期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 71, 期 8, 页码 665-679出版社
WILEY
DOI: 10.1002/dneu.20877
关键词
mesencephalic dopaminergic differentiation; Otx; Fgf8; Shh; Wnt1
资金
- FP7 [222999]
- FP6 [LSHG-CT-2007-037445]
- Fondazione Roma
- Italian Association for Cancer Research (AIRC)
Mesencephalic-diencephalic dopaminergic (mdDA) neurons play a relevant role in the control of movement, behavior, and cognition. Indeed loss and/or abnormal functioning of mdDA neurons are responsible for Parkinson's disease as well as for addictive and psychiatric disorders. In the last years a wealth of information has been provided on gene functions controlling identity, fate, and proliferation of mdDA progenitors. This review will focus on the role exerted by Otx genes in early decisions regulating sequential steps required for the neurogenesis of mesencephalic dopaminergic (mesDA) neurons. In this context, the regulatory network involving Otx functional interactions with signaling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 665-679, 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据