Article
Pharmacology & Pharmacy
Alina Scridon, Vasile Bogdan Halatiu, Alkora Ioana Balan, Dan Alexandru Cozac, Valeriu Moldovan, Claudia Banescu, Marcel Perian, Razvan Constantin Serban
Summary: Chronic administration of ivabradine enhances vagal modulation and shifts the sympatho-vagal balance towards vagal dominance in healthy rats. Ivabradine reduces the heart rate response to direct muscarinic receptors stimulation, cancels the cardioinhibitory response, and blunts the hemodynamic response to in situ vagal stimulation. These findings provide new insights into the mechanisms of ivabradine-related atrial proarrhythmia and suggest potential protective effects of long-term I(f) blockade against excessive bradycardia induced by acute vagal activation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Orthopedics
Amol Saxena, Ryan Allen, Anthony Wright, Filippo Migliorini, Nicola Maffulli
Summary: Resection of tarsal coalitions leads to high patient satisfaction, reduced pain, and improved long-term function. Most patients are able to return to their desired activity level after the surgery.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Multidisciplinary Sciences
Sweta Dash, Sean Yoder, Tania Mesa, Andrew Smith, Ling Cen, Steven Eschrich, Guillermo N. Armaiz-Pena, Alvaro N. A. Monteiro
Summary: The study found that sustained adrenergic stimulation by norepinephrine has significant effects on ovarian cancer initiation and progression, particularly affecting ovarian surface epithelial cells and fallopian tube cells differently. Mutations in the p53 gene also influence the cellular response to NE stimulation.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Masatsune Ishikawa, Shigeki Yamada, Masakazu Miyajima, Hiroaki Kazui, Etsuro Mori
Summary: Idiopathic normal pressure hydrocephalus (iNPH) is a surgically treatable syndrome commonly seen in older adults, but it is unclear if surgery can effectively reduce the long-term care burden (LTCB). A study with 69 participants undergoing shunt surgery found significant improvement in disability grades, but not statistically significant improvement in dementia grades. Variability in LTCB grades was mostly within the 95% confidence intervals for patients, but hospitals showed more variation. Further research is needed to address dementia in iNPH patients, and considering random variables, such as hospitals, is crucial for analyzing multicenter data.
SCIENTIFIC REPORTS
(2021)
Article
Computer Science, Artificial Intelligence
Mehtab Kiran Suddle, Maryam Bashir
Summary: A tremendous amount of opinionated data is added to online platforms every day, particularly in the form of user reviews. To extract sentiment from unstructured reviews, an automated approach is needed. This study proposes a new framework that optimizes the architecture of LSTM using meta-heuristics. Experimental results show significant improvement in sentiment analysis accuracy using the optimized LSTM configuration.
APPLIED SOFT COMPUTING
(2022)
Article
Medicine, General & Internal
Yueli Zhang, Pengli Han, Ningwei Yin, Yongliang Huang, Cien Li, HongKai Lian, Dongwei Yang
Summary: A study conducted in 898 villagers of Chenjiagou found that long-term Tai-Chi practice is associated with lower blood pressure, improved body mass index (BMI), and enhanced mental state. Tai-Chi practice, age, and BMI were significantly associated with blood pressure, with a lower hypertension rate after age 40 in long-term practitioners. However, participants who practiced Tai-Chi for a short time and then stopped did not show significant improvements in the mentioned measurements.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Virology
Brian G. Murphy, Diego Castillo, Sarah Cook, Christina Eckstrand, Samantha Evans, Ellen Sparger, Chris K. Grant
Summary: FIV is a lentivirus that infects domestic cats and causes immunodeficiency. The clinical effects of FIV infection on morbidity and mortality are still debated. In this study, we monitored a cohort of FIV-infected cats for more than thirteen years to investigate the immunopathogenesis and clinical disease of FIV infection.
Article
Orthopedics
Louis F. McIntyre, William S. Beach, Eric Stiefel, Sara E. Pearson
Summary: Based on a 25-year trend, this study estimates that in 2024, the hourly office reimbursement under Medicare will equal the hourly surgical work payment. This looming economic parity between surgical and cognitive work for Medicare patients will have significant impact on patient access to necessary surgical care.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Veterinary Sciences
Ayana Noguchi, Natsume Kurahara, Osamu Yamato, Osamu Ichii, Akira Yabuki
Summary: This study investigated the lectin-binding patterns in normal feline kidneys and established a feline-specific lectin-binding pattern. The findings provide a foundation for future glycopathological studies of feline chronic kidney disease.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Ettore Napoli, Giovanni De Benedetto, Cristina Fazio, Francesco La Russa, Gabriella Gaglio, Emanuele Brianti
Summary: This report presents clinical, diagnostic, and therapeutic findings of a case of feline leishmaniosis (FeL) along with long-term follow-up data. The study highlights the effectiveness of allopurinol in treating FeL and emphasizes how the interruption of treatment often leads to relapse, affecting the cat's health condition and prognosis.
VETERINARY SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Kristina Geue, Anja Mehnert-Theuerkauf, Isabelle Stroske, Hannah Brock, Michael Friedrich, Katja Leuteritz
Summary: This study aims to assess the long-term effects on life satisfaction and psychological distress of young adult cancer survivors by analyzing longitudinal data and cross-sectional topics. It is expected that data from at least 320 participants will be available for analysis after the completion of the sixth survey in 2021.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Jung-Sub An, Wonchae Jeong, Liselotte Sonnesen, Seung-Hak Baek, Sug-Joon Ahn
Summary: This research found that appropriate presurgical mandibular incisor decompensation can play a significant role in the long-term stability of Class III surgical orthodontic treatment. By comparing the treatment process and outcomes of two groups of patients, it was found that the inclination angle of mandibular incisors and the size of overjet post-surgery are correlated with the severity of skeletal Class III relationship.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Jiajie Xu, Bin Bian, Largus T. Angenent, Pascal E. Saikaly
Summary: Membrane-based liquid-liquid extraction is effective for continuously extracting medium-chain carboxylic acids, and a novel submerged extraction system with hollow-fiber membranes increases efficiency. The internal membrane extraction is 3.0 to 4.7 times more efficient than traditional external pertraction.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
A. Broadbent, S. Rahman, B. Grace, R. Walker, F. Noble, J. Kelly, J. Byrne, T. Underwood
Summary: Complications have a significant impact on long-term survival after oesophagectomy for cancer, especially the cumulative effect of multiple complications. Interestingly, multiple minor complications have a worse effect on survival than major complications.
Article
Orthopedics
Annukka Saarensilta, Susanna Aufwerber, Karin Gravare Silbernagel, Paul Ackermann
Summary: This study aimed to investigate the associations of Achilles tendon cross-sectional area (CSA) and elongation (TE) with patient outcomes after acute Achilles tendon rupture repair. The results showed that a larger CSA at 6 weeks postoperatively could predict better long-term functional outcome, while more elongation at 12 months was predictive of inferior functional outcome.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
