Article
Medicine, General & Internal
Malcolm R. Battin, Sian A. Williams, Anna Mackey, Woroud Alzaher, Alexandra Sorhage, N. Susan Stott
Summary: Cerebral palsy is a common physical disability, and early diagnosis has been a focus internationally. New Zealand is developing guidelines for high-risk neonatal intensive care (NICU) graduates based on imaging data from the New Zealand Cerebral Palsy Register (NZCPR). The study reviewed imaging data from a retrospective NICU cohort and found variations in imaging frequency and modality among different gestational subgroups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Jing Lu, Alexander Drobyshevsky, Lei Lu, Yueyue Yu, Michael S. Caplan, Erika C. Claud
Summary: Necrotizing enterocolitis (NEC) is a major cause of gastrointestinal disease in premature infants and poses a significant risk for neurodevelopmental impairment (NDI). This study found that abnormal bacterial colonization in preterm infants contributes to the development of NEC and negatively affects brain development and neurological outcomes. Using a mouse model, the researchers observed decreased occludin and ZO-1 expression, increased inflammation, impaired behavioral performance, delayed brain maturation, and altered metabolic profiles in mice with NEC, indicating the negative impacts of pre-NEC microbiota on brain development and neurological outcomes.
Article
Rehabilitation
Jane Valentine, Sue-Anne Davidson, Natasha Bear, Eve Blair, Roslyn Ward, Ashleigh Thornton, Katherine Stannage, Linda Watson, David Forbes, Catherine Elliott
Summary: This audit focused on examining the long-term outcomes of interventions to improve gross motor function in children with Cerebral Palsy. The study found stability in the majority of patients' motor function levels over time, while also highlighting significant differences in the use of Botulinum Toxin treatment and surgery.
DISABILITY AND REHABILITATION
(2021)
Article
Chemistry, Analytical
Vicente A. Lomelin-Ibarra, Andres E. Gutierrez-Rodriguez, Jose A. Cantoral-Ceballos
Summary: This study investigates different data representation methods for motor imagery EEG signals and achieves strong classification accuracy through transfer learning. Additionally, alternative representations based on spectrograms and multidimensional raw data are explored, leading to promising results.
Article
Clinical Neurology
Thomas L. Evensen, Torstein Vik, Guro L. Andersen, Solveig Bjellmo, Sandra Julsen Hollung
Summary: The aim of this study was to compare the prevalence, birth, and clinical characteristics of children with dyskinetic cerebral palsy (CP) in Norway with spastic quadriplegic CP and other spastic CP subtypes. Data from children born between 1996 and 2015 were collected. Results showed that 170 (6.8%) children had dyskinetic CP. The birth prevalence of dyskinetic CP decreased from 0.21 to 0.07 per 1000 live births during the study period. Dyskinetic CP was associated with term/post-term birth and had more severe motor and associated impairments compared to other spastic CP subtypes. Grey matter injuries were most prevalent in dyskinetic CP and spastic quadriplegic CP, while white matter injuries were most common in spastic bilateral CP and both white and grey matter injuries were equally common in spastic unilateral CP. Normal neuroimaging and brain maldevelopment were present in 25% of children with dyskinetic CP. This study highlights the importance of improved antenatal and perinatal care in reducing the prevalence of dyskinetic CP and the presence of potential sentinel events in this subtype.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Engineering, Biomedical
G. Saussez, R. Bailly, R. Araneda, J. Paradis, D. Ebner-Karestinos, A. Klocker, E. S. Sogbossi, I. Riquelme, S. Brochard, Y. Bleyenheuft
Summary: The study explores the effectiveness of using a virtual device, REAtouch, in the treatment of children with cerebral palsy. The results show that the use of REAtouch device has comparable efficacy to conventional therapy methods in improving motor function and daily life activities.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Clinical Neurology
Catherine Arnaud, Virginie Ehlinger, Malika Delobel-Ayoub, Dana Klapouszczak, Oliver Perra, Owen Hensey, David Neubauer, Katalin Hollody, Daniel Virella, Gija Rackauskaite, Andra Greitane, Kate Himmelmann, Els Ortibus, Ivana Dakovic, Guro L. Andersen, Antigone Papavasiliou, Elodie Sellier, Mary Jane Platt, Inge Kraegeloh-Mann
Summary: The prevalence of cerebral palsy in preterm born children in Europe continues to decrease, except for extremely immature children, with the most severely affected children showing a similar trend.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pediatrics
Sirkku Setanen, Ylva Fredriksson Kaul, Martin Johansson, Cecilia Montgomery, Nima Naseh, Gerd Holmstrom, Katarina Strand-Brodd, Lena Hellstrom-Westas
Summary: The study found that the prevalence of neurodevelopmental impairment (NDI) in very preterm children varies greatly depending on the definitions used, ranging from 2% to 23%. There is also variability in the prevalence of cognitive impairment, cerebral palsy, and severe visual impairment. Better consensus is needed to enable comparisons across studies.
