Article
Behavioral Sciences
Teresa Maletta, Michael Palummieri, Jeff Correa, Matthew R. Holahan
Summary: Social memory involves the ability to recognize social contacts that have been previously encountered. The CA2 region of the hippocampus is important for social memory, and dysfunction in this area can lead to impairments. This study found that exposure to an unrelated adult male during preadolescence resulted in social memory deficits in rats during the postadolescent period.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
David Wegrzyn, Georg Juckel, Andreas Faissner
Summary: Schizophrenia is a severe neuropsychiatric disease that affects normal life. Hippocampal abnormalities play a crucial role in schizophrenia and can be observed in both early and late stages of the disease. Studying hippocampal abnormalities can provide a better understanding of the onset and outcomes of schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Felipe V. Gomes, Anthony A. Grace
Summary: Although currently available antipsychotic drugs can reduce psychotic symptoms in schizophrenia patients, they have numerous side effects and are not effective against negative and cognitive symptoms. Developing new drugs that target the excitatory/inhibitory balance in the brain may offer a more effective approach in treating schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Rym Aouci, Mey El Soudany, Zakaria Maakoul, Anastasia Fontaine, Hiroki Kurihara, Giovanni Levi, Nicolas Narboux-Neme
Summary: The study found that the regulation of Dlx5/6 genes in adult GABAergic neurons has a direct impact on the density of PV-positive neurons, anxiety and compulsivity-like behaviors, reinforcing their importance in neuropsychiatric conditions.
Article
Neurosciences
Junzhan Jing, Corrinne Dunbar, Alina Sonesra, Ana Chavez, Suhyeorn Park, Ryan Yang, Heun Soh, Maxwell Lee, Anastasios V. Tzingounis, Edward C. Cooper, Xiaolong Jiang, Atul Maheshwari
Summary: This study found that preventing the inhibition of inhibitory neurons by the anti-seizure drug RTG can improve its anticonvulsant effect.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Che-Wen Tsai, Shih-Jen Tsai, Yi-Ju Pan, Hsin-Mei Lin, Tsung-Yu Pan, Feng-Yi Yang
Summary: This study aimed to investigate the restorative role of transcranial ultrasound stimulation (TUS) in counteracting cognitive deficits and GABAergic interneuron dysfunction in a simulation of schizophrenia. The results showed that low-intensity pulsed ultrasound (LIPUS) treatment improved cognitive deficits and ameliorated neuropathology in MK-801-treated rats.
Article
Neurosciences
Robert G. K. Munn, Amy Wolff, Lucinda J. Speers, David K. Bilkey
Summary: Maternal immune activation (MIA) increases the risk for schizophrenia and other neurodevelopmental disorders. In rat models, MIA mimics the brain and behavioral changes seen in schizophrenia, including memory impairment. This study re-analyzed previous electrophysiological recordings of the hippocampus in MIA and control rats to investigate temporal dysfunction. The findings suggest abnormal gamma power and coherence, altered phase precession of place cells, and an increase in sharp-wave ripple events in the hippocampus of MIA rats, highlighting circuit-level changes that may contribute to information processing deficits in schizophrenia.
Review
Psychiatry
Pablo Juarez, Veronica Martinez Cerdeno
Summary: Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking interneurons in the cerebral cortex. PV+ Ch cells, a type of PV+ interneuron, play a crucial role in cortical signaling and are associated with neurological disorders like autism spectrum disorder (ASD). Understanding the role of PV and PV+ Ch cell alterations in these disorders is important for both research and treatment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Sofia Leal Santos, Briana K. Chen, Guilherme R. Pereira, Vananh Pham, Christine A. Denny
Summary: Altered fear learning is a significant component of anxiety disorders, and the noradrenergic signaling system plays an important role in regulating stress responses and fear learning processes. Propranolol has been shown to reduce exaggerated fear responses and can impact the activity of the dentate gyrus and hilar layer. These findings contribute to our understanding of the neural mechanisms underlying anxiety disorders and provide a new possibility for improving treatment efficacy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Wiktor Bilecki, Joachim Latusz, Kinga Gawlinska, Magdalena Chmelova, Marzena Mackowiak
Summary: The study showed that short-term adolescent social isolation did not significantly affect fear memory and anxiety in adult rats, but altered protein levels related to synapse maturation and energy transfer. Additionally, the impact of adolescent social isolation on normally developing brains was different than those with a history of MAM administration.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Minghua Li, Jessica L. Kinney, Yu-Qiu Jiang, Daniel K. Lee, Qiwen Wu, Daehoon Lee, Wen-Cheng Xiong, Qian Sun
Summary: A key mode of neuronal communication between distant brain regions is through excitatory synaptic transmission mediated by long-range glutamatergic projections. However, we found that the glutamatergic projection from the hypothalamic supramammillary nucleus (SuM) largely avoids pyramidal neurons in hippocampal CA3 region and instead targets interneurons to provide feedforward inhibition. This novel long-range glutamatergic pathway suppresses the activity of principal neurons and reveals a new means by which SuM regulates hippocampal activity.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Ivana Peric, Andrijana Stanisavljevic, Peter Gass, Dragana Filipovic
Summary: The molecular background of depression focuses on alterations of inhibitory circuits mediated by GABA signalization. Chronic social isolation and chronic fluoxetine treatment have different effects on PV and GAD67 expression in layer-specific manner in rat dorsal hippocampal subregions, also impacting depressive and anxiety-like behaviors.
