期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 71, 期 6, 页码 483-494出版社
WILEY-BLACKWELL
DOI: 10.1002/dneu.20867
关键词
neuronal polarity; PAR (for partitioning-defective) proteins; axon specification; cytoskeleton; signaling pathway
资金
- March of Dimes Birth Defects Foundation
- Whitehall Foundation
- DANA Foundation
- Autism Speaks Foundation
- Klingenstein Foundation
- NARSAD
- McNight Foundation
- NIH
A hallmark of neurons is their ability to polarize with dendrite and axon specification to allow the proper flow of information through the nervous system. Over the past decade, extensive research has been performed in an attempt to understand the molecular and cellular machinery mediating this neuronal polarization process. It has become evident that many of the critical regulators involved in establishing neuronal polarity are evolutionarily conserved proteins that had previously been implicated in controlling the polarization of other cell types. At the forefront of this research are the partition defective (Par) proteins. In this review, we will provide a commentary on the progress of work regarding the central importance of Par proteins in the establishment of neuronal polarity. (C) 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 483-494, 2011
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