Article
Neurosciences
Danielle Rayee, Pamela Meneses Iack, Raissa R. Christoff, Michele R. Lourenco, Christiane Bonifacio, Jurgen Boltz, Roberto Lent, Patricia P. Garcez
Summary: The corpus callosum (CC) is a major interhemispheric commissure of placental mammals. During typical cortical development, axonal bifurcation rates in the cerebral cortex rise from embryonic day (E)17 and are reduced by postnatal day (P)9. In a CC dysgenesis mouse model, increased rates of axonal bifurcations were observed, suggesting a possible facilitation of aberrant connections in the absence of midline guidepost signaling.
Review
Cell Biology
Ray Yueh Ku, Masaaki Torii
Summary: The development of the cortical in humans is a long and ongoing process, especially in adolescence where the neural circuitry continues to be modified. The corpus callosum, the largest white matter tract in the brain, has unique development features in humans, particularly with a significant increase in the number of callosal projection neurons. There are still many missing pieces in understanding the molecular controls over the development of callosal projections.
Review
Cell Biology
Kerstin Hasenpusch-Theil, Thomas Theil
Summary: The formation of the cerebral cortex, a complex process involving various types of neurons and complex connections, is crucial for advanced neural functions. Recent studies have linked cilia to processes such as neurogenesis and neuronal migration during cortex development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Sathish Venkataramanappa, Dagmar Schuetz, Friederike Saaber, Praveen Ashok Kumar, Philipp Abe, Stefan Schulz, Ralf Stumm
Summary: Mutations in the DONSON gene have been linked to skeletal abnormalities and microcephaly. Deletion of Donson in cortical progenitors led to extensive cell death and abnormalities in cortical development. Targeting Donson may be a potential strategy for experimental and therapeutic purposes.
Article
Neurosciences
Benjamin Compans, Juan Burrone
Summary: Uncovering the wiring rules employed by neurons during development is challenging but important for neurodevelopmental disorders. Chandelier cells play a crucial role in the formation and plasticity of inhibitory synapses and recent data have provided insights into the molecules involved and the developmental plasticity of connections formed by Chandelier cells onto pyramidal cells.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Biology
Fernando Martin-Fernandez, Ana Bermejo-Santos, Lorena Bragg-Gonzalo, Carlos G. Briz, Esther Serrano-Saiz, Marta Nieto
Summary: This study reveals that the expression of axonal signaling receptor Neuropilin 1 (Nrp1) in the somatosensory (SS) cortex of mice is temporary and follows patterns that determine corpus callosum (CC) connectivity. Nrp1 expression is important for subsequent S2 innervation and knocking down Nrp1 reduces the number of callosal neurons in S2L2/3, which may play a role in neurodevelopmental disorders.
Article
Cell Biology
Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Hidehiro Ishikawa, Kelly K. Chung, Emiri T. Mandeville, Josephine Lok, Myriam Fornage, Karl Herrup, Kai-Hei Tse, Eng H. Lo, Ken Arai
Summary: White matter damage caused by cerebral hypoperfusion is a major feature of SIVD, and studying transcriptomic profiles of hypoperfused mice may lead to potential therapeutic targets for SIVD in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Chao Ding, Vishalini Emmenegger, Kim Schaffrath, Dirk Feldmeyer
Summary: In this study, a cluster analysis revealed four distinct clusters of L6 interneurons in rat mPFC, showing different morphological and physiological characteristics, suggesting differential roles in mPFC-associated functions.
Article
Obstetrics & Gynecology
P. Maurice, J. Garel, C. Garel, F. Dhombres, S. Friszer, L. Guilbaud, E. Maisonneuve, H. Ducou Le Pointe, E. Blondiaux, J-M Jouannic
Summary: The study found that besides Chiari type 2 malformation, other cerebral anomalies are frequently observed in fetuses with myelomeningocele, with the most common being abnormalities of the corpus callosum. Whether these associated cerebral anomalies affect the selection of cases eligible for fetal surgery requires further evaluation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Neurosciences
Alexandra Tzilivaki, John J. Tukker, Nikolaus Maier, Panayiota Poirazi, Rosanna P. Sammons, Dietmar Schmitz
Summary: This article explores the brain's ability to capture and store information, focusing on the types, plasticity, and activity patterns of interneurons in the hippocampus and their impact on memory processing.