BRAIN RESEARCH BULLETIN
(2021)
Article
Clinical Neurology
Jillian J. Weeks, Anthony A. Grace, Alan F. Sved
Summary: The study showed that both acute and chronic administration of nicotine improved deficits in schizophrenia-like behaviors and normalized neuronal activity in specific brain regions in the schizophrenia rodent model. These findings support the self-medication hypothesis for smoking in schizophrenia and suggest the potential of nicotinic modulation in future pharmacotherapies.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adrienne Matyas, Emoke Borbely, Andras Mihaly
Summary: The present experiments reveal the alterations of hippocampal neuronal populations in chronic epilepsy. The mice exhibited impaired learning and memory functions, decreased neuronal count, activated microglia, increased expression of certain neuropeptides, and reduced number of inhibitory neurons in the hippocampus. These findings shed light on the mechanisms underlying the hippocampal learning and memory deficits in epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Christine Stubbendorff, Ed Hale, Harriet L. L. Day, Jessica Smith, Giuseppe S. Alvaro, Charles H. Large, Carl W. Stevenson
Summary: Psychiatric diseases are characterized by abnormal cognition and emotional regulation. This study investigates the potential of pharmacological modulation of Kv3 voltage-gated potassium channels to regulate fear discrimination and emotional expression, suggesting that targeting these channels may ameliorate cognitive and emotional disturbances in psychiatric diseases.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
David D. Aguilar, Andrea Giuffrida, Daniel J. Lodge
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Fengjiao Sun, Yun Lei, Jingjing You, Chen Li, Linshan Sun, Jacob Garza, Di Zhang, Ming Guo, Phillip E. Scherer, Daniel Lodge, Xin-Yun Lu
MOLECULAR PSYCHIATRY
(2019)
Article
Neurosciences
Jennifer J. Donegan, Angela M. Boley, Daniel J. Lodge
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Psychiatry
Stephanie M. Perez, Jennifer J. Donegan, Angela M. Boley, David D. Aguilar, Andrea Giuffrida, Daniel J. Lodge
SCHIZOPHRENIA RESEARCH
(2019)
Article
Behavioral Sciences
Stephanie M. Perez, Jennifer J. Donegan, Daniel J. Lodge
BEHAVIOURAL BRAIN RESEARCH
(2019)
Meeting Abstract
Psychiatry
Daniel Lodge, Jennifer Donegan
SCHIZOPHRENIA BULLETIN
(2019)
Article
Multidisciplinary Sciences
J. J. Donegan, A. M. Boley, J. Yamaguchi, G. M. Toney, D. J. Lodge
NATURE COMMUNICATIONS
(2019)
Article
Psychiatry
Stephanie M. Perez, Angela Boley, Daniel J. Lodge
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Clinical Neurology
Stephanie M. Perez, Daniel J. Lodge
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Article
Clinical Neurology
Stephanie M. Perez, Daniel J. Lodge
Summary: The hippocampus and paraventricular nucleus of the thalamus (PVT) play important roles in schizophrenia and may represent potential targets for treatment. The dense expression of orexin receptors in the thalamus suggests they may be a target for regulating PVT activity. Research findings suggest the orexin system may be a novel site for therapeutic intervention in psychosis via action in the PVT.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Hannah B. Elam, Stephanie M. Perez, Jennifer J. Donegan, Daniel J. Lodge
Summary: The orexin system may be a novel pharmacological target for treating comorbid psychosis related to PTSD, reversing increases in dopamine neuron activity and behavioral deficits.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Stephanie M. Perez, Angela M. Boley, Alexandra M. McCoy, Daniel J. Lodge
Summary: Antipsychotics increase the risk of death in elderly patients with Alzheimer's disease (AD). There is a need for new therapies to treat comorbid psychosis in AD. This study used a ferrous amyloid buthionine (FAB) rodent model to investigate the relationship between hippocampal activity and dopamine-dependent psychosis in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)