Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Crucial requirement of ERK/MAPK signaling in respiratory tract development

(2014) O. Boucherat et al.   DEVELOPMENT

miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development

(2014) G. Carraro et al.   DEVELOPMENT

Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility

(2014) Jill S. Harunaga et al.   DEVELOPMENTAL BIOLOGY

The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors

(2014) John E. Mahoney et al.   DEVELOPMENTAL CELL

Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells

(2014) Rui Zhao et al.   DEVELOPMENTAL CELL

Tissue Crosstalk in Lung Development

(2014) Elizabeth A. Hines et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas

(2014) Hideo Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

(2014) Barbara Treutlein et al.   NATURE

Lung regeneration: mechanisms, applications and emerging stem cell populations

(2014) Darrell N Kotton et al.   NATURE MEDICINE

Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape

(2014) R. S. Kadzik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells

(2014) A. L. Firth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining a mesenchymal progenitor niche at single-cell resolution

(2014) M. E. Kumar et al.   SCIENCE

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally

(2013) E. El Agha et al.   DEVELOPMENT

Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors

(2013) T. Volckaert et al.   DEVELOPMENT

Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry

(2013) R. Dixit et al.   DEVELOPMENT

Development and Regeneration of Sox2+ Endoderm Progenitors Are Regulated by a HDAC1/2-Bmp4/Rb1 Regulatory Pathway

(2013) Yi Wang et al.   DEVELOPMENTAL CELL

Jagged1 is the major regulator of notch-dependent cell fate in proximal airways

(2013) Shubing Zhang et al.   DEVELOPMENTAL DYNAMICS

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling

(2013) José M. González-Sancho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix

(2013) Mahboobe Ghaedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs

(2013) Chiara Francavilla et al.   MOLECULAR CELL

Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor

(2013) Tien Peng et al.   NATURE

Exploring mechanisms of FGF signalling through the lens of structural biology

(2013) Regina Goetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lung epithelial branching program antagonizes alveolar differentiation

(2013) D. R. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

(2013) B. E. Rockich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Stabilization of  -Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies

(2013) S.-E. Kim et al.   SCIENCE

The Hippo Size Control Pathway--Ever Expanding

(2013) J. I. Lin et al.   Science Signaling

Prolonged FGF signaling is necessary for lung and liver induction in Xenopus

(2012) Emily T Shifley et al.   BMC DEVELOPMENTAL BIOLOGY

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Directing Lung Endoderm Differentiation in Pluripotent Stem Cells

(2012) Rachel S. Kadzik et al.   Cell Stem Cell

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells

(2012) M. Morimoto et al.   DEVELOPMENT

Genetic and cellular mechanisms regulating anterior foregut and esophageal development

(2012) Ian J. Jacobs et al.   DEVELOPMENTAL BIOLOGY

Scribble is required for normal epithelial cell–cell contacts and lumen morphogenesis in the mammalian lung

(2012) Laura L. Yates et al.   DEVELOPMENTAL BIOLOGY

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Catenin–SOX2 signaling regulates the fate of developing airway epithelium

(2012) Shuichi Hashimoto et al.   JOURNAL OF CELL SCIENCE

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation

(2012) Pavel Krejci et al.   PLoS One

Characterization of a Novel Fibroblast Growth Factor 10 (Fgf10) Knock-In Mouse Line to Target Mesenchymal Progenitors during Embryonic Development

(2012) Elie El Agha et al.   PLoS One

Integrin Beta 1 Suppresses Multilayering of a Simple Epithelium

(2012) Jichao Chen et al.   PLoS One

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways

(2012) A. Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling

(2012) J. Bao et al.   Science Signaling

Secreted and Transmembrane Wnt Inhibitors and Activators

(2012) C.-M. Cruciat et al.   Cold Spring Harbor Perspectives in Biology

Signaling Networks Regulating Development of the Lower Respiratory Tract

(2012) D. M. Ornitz et al.   Cold Spring Harbor Perspectives in Biology

Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome

(2012) Xiaoning Mou et al.   Stem Cell Research & Therapy

Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System

(2012) Ripla Arora et al.   PLoS Genetics

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2

(2011) E. T. Domyan et al.   DEVELOPMENT

Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development

(2011) Y. Yin et al.   DEVELOPMENT

Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression

(2011) Ashley M. Goss et al.   DEVELOPMENTAL BIOLOGY

Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury

(2011) Thomas Volckaert et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

(2011) Michael D Green et al.   NATURE BIOTECHNOLOGY

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Control of Mitotic Spindle Angle by the RAS-Regulated ERK1/2 Pathway Determines Lung Tube Shape

(2011) Nan Tang et al.   SCIENCE

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Sox2 Activates Cell Proliferation and Differentiation in the Respiratory Epithelium