Article
Psychology, Biological
Karin Saltoun, Ralph Adolphs, Lynn K. Paul, Vaibhav Sharma, Joern Diedrichsen, B. T. Thomas Yeo, Danilo Bzdok
Summary: This study characterized whole-brain asymmetry patterns and found their associations with specific phenotypes using data from UK Biobank participants.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Neurosciences
Abdullah Ishaque, Daniel Ta, Muhammad Khan, Lorne Zinman, Lawrence Korngut, Angela Genge, Annie Dionne, Hannah Briemberg, Collin Luk, Yee-Hong Yang, Christian Beaulieu, Derek Emery, Dean T. Eurich, Richard Frayne, Simon Graham, Alan Wilman, Nicolas Dupre, Sanjay Kalra
Summary: Progressive cerebral degeneration in ALS was studied using 3D texture analysis on MRI images, revealing texture changes in multiple brain regions at baseline and progressive alterations over follow-up period. Different phenotypes of ALS showed distinct patterns of texture changes in different brain areas, suggesting that the longitudinal gray matter pathology in ALS involves frontotemporal regions rather than the motor cortex.
HUMAN BRAIN MAPPING
(2022)
Article
Chemistry, Analytical
Vijai Krishnan, Lauren C. Wade-Kleyn, Ron R. Israeli, Galit Pelled
Summary: Peripheral nerve injury leads to altered activity of inhibitory interneurons, affecting sensory processing. Injury impacts interhemispheric communication, resulting in an overall decrease in inhibitory interneuron activity.
Article
Behavioral Sciences
Taylor E. Stansberry, Anne L. Willliams, Toshikazu Ikuta
Summary: The integrity of the interhemispheric auditory white matter tract is associated with impulsivity, especially sensation seeking. Stronger interhemispheric auditory integration is suggested to be related to greater impulsivity and sensation seeking.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Shovan Naskar, Jia Qi, Francisco Pereira, Charles R. Gerfen, Soohyun Lee
Summary: Extensive hierarchical yet highly reciprocal interactions among cortical areas are crucial for information processing, but the specificity and rules governing corticocortical connections are poorly understood. The study shows that long-range projections from different areas preferentially engage specific sets of GABAergic neurons in the primary somatosensory cortex, leading to distinct feedback mechanisms between neurons.
Article
Clinical Neurology
Z. Csaba, T. Vitalis, C. Charriaut-Marlangue, I. Margaill, B. Coqueran, P. -L. Leger, I. Parente, A. Jacquens, L. Titomanlio, C. Constans, C. Demene, M. D. Santin, S. Lehericy, N. Perriere, F. Glacial, S. Auvin, M. Tanter, J. -F. Ghersi-Egea, H. Adle-Biassette, J. -F. Aubry, P. Gressens, P. Dournaud
Summary: The impairment of blood-brain barrier is involved in various neurological diseases, and reliable imaging of increased BBB permeability is crucial for research. This study introduces a novel approach based on agonist-induced internalization of neuronal G protein-coupled receptor, providing a simple way to assess BBB dysfunction and development in different conditions.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Review
Immunology
Connie B. Gilfillan, Michael Hebeisen, Nathalie Rufer, Daniel E. Speiser
Summary: The functional avidity (FA) of cytotoxic CD8 T cells plays a crucial role in their functional capabilities and protection from infection and cancer. The factors influencing FA and its regulation mechanisms are still not fully understood, but recent research suggests that FA may be stable in vivo due to continued signaling modulation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Aurelia Zimmerli, Matteo Monti, Craig Fenwick, Isabella Eckerle, Catherine Beigelman-Aubry, Celine Pellaton, Katia Jaton, Dominique Dumas, Gian-Marco Stamm, Laura Infanti, Heidrun Andreu-Ullrich, Daphne Germann, Marie Mean, Peter Vollenweider, Raphael Stadelmann, Maura Prella, Denis Comte, Benoit Guery, David Gachoud, Nathalie Rufer
Summary: In this case report, convalescent plasma treatment of an immunosuppressed patient with COVID-19 showed positive effects, including rapid symptom relief, gradual viral clearance, and eventual full recovery. This indicates the potential value of convalescent plasma in treating immunosuppressed COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Lorenza Magno, Zeinab Asgarian, Valentina Pendolino, Theodora Velona, Albert Mackintosh, Flora Lee, Agata Stryjewska, Celine Zimmer, Francois Guillemot, Mark Farrant, Beverley Clark, Nicoletta Kessaris
Summary: Excessive generation of cortical interneurons during development can lead to behavioral abnormalities, even if cell numbers are subsequently normalized.
Article
Immunology
Stephanie Bibert, Nicolas Guex, Joao Lourenco, Thomas Brahier, Matthaios Papadimitriou-Olivgeris, Lauro Damonti, Oriol Manuel, Robin Liechti, Lou Gotz, Jonathan Tschopp, Mathieu Quinodoz, Peter Vollenweider, Jean-Luc Pagani, Mauro Oddo, Olivier Hugli, Frederic Lamoth, Veronique Erard, Cathy Voide, Mauro Delorenzi, Nathalie Rufer, Fabio Candotti, Carlo Rivolta, Noemie Boillat-Blanco, Pierre-Yves Bochud
Summary: The dysregulated immunity in COVID-19 patients plays a key role in the severity of the disease, including defects in IFN responses, reduced toxicity-related molecules in NK cells, and increased neutrophil degranulation. Additionally, differences in gene expression patterns are also determinants of COVID-19 severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Nicoletta Kessaris
Article
Multidisciplinary Sciences
Quentin Perrenoud, Clemence Leclerc, Helene Geoffroy, Tania Vitalis, Kevin Richetin, Claire Rampon, Thierry Gallopin
Summary: This study compares the electrophysiological and molecular properties of GABAergic interneurons in the hilus and primary sensory cortex of mice. The results suggest that the commonly used features for defining these classes do not have strong discriminative capabilities in the hilus.
