Article
Developmental Biology
Takayoshi Yamamoto, Toki Kaneshima, Kohei Tsukano, Tatsuo Michiue
Summary: The nervous system is derived from three neuroectodermal regions and their differentiation is regulated by morphogens. The role of the extracellular component heparan sulfate (HS) in regulating morphogen gradients in neural patterning is still debated. This study focused on Hs6st1, an HS modification enzyme, and found that it selectively regulates morphogen distribution in neuroectodermal patterning. The results suggest that cell-autonomous 6-O sulfation of HS affects neuroectodermal patterning through both morphogen accumulation and dispersal.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hong-Nhung Tran, Quy-Hoai Nguyen, Ji-eun Jeong, Duc-Linh Loi, Youn Hee Nam, Tong Ho Kang, Jaeseung Yoon, Kwanghee Baek, Yongsu Jeong
Summary: Our study identifies the embryonic patterning gene Dbx1 as a key player in the development and survival of the inferior colliculus (IC) in the midbrain. We find that Dbx1 prevents apoptotic cell death in postnatal IC by repressing genes involved in cell death. Furthermore, we uncover that Tcf7l2 functions downstream of Dbx1 and loss of Tcf7l2 leads to IC phenotypes similar to Dbx1 mutant mice. We also demonstrate that the Dbx1-Tcf7l2 cascade functions upstream of Ap-2 delta, essential for IC development and survival.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Jian He, Jing Yan, Jianfang Wang, Liangyu Zhao, Qian Xin, Yang Zeng, Yuxi Sun, Han Zhang, Zhijie Bai, Zongcheng Li, Yanli Ni, Yandong Gong, Yunqiao Li, Han He, Zhilei Bian, Yu Lan, Chunyu Ma, Lihong Bian, Heng Zhu, Bing Liu, Rui Yue
Summary: This study utilized single-cell transcriptomics to uncover the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis, identifying distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. Additionally, a perichondrial embryonic skeletal stem/progenitor cell subset marked by CADM1 and enriched with FOXP1/2 transcriptional network was identified, shedding light on the early development of skeletal tissues.
Article
Multidisciplinary Sciences
Jacinta I. Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E. Harris, Helena Rodriguez-Caro, Aimee Jacquemot, Jack J. Miller, Eleanor M. Stuart, Magda Wolna, Emily Hardman, Fabrice Prin, Eva Lana-Elola, Rifdat Aoidi, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Timothy J. Mohun, Samira Lakhal-Littleton, Sarah De Val, Eleni Giannoulatou, Duncan B. Sparrow
Summary: Congenital heart disease is a common human birth defect with many cases potentially caused by maternal iron deficiency, which can be prevented by iron administration in early pregnancy. Genetic predisposition and environmental factors may interact to impact the development of heart disease.
NATURE COMMUNICATIONS
(2021)
Review
Biology
Makoto Osanai, Akira Takasawa, Kumi Takasawa, Daisuke Kyuno, Yusuke Ono, Kazufumi Magara
Summary: Retinoic acid (RA), an active metabolite of vitamin A, plays a crucial role in cell fate decisions. Cytochrome P450 family 26A1, B1, and C1 (CYP26A1, B1, and C1) enzymes protect cells from RA exposure by converting it into rapidly excreted derivatives. High expression levels of CYP26 enzymes in various types of cancer suggest their potential as therapeutic targets for CYP26-expressing malignancies.