(2010) David H. Tompkins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

FGF10 controls the patterning of the tracheal cartilage rings via Shh

(2010) F. G. Sala et al.   DEVELOPMENT

Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development

(2010) Shibin Yu et al.   DEVELOPMENTAL BIOLOGY

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development

(2010) Edward E. Morrisey et al.   DEVELOPMENTAL CELL

The building blocks of mammalian lung development

(2010) Emma L. Rawlins   DEVELOPMENTAL DYNAMICS

Patterning and plasticity in development of the respiratory lineage

(2010) Eric T. Domyan et al.   DEVELOPMENTAL DYNAMICS

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

(2010) M. Morimoto et al.   JOURNAL OF CELL SCIENCE

A retinoic acid–dependent network in the foregut controls formation of the mouse lung primordium

(2010) Felicia Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin A deficiency in an infant with PAGOD syndrome

(2009) Ralitza Gavrilova et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Vertebrate Endoderm Development and Organ Formation

(2009) Aaron M. Zorn et al.   Annual Review of Cell and Developmental Biology

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells

(2009) E. L. Rawlins et al.   DEVELOPMENT

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

(2009) P.-N. Tsao et al.   DEVELOPMENT

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development

(2009) J. S. Guseh et al.   DEVELOPMENT

Multiple roles for Sox2 in the developing and adult mouse trachea

(2009) J. Que et al.   DEVELOPMENT

Stabilized β-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis

(2009) Changgong Li et al.   DEVELOPMENTAL BIOLOGY

Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut

(2009) Ashley M. Goss et al.   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Conditional gene inactivation reveals roles forFgf10andFgfr2in establishing a normal pattern of epithelial branching in the mouse lung

(2009) Lisa L. Abler et al.   DEVELOPMENTAL DYNAMICS

Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway

(2009) Ethan David Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblast Growth Factor 10 Plays a Causative Role in the Tracheal Cartilage Defects in a Mouse Model of Apert Syndrome

(2009) Caterina Tiozzo et al.   PEDIATRIC RESEARCH

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

(2009) Rose-Anne Romano et al.   PLoS One

Sox2 Is Required for Maintenance and Differentiation of Bronchiolar Clara, Ciliated, and Goblet Cells

(2009) David H. Tompkins et al.   PLoS One

 -Catenin promotes respiratory progenitor identity in mouse foregut

(2009) K. S. Harris-Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

Prenatal Lung Epithelial Cell-Specific Abrogation of Alk3-Bone Morphogenetic Protein Signaling Causes Neonatal Respiratory Distress by Disrupting Distal Airway Formation

(2008) Jianping Sun et al.   AMERICAN JOURNAL OF PATHOLOGY

Sprouty proteins, masterminds of receptor tyrosine kinase signaling

(2008) Miguel A. Cabrita et al.   ANGIOGENESIS

FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia

(2008) Pia Nyeng et al.   BMC DEVELOPMENTAL BIOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme

(2008) J. Rajagopal et al.   DEVELOPMENT

Bmp4 is required for tracheal formation: A novel mouse model for tracheal agenesis

(2008) Yina Li et al.   DEVELOPMENTAL BIOLOGY

Sox2 is important for two crucial processes in lung development: Branching morphogenesis and epithelial cell differentiation

(2008) Cristina Gontan et al.   DEVELOPMENTAL BIOLOGY

An FGF–WNT gene regulatory network controls lung mesenchyme development

(2008) Yongjun Yin et al.   DEVELOPMENTAL BIOLOGY

Centrifugal migration of mesenchymal cells in embryonic lung

(2008) Lin Shan et al.   DEVELOPMENTAL DYNAMICS

Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung

(2008) Lan Yi et al.   DEVELOPMENTAL DYNAMICS

Transcriptional dynamics of endodermal organ formation

(2008) Richard I. Sherwood et al.   DEVELOPMENTAL DYNAMICS

γ-Secretase Activation of Notch Signaling Regulates the Balance of Proximal and Distal Fates in Progenitor Cells of the Developing Lung

(2008) Po-Nien Tsao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction

(2008) Xiao-qing Gan et al.   JOURNAL OF CELL BIOLOGY

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

(2008) P. Bovolenta et al.   JOURNAL OF CELL SCIENCE

The branching programme of mouse lung development

(2008) Ross J. Metzger et al.   NATURE

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration

(2008) Yuzhen Zhang et al.   NATURE GENETICS

Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by β-catenin Signaling

(2008) Stijn P. De Langhe et al.   PLoS One

Conditional Stabilization of β-Catenin Expands the Pool of Lung Stem Cells

(2008) Susan D. Reynolds et al.   STEM CELLS