Article
Immunology
Petra Baumgaertner, Julien Schmidt, Carla-Marisa Costa-Nunes, Natacha Bordry, Philippe Guillaume, Immanuel Luescher, Daniel E. Speiser, Nathalie Rufer, Michael Hebeisen
Summary: This study investigates the impact of peptide:HLA and TCR-pHLA affinities on CD8 T cell responses and cross-reactivity. It is found that vaccines containing native tumor epitopes generate T cells with better functionality and superior cross-reactivity against low affinity escape epitopes. Moreover, different clonotypes of tumor antigen-specific T cells display heterogeneous functional and cross-reactive profiles.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
David Gachoud, Trestan Pillonel, Gerasimos Tsilimidos, Dunia Battolla, Dominique Dumas, Onya Opota, Stefano Fontana, Peter Vollenweider, Oriol Manuel, Gilbert Greub, Claire Bertelli, Nathalie Rufer
Summary: This study found that COVID-19 patients who were pre-exposed to anti-CD20 treatments experienced a more rapid decline in anti-spike IgG levels after plasma therapy, along with longer clinical symptoms and higher viral loads. These patients also had higher mutation rates compared to those who were able to mount an endogenous humoral response, potentially indicating immune escape.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Zeinab Asgarian, Marcio Guiomar Oliveira, Agata Stryjewska, Ioannis Maragkos, Anna Noren Rubin, Lorenza Magno, Vassilis Pachnis, Mohammadmersad Ghorbani, Scott Wayne Hiebert, Myrto Denaxa, Nicoletta Kessaris
Summary: This study identifies MTG8 as a co-factor of LHX6, which plays a crucial role in the development of cortical interneurons. The findings suggest that early specification programs, mediated by transcriptional co-factors, are important for the emergence of cortical interneuron heterogeneity from the embryonic telencephalic germinal zones.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Lorenza Magno, Zeinab Asgarian, Migle Apanaviciute, Yasmin Milner, Nora Bengoa-Vergniory, Anna Noren Rubin, Nicoletta Kessaris
Summary: Using Cre transgene-based fate mapping in mice, this study reveals that most septal neurons originate from progenitor domains in the septum and identifies Bsx as an embryonic marker and essential regulator of glutamatergic neuron development and locomotion behaviour. The findings highlight the importance of understanding the development and diversity of septal neurons in supporting cognition and behaviors such as feeding and locomotion.
COMMUNICATIONS BIOLOGY
(2022)
Letter
Hematology
David Gachoud, Claire Bertelli, Nathalie Rufer
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Clinical Neurology
Cindy Bokobza, Alice Jacquens, David Guenoun, Blandine Bianco, Anne Galland, Maxime Pispisa, Alexandra Cruz, Manuela Zinni, Valerie Faivre, Anne Roumier, Sophie Lebon, Tania Vitalis, Zsolt Csaba, Tifenn Le Charpentier, Leslie Schwendimann, Pierrette Young-Ten, Vincent Degos, Patricia Monteiro, Pascal Dournaud, Pierre Gressens, Juliette Van Steenwinckel
Summary: Approximately 15 million babies are born prematurely every year, and many of them will face motor and cognitive deficits in their lifetime. Systemic inflammation-induced neuroinflammation is a prominent process of perinatal brain injuries, especially white matter injuries (WMI). Serotonin and its receptors, particularly HTR7, play a significant role in inflammation regulation. The study suggests that targeting HTR7 may serve as an innovative therapeutic strategy to protect the developing brain from preterm brain injuries.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Letter
Hematology
Mathilde Gavillet, Nathalie Rufer, Francesco Grandoni, Mattia Rizzi, Nicolas Vulliemoz, David Baud, Lorenzo Alberio, Giorgia Canellini, Helene Legardeur
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Neurosciences
Nicoletta Kessaris, Myrto Denaxa
Summary: Inhibition in the mammalian cerebral cortex is regulated by a small population of diverse GABAergic interneurons. These local neurons play a crucial role in the formation and function of cortical circuits. Recent findings and new technologies are advancing our understanding of the diversity and development of inhibitory neurons. This knowledge is essential for stem cell therapy and correcting human disorders involving inhibitory dysfunction.
CURRENT OPINION IN NEUROBIOLOGY
(2023)