Review
Biochemistry & Molecular Biology
Chuin Hau Teo, Ally Chai Hui Wong, Rooba Nair Sivakumaran, Ishwar Parhar, Tomoko Soga
Summary: Stress has a significant impact on mental health, and there are gender differences in stress response and mental disorders. However, there is limited research on the neuronal mechanisms of these gender differences. Recent clinical studies have discussed the role of gender and cortisol in depression, as well as the differences in glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs) between males and females in stress-associated mental disorders. The functional heterogeneity and imbalance of GRs and MRs in the brain may explain the gender differences in mental disorders. Understanding these mechanisms can contribute to the development of gender-specific diagnostic markers for depression involving GRs and MRs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xiaoqing Zhang, Xiaolin Yang, Bing Chen, Kaifeng Shen, Guolong Liu, Zhongke Wang, Kaixuan Huang, Gang Zhu, Tingting Wang, Shengqing Lv, Chunqing Zhang, Hui Yang, Zhi Hou, Shiyong Liu
Summary: Glucocorticoid receptors (GRs) play an important role in epilepsy in focal cortical dysplasia II (FCDII) and GR activation may have protective and antiepileptic effects in FCDII.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Biochemistry & Molecular Biology
Alexandros Tsimpolis, Maria Kokkali, Aris Logothetis, Konstantinos Kalafatakis, Ioannis Charalampopoulos
Summary: Novel research studies have discovered complex interactions between glucocorticoid hormones and brain-derived neurotrophic factor, regulating crucial physiological processes in neuronal cells. This study investigated the acute effects of glucocorticoid stimulation on gene expression of BDNF and TrkB in astrocytes, revealing a biphasic response characterized by an initial rapid upregulation and subsequent downregulation of BDNF mRNA under the influence of glucocorticoid receptors. These findings demonstrate a rhythmic regulation of the neurotrophin system based on glucocorticoid levels, indicating the intricate trophic responses to temporal hormonal mechanisms in the brain microenvironment.
Article
Biochemistry & Molecular Biology
Elena Carceller-Zazo, Lisa M. Sevilla, Omar Pons-Alonso, Alvaro Chiner-Oms, Larbi Amazit, Thi An Vu, Geraldine Vitellius, Say Viengchareun, Inaki Comas, Yan Jaszczyszyn, Montserrat Abella, Andrea Alegre-Marti, Eva Estebanez-Perpina, Marc Lombes, Paloma Perez
Summary: Glucocorticoids exert therapeutic effects on skin diseases through binding to the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). The MR has an impact on the genomic binding and transcriptional response of GR, affecting the specificity and magnitude of gene expression in keratinocytes.
Review
Biochemistry & Molecular Biology
Margaux Laulhe, Laurence Dumeige, Thi An Vu, Imene Hani, Eric Pussard, Marc Lombes, Say Viengchareun, Laetitia Martinerie
Summary: Sexual dimorphism involves differences between biological sexes beyond sexual characteristics, impacting biological processes such as blood pressure and predisposition to develop hypertension. Recent studies suggest distinct tissue-specific expression and regulation of corticosteroid signaling pathways in a sex-dependent manner, particularly in the kidney, which may have significant physiological implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marta Zola, Dan Mejlachowicz, Raquel Gregorio, Marie-Christine Naud, Frederic Jaisser, Min Zhao, Francine Behar-Cohen
Summary: This study explores the link between hypothalamic-pituitary-adrenal axis (HPA) brake and central serous chorioretinopathy (CSCR). The results show that HPA axis brake leads to a decrease in intraocular corticosterone levels and activation of the MR pathway in the RPE/choroid, which may contribute to the occurrence of CSCR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Rachel M. B. Bell, Elisa Villalobos, Mark Nixon, Allende Miguelez-Crespo, Lee Murphy, Angie Fawkes, Audrey Coutts, Matthew G. F. Sharp, Martha Koerner, Emma Allan, Onno C. Meijer, Rene Houtman, Alex Odermatt, Katharina R. Beck, Scott G. Denham, Patricia Lee, Natalie Z. M. Homer, Brian R. Walker, Ruth A. Morgan
Summary: Carbonyl reductase 1 regulates glucocorticoid and mineralocorticoid receptor activation in adipose tissue, influencing glucose homeostasis in lean mice.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Carol Best, Erin Faught, Mathilakath M. Vijayan, Kathleen M. Gilmour
