期刊
DEVELOPMENTAL CELL
卷 29, 期 6, 页码 729-739出版社
CELL PRESS
DOI: 10.1016/j.devcel.2014.04.025
关键词
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资金
- Austrian Science Funds FWF [W901-B12, SFB F3402-B3, P2465-B24, TRP 308-N15]
- NIH [GM19629]
- Austrian Federal Ministry for Science and Research
- European Commission
- NAWI Graz
- [F3005-B12 LIPOTOX]
- Austrian Science Fund (FWF) [F 3005, W 901, TRP 308] Funding Source: researchfish
Membrane phospholipids typically contain fatty acids (FAs) of 16 and 18 carbon atoms. This particular chain length is evolutionarily highly conserved and presumably provides maximum stability and dynamic properties to biological membranes in response to nutritional or environmental cues. Here, we show that the relative proportion of C16 versus C18 FAs is regulated by the activity of acetyl-CoA carboxylase (Acc1), the first and rate-limiting enzyme of FA de novo synthesis. Acc1 activity is attenuated by AMPK/Snf1-dependent phosphorylation, which is required to maintain an appropriate acyl-chain length distribution. Moreover, we find that the transcriptional repressor Opi1 preferentially binds to C16 over C18 phosphatidic acid (PA) species: thus, C16-chain containing PA sequesters Opi1 more effectively to the ER, enabling AMPK/Snf1 control of PA acyl-chain length to determine the degree of derepression of Opi1 target genes. These findings reveal an unexpected regulatory link between the major energy-sensing kinase, membrane lipid composition, and transcription.
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