Article
Orthopedics
Lieke Brauers, Rob Smeets, Peter Feys, Andrew M. Gordon, Yvonne Janssen-Potten, Els Ortibus, Hilde Feys, Eugene Rameckers, Katrijn Klingels
Summary: The study aimed to investigate differences in static and dynamic motor fatigability during grip and pinch tasks between children with unilateral spastic cerebral palsy (USCP) and children with typical development (TD), as well as between preferred and nonpreferred hands. Higher static fatigability was found in USCP group for grip and pinch, both within and between hands. Dynamic motor fatigability showed inconsistent results, with higher levels of fatigability in TD group for grip in nonpreferred hands and in the ratio of number of peaks in preferred hands. The findings suggest that static motor fatigability should be considered in comprehensive upper limb assessments and as a target for individualized interventions.
Article
Medicine, Research & Experimental
Tao Wang, Yusheng Zhang, Weiwu Chen, Jin Tao, Qiao Xue, Wei Ge, Wanchen Dou, Chao Ma
Summary: This study utilized a high throughput quantitative proteomic approach to evaluate proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy (CP) induced by lipopolysaccharide (LPS) combined with hypoxia/ischemia (H/I). The research revealed that neuroinflammatory responses in the brain induced by the CP model could be reversed by the topical application of Baimai ointment. Furthermore, the application of Baimai ointment not only alleviated motor deficits in CP model rats, but also restored the proteomes in the brain cortex.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Biomedical
Alyssa M. Spomer, Benjamin C. Conner, Michael H. Schwartz, Zachary F. Lerner, Katherine M. Steele
Summary: This study showed that audiovisual biofeedback was crucial in increasing plantarflexor engagement during walking, while combining audiovisual and sensorimotor modalities further boosted the rate of gait adaptation. Understanding how individuals may prioritize different forms of sensory information can inform the design and selection of biofeedback systems for clinical care.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Aditya Narayan, Mohammad Muhit, John Whitehall, Iskander Hossain, Nadia Badawi, Gulam Khandaker, Israt Jahan
Summary: This study aimed to describe the burden, severity, and underlying factors of associated impairments among children with cerebral palsy (CP) in rural Bangladesh. The results showed that 81% of CP children had associated impairments such as hearing, speech, intellectual, visual, and epilepsy. Most of the children had never received rehabilitation services or enrolled in any mainstream or special education system.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Mustafa Cemali, Serkan Pekcetin, Esra Aki
Summary: This study examined the effectiveness of sensory integration interventions on sensory, motor, and oculomotor skills in infants with cortical vision impairment (CVI) and cerebral palsy (CP). The results showed that sensory integration intervention combined with conventional physiotherapy could improve sensory processing skills in infants with CVI and CP.
Article
Neurosciences
Jessica Galli, Erika Loi, Anna Molinaro, Stefano Calza, Alessandra Franzoni, Serena Micheletti, Andrea Rossi, Francesco Semeraro, Elisa Fazzi, Patrizia Accorsi, Paola Martelli, Anna Alessandrini, Nicole D'Adda, Melissa Marras, Lorenzo Pinelli, Nadia Pasini, Alice Bertoletti
Summary: This study investigated the characteristics of CVI in a large group of children with CP and CVI, and described their neurovisual profiles according to different age subgroups. The results showed that CVI was present in all three subgroups, with younger children showing more severe impairment. Additionally, there were differences in ophthalmological characteristics and visual functions among different age groups.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Orthopedics
Barbara Sargent, Kathryn L. Havens, Masayoshi Kubo, Jessica L. Wisnowski, Tai-Wei Wu, Linda Fetters
Summary: This study aimed to investigate whether an in-home kicking-activated mobile task could enhance selective hip-knee control in infants at high risk of CP. Results showed that infants demonstrated more selective hip-knee control during intervals of the task when they demonstrated learning. This study is the first step towards developing interventions to promote selective hip-knee control in infants at high risk of CP.