Summary: The formation of dominance hierarchies in juvenile rainbow trout results in chronically elevated plasma cortisol levels in subordinate individuals. The mechanisms contributing to this chronic cortisol elevation during social stress are not well established, but the study found that negative feedback and clearance mechanisms appear unaffected. However, subtle regulatory changes in the pituitary may alter negative feedback, contributing to the observed cortisol elevation during social subordination.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Stefanny M. Figueroa, Jean-Philippe Bertocchio, Toshifumi Nakamura, Soumaya El-Moghrabi, Frederic Jaisser, Cristian A. Amador
Summary: Tac treatment can lead to hypertension, nephrotoxicity, and increased aldosterone levels. The mineralocorticoid receptor (MR) plays a role in the proinflammatory response and vascular contraction in the kidney. This study showed that the MR expressed in vascular smooth muscle cells (SMC) is involved in the renal damage caused by Tac. Administration of an MR antagonist or targeted deletion of MR in SMC mitigated the adverse effects of Tac.
Review
Behavioral Sciences
Edo Ronald de Kloet
Summary: As the end product of the hypothalamus-pituitary-adrenal (HPA) axis, glucocorticoid hormones coordinate various activities in the body and brain, including energy metabolism and defense reactions. The glucocorticoid feedback paradox in the HPA-axis is examined, highlighting the conditional nature of the excitation/inhibition balance in feedback regulation and the potential of glucocorticoids in resetting the stress response system. Understanding the role of glucocorticoid hormone in resilience and vulnerability during stress is crucial.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
Article
Biochemistry & Molecular Biology
Paula Aldaz, Amaya Fernandez-Celis, Natalia Lopez-Andres, Imanol Arozarena
Summary: Dexamethasone (DEXA) is commonly used in glioblastoma (GBM) patients to reduce brain inflammation, activating the glucocorticoid receptor (GR) which can influence the mineralocorticoid receptor (MR) signaling. MR signaling in GBM has been shown to have anti-proliferative effects and inhibit the self-renewal of GSCs, while spironolactone (SPI) may not have significant anti-neoplastic potential in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alberto Dinarello, Annachiara Tesoriere, Paolo Martini, Camilla Maria Fontana, Davide Volpato, Lorenzo Badenetti, Francesca Terrin, Nicola Facchinello, Chiara Romualdi, Oliana Carnevali, Luisa Dalla Valle, Francesco Argenton
Summary: In this study, zebrafish mutant lines and transgenic models were used to analyze the mechanism of action of glucocorticoids. The differences in gene expression patterns between different mutant lines revealed a complex network of GC-dependent transcription. The study also showed that the glucocorticoid receptor GR plays a crucial role in the transcriptional activity of Stat3, and both glucocorticoids and the mineralocorticoid receptor MR are necessary for the correct transcription of certain target genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Alessandra Caruso, Laura Ricceri, Angela Caruso, Ferdinando Nicoletti, Alessandra Gaetano, Sergio Scaccianoce
Summary: Adolescence is a critical period for brain development, and disturbances during this time can increase the risk of neuropsychiatric disorders. This study compared the effects of postweaning social isolation (PWSI) on inbred C57BL/6 N mice and BTBR mice, which are a model for autism spectrum disorders. The results showed that both PWSI mice and BTBR mice exhibited reduced social responsiveness and altered levels of certain receptors in the brain, suggesting that absence of social stimuli during adolescence can induce a phenotype similar to autism spectrum disorders.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Robert H. Oakley, Shannon D. Whirledge, Maria G. Petrillo, Natallia Riddick, Xiaojiang Xu, Sheryl S. Moy, John A. Cidlowski
Summary: The study revealed that mice lacking MR or both GR and MR in the hippocampus exhibited altered expression of neuronal markers and enhanced cue-dependent learning in behavior experiments. Furthermore, mice depleted of both GR and MR showed profound neurodegeneration of the hippocampus, with increased cell death and reduced neurogenesis. Global gene expression assays indicated a synergistic increase in dysregulated genes in the hippocampus lacking both GR and MR, associated with cell death and proliferation pathways.
