Article
Oncology
Ruping Xiang, Juan Xu, Huiyun Yu, Qiong Chen, Yujuan Huang, Zhi Li, Cheng Yu, Rong Cu
Summary: The study showed that both carbamazepine and sodium valproate can significantly improve cognitive function in patients with first generalized seizures, with similar clinical efficacy. The blood uric acid levels of patients increase after treatment, showing a positive correlation between blood uric acid level and cognitive function.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Clinical Neurology
Samira Khani, Seyed Amir Hejazi, Mehdi Yaghoubi, Ehsan Sharifipour
Summary: The study assessed the efficacy of concurrent magnesium-sodium valproate therapy in comparison to magnesium or sodium valproate alone in migraine prophylaxis. Results showed that magnesium enhances the antimigraine properties of sodium valproate and reduces the required valproate dose for migraine prophylaxis.
JOURNAL OF HEADACHE AND PAIN
(2021)
Review
Clinical Neurology
Yifei Zhu, Junlan Yang, Xinjian Zhu
Summary: Based on the meta-analysis, the combination of sodium valproate and levetiracetam in the treatment of pediatric epilepsy significantly improves the overall therapeutic effect and reduces the occurrence of adverse drug reactions.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Clinical Neurology
Zhen-Ye Ji, Yi-Qian Huang, Wen-Zhen He
Summary: Sodium valproate combined with topiramate is more effective than sodium valproate alone for treating refractory epilepsy, and it also shows better control over the frequency of absence seizures, atonic seizures, and tonic-clonic seizures.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
M. N. Sachidananda Adiga, P. B. Nandit, Usha Adiga, Vijaya Shenoy
Summary: This study aimed to explore the association between UGT2B7 genetic polymorphism and clinical efficacy and safety in pediatric epileptic patients on sodium valproate monotherapy. The results showed no significant difference in clinical outcome based on UGT2B7 genetic polymorphism patterns, but C161T and G211T were significantly associated with treatment response.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pediatrics
P. B. Nandith, Usha Adiga, Vijaya Shenoy, Sachidananda M. N. Adiga
Summary: The study evaluated the pattern of UGT1A6 and UGT2B7 gene polymorphism in pediatric epileptic patients, and found that although there were differences in gene polymorphisms, they did not contribute to variations in sodium valproate serum concentration in this study population.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Review
Pharmacology & Pharmacy
Hannah Batchelor
Summary: This study compared the adherence, healthcare resource, and cost implications of using Episenta (R) minitablets and Epilim (R) monolithic tablet in the treatment of epilepsy in children in England. The results suggest that minitablet formulations may provide better therapeutic outcomes and reduced healthcare resource costs in pediatric populations, particularly for patients aged 0-17. Additional investigation is needed to further understand this difference in outcomes between the two formulations.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Clinical Neurology
Lingyan Yu, Wenjie Zhu, Xiuping Zhu, Yan Lu, Zhenwei Yu, Haibin Dai
Summary: The study found that from 2013 to 2018, there was a rapid increase in the number and cost of anti-seizure medication prescriptions for Chinese adult outpatients with epilepsy. The use of newer anti-seizure medications increased, with sodium valproate use decreasing and levetiracetam use dramatically increasing. Monotherapy was more common than combination therapy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Emergency Medicine
Sinem Dogruyol, Sultan Tuna Akgol Gur, Ilker Akbas, Meryem Betos Kocak, Abdullah Osman Kocak, Mustafa Ceylan, Davut Tekyol
Summary: This study compared the efficacy of sodium valproate and ibuprofen in the treatment of acute migraine attacks. The results showed that sodium valproate was superior to ibuprofen in relieving pain, with a significantly higher number of patients achieving the primary endpoint.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Psychiatry
Jing Guo, Yan Liu, Lingling Kong, Yaoyao Sun, Zhe Lu, Tianlan Lu, Haiying Qu, Weihua Yue
Summary: This study aimed to evaluate the prevalence of polycystic ovary syndrome (PCOS) in women taking anticonvulsant mood stabilizers and compare the likelihood of PCOS caused by different medications. The results showed that female patients treated with anticonvulsant mood stabilizers had a higher incidence of PCOS, with valproate having the highest probability.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Endocrinology & Metabolism
Jie Fu, Tao Tao, Zuoxiao Li, Yangmei Chen, Xiu Chen, Jinglun Li, Lilei Peng
Summary: The meta-analysis found that blood AST and GGT levels significantly increased in epileptic patients receiving VPA monotherapy, while elevated blood ALT levels were observed in Asian patients and those in the early stage of VPA treatment. However, caution is needed in interpreting these results due to the small number of included studies.
HORMONE AND METABOLIC RESEARCH
(2021)
Review
Endocrinology & Metabolism
Shuang Li, Linhai Zhang, Nian Wei, Zhenzhen Tai, Changyin Yu, Zucai Xu
Summary: Women with epilepsy are susceptible to polycystic ovary syndrome (PCOS), with a higher prevalence among those taking valproate (VPA) and other anti-seizure medications (ASMs). Epileptiform discharges may disrupt the hypothalamic-pituitary-ovarian (HPO) axis balance, leading to reproductive endocrine abnormalities. Factors such as hormone metabolism and signaling pathways also contribute to these disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Kensuke Nakamura, Aiki Marushima, Yuji Takahashi, Masaki Mochizuki, Akio Kimura, Yu Fukuda, Masahiro Asami, Hidetoshi Nakamoto, Satoshi Egawa, Junya Kaneko, Kyoko Unemoto, Yutaka Kondo, Chikara Yonekawa, Masatoshi Uchida, Eisei Hoshiyama, Takeshi Yamada, Kazushi Maruo, Eiichi Ishikawa, Yuji Matsumaru, Yoshiaki Inoue
Summary: This study compared the efficacy and safety of levetiracetam (LEV) and fosphenytoin (FPHT) in the treatment of adult status epilepticus (SE). The results showed that LEV had similar efficacy to FPHT, but with higher safety. Therefore, LEV may be recommended as a second-line treatment for adult SE.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Psychiatry
Arto Puranen, Marjaana Koponen, Markku Lahteenvuo, Antti Tanskanen, Jari Tiihonen, Heidi Taipale
Summary: Mood stabilizers are commonly used as adjunctive treatment in schizophrenia, and their use is associated with a decreased risk of psychosis rehospitalization.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Biotechnology & Applied Microbiology
Yi Guo, Lang Chen, Dongmei Wu, Liang Yu, Hongbin Sun, Qiong Zhu
Summary: This study found that sexual function and sperm quality are reduced in young males with epilepsy, with VPA possibly having a negative impact on sperm quality while OXC does not affect sexual function and sperm quality in these patients.
BIOMED RESEARCH INTERNATIONAL
(2021)