MEDICAL MOLECULAR MORPHOLOGY
(2023)
Article
Immunology
Amelie V. Bos, Martje N. Erkelens, Sebastiaan T. A. Koenders, Mario van der Stelt, Marjolein van Egmond, Reina E. Mebius
Summary: The uptake and metabolism of vitamin A within human immune cells has been difficult to study due to the small, lipophilic nature of retinoids. By synthesizing novel bio-orthogonal retinoid-based probes, researchers were able to monitor retinoid molecules in real-time in immune cells, revealing that various immune cell subsets have the capacity to internalize and metabolize retinoids. This study sheds light on the mechanism of vitamin A metabolism and its importance for human adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fumihiro Fujiki, Soyoko Morimoto, Akiko Katsuhara, Akane Okuda, Saeka Ogawa, Eriko Ueda, Maki Miyazaki, Ayako Isotani, Masahito Ikawa, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama
Summary: In this study, researchers identified a key molecule called retinol dehydrogenase 10 (Rdh10) that plays a crucial role in regulating T cell differentiation. They found that vitamin A metabolites activate retinoic acid receptor (RAR) signaling, leading to comprehensive epigenetic repression of memory T cell-associated genes and promoting effector T cell differentiation. Importantly, memory T cells generated through blocking RAR signaling showed strong anti-tumor responses in adoptive T cell transfer setting. This study highlights the importance of vitamin A metabolism and its signaling in memory T cell-based cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Elhusseiny Mohamed Mahmoud Abdelwahab, Judit Bovari-Biri, Gabor Smuk, Tunde Harko, Janos Fillinger, Judit Moldvay, Vera P. Krymskaya, Judit E. Pongracz
Summary: The study found that TSC mutation leads to dysregulation of vitamin A metabolic enzymes and downregulation of RARβ, while RA can restore RARβ levels and limit cell migration with minimal effect on proliferation. Combination of RA and rapamycin can normalize enzyme expression and activity, restore RARβ expression, and reduce cell proliferation and migration.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Shuangshuang Guo, Lai He, Yuanke Zhang, Junlong Niu, Changwu Li, Zhengfan Zhang, Peng Li, Binying Ding
Summary: The effects of vitamin A on the immune responses and vitamin A metabolism in broiler chickens challenged with necrotic enteritis were investigated. The results showed that necrotic enteritis induced intestinal injury and upregulated the expression of Th2 and Treg cell-related cytokines, as well as RALDH and RAR/RXR mRNA expression. Vitamin A supplementation did not alleviate intestinal injury or Th2 cell-related cytokine expression, but improved hepatic vitamin A deposition and inhibited the expression of RALDH-3, RXR, and the JAK/STAT signaling pathway in the spleen.
Review
Biodiversity Conservation
Alice M. H. Bedois, Hugo J. Parker, Robb Krumlauf
Summary: Hox genes are key drivers of morphogenesis in metazoans, playing important roles in patterning the antero-posterior axis in chordates. Their collinear expression is linked to their response to major signaling pathways like retinoic acid. RA signaling is a key regulator of the gene regulatory network underlying hindbrain segmentation in vertebrates, including the Hox genes.
Article
Nutrition & Dietetics
King Clyde B. Yabut, Nina Isoherranen
Summary: Cellular retinoic acid binding proteins (CRABP1 and CRABP2) have a high affinity for all-trans-retinoic acid (atRA), and bind to atRA-clearing enzymes and nuclear receptors. This study shows that CRABP1 and CRABP2 also impact atRA metabolism by CYP26A1, suggesting their critical role in modulating atRA concentrations.
Article
Multidisciplinary Sciences
Hyunyoung Jeong, Abigail T. Armstrong, Nina Isoherranen, Lindsay Czuba, Amy Yang, Katelynn Zumpf, Jody Ciolino, Elizabeth Torres, Catherine S. Stika, Katherine L. Wisner
Summary: This study aimed to investigate the changes in systemic retinoid levels during pregnancy. Blood samples from 20 healthy pregnant women were analyzed, revealing significant decreases in 13-cis-retinoic acid levels during pregnancy, with rebound increases in retinol and 13-cis-retinoic acid levels after delivery. Additionally, all-trans-retinoic acid levels peaked in mid-pregnancy. The comprehensive profiling of retinoid levels provides insights into the metabolism and homeostasis of vitamin A during pregnancy.
Article
Developmental Biology
Bhaval Parmar, Urja Verma, Kashmira Khaire, Dhanush Danes, Suresh Balakrishnan
Summary: The recent study reveals the vital role of COX-2 in orchestrating craniofacial structures in chick embryos by modulating CNCC proliferation and migration.
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2021)
Review
Hematology
Noga Ussishkin, Daphna Nachmani
Summary: Hematopoietic stem cells play a vital role in blood production and their dysfunction can lead to diseases. Recent research has shown that specific vitamins and amino acids can affect normal hematopoiesis and stem cell function, highlighting the importance of understanding the link between nutrition and blood physiology.
