Synaptic plasticity and signaling in rett syndrome

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

(2013) Matthew J Lyst et al.   NATURE NEUROSCIENCE

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome

(2012) Lianne Robinson et al.   BRAIN

Preclinical research in Rett syndrome: setting the foundation for translational success

(2012) D. M. Katz et al.   Disease Models & Mechanisms

SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression

(2012) Loredana Zocchi et al.   Epigenetics

Epilepsy in Rett syndrome, andCDKL5- andFOXG1-gene-related encephalopathies

(2012) Renzo Guerrini et al.   EPILEPSIA

The CDKL5 disorder is an independent clinical entity associated with early-onset encephalopathy

(2012) Stephanie Fehr et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows

(2012) Hélène Cheval et al.   HUMAN MOLECULAR GENETICS

A Critical and Cell-Autonomous Role for MeCP2 in Synaptic Scaling Up

(2012) M. P. Blackman et al.   JOURNAL OF NEUROSCIENCE

A Mouse Model for MeCP2 Duplication Syndrome: MeCP2 Overexpression Impairs Learning and Memory and Synaptic Transmission

(2012) E. S. Na et al.   JOURNAL OF NEUROSCIENCE

MeCP2 Phosphorylation Is Required for Modulating Synaptic Scaling through mGluR5

(2012) X. Zhong et al.   JOURNAL OF NEUROSCIENCE

Isoform-Specific Toxicity of Mecp2 in Postmitotic Neurons: Suppression of Neurotoxicity by FoxG1

(2012) S. G. Dastidar et al.   JOURNAL OF NEUROSCIENCE

Foxg1 Has an Essential Role in Postnatal Development of the Dentate Gyrus

(2012) C. Tian et al.   JOURNAL OF NEUROSCIENCE

The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling

(2012) Z. Qiu et al.   JOURNAL OF NEUROSCIENCE

Brain Activity Mapping in Mecp2 Mutant Mice Reveals Functional Deficits in Forebrain Circuits, Including Key Nodes in the Default Mode Network, that are Reversed with Ketamine Treatment

(2012) M. Kron et al.   JOURNAL OF NEUROSCIENCE

A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome

(2012) D. A. Schmid et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Distinct Sites in MeCP2 Modifies Cofactor Associations and the Dynamics of Transcriptional Regulation

(2012) M. L. Gonzales et al.   MOLECULAR AND CELLULAR BIOLOGY

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1–PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons

(2012) Sara Ricciardi et al.   NATURE CELL BIOLOGY

Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

(2012) Rodney C Samaco et al.   NATURE GENETICS

NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2

(2012) Severine Durand et al.   NEURON

Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors into the Cortical Plate

(2012) Goichi Miyoshi et al.   NEURON

Elimination of Inhibitory Synapses Is a Major Component of Adult Ocular Dominance Plasticity

(2012) Daniëlle van Versendaal et al.   NEURON

Clustered Dynamics of Inhibitory Synapses and Dendritic Spines in the Adult Neocortex

(2012) Jerry L. Chen et al.   NEURON

The Impact of MeCP2 Loss- or Gain-of-Function on Synaptic Plasticity

(2012) Elisa S Na et al.   NEUROPSYCHOPHARMACOLOGY

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

(2012) I.-T. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Modeling Using Embryonic Stem Cells: MeCP2 Regulates Nuclear Size and RNA Synthesis in Neurons

(2012) Morteza Yazdani et al.   STEM CELLS

The role of microglia in brain maintenance: implications for Rett syndrome

(2012) Noël C. Derecki et al.   TRENDS IN IMMUNOLOGY

The Role of MeCP2 in the Brain

(2011) Jacky Guy et al.   Annual Review of Cell and Developmental Biology

A MECP2 missense mutation within the MBD domain in a Brazilian male with autistic disorder

(2011) Mário Campos et al.   BRAIN & DEVELOPMENT

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

(2011) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome

(2011) Rebecca A. Johnson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Altered responses of MeCP2-deficient mouse brain stem to severe hypoxia

(2011) Miriam Kron et al.   JOURNAL OF NEUROPHYSIOLOGY

Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging

(2011) Gaston Calfa et al.   JOURNAL OF NEUROPHYSIOLOGY

FoxG1 Promotes the Survival of Postmitotic Neurons

(2011) S. G. Dastidar et al.   JOURNAL OF NEUROSCIENCE

A role for glia in the progression of Rett’s syndrome

(2011) Daniel T. Lioy et al.   NATURE

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses

(2011) Darren Goffin et al.   NATURE NEUROSCIENCE

Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory

(2011) Hongda Li et al.   NATURE NEUROSCIENCE

Experience-Dependent Retinogeniculate Synapse Remodeling Is Abnormal in MeCP2-Deficient Mice

(2011) Joao Noutel et al.   NEURON

Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

(2011) Sonia Cohen et al.   NEURON

Modulation of RhoGTPases Improves the Behavioral Phenotype and Reverses Astrocytic Deficits in a Mouse Model of Rett Syndrome

