Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities

Mouse models of cognitive disabilities in trisomy 21 (Down syndrome)

(2010) Pierre L. Roubertoux et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome

(2010) Arnaud Duchon et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

(2010) Tao Yu et al.   BRAIN RESEARCH

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

(2010) Tao Yu et al.   HUMAN MOLECULAR GENETICS

Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome

(2010) Victor I. Popov et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Down Syndrome: From Understanding the Neurobiology to Therapy

(2010) K. Gardiner et al.   JOURNAL OF NEUROSCIENCE

Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice

(2010) Tao Yu et al.   MAMMALIAN GENOME

Transcriptome genetics using second generation sequencing in a Caucasian population

(2010) Stephen B. Montgomery et al.   NATURE

Production of p53 gene knockout rats by homologous recombination in embryonic stem cells

(2010) Chang Tong et al.   NATURE

Understanding mechanisms underlying human gene expression variation with RNA sequencing

(2010) Joseph K. Pickrell et al.   NATURE

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

(2010) Lina Chakrabarti et al.   NATURE NEUROSCIENCE

Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

(2009) Julien Laffaire et al.   BMC GENOMICS

A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

(2009) Patricia Lopes Pereira et al.   HUMAN MOLECULAR GENETICS

The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

(2009) N. P. Belichenko et al.   JOURNAL OF NEUROSCIENCE

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

(2009) Kwan-Hyuck Baek et al.   NATURE

Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner

(2009) A. S. Dimas et al.   SCIENCE

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts

(2008) Ping Li et al.   CELL

Capture of Authentic Embryonic Stem Cells from Rat Blastocysts

(2008) Mia Buehr et al.   CELL

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome

(2008) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

(2008) E. Morice et al.   LEARNING & MEMORY

Towards a transgenic model of Huntington’s disease in a non-human primate

(2008) Shang-Hsun Yang et al.   NATURE

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

(2008) Thomas E. Sussan et al.   NATURE