Article
Neurosciences
Andrew N. Stewart, Katelyn E. McFarlane, Hemendra J. Vekaria, William M. Bailey, Stacey A. Slone, Lauren A. Tranthem, Bei Zhang, Samir P. Patel, Patrick G. Sullivan, John C. Gensel
Summary: This study found that low doses of DNP administered to older mice (14 months) after spinal cord injury improved symptoms and recovery of neurodegenerative diseases, while the same treatment in younger mice (4 months) exacerbated neurodegeneration. This suggests that mitochondrial contributions to neurodegeneration diverge with age after SCI.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Matthew W. McDonald, Angela Dykes, Matthew S. Jeffers, Anthony Carter, Ralph Nevins, Allyson Ripley, Gergely Silasi, Dale Corbett
Summary: Remote ischemic conditioning (RIC) shows neuroprotective effects in stroke patients by inducing ischemia at specific time points, but fails to enhance post-stroke behavioral recovery in the later acute phase.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Multidisciplinary Sciences
Noor Sajid, Emma Holmes, Thomas M. Hope, Zafeirios Fountas, Cathy J. Price, Karl J. Friston
Summary: Functional recovery after brain damage varies depending on factors such as lesion site and extent. Recovery can occur by engaging residual components or utilizing intact neural structures, with different types of lesions having different effects.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Gloria Cecchini, Alessandro Scaglione, Anna Letizia Allegra Mascaro, Curzio Checcucci, Emilia Conti, Ihusan Adam, Duccio Fanelli, Roberto Livi, Francesco Saverio Pavone, Thomas Kreuz
Summary: This study explores new spatiotemporal propagation indicators to track neural correlates of motor deficits and functional recovery following stroke. Combining motor training and pharmacological intervention leads to new propagation patterns that are faster and smoother than pre-stroke patterns, suggesting potential for more targeted post-stroke therapies.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Andrea Faggiano, Elisa Gherbesi, Ashot Avagimyan, Massimiliano Ruscica, Luca Donisi, Maria Antonia Fedele, Carlo Maria Cipolla, Marco Vicenzi, Stefano Carugo, Daniela Cardinale
Summary: Melatonin can mitigate the oxidative damage induced by anthracycline in a mouse model, demonstrating its potential as a preventive and therapeutic strategy for anthracycline-induced cardiotoxicity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Rosario Amato, Alessio Canovai, Alberto Melecchi, Salvatore Pezzino, Roberta Corsaro, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli, Maurizio Cammalleri
Summary: Studies have shown that the combination of lutein and C3G can prevent oxidative stress, inflammation, gliotic and apoptotic responses caused by LD, thus protecting photoreceptor cells more effectively than each component alone. Furthermore, they can improve dysfunctional electroretinogram and enhance rod and cone photoreceptor responses.
Article
Environmental Sciences
Grethel Leon-Mejia, Robinson Alvarez Rueda, Jose Perez Perez, Alvaro Miranda-Guevara, Ornella Fiorillo Moreno, Milton Quintana-Sosa, Cristiano Trindade, Yurina Sh De Moya, Martha Ruiz-Benitez, Yesit Bello Lemus, Ibeth Luna Rodriguez, Ludis Oliveros-Ortiz, Antonio Acosta-Hoyos, Leonardo C. Pacheco-Londono, Amner Munoz, Samuel P. Hernandez-Rivera, Jesus Olivero-Verbel, Juliana da Silva, Antonio Pegas Henriques Joao
Summary: Coal mining activities release compounds into the environment that can negatively impact human health. This study evaluated the cytotoxic and genotoxic effects of chronic exposure to coal residues in individuals. The results showed significant differences in cell aberrations and increased concentrations of certain substances in exposed individuals compared to the control group.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Neurosciences
Yun-Mi Kim, Su Yeon Choi, Onyou Hwang, Joo-Yong Lee
Summary: This study investigated the potential neuroprotective effects of exogenous pyruvate in a mouse model of Parkinson's disease. The results showed that sodium pyruvate administration could protect nigral DA neurons from degeneration and alleviate the associated motor deficits, indicating its therapeutic potential for PD and related neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Nicolas A. M. Zang, Marlieke Schneider, Daniel Weiss
Summary: The study aimed to explore the cortical neuronal mechanisms underlying movement recovery after freezing episodes in Parkinson's disease patients. The findings suggest that different cortical pathways are used when re-initiating movement after freezing or voluntary stops. These findings may facilitate the development of neuromodulation strategies to counteract freezing behavior.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Heonuk Jeong, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, Ken Nishioka, Kazuno Negishi, Jun Yoshino, Toshihide Kurihara
Summary: This study demonstrated for the first time the protective effect of NMN in cardiovascular disease-induced retinal ischemia in a mouse model, suppressing retinal dysfunction and pathological gliosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jian Zhao, Ailang Pang, Saige Yin, Meifeng Yang, Xuemei Zhang, Rong Zhang, Jingfei Liu, Yuanqi Gu, Shanshan Li, Yan Hu, Yue Zhang, Yingchun Ba, Buliang Meng, Xinwang Yang
Summary: OM-LV20 promotes structural and functional recovery of spinal cord injury by increasing neuronal survival, enhancing BDNF and TrkB expression, and regulating oxidative stress balance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Neurosciences
S. Conti, C. Spalletti, M. Pasquini, N. Giordano, N. Barsotti, M. Mainardi, S. Lai, A. Giorgi, M. Pasqualetti, S. Micera, M. Caleo
Summary: Despite limited efficacy of robotic rehabilitation technologies for post-stroke motor recovery, combining robotic rehabilitation with chemogenetic stimulation of serotonin release shows promise in enhancing post-stroke motor performance. This combined approach results in substantial functional gains in mice that persist beyond treatment period and is associated with a reduction in GABAergic neurotransmission in perilesional areas. The immediate translational potential of this combined approach is demonstrated by the administration of a clinically approved drug, Buspirone, targeting the serotonin 1A receptor to significantly improve motor recovery after stroke.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Chemistry, Applied
Shun-Hua Gao, Tian-Rui Zhao, Ya-Ping Liu, Yi-Fen Wang, Gui-Guang Cheng, Jian-Xin Cao
Summary: Vaccinium dunalianum Wight is an important healthy tea resource in China, rich in phenolic and flavonoid compounds. Its extracts show neuroprotective effects against H2O2-induced PC12 cell damage, possibly through upregulating endogenous antioxidant enzymes expressions and activating the Nrf2/HO-1 signaling pathway.
Article
Cell Biology
Ling Guo, Sravani Kondapavulur, Stefan M. Lemke, Seok Joon Won, Karunesh Ganguly
Summary: The study reveals the importance of consistent neural activity patterns across brain structures during recovery poststroke, and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function.
Article
Biochemistry & Molecular Biology
Kamran Saeed, Myeung Hoon Jo, Jun Sung Park, Sayed Ibrar Alam, Ibrahim Khan, Riaz Ahmad, Amjad Khan, Rahat Ullah, Myeong Ok Kim
Summary: The study demonstrates that 17β-estradiol effectively alleviates energy dyshomeostasis and oxidative stress induced by traumatic brain injury, regulates antioxidant genes and enzymes to mitigate ROS, reduces gliosis and proinflammatory markers, and enhances anti-inflammatory response post-injury. It also reduces inflammatory mediators and rescues apoptotic cell death, resulting in reduced brain lesion volume and enhanced neurotrophic effects and synaptic protein expression. Further studies are needed to explore the exact mechanisms of its therapeutic effects against secondary brain injury.