EXPERIMENTAL HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Himanshu Arora, Mounia Boulberdaa, Rehana Qureshi, Verda Bitirim, Nadia Messadeq, Pascal Dolle, Canan G. Nebigil
Correction
Neurosciences
Monika Rataj-Baniowska, Anna Niewiadomska-Cimicka, Marie Paschaki, Monika Szyszka-Niagolov, Laura Carramolino, Miguel Torres, Pascal Dolle, Wojciech Krezel
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Anna Niewiadomska-Cimicka, Agnieszka Krzyzosiak, Tao Ye, Anna Podlesny-Drabiniok, Doulaye Dembele, Pascal Dolle, Wojciech Krezel
MOLECULAR NEUROBIOLOGY
(2017)
Article
Multidisciplinary Sciences
Diana Langer, Igor Martianov, Daniel Alpern, Muriel Rhinn, Celine Keime, Pascal Dolle, Gabrielle Mengus, Irwin Davidson
NATURE COMMUNICATIONS
(2016)
Article
Multidisciplinary Sciences
Himanshu Arora, Mounia Boulberdaa, Rehana Qureshi, Verda Bitirim, Adeline Gasser, Nadia Messaddeq, Pascal Dolle, Canan G. Nebigil
SCIENTIFIC REPORTS
(2016)
Article
Biology
Carole Haushalter, Brigitte Schuhbaur, Pascal Dolle, Muriel Rhinn
Article
Dentistry, Oral Surgery & Medicine
Supawich Morkmued, Joseph Hemmerle, Eric Mathieu, Virginie Laugel-Haushalter, Branka Dabovic, Daniel B. Rifkin, Pascal Dolle, Karen Niederreither, Agnes Bloch-Zupan
EUROPEAN JOURNAL OF ORAL SCIENCES
(2017)
Article
Ophthalmology
Sandeep Kumar, Pascal Dolle, Norbert B. Ghyselinck, Gregg Duester
EXPERIMENTAL EYE RESEARCH
(2017)
Article
Physiology
Supawich Morkmued, Virginie Laugel-Haushalter, Eric Mathieu, Brigitte Schuhbaur, Joseph Hemmerle, Pascal Dolle, Agnes Bloch-Zupan, Karen Niederreither
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Multidisciplinary Sciences
Anna Podlesny-Drabiniok, Joanna Sobska, Angel R. de Lera, Krystyna Golembiowska, Katarzyna Kaminska, Pascal Dolle, Malgorzata Cebrat, Wojciech Krezel
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Supawich Morkmued, Francois Clauss, Brigitte Schuhbaur, Valerie Fraulob, Eric Mathieu, Joseph Hemmerle, Hans Clevers, Bon-Kyoung Koo, Pascal Dolle, Agnes Bloch-Zupan, Karen Niederreither
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Glenda Evangelina Comai, Marketa Tesarova, Valerie Dupe, Muriel Rhinn, Pedro Vallecillo-Garcia, Fabio da Silva, Betty Feret, Katherine Exelby, Pascal Dolle, Leif Carlsson, Brian Pryce, Francois Spitz, Sigmar Stricker, Tomas Zikmund, Jozef Kaiser, James Briscoe, Andreas Schedl, Norbert B. Ghyselinck, Ronen Schweitzer, Shahragim Tajbakhsh
Review
Neurosciences
Marion Ciancia, Monika Rataj-Baniowska, Nicolas Zinter, Vito Antonio Baldassarro, Valerie Fraulob, Anne-Laure Charles, Rosana Alvarez, Shin-ichi Muramatsu, Angel R. de Lera, Bernard Geny, Pascal Dolle, Anna Niewiadomska-Cimicka, Wojciech Krezel
Summary: Retinoic acid receptor beta (RAR beta) plays an important role in brain development and neuroprotection of a specific type of neurons called striatopallidal medium spiny neurons (spMSNs). Lack of RAR beta leads to mitochondrial dysfunction and neurodegeneration, making the neurons more vulnerable. In vitro experiments show that an RAR beta agonist can reduce toxicity to striatal neurons, while in vivo experiments show that RAR beta-deficient neurons are more sensitive to a specific mitochondrial toxin. These findings are significant for understanding the role of retinoic acid in brain development and neurodegenerative diseases.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biology
Fabio Da Silva, Fariba Jian Motamedi, Lahiru Chamara Weerasinghe Arachchige, Amelie Tison, Stephen T. Bradford, Jonathan Lefebvre, Pascal Dolle, Norbert B. Ghyselinck, Kay D. Wagner, Andreas Schedl
Summary: Retinoic acid (RA) plays a crucial role in cardiac development and post-myocardial infarction heart protection, with direct effects on cardiomyocytes and potential links to genes involved in cardiac repair.
Article
Developmental Biology
Carole Haushalter, Laure Asselin, Valerie Fraulob, Pascal Dolle, Muriel Rhinn
DEVELOPMENTAL BIOLOGY
(2017)