Article
Clinical Neurology
Andrew T. Hale, Oluwatoyin Akinnusotu, Jing He, Janey Wang, Natalie Hibshman, Chevis N. Shannon, Robert P. Naftel
Summary: This study is the first genome-wide association study of spastic CP, identifying a SNP (rs78686911) associated with CP by decreasing expression of GRIK4. The findings suggest that genetic variation contributes to the risk of CP.
Article
Clinical Neurology
Nathalie De Beukelaer, Lynn Bar-On, Britta Hanssen, Nicky Peeters, Sandra Prinsen, Els Ortibus, Kaat Desloovere, Anja Van Campenhout
Summary: Hereditary spastic paraplegia (HSP) is a neurological, genetic disorder characterized by lower limb spasticity and muscle weakness, similar to children with bilateral spastic cerebral palsy (SCP). Muscle data analysis revealed significant ankle clonus issues in children with HSP.
FRONTIERS IN NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Stephanie Lee, Karyn Robinson, Madison Lodge, Mary Theroux, Freeman Miller, Robert Akins
Summary: Individuals with spastic cerebral palsy require higher doses of rocuronium for surgical intubation, with dosing influenced by GMFCS level, gestational age, and birthweight.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Clinical Neurology
Luh Karunia Wahyuni
Summary: Spastic quadriplegic cerebral palsy (CP) is a permanent neuromuscular disorder characterized by weak and inactive postural muscles, leading to atypical movement patterns and multisystem consequences that reduce the quality of life. The relationship between these factors has not yet been explored. Understanding of compensatory strategies and multisystem consequences offers the opportunity for early intervention to improve the quality of life for children with spastic quadriplegic CP.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Meta N. Eek, Jesper Augustsson, Roland Zugner, Roy Tranberg
Summary: This study aimed to investigate the feasibility and usefulness of measuring single-leg vertical jumping in young adults with cerebral palsy (CP). The results showed that this test was able to accurately measure jump height and power generation in individuals with CP, providing additional information about motor function.
Article
Neurosciences
Xiao-Kun Wang, Chao Gao, He-Quan Zhong, Xiang-Yu Kong, Rui Qiao, Hui-Chun Zhang, Bai-Yun Chen, Yang Gao, Bing Li
Summary: This study aimed to identify relevant factors in the pathogenesis of spastic cerebral palsy (CP) through protein profiling. Tissue-nonspecific alkaline phosphatase (TNAP) was found to be downregulated in spastic CP. The levels of TNAP were significantly lower in children with CP and model rats. In addition, the model rats showed an increase in osteopontin and proinflammatory biomarkers, as well as a decrease in serum 25 hydroxyvitamin D and IL-10. Serum TNAP level was positively correlated with serum CRP and IL-10 in model rats.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Food Science & Technology
Dongwoo Lee, Jaewon Kim, Ja-Young Oh, Mi-Hyang Han, Da-Ye Kim, Ji-Hye Kang, Dae-Hyun Jang
Summary: In children with spastic hemiplegic cerebral palsy, muscle mass of the affected leg decreases at 4 weeks after BoNT injection but significantly recovers by 12 weeks post-injection. The LBM of both legs and total limbs show a significant increase over the 12-week study period, indicating positive outcomes for rehabilitation.
Article
Clinical Neurology
Ivana Dzinovic, Matej Skorvanek, Petra Pavelekova, Chen Zhao, Boris Keren, Sandra Whalen, Somayeh Bakhtiari, Sheng Chih Jin, Michael C. Kruer, Robert Jech, Juliane Winkelmann, Michael Zech
Summary: Research has found a possible link between variant FBXO31 gene and a neurodevelopmental disorder characterized by prominent motor dysfunction.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Neurosciences
Sujiao Li, Xueqin Luo, Song Zhang, Yuanmin Tang, Jiming Sun, Qingyun Meng, Hongliu Yu, Chengyan Sun
Summary: The study investigated changes in muscle force and tension after multilevel surgical treatments in children with spastic cerebral palsy, as well as evaluated the clinical effects of the surgeries on neuromuscular function during walking. Results showed significant improvements in muscle activation state and electromyography signals post-surgery, indicating the feasibility and effectiveness of the treatments.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Aleksander Koch, Joanna Krasny, Magdalena Dziurda, Magdalena Ratajczyk, Marek Jozwiak
Summary: This study presented four palliative methods of treating spastic hip dislocation in children with CP, including steroid injections, hip interposition arthroplasty, valgus subtrochanteric osteotomy, and proximal femoral resection. All procedures can be considered as palliative treatment options for pain complaints.
FRONTIERS IN NEUROLOGY
(2021)
Article
Microbiology
Adan Israel Rodriguez-Hernandez, Eva Salinas, Deli Nazmin Tirado Gonzalez, Carlos Velasco Benitez, Mariela Jimenez, Laura E. Cordova-Davalos, Daniel Cervantes-Garcia, Victor Federico Rodriguez Nava, Luis G. Bermudez-Humaran
Summary: The study found that consuming modern kefir can significantly increase weight and height in children with cerebral palsy, reduce functional constipation and stool hardness, and increase blood lymphocyte count.
Article
Medicine, General & Internal
Nathalie De Beukelaer, Ines Vandekerckhove, Ester Huyghe, Geert Molenberghs, Nicky Peeters, Britta Hanssen, Els Ortibus, Anja Van Campenhout, Kaat Desloovere
Summary: This prospective longitudinal study modeled morphological muscle growth in 87 children with SCP, finding that children with moderate to severe SCP had slower muscle growth rates before the age of 2 compared to those with mild SCP, and had even worse muscle growth rates after the age of 9. These findings highlight the importance of early monitoring of SCP muscle pathology and its relationship to motor mobility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Claudia Guizar-Sanchez, Cristina Hernandez-Diaz, Diana Guizar-Sanchez, Ana Victoria Meza-Sanchez, Alejandra Torres-Serrano, Maria Elena Camacho Cruz, Lucio Ventura-Rios
Summary: A retrospective case-matched-control study was conducted to investigate the factors associated with painful spastic hip in children with cerebral palsy (CP) and to compare ultrasound findings, particularly muscle thickness, between CP and typically developing peers. The study found that chronic hip pain in children with CP was associated with hip displacement, spasticity level, and gross motor function. The results of this study provide valuable insights for better treatment choices and maintaining muscle mass in children with CP.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Medicine, General & Internal
Kyeongbong Lee, JungHee Jung, HyeonHui Shin, GyuChang Lee
Summary: This study analyzed the activity of trunk muscles during horseback riding machine exercise in children with spastic cerebral palsy. The results showed that horseback riding machine exercise increased the activity of rectus abdominis, external oblique, latissimus dorsi, and erector spinae compared to quiet sitting posture. There were significant differences in the activities of trunk muscles between sitting posture and horseback riding machine exercise, except for the left external oblique and the left latissimus dorsi. Horseback riding machine exercise provides more opportunities for children with spastic cerebral palsy to use their trunk muscles. Further research on the effects of horseback riding machine exercise in patients with cerebral palsy would be valuable.
Article
Medicine, General & Internal
Can Zhang, Guangyi Xiong, Jian Wang, Xinan Shi, Taipin Guo, Yaju Jin, Yan Zhao, Xiantao Tai
Summary: This study aims to evaluate the efficacy of pediatric massage on children with spastic cerebral palsy, providing a reference for further promotion and application.
