期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 68, 期 2, 页码 152-165出版社
JOHN WILEY & SONS INC
DOI: 10.1002/dneu.20562
关键词
Wnt; Drl; Ryk; NMJ; synapse; boutons
资金
- NICHD NIH HHS [T32 HD007333, HD 07333] Funding Source: Medline
- NIDCD NIH HHS [1 F32 DC 08443-01, R01 DC005408, F32 DC008443, DC 5408-01] Funding Source: Medline
- NINDS NIH HHS [R01 NS045628-03, R01 NS 045628, R01 NS045628-04, R01 NS045628-01, R01 NS045628-02, R01 NS045628] Funding Source: Medline
Neural function is dependent upon the proper formation and development of synapses. We show here that Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor. Mutations in both wnt5 and drl result in a significant reduction in the number of synaptic boutons. Cell-type specific rescue experiments show that wnt5 functions in the presynaptic motor neuron while drl likely functions in the postsynaptic muscle cell. Epistatic analyses indicate that drl acts downstream of wnt5 to promote synaptic growth. Structure-function analyses of the Drl protein indicate that normal synaptic growth requires the extracellular Wnt inhibitory factor domain and the intracellular domain, which includes an atypical kinase. Our findings reveal a novel signaling mechanism that regulates morphology of the Drosophila NMJ. (c) 2007 Wiley Periodicals, Inc.
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