Review
Biochemistry & Molecular Biology
Yi Hu, Qinglin Hu, Yongsheng Li, Ligong Lu, Zheng Xiang, Zhinan Yin, Dieter Kabelitz, Yangzhe Wu
Summary: This review comprehensively examines the immunological role of gamma delta T cells in diseases and proposes future strategies for utilizing their therapeutic potential.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Food Science & Technology
Kaiyu Jiang, Caihuan Huang, Fu Liu, Jie Zheng, Juanying Ou, Danyue Zhao, Shiyi Ou
Summary: Acrolein, a highly toxic agent that is pervasive in various foods, is mainly ingested through dietary intake. This review focuses on the formation and fate of acrolein in food, discussing its interactions with small molecules and biomacromolecules, as well as proposing future research directions.
Review
Gastroenterology & Hepatology
Hyun Young Kim, Sadatsugu Sakane, Alvaro Eguileor, Raquel Carvalho Gontijo Weber, Wonseok Lee, Xiao Liu, Kevin Lam, Kei Ishizuka, Sara Brin Rosenthal, Karin Diggle, David A. Brenner, Tatiana Kisseleva
Summary: Liver fibrosis is a serious global health problem with no effective therapy currently available. Studies have shown that liver fibrosis is reversible and regression can occur when the underlying cause is removed. This review discusses the research progress in understanding the molecular mechanisms underlying the development and reversibility of liver fibrosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)
Article
Chemistry, Multidisciplinary
Yingxian Chen, Jack Rivers-Auty, Livia Elena Crica, Katie Barr, Vinicio Rosano, Adrian Esteban Arranz, Thomas Loret, David Spiller, Cyrill Bussy, Kostas Kostarelos, Sandra Vranic
Summary: This study investigated the interaction mechanisms of graphene oxide (GO) with non-phagocytic cell lines over time. It was found that small GO (s-GO) was mainly internalized via macropinocytosis, while ultra-small GO (us-GO) was mainly internalized via clathrin- and caveolae-mediated endocytosis. Additionally, a shift from macropinocytosis to clathrin-dependent endocytosis in the uptake of s-GO at 24 h was observed. Both types of GO terminated in lysosomal compartments for up to 48 h, providing insight for the design of biomedically-applicable 2D transport systems.
NANOSCALE ADVANCES
(2021)
Review
Biochemistry & Molecular Biology
Zhiguo Ling, Chuan Yang, Jiulin Tan, Ce Dou, Yueqi Chen
Summary: MDSCs, a heterogeneous population of immature myeloid cells with immunosuppressive functions, play crucial roles in cancer-related bone metastasis and bone repair. They interact closely with stromal cells within the bone microenvironment and have promising value in the treatment of bone-related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Medicine, Research & Experimental
Nathaniel H. Boyd, Anh Nhat Tran, Joshua D. Bernstock, Tina Etminan, Amber B. Jones, G. Yancey Gillespie, Gregory K. Friedman, Anita B. Hjelmeland
Summary: Tumor microenvironments result from cellular alterations in cancer that promote unrestricted growth and angiogenesis, with hypoxia and acidic stress known to modulate therapeutic resistance. Understanding the interplay between tumor microenvironments and glioma stem cells is crucial for developing better treatment options for glioblastoma.
Review
Oncology
Sarmishta Kannan, Ian Lock, Benjamin B. Ozenberger, Kevin B. Jones
Summary: Sarcoma, a group of malignancies consisting of over 100 individual disease entities, is characterized by type-specific genetic events occurring within a specific cellular context. All sarcomas are related to mesenchymal tissues of origin, with conceptual models developed for each specific route towards sarcomagenesis. Advances in clinical, cellular, and molecular observations have led to the testing of hypotheses in experimental systems, contributing to the understanding of sarcoma genetics.
JOURNAL OF PATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhichao Ni, Lingxia Lyu, Hui Gong, Luping Du, Zuoshi Wen, Hua Jiang, Hao Yang, Yanhua Hu, Bohuan Zhang, Qingbo Xu, Xiaogang Guo, Ting Chen
Summary: This study aimed to investigate the cellular sources that reshape vein grafts. By analyzing transcriptomics data and constructing inducible lineage-tracing mouse models, the researchers demonstrated that Sca-1(+) cells played important roles in vein grafts and could serve as progenitors for multilineage commitment. They also found that recipient Sca-1(+) cells dominated reendothelialization and the formation of adventitial microvessels, while bone-marrow-derived Sca-1(+) cells differentiated into inflammatory cells in vein grafts. Furthermore, non-bone-marrow-derived circulatory Sca-1(+) cells were vital for the formation of adventitial microvessels, while Sca-1(+) cells derived from local carotid arteries were the source of endothelium restoration.
