期刊
DEVELOPMENTAL DYNAMICS
卷 238, 期 5, 页码 1092-1099出版社
WILEY
DOI: 10.1002/dvdy.21947
关键词
diet-induced obesity; mammary duct development; nonpregnant mice; mammary gland; ductal development; fibrillar collagen; myopeithelium; leptin
资金
- JSPS Research Fellowships
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Kao Research Council for the Study of Healthcare Science
Mammary glands develop postnatally in response to the hypothalamic-pituitary-gonadal axis. Obesity-induced changes in the local environment, however, retard mammary gland development during late pregnancy and lactation. To clarify the effects of obesity on fundamental duct development, we compared the mammary glands of nulliparous nonpregnant obese mice fed a high-fat diet with those of lean mice fed a normal diet. Obese mice had enlarged mammary glands, reflecting fat pad size, whereas the ducts in obese mice showed a less dense distribution with less frequent branching. Additionally, the ducts were surrounded by thick collagen layers, and were incompletely lined with myoepithelium. Because leptin receptors were localized in the epithelium region and leptin that was highly expressed in the obese glands suppressed mammary epithelial cell proliferation in vitro, the present results suggest that obesity disrupts mammary ductal development, possibly by remodeling the mammary microenvironment and promoting the expression of such paracrine factors as leptin. Developmental Dynamics 238:1092-1099, 2009. (C) 2009 Wiley-Liss, Inc.
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