Article
Psychology, Clinical
Courtney P. Gilchrist, Deanne K. Thompson, Bonnie Alexander, Claire E. Kelly, Karli Treyvaud, Lillian G. Matthews, Leona Pascoe, Diana Zannino, Rosemary Yates, Chris Adamson, Mary Tolcos, Jeanie L. Y. Cheong, Terrie E. Inder, Lex W. Doyle, Angela Cumberland, Peter J. Anderson
Summary: This study aimed to compare the developmental trajectories of corticolimbic regions in very preterm (VP) children with and without anxiety diagnosis at 13 years. The results showed that VP children with anxiety disorders displayed altered trajectories in whole brain and specific regions compared to VP children without anxiety. These alterations mainly reflected slower growth in early childhood and did not persist after adjusting for total brain volume and social risk.
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Psychology, Developmental
Peter J. Anderson
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Neurosciences
Claire Kelly, Gareth Ball, Lillian G. Matthews, Jeanie Ly Cheong, Lex W. Doyle, Terrie E. Inder, Deanne K. Thompson, Peter J. Anderson
Summary: Very preterm (VP) birth may impact brain development, but between the ages of 7 and 13, children and adolescents born VP may have similar trajectories of brain structural development as term-born peers.
Article
Clinical Neurology
Deanne K. Thompson, Joseph Y. M. Yang, Jian Chen, Claire E. Kelly, Christopher L. Adamson, Bonnie Alexander, Courtney Gilchrist, Lillian G. Matthews, Katherine J. Lee, Rodney W. Hunt, Jeanie L. Y. Cheong, Megan Spencer-Smith, Jeffrey J. Neil, Marc L. Seal, Terrie E. Inder, Lex W. Doyle, Peter J. Anderson
Summary: This study investigated brain regional white matter development in full-term and very preterm children using MRI. The longitudinal changes did not differ significantly between birth groups or sexes, but very preterm birth and perinatal risk factors were associated with reduced white matter development in childhood and adolescence. Increased T-1-w/T-2-w ratio at 13 years was associated with better motor and working memory function, but there were developmental differences between very preterm and full-term children in attention, executive functioning, and mathematics performance.
Review
Pediatrics
Rachel Robinson, Polina Girchenko, Anna Pulakka, Kati Heinonen, Anna Lahdepuro, Marius Lahti-Pulkkinen, Petteri Hovi, Marjaana Tikanmaki, Peter Bartmann, Aulikki Lano, Lex W. Doyle, Peter J. Anderson, Jeanie L. Y. Cheong, Brian A. Darlow, Lianne J. Woodward, L. John Horwood, Marit S. Indredavik, Kari Anne Evensen, Neil Marlow, Samantha Johnson, Marina Goulart de Mendonca, Eero Kajantie, Dieter Wolke, Katri Raikkonen
Summary: This study examined the differences in ADHD symptoms and diagnosis between preterm and term-born adults and found that while preterm adults may not report higher levels of ADHD symptoms, they have a higher risk of receiving an ADHD diagnosis in adulthood.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Evelyne Muggli, Jane Halliday, Elizabeth J. Elliott, Anthony Penington, Deanne Thompson, Alicia Jane Spittle, Della Forster, Sharon Lewis, Stephen Hearps, Peter J. Anderson
Summary: The AQUA study aims to assess the impact of low to moderate prenatal alcohol exposure and sporadic binge drinking on long-term child development. Current findings suggest some associations, but at 2 years of age, there was no evidence of cognitive, language, or motor developmental delays related to alcohol exposure. Future plans include investigating neurodevelopmental aspects at 6-8 years and exploring the role of genetics and epigenetics in outcomes.
Article
Neurosciences
Courtney P. Gilchrist, Deanne K. Thompson, Claire E. Kelly, Richard Beare, Christopher Adamson, Thijs Dhollander, Katherine Lee, Karli Treyvaud, Lillian G. Matthews, Mary Tolcos, Jeanie L. Y. Cheong, Terrie E. Inder, Lex W. Doyle, Angela Cumberland, Peter J. Anderson
Summary: This study investigated the neurobiological basis of emotional and behavioral problems in children born very preterm (VP) compared to full-term (FT) children. The results showed that lower network integration was associated with higher internalizing symptoms in both VP and FT children at 7 years, but not at 13 years. There was also some evidence for differential associations between network integration and externalizing symptoms, with lower integration in the VP group and higher integration in the FT group associated with higher externalizing symptoms. Furthermore, associations between network segregation and externalizing symptoms differed between the VP and FT groups at 13 years, with stronger positive associations in the VP group.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychology, Educational
Priscilla Savopoulos, Stephanie Brown, Peter J. Anderson, Deirdre Gartland, Christina Bryant, Rebecca Giallo
Summary: This study examines the long-term impact of early life exposure to intimate partner violence (IPV) on children's cognition, particularly general cognitive ability and executive attention. The results highlight the importance of early intervention for optimizing children's development.