NEUROBIOLOGY OF STRESS
(2021)
Article
Endocrinology & Metabolism
Ahmed Torky, Ninet Sinaii, Smita Jha, Jay Desai, Diala El-Maouche, Ashwini Mallappa, Deborah P. Merke
Summary: Patients with CAH have a higher prevalence of obesity, hypertension, insulin resistance, fasting hyperglycemia, and dyslipidemia during childhood and adulthood compared to the general US population, indicating an early onset of metabolic morbidity in this population. Treatment-related and familial factors play a role in the development of these metabolic conditions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biology
Haruka Wada, Buddhamas Kriengwatana, Natalie Allen, Kimberly L. Schmidt, Kiran K. Soma, Scott A. MacDougall-Shackleton
JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)
Editorial Material
Behavioral Sciences
L. Michael Romero, Steven H. Platts, Stephan J. Schoech, Haruka Wada, Erica Crespi, Lynn B. Martin, C. Loren Buck
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2015)
Article
Ecology
Alexandra B. Bentz, Aubrey E. Sirman, Haruka Wada, Kristen J. Navara, Wendy R. Hood
ECOLOGY AND EVOLUTION
(2016)
Article
Ornithology
J. W. Finger, A. J. Hoffman, H. Wada
Article
Zoology
Haruka Wada, Buddhamas P. Kriengwatana, Todd D. Steury, Scott A. MacDougall-Shackleton
CANADIAN JOURNAL OF ZOOLOGY
(2018)
Article
Physiology
Bain Gurley, John W. Finger, Haruka Wada
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
(2018)
Article
Developmental Biology
Haruka Wada, Amy E. M. Newman, Zachary J. Hall, Kiran K. Soma, Scott A. MacDougall-Shackleton
DEVELOPMENTAL NEUROBIOLOGY
(2014)
Article
Engineering, Environmental
Haruka Wada, Christine M. Bergeron, F. M. Anne McNabb, Brian D. Todd, William A. Hopkinsi
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2011)
Article
Behavioral Sciences
B. Kriengwatana, H. Wada, K. L. Schmidt, M. D. Taves, K. K. Soma, S. A. MacDougall-Shackleton
HORMONES AND BEHAVIOR
(2014)
Article
Zoology
Haruka Wada, Kendra B. Sewall
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2014)
Article
Zoology
Marco Del Giudice, C. Loren Buck, Lauren E. Chaby, Brenna M. Gormally, Conor C. Taff, Christopher J. Thawley, Maren N. Vitousek, Haruka Wada
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2018)
Article
Physiology
Buddhamas Kriengwatana, Haruka Wada, Alexander Macmillan, Scott A. MacDougall-Shackleton
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
(2013)
Article
Environmental Sciences
Christine M. Bergeron, William A. Hopkins, Catherine M. Bodinof, Sarah A. Budischak, Haruka Wada, Jason M. Unrine
SCIENCE OF THE TOTAL ENVIRONMENT
(2011)
Article
Environmental Sciences
John W. Finger, Juan Botero, Yufeng Zhang, Shelby E. Still, Alexander J. Hoffman, Andreas N. Kavazis, Daniel A. Cristol, Haruka Wada
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2017)
Article
Zoology
Alexander J. Hoffman, John W. Finger, Haruka Wada
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2018)