(2011) Bianca De Filippis et al.   NEUROPSYCHOPHARMACOLOGY

Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome

(2011) K.-Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult Neural Function Requires MeCP2

(2011) C. M. McGraw et al.   SCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

The short-time structural plasticity of dendritic spines is altered in a model of Rett syndrome

(2011) Silvia Landi et al.   Scientific Reports

Rett syndrome: Revised diagnostic criteria and nomenclature

(2010) Jeffrey L. Neul et al.   ANNALS OF NEUROLOGY

Reversibility of functional deficits in experimental models of Rett syndrome

(2010) Stuart Cobb et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Early Environmental Enrichment Moderates the Behavioral and Synaptic Phenotype of MeCP2 Null Mice

(2010) Giuseppina Lonetti et al.   BIOLOGICAL PSYCHIATRY

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Exogenous Brain-Derived Neurotrophic Factor Rescues Synaptic Dysfunction in Mecp2-Null Mice

(2010) D. D. Kline et al.   JOURNAL OF NEUROSCIENCE

Delayed Stabilization of Dendritic Spines in Fragile X Mice

(2010) A. Cruz-Martin et al.   JOURNAL OF NEUROSCIENCE

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Genome-wide expression studies in Autism spectrum disorder, Rett syndrome, and Down syndrome

(2010) Carla Lintas et al.   NEUROBIOLOGY OF DISEASE

Synaptic Maturation at Cortical Projections to the Lateral Amygdala in a Mouse Model of Rett Syndrome

(2010) Frédéric Gambino et al.   PLoS One

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

(2010) Feng Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Spine Dynamics

(2009) D. Harshad Bhatt et al.   Annual Review of Physiology

Synapse elimination in the central nervous system

(2009) Masanobu Kano et al.   CURRENT OPINION IN NEUROBIOLOGY

Integration of Telencephalic Wnt and Hedgehog Signaling Center Activities by Foxg1

(2009) Catherine Danesin et al.   DEVELOPMENTAL CELL

CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery

(2009) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

Widespread changes in dendritic and axonal morphology inMecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

(2009) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism

(2009) Christopher A. Chapleau et al.   Journal of Neurodevelopmental Disorders

Pathophysiology of Locus Ceruleus Neurons in a Mouse Model of Rett Syndrome

(2009) P. Taneja et al.   JOURNAL OF NEUROSCIENCE

Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions

(2009) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Synaptic Circuit Abnormalities of Motor-Frontal Layer 2/3 Pyramidal Neurons in an RNA Interference Model of Methyl-CpG-Binding Protein 2 Deficiency

(2009) L. Wood et al.   JOURNAL OF NEUROSCIENCE

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Autism

(2009) Susan E Levy et al.   LANCET

The NGL family of leucine-rich repeat-containing synaptic adhesion molecules

(2009) Jooyeon Woo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

(2009) Nurit Ballas et al.   NATURE NEUROSCIENCE

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

(2009) Nadia P. Belichenko et al.   NEUROBIOLOGY OF DISEASE

Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities

(2009) R. C. Samaco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

(2009) J. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

(2009) Daniela Tropea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXG1 Is Responsible for the Congenital Variant of Rett Syndrome

(2008) Francesca Ariani et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MECP2promoter methylation and X chromosome inactivation in autism

(2008) Raman P. Nagarajan et al.   Autism Research

Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp21lox mice

(2008) Nupur Nag et al.   BEHAVIOURAL BRAIN RESEARCH

Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndromeMecp2gene dosage effects and BDNF expression

(2008) Mari Kondo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rett Syndrome: From the Gene to the Disease

(2008) Tanja Matijevic et al.   EUROPEAN NEUROLOGY

Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism

(2008) Susan E. Swanberg et al.   HUMAN MOLECULAR GENETICS

CDKL5 Expression Is Modulated during Neuronal Development and Its Subcellular Distribution Is Tightly Regulated by the C-terminal Tail

(2008) Laura Rusconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome

(2008) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced Hypoxia Susceptibility in Hippocampal Slices From a Mouse Model of Rett Syndrome

(2008) Marc Fischer et al.   JOURNAL OF NEUROPHYSIOLOGY

Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone

(2008) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Vision Triggers an Experience-Dependent Sensitive Period at the Retinogeniculate Synapse

(2008) B. M. Hooks et al.   JOURNAL OF NEUROSCIENCE

MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively

(2008) Amy Palmer et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Specific mutations in Methyl-CpG-Binding Protein 2 confer different severity in Rett syndrome

(2008) J. L. Neul et al.   NEUROLOGY

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

The MeCP2-null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability

(2007) Liang Zhang et al.   HIPPOCAMPUS

Early Defects of GABAergic Synapses in the Brain Stem of a MeCP2 Mouse Model of Rett Syndrome

(2007) L. Medrihan et al.   JOURNAL OF NEUROPHYSIOLOGY

Synaptic adhesion molecules and PSD-95

(2007) Kihoon Han et al.   PROGRESS IN NEUROBIOLOGY