期刊
DEVELOPMENTAL CELL
卷 31, 期 5, 页码 599-613出版社
CELL PRESS
DOI: 10.1016/j.devcel.2014.10.012
关键词
-
资金
- Biotechnology and Biological Sciences Research Council [BB/E0154761]
- European Research Council under the European Community, ERC [243273]
- European Blaschko Visiting Research Fellowship
- EMBO Long-Term Fellowship
- Biotechnology and Biological Sciences Research Council [BB/E015476/1] Funding Source: researchfish
- European Research Council (ERC) [243273] Funding Source: European Research Council (ERC)
- BBSRC [BB/E015476/1] Funding Source: UKRI
Both developing and adult organisms need efficient strategies for wound repair. In adult mammals, wounding triggers an inflammatory response that can exacerbate tissue injury and lead to scarring. In contrast, embryonic wounds heal quickly and with minimal inflammation, but how this is achieved remains incompletely understood. Using in vivo imaging in the developing brain of Xenopus laevis, we show that ATP release from damaged cells and subsequent activation of purinergic receptors induce long-range calcium waves in neural progenitor cells. Cytoskeletal reorganization and activation of the actomyosin contractile machinery in a Rho kinase-dependent manner then lead to rapid and pronounced apical-basal contractions of the neuroepithelium. These contractions drive the expulsion of damaged cells into the brain ventricle within seconds. Successful cell expulsion prevents the death of nearby cells and an exacerbation of the injury. Cell expulsion through neuroepithelial contraction represents a mechanism for rapid wound healing in the developing brain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据