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Orthopedics
Wee L. Lam, Julia D. H. Oh, Edward J. Johnson, Sandra Poyatos Pertinez, Chloe Stephens, Megan G. Davey
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2019)
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Biochemistry & Molecular Biology
William K. W. Ho, Lucy Freem, Debiao Zhao, Kevin J. Painter, Thomas E. Woolley, Eamonn A. Gaffney, Michael J. McGrew, Athanasia Tzika, Michel C. Milinkovitch, Pascal Schneider, Armin Drusko, Franziska Matthaeus, James D. Glover, Kirsty L. Wells, Jeanette A. Johansson, Megan G. Davey, Helen M. Sang, Michael Clinton, Denis J. Headon
Correction
Immunology
C. Pridans, A. Raper, G. M. Davis, J. Alves, K. A. Sauter, L. Lefevre, T. Regan, S. Meek, L. Sutherland, A. J. Thomson, S. Clohisey, S. J. Bush, R. Rojo, Z. M. Lisowski, R. Wallace, K. Grabert, K. R. Upton, Y. T. Tsai, D. Brown, L. B. Smith, K. M. Summers, N. A. Mabbott, P. Piccardo, M. T. Cheeseman, T. Burdon, D. A. Hume
JOURNAL OF IMMUNOLOGY
(2019)
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Cell Biology
Katharine M. Irvine, Melanie Caruso, Michelle Ferrari Cestari, Gemma M. Davis, Sahar Keshvari, Anuj Sehgal, Clare Pridans, David A. Hume
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
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Biochemistry & Molecular Biology
Katherine A. Staines, Mark Hopkinson, Scott Dillon, Louise A. Stephen, Robert Fleming, Antonia Sophocleous, David J. Buttle, Andrew A. Pitsillides, Colin Farquharson
BIOSCIENCE REPORTS
(2020)
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Multidisciplinary Sciences
Anirudh Patir, Amy M. Fraser, Mark W. Barnett, Lynn McTeir, Joe Rainger, Megan G. Davey, Tom C. Freeman
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Masahiro Horita, Colin Farquharson, Louise A. Stephen
Summary: This review summarizes the differential expression patterns and functional roles of the miR-29 family in diseases such as osteoarthritis, osteoporosis, cardiorenal, and immune disease, highlighting their therapeutic potential. Further research is needed to identify the precise mechanisms of the miR-29 family in these diseases and their potential in therapeutics.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
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Neurosciences
Jean Marie Delalande, Nandor Nagy, Conor J. McCann, Dipa Natarajan, Julie E. Cooper, Gabriela Carreno, David Dora, Alison Campbell, Nicole Laurent, Polychronis Kemos, Sophie Thomas, Caroline Alby, Tania Attie-Bitach, Stanislas Lyonnet, Malcolm P. Logan, Allan M. Goldstein, Megan G. Davey, Robert M. W. Hofstra, Nikhil Thapar, Alan J. Burns
Summary: The study revealed the important role of TALPID3 in GI and ENS development, with its absence leading to abnormal GI tract development in chicken embryos. ENS formation was found not to depend on TALPID3 but on environmental cues. The presence of KIAA0586 mutation in human fetal tissues showed similar findings to animal models, highlighting the essential role of TALPID3 in human GI tract development and patterning.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Correction
Neurosciences
Jean Marie Delalande, Nandor Nagy, Conor J. McCann, Dipa Natarajan, Julie E. Cooper, Gabriela Carreno, David Dora, Alison Campbell, Nicole Laurent, Polychronis Kemos, Sophie Thomas, Caroline Alby, Tania Attie-Bitach, Stanislas Lyonnet, Malcolm P. Logan, Allan M. Goldstein, Megan G. Davey, Robert M. W. Hofstra, Nikhil Thapar, Alan J. Burns
FRONTIERS IN MOLECULAR NEUROSCIENCE
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Endocrinology & Metabolism
Shun-Neng Hsu, Louise A. Stephen, Scott Dillon, Elspeth Milne, Behzad Javaheri, Andrew A. Pitsillides, Amanda Novak, Jose Luis Millan, Vicky E. MacRae, Katherine A. Staines, Colin Farquharson
Summary: This study found that in mice with advanced CKD, bone density increased in cortical bone but decreased in trabecular bone. TNAP expression was decreased while PHOSPHO1 expression was increased in CKD bones. In P1KO CKD mice, cortical BMD was restored and other structural parameters improved. In vitro experiments showed that hyperphosphatemia and/or hyperparathyroidism downregulated TNAP and PHOSPHO1 expressions.
JOURNAL OF ENDOCRINOLOGY
(2022)
Editorial Material
Orthopedics
Wee Lam, Julia Oh, Megan G. Davey
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
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Biochemistry & Molecular Biology
Dean A. Houston, Louise A. Stephen, Soher N. Jayash, Katherine Myers, Kirsty Little, Mark Hopkinson, Andrew A. Pitsillides, Vicky E. MacRae, Jose Luis Millan, Katherine A. Staines, Colin Farquharson
Summary: The administration of intermittent parathyroid hormone (iPTH) can enhance bone mineralization and osteogenesis by regulating the expression of key enzymes such as PHOSPHO1.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
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Biology
Jenaid M. Rees, Victoria A. Sleight, Stephen J. Clark, Tetsuya Nakamura, J. Andrew Gillis, Megan G. Davey
Summary: The anterior-posterior polarity in the gill skeleton of cartilaginous fishes is regulated by the interaction between Wnt and Shh signaling. Wnt signaling restricts the formation of posterior branchial ray cartilages by inhibiting Shh signal transduction, determining the distribution of gill arches. This study highlights the importance of signaling interactions at embryonic tissue boundaries for cell fate determination in vertebrate pharyngeal arches.
Article
Biochemistry & Molecular Biology
Masahiro Horita, Shun-Neng Hsu, Anna Raper, Colin Farquharson, Louise A. Stephen
Summary: The study found that miR-29b-3p plays an inhibitory role in the downregulation induced by TGF-beta 1, thereby affecting the cell cycle distribution of murine articular chondrocytes, suggesting that miR-29b-3p may contribute to reduced chondrocyte proliferation in OA.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Endocrinology & Metabolism
Scott Dillon, Karla Suchacki, Shun-Neng Hsu, Louise A. Stephen, Rongling Wang, William P. Cawthorn, Alan J. Stewart, Fabio Nudelman, Nicholas M. Morton, Colin Farquharson
Summary: This study characterized the skeletal phenotype of Enpp6(-/-) mice for the first time, revealing transient hypomineralization in young animals compared with WT controls. The data suggest that ENPP6 is important for bone mineralization and may function upstream of PHOSPHO1 as a novel means of generating its substrates inside matrix vesicles.