D'Arcangelo