Article
Psychology, Developmental
Rosemary Yates, Peter J. Anderson, Katherine J. Lee, Lex W. Doyle, Jeanie L. Y. Cheong, Carmen C. Pace, Alicia J. Spittle, Megan Spencer-Smith, Karli Treyvaud
Summary: Mothers of very preterm children may face increased risks of postnatal depression, anxiety, and post-traumatic stress symptoms. However, mental health disorder rates are rarely assessed in this population, and it is unclear if postnatal distress symptoms precede higher rates of maternal mental health disorders at 5 years post-birth in both birth groups.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2022)
Article
Behavioral Sciences
Glen P. Aylward, H. Gerry Taylor, Peter J. Anderson, Louis Charles Vannier
Summary: This study investigates the development of executive function in infants and toddlers, and explores whether it is a unitary concept or can be divided into discrete components. The results show that executive function tasks measured by Bayley-4 are related to age, becoming more complex with increasing age, corresponding to further brain development and integration.
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2022)
Article
Clinical Neurology
Paulina M. Stedall, Megan M. Spencer-Smith, Suncica Lah, Lex W. Doyle, Alicia J. Spittle, Alice C. Burnett, Peter J. Anderson
Summary: This study examined episodic and prospective memory functioning in children born very preterm (VP) compared to term-born children. The results showed that VP children performed worse on verbal and visuospatial episodic memory tests, as well as time-based and short-term prospective memory tasks. Parents of VP children also reported more everyday memory difficulties. This highlights the importance of monitoring and addressing memory challenges in children born very preterm.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Review
Psychology, Educational
Garance Delagneau, E. Sabrina Twilhaar, Renee Testa, Sarit van Veen, Peter Anderson
Summary: This meta-analysis examined the relationship between prenatal maternal stress and/or anxiety and the outcomes of children aged 3 months to 9 years. Of the 8754 studies published before June 2021 that were synthesized, 17 conducted in Western countries were included in the meta-analysis (N-total = 23,307; M-males 54%; M-ethnicity White 77%, Pacific 15%, African American/Black 10%, Middle Eastern 7%, Eastern 8%). Effect sizes ranged from -0.41 to 0.15. A weak negative association was found between prenatal stress and/or anxiety exposure and children's general intellectual development. Associations varied based on the type of exposure. Findings are limited to developed counties and cannot be generalized to low- and middle-income countries. Directions for maternal prenatal intervention and future studies are discussed.
Article
Pediatrics
Megan Spencer-Smith, Amber Weinman, Jon Quach, Leona Pascoe, Fiona Mensah, Melissa Wake, Gehan Roberts, Peter J. Anderson
Article
Clinical Neurology
Emilyn Soon, Vanessa Siffredi, Peter J. Anderson, Vicki A. Anderson, Alissandra McIlroy, Richard J. Leventer, Amanda G. Wood, Megan M. Spencer-Smith
Summary: This study examined the differences in interference control and response inhibition between children with AgCC and typically developing children. It also explored the impact of different anatomical features of AgCC on these abilities. The results showed that children with AgCC had poorer performance in inhibitory control measures compared to TD children, and those with a complex AgCC had worse response inhibition performance than those with isolated AgCC. The study also found that the volume and microstructure of the anterior and posterior commissures may compensate for the absence of the corpus callosum, contributing to better inhibitory control outcomes.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Health Care Sciences & Services
Regine Cassandra Lau, Peter John Anderson, Joshua F. Wiley, Derek Huang, Faisha Surjatin, Paul Mcintosh, Susan Gathercole, Megan Spencer-Smith
Summary: This study aims to test the effects of working memory training on cognitive improvement in children, using different methods of difficulty setting and comparing with an active control group. The study uses experimental interventions and various assessment measures, providing valuable information for future research and design of cognitive training interventions.
JMIR RESEARCH PROTOCOLS
(2023)