Article
Oncology
Yingxi Xu, Yi-Hsuan Chiang, Ping-Chih Ho, Nicola Vannini
Summary: This article gives an overview of the role of mitochondria in shaping the behavior of hematopoietic stem cells and T cells. It discusses the potential of novel mitochondria-targeting strategies for enhancing immunotherapies and emphasizes the need to consider the metabolic similarities and differences between these cell populations when designing and applying such approaches.
CANCER IMMUNOLOGY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xintong Zhong, Xun Sun, Minhui Shan, Xige Zhao, Rui Zhang, Yanhong Zhao, Qiang Yang
Summary: Irisin is a muscle factor discovered in 2012 that plays a crucial role in various tissues, including bone. Despite controversies surrounding its molecular biology, detection, and effects on bone, the information reviewed in this article lays a useful foundation for future research.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Endocrinology & Metabolism
Romain Fontaine, Muhammad Rahmad Royan, Christiaan Henkel, Kjetil Hodne, Eirill Ager-Wick, Finn -Arne Weltzien
Summary: This review discusses the discovery history, technical limitations, origin, and biological role of multi-hormonal cells in the vertebrate pituitary, providing a comprehensive review of pituitary plasticity.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Cell Biology
Ziyao Zhuang, Lingfei Jia, Weiran Li, Yunfei Zheng
Summary: Circular RNAs have unique expression profiles in stem cell differentiation and can serve as promising biomarkers. Key circRNAs are involved in the differentiation, proliferation, and apoptosis of stem cells through mechanisms like sponging miRNAs.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Peter Wieghofer, Nora Hagemeyer, Roman Sankowski, Anja Schlecht, Ori Staszewski, Lukas Amann, Markus Gruber, Jana Koch, Annika Hausmann, Peipei Zhang, Stefaniya Boneva, Takahiro Masuda, Ingo Hilgendorf, Tobias Goldmann, Chotima Boettcher, Josef Priller, Fabio M. Rossi, Clemens Lange, Marco Prinz
Summary: The study identified different transcriptional states of myeloid subsets in the eye, particularly disease-specific macrophage subpopulations with distinct molecular signatures during choroidal neovascularization, a hallmark of neovascular age-related macular degeneration (AMD). These findings provide new insights into the innate immune system in the eye and potential therapeutic targets for ophthalmological diseases.
Article
Cell & Tissue Engineering
Sher Bahadur Poudel, Han-Sol So, Hyun-Jaung Sim, Joon-Seok Cho, Eui-Sic Cho, Young-Mi Jeon, Sung-Ho Kook, Jeong-Chae Lee
Summary: Deletion of osteoblastic Wls affects hematopoiesis, BM microenvironment, and BMSCs and HSCs maintenance, with age-dependent impacts. The deterioration in BM microenvironment contributes to age-related HSC senescence and impaired hematopoiesis, indicating potential roles of osteoblastic Wls in maintaining BM HSCs.
Article
Biology
Zengdi Zhang, Zan Huang, Mohamed Awad, Mohammed Elsalanty, James Cray, Lauren E. Ball, Jason C. Maynard, Alma L. Burlingame, Hu Zeng, Kim C. Mansky, Hai-Bin Ruan
Summary: In mammals, the interaction between bone marrow stroma and hematopoietic progenitors contributes to bone-BM homeostasis, but the mechanisms and interactions between the development of skeletal and hematopoietic systems are largely unknown. This study reveals that the intracellular O-GlcNAc modification plays a role in dictating the fate and function of early BM stromal cells (BMSCs). O-GlcNAcylation promotes osteogenic differentiation of BMSCs and supports lymphopoiesis, while inhibiting adipogenesis and myelopoiesis. Impaired bone formation and defective hematopoiesis were observed when O-GlcNAc transferase (OGT) was ablated in BMSCs.
